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Biomolecular phase separation in tumorigenesis: from aberrant condensates to therapeutic vulnerabilities
Biomolecular phase separation in tumorigenesis: from aberrant condensates to therapeutic vulnerabilities
Biomolecular phase separation has emerged as a fundamental mechanism governing intracellular spatial organization and func...
The application of organoids in treatment decision-making for digestive system cancers: progress and challenges
The application of organoids in treatment decision-making for digestive system cancers: progress and challenges
Digestive system cancers—including gastric, liver, colorectal, esophageal, and pancreatic malignancies—remain ...
Single-cell multi-omics in cancer immunotherapy: from tumor heterogeneity to personalized precision treatment
Single-cell multi-omics in cancer immunotherapy: from tumor heterogeneity to personalized precision treatment
Cancer immunotherapy has revolutionized clinical oncology; however, the inherent complexity and heterogeneity of cancer pr...
Advances in novel cell death mechanisms in breast cancer: intersecting perspectives on ferroptosis, cuproptosis, disulfidptosis, and pyroptosis
Advances in novel cell death mechanisms in breast cancer: intersecting perspectives on ferroptosis, cuproptosis, disulfidptosis, and pyroptosis
The advent of molecular classification has ushered breast cancer treatment into the era of precision medicine. Nevertheles...
AXL: shapers of tumor progression and immunosuppressive microenvironments
AXL: shapers of tumor progression and immunosuppressive microenvironments
As research progresses, our understanding of the tumor microenvironment (TME) has undergone profound changes. The TME evol...
Commentary on “Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth”
Commentary on “Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth”
VTRNA2-1 is a polymorphically imprinted locus. The proportion of individuals with a maternally imprinted VTRNA2-1 locus is...
The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy
The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy
KRAS is one of the most mutated genes, driving alternations in metabolic pathways that include enhanced nutrient uptaking,...
Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity
Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity
Lipid nanoparticles (LNPs) for mRNA delivery have advanced significantly, but LNP-mediated DNA delivery still faces clinic...
Emerging role of exosomes in cancer therapy: progress and challenges
Emerging role of exosomes in cancer therapy: progress and challenges
This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, car...
Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies
Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies
Autophagy is an essential cellular homeostasis pathway initiated by multiple stimuli ranging from nutrient deprivation to ...
Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study
Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study
Commercial anti-CD19 chimeric antigen receptor T-cell therapies (CART19) are efficacious against advanced B-cell non-Hodgk...
Effects of RNA methylation on Tumor angiogenesis and cancer progression
Effects of RNA methylation on Tumor angiogenesis and cancer progression
Tumor angiogenesis plays vital roles in the growth and metastasis of cancer. RNA methylation is one of the most common mod...
A liquid biopsy signature of circulating extracellular vesicles-derived RNAs predicts response to first line chemotherapy in patients with metastatic colorectal cancer
A liquid biopsy signature of circulating extracellular vesicles-derived RNAs predicts response to first line chemotherapy in patients with metastatic colorectal cancer
Colorectal cancer (CRC) is one of the most threatening tumors in the world, and chemotherapy remains dominant in the treat...
Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects
Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects
The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on the cell surface, which provid...
Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT...
hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma
hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma
Circular RNAs (circRNAs) play important roles in the occurrence and development of cancer and chemoresistance. DNA damage ...
Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer?
Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer?
Hepatocellular carcinoma (HCC), one of the most prevalent forms of cancer worldwide, presents a significant global healthc...
The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
Current research has demonstrated that extracellular vesicles (EVs) and circulating tumor cells (CTCs) are very closely re...
Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients
Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients
Immune checkpoint inhibitors (ICIs) are a therapeutic strategy for various cancers although only a subset of patients resp...
A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state
A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state
Despite major improvements in immunotherapeutic strategies, the immunosuppressive tumor microenvironment remains a major o...
Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lac...
The University of Kansas Cancer Center (KUCC), an NCI designated comprehensive cancer center
The University of Kansas Cancer Center (KUCC), an NCI designated comprehensive cancer center
With world-class, transdisciplinary, expertise and technical capabilities in drug discovery and cellular immunotherapeutic...
Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy
Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy
The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for...
CDK5: an oncogene or an anti-oncogene: location location location
CDK5: an oncogene or an anti-oncogene: location location location
Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 an...
Exploiting innate immunity for cancer immunotherapy
Exploiting innate immunity for cancer immunotherapy
Immunotherapies have revolutionized the treatment paradigms of various types of cancers. However, most of these immunomodu...
The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer
The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer
Currently, only limited knowledge is available regarding the phenotypic association between fibroblast growth factor recep...
ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma
ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma
Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system. Angiogenesis is a main contributing factor f...
Outsmarting trogocytosis to boost CAR NK/T cell therapy
Outsmarting trogocytosis to boost CAR NK/T cell therapy
Chimeric antigen receptor (CAR) NK and T cell therapy are promising immunotherapeutic approaches for the treatment of canc...
CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Noncoding RNAs such as circular RNAs (circRNAs) are abundant in the human body and influence the occurrence and developmen...
Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid
Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid
Knowing the homologous recombination deficiency (HRD) status in advanced epithelial ovarian cancer (EOC) is vital for pati...
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