Bray F, Laversanne M, Sung H et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2024;74(3):229–63. https://doi.org/10.3322/caac.21834

Han B, Zheng R, Zeng H, et al. Cancer incidence and mortality in china, 2022. J Natl Cancer Cent. 2024;4(1):47–53. https://doi.org/10.1016/j.jncc.2024.01.006.

Article  PubMed  PubMed Central  Google Scholar 

Howlader N, Cronin KA, Kurian AW et al. Differences in breast cancer survival by molecular subtypes in the united States. Cancer Epidemiol Biomarkers Prev. 27(6):619–26. https://doi.org/10.1158/1055-9965

Moasser MM. The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene. 2007;26(45):6469–87. https://doi.org/10.1038/sj.onc.1210477.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmid P, Rugo HS, Adams S et al. Atezolizumab plus Nab-Paclitaxel as First-Line treatment for unresectable, locally advanced or metastatic Triple-Negative breast cancer (IMpassion130): updated efficacy and safety from a randomised, Double-Blind, Placebo-Controlled, phase 3 trial. Lancet Oncol. 21(1):44–59. https://doi.org/10.1016/S1470-2045(19)30689-8

Obeng E. Apoptosis (programmed cell death) and its signals - A review. Braz J Biol. 2021;81(4):1133–43. https://doi.org/10.1590/1519-6984.228437.

Galluzzi L, Vitale I, Aaronson SA et al. Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. Cell Death Differ. 25(3):486–541. https://doi.org/10.1038/s41418-017-0012-4

Tang D, Kang R, Berghe TV et al. The molecular machinery of regulated cell death. Cell Res. 31(12):1077–94. https://doi.org/10.1038/s41422-021-00546-1

Dixon SJ, Lemberg KM, Lamprecht MR et al. Ferroptosis: an Iron-Dependent form of nonapoptotic cell death. Cell. 149(5):1060–72. https://doi.org/10.1016/j.cell.2012.03.042

Wang Q, Wang Y, Ding J et al. A bioorthogonal system reveals antitumour immune function of pyroptosis. Nature. 579(7799):421–6. https://doi.org/10.1038/s41586-020-2079-1

Xie J, Yang Y, Gao Y, et al. Cuproptosis: mechanisms and links with cancers. Mol Cancer. 2023;22(1):46. https://doi.org/10.1186/s12943-023-01732-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Zhuang L, Gan B. Disulfidptosis: disulfide stress-induced cell death. Trends Cell Biol. 2024;34(4):327–37. https://doi.org/10.1016/j.tcb.2023.07.009.

Article  CAS  PubMed  Google Scholar 

Viswanathan VS, Ryan MJ, Dhruv HD et al. Dependency of a Therapy-Resistant state of cancer cells on a lipid peroxidase pathway. Nature. 547(7664):453–7. https://doi.org/10.1038/nature23007

Tsvetkov P, Coy S, Petrova B et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 375(6586):1254–61. https://doi.org/10.1126/science.abf0529

Zhang Z, Zhang Y, Xia S et al. Gasdermin E suppresses tumour growth by activating Anti-Tumour immunity. Nature. 579(7799):415–20. https://doi.org/10.1038/s41586-020-2071-9

Shi J, Zhao Y, Wang K et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 526(7575):660–5. https://doi.org/10.1038/nature15514

Bian Z, Fan R, Xie LA. Novel Cuproptosis-Related prognostic gene signature and validation of differential expression in breast cancer. Front Pharmacol. 13:938259. https://doi.org/10.3389/fphar.2022.938259

Manz DH, Blanchette NL, Paul BT, et al. Iron and cancer: recent insights. Ann N Y Acad Sci. 2016;1368(1):149–61. https://doi.org/10.1111/nyas.13008.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma S, Henson ES, Chen Y, et al. Ferroptosis is induced following Siramesine and lapatinib treatment of breast cancer cells. Cell Death Dis. 2016;7(7):e2307. https://doi.org/10.1038/cddis.2016.208.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Doll S, Proneth B, Tyurina YY, et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2017;13(1):91–8. https://doi.org/10.1038/nchembio.2239.

Article  CAS  PubMed  Google Scholar 

Dinarvand N, Khanahmad H, Hakimian SM, et al. Evaluation of long-chain acyl-coenzyme A synthetase 4 (ACSL4) expression in human breast cancer. Res Pharm Sci. 2020;15(1):48–56. https://doi.org/10.4103/1735-5362.278714.

