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Antibody-Drug Conjugates Reshape the Landscape of Cancer Therapy: Evolution, Challenges and Future Perspectives from the Concept of “Magic Bullet” to Clinical Application
Antibody-Drug Conjugates Reshape the Landscape of Cancer Therapy: Evolution, Challenges and Future Perspectives from the Concept of “Magic Bullet” to Clinical Application
Antibody-drug conjugates (ADCs), generated by covalently linking tumor-targeted monoclonal antibodies to highly potent cyt...
Artificial Intelligence in Lung Cancer: From Early Detection to Personalized Therapy
Artificial Intelligence in Lung Cancer: From Early Detection to Personalized Therapy
This review highlights recent advances in the use of artificial intelligence (AI) for lung cancer screening, risk stratifi...
Unveiling the Intricate Dance: Signaling Pathways in Liver Cancer Metabolism and Immunity
Unveiling the Intricate Dance: Signaling Pathways in Liver Cancer Metabolism and Immunity
Hepatocellular carcinoma is a type of cancer with high rates of occurrence and death worldwide. Recently, the marked incre...
Clinical Development of Novel-Novel Multi-Company Combination Therapies in Oncology
Clinical Development of Novel-Novel Multi-Company Combination Therapies in Oncology
Most novel anti-cancer therapies involve combining multiple immuno-oncology and/or targeted drugs. The historical paradigm...
Malignant Fungating Wounds in Advanced Cancer: Pathophysiology, Odor Control, and Dignity-Centered Management
Malignant Fungating Wounds in Advanced Cancer: Pathophysiology, Odor Control, and Dignity-Centered Management
Malignant fungating wounds (MFWs) represent a profoundly distressing complication of advanced cancer, affecting an estimat...
Physicians’ Knowledge and Experiences of Counseling on Complementary, Alternative, and Integrative Medicine in Cancer Care: a Qualitative Systematic Review
Physicians’ Knowledge and Experiences of Counseling on Complementary, Alternative, and Integrative Medicine in Cancer Care: a Qualitative Systematic Review
The increasing use of complementary, alternative, and integrative medicine (CAIM) among patients with cancer raises questi...
Immunological Drug–Drug Interactions in Immune Checkpoint Inhibitor Therapy: Mechanisms, Clinical Evidence, and Artificial Intelligence
Immunological Drug–Drug Interactions in Immune Checkpoint Inhibitor Therapy: Mechanisms, Clinical Evidence, and Artificial Intelligence
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, producing durable responses across multiple malignanc...
Mind-Body Therapies for Depression and Anxiety Symptoms in People with Cancer: A Systematic Review with Network Meta-Analysis
Mind-Body Therapies for Depression and Anxiety Symptoms in People with Cancer: A Systematic Review with Network Meta-Analysis
Mind-body therapies (MBTs) are promising forms of treatment for depression and anxiety symptoms in people with cancer, how...
Impact of 18-FDG PET/CT on Multidisciplinary Decision-Making and Management in Abdominal Malignancies: A Systematic Review and Meta-Analysis
Impact of 18-FDG PET/CT on Multidisciplinary Decision-Making and Management in Abdominal Malignancies: A Systematic Review and Meta-Analysis
To systematically review and assess the impact of 18 F-FDG PET/CT on multidisciplinary team (MDT) decision-making...
Preventive and Therapeutic Interventions for Anticancer Drug-induced Dermatologic Toxicities: a Scoping Review
Preventive and Therapeutic Interventions for Anticancer Drug-induced Dermatologic Toxicities: a Scoping Review
Anticancer drug-induced dermatologic toxicities frequently compromise quality of life and treatment adherence. While diver...
Targeting GD2 with CAR-T Cell Therapy in Neuroblastoma: Updates, Challenges, and Future Perspectives
Targeting GD2 with CAR-T Cell Therapy in Neuroblastoma: Updates, Challenges, and Future Perspectives
High-risk neuroblastoma remains a challenging pediatric cancer, with survival rates lagging despite advances in multimodal...
Advancing Systemic Treatment beyond First Line for Advanced Hepatocellular Carcinoma
Advancing Systemic Treatment beyond First Line for Advanced Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) ranks among the most prevalent solid malignancies worldwide. A substantial proportion of pa...
Microbiome in Gastrointestinal Tumors: Implications in Oncogenesis and Therapeutic Response
Microbiome in Gastrointestinal Tumors: Implications in Oncogenesis and Therapeutic Response
To provide an updated overview of the role of the human microbiome in the initiation, progression, and therapeutic respons...
Liquid Biopsy in Modern Oncology: Advances, Challenges, and Future Perspectives in Early Cancer Detection, Minimal Residual Disease, and Dynamic Patient Monitoring
Liquid Biopsy in Modern Oncology: Advances, Challenges, and Future Perspectives in Early Cancer Detection, Minimal Residual Disease, and Dynamic Patient Monitoring
Liquid biopsy has emerged as a minimally invasive approach to overcome the limitations of tissue biopsy in oncology. This ...
