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An FDA-approved drug library screening identifies proteasome inhibitors as selective cytotoxic agents for angiosarcoma cells
An FDA-approved drug library screening identifies proteasome inhibitors as selective cytotoxic agents for angiosarcoma cells
Cutaneous angiosarcoma (CAS) is a life-threatening neoplasm with a 5-year survival rate of under 40% in advanced cases. As...
Sequential ATR and PARP inhibition overcomes acquired DNA damaging agent resistance in pancreatic ductal adenocarcinoma
Sequential ATR and PARP inhibition overcomes acquired DNA damaging agent resistance in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains the most lethal cancer. While DNA damaging agents such as platinum and PAR...
Cyst fluid ctDNA as a biomarker for genetic profiling and treatment monitoring in cystic brain metastases
Cyst fluid ctDNA as a biomarker for genetic profiling and treatment monitoring in cystic brain metastases
Cystic brain metastases (CBM) present significant clinical challenges due to their heterogeneity and the limitations of cu...
The predictive and prognostic role of radiologically defined sarcopenia in head and neck cancer: a systematic review and multi-level meta-analysis
The predictive and prognostic role of radiologically defined sarcopenia in head and neck cancer: a systematic review and multi-level meta-analysis
Radiologically defined sarcopenia (RS), defined as a lack of skeletal muscle mass (SMM) measured on cross-sectional CT or ...
Spatial omics technology potentially promotes the progress of tumor immunotherapy
Spatial omics technology potentially promotes the progress of tumor immunotherapy
Immunotherapy has become an indispensable modality in the treatment of cancer, yet challenges such as resistance and subst...
Preferences for multi-cancer tests (MCTs) in primary care: discrete choice experiments of general practitioners and the general public in England
Preferences for multi-cancer tests (MCTs) in primary care: discrete choice experiments of general practitioners and the general public in England
Multi-Cancer tests (MCTs) hold potential to detect cancer across multiple sites and some predict the origin of the cancer ...
Ending nuclear weapons, before they end us
This May, the World Health Assembly (WHA) will vote on re-establishing a man...
EHMT1 mediates cellular motility in embryonal rhabdomyosarcoma by activating SOX8 expression
EHMT1 mediates cellular motility in embryonal rhabdomyosarcoma by activating SOX8 expression
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. When metastatic, survival of children with RMS is...
Urinary microbiome-based metagenomic signature for the noninvasive diagnosis of hepatocellular carcinoma
Urinary microbiome-based metagenomic signature for the noninvasive diagnosis of hepatocellular carcinoma
Gut microbial dysbiosis is implicated in chronic liver disease and hepatocellular carcinoma (HCC), but the role of microbi...
Farnesyl-transferase inhibitors show synergistic anticancer effects in combination with novel KRAS-G12C inhibitors
Farnesyl-transferase inhibitors show synergistic anticancer effects in combination with novel KRAS-G12C inhibitors
Inhibition of mutant KRAS challenged cancer research for decades. Recently, allele-specific inhibitors were approved for t...
wMKL: multi-omics data integration enables novel cancer subtype identification via weight-boosted multi-kernel learning
wMKL: multi-omics data integration enables novel cancer subtype identification via weight-boosted multi-kernel learning
Cancer is a heterogeneous disease driven by complex molecular alterations. Cancer subtypes determined from multi-omics dat...
Albendazole inhibits colon cancer progression and therapy resistance by targeting ubiquitin ligase RNF20
Albendazole inhibits colon cancer progression and therapy resistance by targeting ubiquitin ligase RNF20
The repurposing of FDA-approved drugs for anti-cancer therapies is appealing due to their established safety profiles and ...
Rethinking surgical revisions: impact of the MonarchE trial on axillary dissection in hormone-positive HER2-negative early breast cancer patients potentially eligible for abemaciclib
Rethinking surgical revisions: impact of the MonarchE trial on axillary dissection in hormone-positive HER2-negative early breast cancer patients potentially eligible for abemaciclib
The MonarchE trial explored the use of abemaciclib, a CDK4/6 inhibitor, as an adjuvant treatment in high-risk early-stage ...
Identification of novel molecular subtypes to improve the classification framework of nasopharyngeal carcinoma
Identification of novel molecular subtypes to improve the classification framework of nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) treatment is largely based on a ‘one-drug-fits-all’ strategy in patients with s...
Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells
Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells
5-Fluorouracil (5-FU) remains a core component of systemic therapy for colorectal cancer (CRC). However, response rates re...
A phase I study of ATR inhibitor gartisertib (M4344) as a single agent and in combination with carboplatin in patients with advanced solid tumours
A phase I study of ATR inhibitor gartisertib (M4344) as a single agent and in combination with carboplatin in patients with advanced solid tumours
Gartisertib is an oral inhibitor of ataxia telangiectasia and Rad3-related protein (ATR), a key kinase of the DNA damage r...
The presenting symptom signatures of incident cancer: evidence from the English 2018 National Cancer Diagnosis Audit
The presenting symptom signatures of incident cancer: evidence from the English 2018 National Cancer Diagnosis Audit
Understanding relationships between presenting symptoms and subsequently diagnosed cancers can inform symptom awareness ca...
Epithelial ovarian cancer survival by race and ethnicity in an equal-access healthcare population
Previous studies in the general population observed that compared with non-Hispanic White women, Pacific Islander and Blac...
Correction: Efficacy of GV1001 with gemcitabine/capecitabine in previously untreated patients with advanced pancreatic ductal adenocarcinoma having high serum eotaxin levels (KG4/2015): an open-label, randomised, Phase 3 trial
Division of Gastroenterology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, ...
Fatal and non-fatal breast cancers in women targeted by BreastScreen Norway: a cohort study
Fatal and non-fatal breast cancers in women targeted by BreastScreen Norway: a cohort study
Many breast cancer survivors experience anxiety related to dying from their disease even if it is detected at an early sta...
Characterisation of FLT3 alterations in childhood acute lymphoblastic leukaemia
Characterisation of FLT3 alterations in childhood acute lymphoblastic leukaemia
Alterations of FLT3 are among the most common driver events in acute leukaemia with important clinical implications, since...
Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer
Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer
The determinants of metastasis in mismatch repair deficiency with high levels of microsatellite instability (MSI-H) in col...
Downregulation of N4-acetylcytidine modification in myeloid cells attenuates immunotherapy and exacerbates hepatocellular carcinoma progression
Downregulation of N4-acetylcytidine modification in myeloid cells attenuates immunotherapy and exacerbates hepatocellular carcinoma progression
N4-acetylcytidine (ac4C) is a conserved and abundant mRNA modification that controls protein expression by affecting trans...
Opposing roles by KRAS and BRAF mutation on immune cell infiltration in colorectal cancer – possible implications for immunotherapy
Opposing roles by KRAS and BRAF mutation on immune cell infiltration in colorectal cancer – possible implications for immunotherapy
The immune response has important clinical value in colorectal cancer (CRC) in both prognosis and response to immunotherap...
Risk-reducing mastectomy and breast cancer mortality in women with a BRCA1 or BRCA2 pathogenic variant: an international analysis
Risk-reducing mastectomy and breast cancer mortality in women with a BRCA1 or BRCA2 pathogenic variant: an international analysis
Risk-reducing mastectomy (RRM) is offered to women with a BRCA1 or BRCA2 pathogenic variant, however, there are limited da...
Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against
Aspirin as a possible treatment of cancer has been of increasing interest for over 50 years, but the balance of the risks ...
Health benefits and harms of mammography screening in older women (75+ years)—a systematic review
Health benefits and harms of mammography screening in older women (75+ years)—a systematic review
There is little evidence on the balance between potential benefits and harms of mammography screening in women 75 years an...
Low-dose metronomic cisplatin as an antiangiogenic and anti-inflammatory strategy for cancer
Low-dose metronomic cisplatin as an antiangiogenic and anti-inflammatory strategy for cancer
Conventional chemotherapy is based on the maximum tolerated dose (MTD) and requires treatment-free intervals to restore no...
Multivitamin use and all-cause and cause-specific mortality in cancer survivors
Multivitamin use and all-cause and cause-specific mortality in cancer survivors
Despite no sufficient evidence on benefits and harms of multivitamin use, cancer survivors use multivitamins as a self-car...
Educational attainment in survivors of childhood cancer in Denmark, Finland, and Sweden
Educational attainment in survivors of childhood cancer in Denmark, Finland, and Sweden
Survivors of childhood cancer may face difficulties at school. We investigated whether childhood cancer affects attainment...
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