Article  PubMed  PubMed Central  Google Scholar 

Zhang C, Zhou Y, Chen T, et al. Isocitrate dehydrogenase 2 regulates the proliferation of triple-negative breast cancer through the ferroptosis pathway. Sci Rep. 2024;14(1):4732. https://doi.org/10.1038/s41598-024-55561-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moasser MM. The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene. 26(45):6469–87. https://doi.org/10.1038/sj.onc.1210477

Loibl S, Poortmans P, Morrow M, et al. Breast cancer. Lancet. 2021;397(10286):1750–69. https://doi.org/10.1016/S0140-6736(20)32381-3.

Article  CAS  PubMed  Google Scholar 

Sevieri M, Mazzucchelli S, Barbieri L, et al. Ferritin nanoconjugates guide trastuzumab brain delivery to promote an antitumor response in murine HER2 + breast cancer brain metastasis. Pharmacol Res. 2023;196:106934. https://doi.org/10.1016/j.phrs.2023.106934.

Article  CAS  PubMed  Google Scholar 

Ye T, Yang W, Gao T, et al. Trastuzumab-induced cardiomyopathy via ferroptosis-mediated mitochondrial dysfunction. Free Radic Biol Med. 2023;206:143–61. https://doi.org/10.1016/j.freeradbiomed.2023.06.019.

Article  CAS  PubMed  Google Scholar 

Xie Y, Wang B, Zhao Y, et al. Mammary adipocytes protect triple-negative breast cancer cells from ferroptosis. J Hematol Oncol. 2022;15(1):72. https://doi.org/10.1186/s13045-022-01297-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Wang X, Lu S, et al. Erastin triggers autophagic death of breast cancer cells by increasing intracellular iron levels. Oncol Lett. 2020;20(4):57. https://doi.org/10.3892/ol.2020.11918.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park SY, Jeong KJ, Poire A, et al. Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer. Cell Death Dis. 2023;14(8):532. https://doi.org/10.1038/s41419-023-06042-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen T, Leng J, Tan J, et al. Discovery of novel potent covalent glutathione peroxidase 4 inhibitors as highly selective ferroptosis inducers for the treatment of Triple-Negative breast cancer. J Med Chem. 2023;66(14):10036–59. https://doi.org/10.1021/acs.jmedchem.3c00967.

Article  CAS  PubMed  Google Scholar 

Yang J, Zhou Y, Xie S, et al. Metformin induces ferroptosis by inhibiting ufmylation of SLC7A11 in breast cancer. J Exp Clin Cancer Res. 2021;40(1):206. https://doi.org/10.1186/s13046-021-02012-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mutlu T, Ozoran E, Trabulus DC, et al. Expression of genes related to iron homeostasis in breast cancer. Mol Biol Rep. 2023;50(6):5157–63. https://doi.org/10.1007/s11033-023-08433-1.

Article  CAS  PubMed  Google Scholar 

Lin Z, Yang M. Lipidomics analysis in ferroptosis. Methods Mol Biol. 2023;2712:149–56. https://doi.org/10.1007/978-1-0716-3433-2_13.

Article  CAS  PubMed  Google Scholar 

Li W, Zhang Y, Wang Q, et al. 6-Gingerol ameliorates ulcerative colitis by inhibiting ferroptosis based on the integrative analysis of plasma metabolomics and network Pharmacology. Food Funct. 2024;15(11):6054–67. https://doi.org/10.1039/d4fo00952e.

Article  CAS  PubMed  Google Scholar 

Chang Y, Jiang X, Dou J, et al. Investigating the potential risk of cadmium exposure on seizure severity and anxiety-like behaviors through the ferroptosis pathway in epileptic mice: an integrated multi-omics approach. J Hazard Mater. 2024;480:135814. https://doi.org/10.1016/j.jhazmat.2024.135814.

Article  CAS  PubMed  Google Scholar 

Ishida S, Andreux P, Poitry-Yamate C et al. Bioavailable Copper Modulates Oxidative Phosphorylation and Growth of Tumors. Proc Natl Acad Sci. 110(48):19507–19512. https://doi.org/10.1073/pnas.1318431110

Li L, Li L, Sun Q. High expression of cuproptosis-related SLC31A1 gene in relation to unfavorable outcome and deregulated immune cell infiltration in breast cancer: an analysis based on public databases. BMC Bioinformatics. 2022;23(1):350. https://doi.org/10.1186/s12859-022-04894-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu J, Ling X, Sun Y, et al. FDX1 enhances endometriosis cell Cuproptosis via G6PD-mediated redox homeostasis. Apoptosis. 2023;28(7–8):1128–40. https://doi.org/10.1007/s10495-023-01845-1.

Article  CAS  PubMed