Egas-Bejar D, Huh WW. Rhabdomyosarcoma in adolescent and young adult patients: current perspectives. Adolesc Health Med Ther. 2014;5:115–25.

PubMed  PubMed Central  Google Scholar 

Keller C, Guttridge DC. Mechanisms of impaired differentiation in rhabdomyosarcoma. FEBS J. 2013;280:4323–34.

Parham DM, Barr FG. Classification of rhabdomyosarcoma and its molecular basis. Adv Anat Pathol. 2013;20:387–97.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Galili N, Davis RJ, Fredericks WJ, Mukhopadhyay S, Rauscher FJ, Emanuel BS, et al. Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. Nat Genet. 1993;5:230–5.

Bennicelli JL, Fredericks WJ, Wilson RB, Rauscher FJ, Barr FG. Wild type PAX3 protein and the PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma contain potent, structurally distinct transcriptional activation domains. Oncogene. 1995;11:119–30.

PubMed  CAS  Google Scholar 

Perkins SM, Shinohara ET, DeWees T, Frangoul H. Outcome for children with metastatic solid tumors over the last four decades. PLoS ONE. 2014;9:e100396.

Article  PubMed  PubMed Central  Google Scholar 

Hedrick E, Crose L, Linardic CM, Safe S. Histone deacetylase inhibitors inhibit rhabdomyosarcoma by reactive oxygen species-dependent targeting of specificity protein transcription factors. Mol Cancer Ther. 2015;14:2143–53.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, et al. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev. 2002;16:1779–91.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tachibana M, Ueda J, Fukuda M, Takeda N, Ohta T, Iwanari H, et al. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev. 2005;19:815–26.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang Z, Wu H, Jiang Y, Meng L, Xiong J, Zhao Z, et al. Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability. Genes Dev. 2015;29:379–93.

Article  PubMed  PubMed Central  Google Scholar 

Ohno H, Shinoda K, Ohyama K, Sharp LZ, Kajimura S. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature. 2013;504:163–7.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Schaefer A, Sampath SC, Intrator A, Min A, Gertler TS, Surmeier DJ, et al. Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron. 2009;64:678–91.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shinkai Y, Tachibana M. H3K9 methyltransferase G9a and the related molecule GLP. Genes Dev. 2011;25:781–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shankar SR, Bahirvani AG, Rao VK, Bharathy N, Ow JR, Taneja R. G9a, a multipotent regulator of gene expression. Epigenetics. 2013;8:16–22.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Casciello F, Windloch K, Gannon F, Lee JS. Functional role of G9a histone methyltransferase in cancer. Front Immunol. 2015;6:487.

Article  PubMed  PubMed Central  Google Scholar 

Bhat AV, Palanichamy Kala M, Rao VK, Pignata L, Lim HJ, Suriyamurthy S, et al. Epigenetic regulation of the PTEN–AKT–RAC1 axis by G9a Is critical for tumor growth in alveolar rhabdomyosarcoma. Cancer Res. 2019;79:2232–43.

Article  PubMed  CAS  Google Scholar 

Nachiyappan A, Soon JLJ, Lim HJ, Lee VK, Taneja R. EHMT1 promotes tumor progression and maintains stemness by regulating ALDH1A1 expression in alveolar rhabdomyosarcoma. J Pathol. 2022;256:349–62.

Article  PubMed  CAS  Google Scholar 

Yang Y, Shen J, Yan D, Yuan B, Zhang S, Wei J, et al. Euchromatic histone lysine methyltransferase 1 regulates cancer development in human gastric cancer by regulating E-cadherin. Oncol Lett. 2018;15:9480–6.

PubMed  PubMed Central  Google Scholar 

Guan X, Zhong X, Men W, Gong S, Zhang L, Han Y. Analysis of EHMT1 expression and its correlations with clinical significance in esophageal squamous cell cancer. Mol Clin Oncol. 2014;2:76–80.

Article  PubMed  CAS  Google Scholar 

Huang J, Dorsey J, Chuikov S, Pérez-Burgos L, Zhang X, Jenuwein T, et al. G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem. 2010;285:9636–41.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cebrian A, Pharoah PD, Ahmed S, Ropero S, Fraga MF, Smith PL, et al. Genetic variants in epigenetic genes and breast cancer risk. Carcinogenesis. 2006;27:1661–9.

Article  PubMed  CAS  Google Scholar 

Han YC, Zheng ZL, Zuo ZH, Yu YP, Chen R, Tseng GC, et al. Metallothionein 1 h tumour suppressor activity in prostate cancer is mediated by euchromatin methyltransferase 1: MT1h suppresses prostate cancer through activation of EHMT1. J Pathol 2013;230:184–93.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pal A, Leung JY, Ang GCK, Rao VK, Pignata L, Lim HJ, et al. EHMT2 epigenetically suppresses Wnt signaling and is a potential target in embryonal rhabdomyosarcoma. eLife. 2020;9:e57683.

Article  PubMed  PubMed Central  CAS  Google Scholar 

McLeod C, Gout AM, Zhou X, Thrasher A, Rahbarinia D, Brady SW, et al. St. Jude Cloud: a pediatric cancer genomic data-sharing ecosystem. Cancer Discov. 2021;11:1082–99.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang S, Zhu C, Zhu L, Liu H, Liu S, Zhao N, et al. Oncogenicity of the transcription factor SOX8 in hepatocellular carcinoma. Med Oncol. 2014;31:918.

Xie SL, Fan S, Zhang SY, Chen WX, Li QX, Pan GK, et al. SOX8 regulates cancer stem-like properties and cisplatin-induced EMT in tongue squamous cell carcinoma by acting on the Wnt/β-catenin pathway. Int J Cancer. 2018;142:1252–65.

Article  PubMed  CAS  Google Scholar 

Chen S, Li H, Li X, Chen W, Zhang X, Yang Z, et al. High SOX8 expression promotes tumor growth and predicts poor prognosis through GOLPH3 signaling in tongue squamous cell carcinoma. Cancer Med. 2020;9:4274–89.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tang H, Chen B, Liu P, Xie X, He R, Zhang L, et al. SOX8 acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer. Carcinogenesis. 2019;40:1278–87.

Article  PubMed  CAS  Google Scholar 

An B, Ji X, Gong Y. Role of CITED2 in stem cells and cancer. Oncol Lett. 2020;20:107.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sock E, Schmidt K, Hermanns-Borgmeyer I, Bösl MR, Wegner M. Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8. Mol Cell Biol. 2001;21:6951–9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

González Alvarado MN, Aprato J. Sox8: a multifaceted transcription factor in development and disease. Biol Open. 2025;14:bio061840.

Article  PubMed  PubMed Central  Google Scholar 

Bamforth SD, Bragança J, Eloranta JJ, Murdoch JN, Marques FI, Kranc KR, et al. Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Nat Genet. 2001;29:469–74.

Article