Ghantous A, Nusslé SG, Nassar FJ, Spitz N, Novoloaca A, Krali O, Nickels E, Cahais V, Cuenin C, Roy R, Li S, Caron M, Lam D, Fransquet PD, Casement J, Strathdee G, Pearce MS, Hansen HM, Lee HH, Lee YS, de Smith AJ, Sinnett D, Håberg SE, McKay JA, Nordlund J, Magnus P, Dwyer T, Saffery R, Wiemels JL, Munthe-Kaas MC, Herceg Z. Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth. Mol Cancer. 2024;23(1):238. https://doi.org/10.1186/s12943-024-02118-4.
Article CAS PubMed PubMed Central Google Scholar
Raitoharju E, Rajić S, Marttila S. Non-coding 886 (nc886/vtRNA2-1), the epigenetic odd duck - implications for future studies. Epigenetics. 2024;19(1):2332819. https://doi.org/10.1080/15592294.2024.2332819.
Article PubMed PubMed Central Google Scholar
Lee YS, Lee YS. The mystique of epigenetic regulation: the remarkable case of a human noncoding RNA, nc886. Epigenomics 2024 Oct 28:1–17. https://doi.org/10.1080/17501911.2024.2415278
Marttila S, Tamminen H, Rajić S, Mishra PP, Lehtimäki T, Raitakari O, Kähönen M, Kananen L, Jylhävä J, Hägg S, Delerue T, Peters A, Waldenberger M, Kleber ME, März W, Luoto R, Raitanen J, Sillanpää E, Laakkonen EK, Heikkinen A, Ollikainen M, Raitoharju E. Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues. Epigenomics. 2022;14(18):1105–24. https://doi.org/10.2217/epi-2022-0228.
Article CAS PubMed Google Scholar
Silver MJ, Kessler NJ, Hennig BJ, Dominguez-Salas P, Laritsky E, Baker MS, Coarfa C, Hernandez-Vargas H, Castelino JM, Routledge MN, Gong YY, Herceg Z, Lee YS, Lee K, Moore SE, Fulford AJ, Prentice AM, Waterland RA. Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment. Genome Biol. 2015;16(1):118. https://doi.org/10.1186/s13059-015-0660-y.
Article CAS PubMed PubMed Central Google Scholar
Marttila S, Viiri LE, Mishra PP, Kühnel B, Matias-Garcia PR, Lyytikäinen LP, Ceder T, Mononen N, Rathmann W, Winkelmann J, Peters A, Kähönen M, Hutri-Kähönen N, Juonala M, Aalto-Setälä K, Raitakari O, Lehtimäki T, Waldenberger M, Raitoharju E. Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs. Clin Epigenetics. 2021;13(1):143. https://doi.org/10.1186/s13148-021-01132-3.
Article CAS PubMed PubMed Central Google Scholar
Carpenter BL, Remba TK, Thomas SL, Madaj Z, Brink L, Tiedemann RL, Odendaal HJ, Jones PA. Oocyte age and preconceptual alcohol use are highly correlated with epigenetic imprinting of a noncoding RNA (nc886). Proc Natl Acad Sci U S A. 2021;118(12):e2026580118. https://doi.org/10.1073/pnas.2026580118.
Article CAS PubMed PubMed Central Google Scholar
Park JL, Lee YS, Song MJ, Hong SH, Ahn JH, Seo EH, Shin SP, Lee SJ, Johnson BH, Stampfer MR, Kim HP, Kim SY, Lee YS. Epigenetic regulation of RNA polymerase III transcription in early breast tumorigenesis. Oncogene. 2017;36(49):6793–804. https://doi.org/10.1038/onc.2017.285. Epub 2017 Aug 28. PMID: 28846112.
Article CAS PubMed Google Scholar
Treppendahl MB, Qiu X, Søgaard A, Yang X, Nandrup-Bus C, Hother C, Andersen MK, Kjeldsen L, Möllgård L, Hellström-Lindberg E, Jendholm J, Porse BT, Jones PA, Liang G, Grønbæk K. Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML. Blood. 2012;119(1):206–16. https://doi.org/10.1182/blood-2011-06-362541.
Article CAS PubMed PubMed Central Google Scholar
Fort RS, Duhagon MA. Pan-cancer chromatin analysis of the human vtRNA genes uncovers their association with cancer biology. F1000Res. 2021;10:182. https://doi.org/10.12688/f1000research.28510.2. PMID: 34354812; PMCID: PMC8287541.
Article CAS PubMed PubMed Central Google Scholar
Dugué PA, Dowty JG, Joo JE, Wong EM, Makalic E, Schmidt DF, English DR, Hopper JL, Pedersen J, Severi G, MacInnis RJ, Milne RL, Giles GG, Southey MC. Heritable methylation marks associated with breast and prostate cancer risk. Prostate. 2018;78(13):962–969. doi: 10.1002/pros.23654. Epub 2018 May 29. PMID: 30133758.
FDA-NIH Biomarker Working Group. BEST (Biomarkers, EndpointS, and other Tools) Resource [Internet]. Silver Spring (MD): Food and Drug Administration (US); 2016-. Diagnostic Biomarker. 2016 Dec 22 [Updated 2020 Nov 16]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK402285/ Co-published by National Institutes of Health (US), Bethesda (MD).
Hannon E, Knox O, Sugden K, Burrage J, Wong CCY, Belsky DW, Corcoran DL, Arseneault L, Moffitt TE, Caspi A, Mill J. Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins. PLoS Genet. 2018;14(8):e1007544. https://doi.org/10.1371/journal.pgen.1007544.
Article CAS PubMed PubMed Central Google Scholar
Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, Yefanov A, Lee H, Zhang N, Robertson CL, Serova N, Davis S, Soboleva A. NCBI GEO: archive for functional genomics data sets–update. Nucleic Acids Res. 2013;41(Database issue):D991–5. https://doi.org/10.1093/nar/gks1193. Epub 2012 Nov 27. PMID: 23193258; PMCID: PMC3531084.
Article CAS PubMed Google Scholar
Busche S, Ge B, Vidal R, Spinella JF, Saillour V, Richer C, Healy J, Chen SH, Droit A, Sinnett D, Pastinen T. Integration of high-resolution methylome and transcriptome analyses to dissect epigenomic changes in childhood acute lymphoblastic leukemia. Cancer Res. 2013;73(14):4323–36. https://doi.org/10.1158/0008-5472.CAN-12-4367.
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