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Biological and clinical significance of tumour-infiltrating lymphocytes in the era of immunotherapy: a multidimensional approach
Biological and clinical significance of tumour-infiltrating lymphocytes in the era of immunotherapy: a multidimensional approach
Immune-checkpoint inhibitors (ICIs) have improved clinical outcomes across several solid tumour types. Prominent efforts h...
Adding brentuximab vedotin to lenalidomide and rituximab improves OS in R/R DLBCL
Haematopoietic stem cell transplantation (HSCT) and CD19-targeted chimeric antigen receptor (CAR) T cells are potentially ...
Circulating tumour DNA in early stage and locally advanced NSCLC: ready for clinical implementation?
Circulating tumour DNA in early stage and locally advanced NSCLC: ready for clinical implementation?
Circulating tumour DNA (ctDNA) can be released by cancer cells into biological fluids through apoptosis, necrosis or activ...
Early intervention with daratumumab improves survival for patients with high-risk smouldering myeloma
Recent results from the phase III AQUILA trial demonstrate the benefit of fixed-duration monotherapy with daratumumab over...
Early promising results with addition of an ICI and an anti-angiogenic to TACE
Transarterial chemoembolization (TACE) is the standard-of-care treatment for patients with intermediate-stage hepatocellul...
Transforming paediatric AML trials: from failing one-size-fits-all methods to precision oncology
Transforming paediatric AML trials: from failing one-size-fits-all methods to precision oncology
Paediatric acute myeloid leukaemia (AML) highlights the challenges of drug development for rare diseases, in which limited...
Thermal ablation is safer than resection of colorectal liver lesions
Surgical resection is the standard of care for patients with colorectal liver metastases. Thermal ablation has emerged as ...
Perioperative chemotherapy superior to preoperative chemoradiotherapy for locally advanced EAC
Two multimodal treatment strategies, perioperative chemotherapy and preoperative chemoradiotherapy, have been shown to imp...
Patients with uncommon EGFR mutations also benefit from first-line osimertinib
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Chemotherapy in EGFR-mutated NSCLC: optimizing combinations with TKIs and amivantamab
Recent results from the FLAURA2 and MARIPOSA-2 trials underline the continued role of chemotherapy in the treatment of pat...
Personalizing adjuvant therapy for patients with colorectal cancer
Personalizing adjuvant therapy for patients with colorectal cancer
The current standard-of-care adjuvant treatment for patients with colorectal cancer (CRC) comprises a fluoropyrim...
Combination neoadjuvant therapies are paving the way for bladder preservation to become the standard for selected patients
Neoadjuvant cisplatin-based combination chemotherapy followed by radical cystectomy with pelvic lymphadenectomy is the cur...
CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn
CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn
Chimeric antigen receptor (CAR) T cells have been approved for use in patients with B cell malignancies or relapsed and/or...
From the ESMO Congress 2023
As in 2017, this year’s ESMO Congress brought many members of the oncology community together in Madrid, this time with &g...
Computational immunogenomic approaches to predict response to cancer immunotherapies
Computational immunogenomic approaches to predict response to cancer immunotherapies
Cancer immunogenomics is an emerging field that bridges genomics and immunology. The establishment of large-scale genomic ...
THOR provides new data on the efficacy of erdafitinib
The outcomes of patients with metastatic urothelial carcinoma (mUC) and non-muscle invasive urothelial carcinoma (NMIBC) f...
Activity of selpercatinib confirmed in phase III trials
In May 2020, the FDA granted Accelerated Approval to the RET kinase inhibitor selpercatinib for patients with metastatic n...
From ESMO 2023: advances in lung cancer
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From CHRYSALIS to PAPILLON: the metamorphosis of amivantamab into frontline therapy for NSCLC
In 2021, data from the phase I CHRYSALIS trial supported the FDA Accelerated Approval of amivantamab, an EGFR–MET bispecif...
Progress in systemic therapy for advanced-stage urothelial carcinoma
Progress in systemic therapy for advanced-stage urothelial carcinoma
Despite recent advances, advanced-stage urothelial carcinoma (aUC) remains incurable, with 5-year survival rates of approx...
Dose-reduction trials in oncology — aiming for less toxicity and better quality of life at lower costs
Projected increases of cancer-attributable health-care costs, accompanied by staff shortages, will impose future economic ...
Molecular tumour boards — current and future considerations for precision oncology
Molecular tumour boards — current and future considerations for precision oncology
Over the past 15 years, rapid progress has been made in developmental therapeutics, especially regarding the use of matche...
Progression-free survival, disease-free survival and other composite end points in oncology: improved reporting is needed
Progression-free survival, disease-free survival and other composite end points in oncology: improved reporting is needed
Composite outcome measures such as progression-free survival and disease-free survival are increasingly used as surrogate ...
Heterogeneity and treatment landscape of ovarian carcinoma
Heterogeneity and treatment landscape of ovarian carcinoma
Ovarian carcinoma is characterized by heterogeneity at the molecular, cellular and anatomical levels, both spatially and t...
Nasopharyngeal cancer screening with an anti-BNLF2b antibody: a new arrow in the quiver?
Epstein–Barr virus (EBV)-based biomarkers are used for nasopharyngeal carcinoma (NPC) screening in endemic regions. ...
Irradiation of asymptomatic bone metastases improves outcomes
Bone metastases are associated with considerable morbidity, and radiotherapy is widely used for palliation of symptomatic ...
Dabrafenib–trametinib moves to the first line in low-grade glioma
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Dabrafenib–trametinib is effective in paediatric high-grade glioma
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Biomarkers for immunotherapy of hepatocellular carcinoma
Biomarkers for immunotherapy of hepatocellular carcinoma
Immune-checkpoint inhibitors (ICIs) are now widely used for the treatment of patients with advanced-stage hepatocellular c...
Complicated regulatory decision-making following inconsistent trial results: the issue with ibrutinib for mantle cell lymphoma
In 2023, a decade after granting Accelerated Approval to the first-in-class BTK inhibitor ibrutinib for the treatment of m...
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