Regimen-Related Oral Mucosal Injury: Pathobiology, Clinical Consequences and Rationale for Intervention Across Cancer Treatment Modalities
Regimen-Related Oral Mucosal Injury: Pathobiology, Clinical Consequences and Rationale for Intervention Across Cancer Treatment Modalities
Mucosal injury of the alimentary tract (mucositis) has been a consistent, markedly symptomatic, and clinically disruptive ...
Plant-Derived Diterpenoids as Potential Chemotherapeutics for Gastric Cancer
Plant-Derived Diterpenoids as Potential Chemotherapeutics for Gastric Cancer
Gastric cancer remains a leading contributor to cancer-related mortality worldwide despite its declining incidence, with p...
Decoding the 2023 FIGO Staging System in Endometrial Cancer: A Practical, Visually Guided Framework for Molecular Risk-Adapted Care Incorporating the 2025 Risk Group Update
Decoding the 2023 FIGO Staging System in Endometrial Cancer: A Practical, Visually Guided Framework for Molecular Risk-Adapted Care Incorporating the 2025 Risk Group Update
The FIGO staging system for endometrial cancer has evolved substantially over the past five decades, progressing from the ...
PARP Inhibitors as Radiosensitizers: Current Evidence and Future Directions
PARP Inhibitors as Radiosensitizers: Current Evidence and Future Directions
Radiotherapy remains a fundamental pillar of cancer treatment, however its efficacy is still often limited by tumor radior...
Hereditary Hematopoietic Malignancies: Considerations for Optimizing Diagnosis and Management
Hereditary Hematopoietic Malignancies: Considerations for Optimizing Diagnosis and Management
Hereditary hematopoietic malignancies (HHMs) were once considered extremely rare. As diagnostic testing indications and me...
Brain Tumor Related Epilepsy: Pathophysiology and Multimodal Approach to Management
Brain Tumor Related Epilepsy: Pathophysiology and Multimodal Approach to Management
Patients with brain tumor related epilepsy (BTRE) represent a heterogenous group whose management is complicated by two di...
The Role of Circulating Tumor DNA in Patients Treated with Adjuvant Immune Checkpoint Inhibitors: Clinical Reality or Distant Horizon?
The Role of Circulating Tumor DNA in Patients Treated with Adjuvant Immune Checkpoint Inhibitors: Clinical Reality or Distant Horizon?
Adjuvant immunotherapy has improved outcomes in several cancers, although patient selection and toxicity remain challenges...
Ivermectin in Cancer Treatment: Should Healthcare Providers Caution or Explore Its Therapeutic Potential?
Ivermectin in Cancer Treatment: Should Healthcare Providers Caution or Explore Its Therapeutic Potential?
This review evaluates the scientific evidence for Ivermectin’s potential anticancer properties, an antiparasitic dru...
Indications of Cannabinoids for the Palliation of Cancer-Associated Symptoms: A Systematic Review and Meta-Analysis
Indications of Cannabinoids for the Palliation of Cancer-Associated Symptoms: A Systematic Review and Meta-Analysis
As cancer survival rates are increasing, alternative treatments to improve quality of life, such as cannabinoids, are gain...
Navigating the Colorectal Cancer Maze: Unveiling Pathways To Diagnosis, Management, Pathophysiology and Prevention
Navigating the Colorectal Cancer Maze: Unveiling Pathways To Diagnosis, Management, Pathophysiology and Prevention
Colorectal cancer is the third most prevalent cancer globally and the second leading cause of cancer-related mortality. It...
Cardiotoxic Effects Following CAR-T Cell Therapy: A Literature Review
Cardiotoxic Effects Following CAR-T Cell Therapy: A Literature Review
This paper reviewed the current literature on incidence, clinical manifestations, and risk factors of Chimeric Antigen Rec...
Advances in Radiation Oncology in Soft Tissue Sarcoma
Advances in Radiation Oncology in Soft Tissue Sarcoma
To review recent advances with radiation therapy (RT) for soft tissue sarcomas (STS). Newer data showcases hypofractionate...
Quality End-of-Life Cancer Care: An Unfulfilled but Achievable Imperative
Quality End-of-Life Cancer Care: An Unfulfilled but Achievable Imperative
Disease-focus management of late-stage cancer without addressing patients’ preferences or quality of life (QoL) can ...
Novel Surgical Initiatives in Gastroenteropancreatic Neuroendocrine Tumours
Novel Surgical Initiatives in Gastroenteropancreatic Neuroendocrine Tumours
Neuroendocrine tumours (NET) are rare entities arising from hormone producing cells in the gastroentero-pancreatic (GEP) t...
Weight Management for Fertility-Preservation Therapy in Endometrial Cancer: Opportunities and Challenges
Weight Management for Fertility-Preservation Therapy in Endometrial Cancer: Opportunities and Challenges
Obesity is increasingly recognized as a significant factor impacting the outcomes of fertility-preserving therapies for en...
Paediatric Renal Tumors: A State-of-the-Art Review
Paediatric Renal Tumors: A State-of-the-Art Review
Pediatric renal tumors comprise a wide range of conditions, both malignant and benign, that affect children and require a ...
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