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Differential mitochondrial priming by BCR::ABL1 in B-cell precursor acute lymphoblastic leukemia
Differential mitochondrial priming by BCR::ABL1 in B-cell precursor acute lymphoblastic leukemia
Despite targeted therapies including tyrosine kinase inhibitors (TKI) and immune effector cell-based approaches, BCR::ABL1...
BCR::ABL1 tyrosine kinase inhibitors induce ribosome collisions to activate ZAK-dependent ribotoxic stress and apoptosis in chronic myeloid leukemia
BCR::ABL1 tyrosine kinase inhibitors induce ribosome collisions to activate ZAK-dependent ribotoxic stress and apoptosis in chronic myeloid leukemia
Ribosome collisions act as molecular sensors of cellular stress, yet their role in disease physiology remains unclear. Her...
Isatuximab induces antitumor activity in blastic plasmacytoid dendritic cell neoplasm through cellular cytotoxicity
Isatuximab induces antitumor activity in blastic plasmacytoid dendritic cell neoplasm through cellular cytotoxicity
Competing interests DM has received consultancy from Janssen, AstraZeneca, Chuga...
Loss of GPRC5D enhances the proliferative capacity and competitive fitness of myeloma upon anti-GPRC5D immunotherapy
Loss of GPRC5D enhances the proliferative capacity and competitive fitness of myeloma upon anti-GPRC5D immunotherapy
Immunotherapies targeting surface antigens have transformed the treatment landscape of multiple myeloma (MM), with GPRC5D ...
Pharmacokinetics of CAR T cells in multiple myeloma – the good, the bad, and the ugly
Pharmacokinetics of CAR T cells in multiple myeloma – the good, the bad, and the ugly
CAR T-cell expansion is a critical determinant of efficacy, as it shifts the effector-to-target ratio in favor of the ther...
New insights into JAK2 germline variant-driven stromal cell alterations and proinflammatory bone marrow niche remodeling in myeloproliferative neoplasms
New insights into JAK2 germline variant-driven stromal cell alterations and proinflammatory bone marrow niche remodeling in myeloproliferative neoplasms
Mead AJ, Rugless MJ, Jacobsen SE, Schuh A. Germline JAK2 mutation in a family with hereditary thrombocytosis. N Engl J Med...
Testicular organoids formation from leukaemia-infiltrated prepubertal testicular tissue: implications for fertility preservation
Testicular organoids formation from leukaemia-infiltrated prepubertal testicular tissue: implications for fertility preservation
To identify leukaemic infiltration, testicular biopsy samples from both the enlarged and normal-sized testes were fixed in...
Outcomes of adult patients with newly diagnosed IDH-mutated AML treated with intensive chemotherapy and venetoclax
Outcomes of adult patients with newly diagnosed IDH-mutated AML treated with intensive chemotherapy and venetoclax
DiNardo CD, Ravandi F, Agresta S, Konopleva M, Takahashi K, Kadia T, et al. Characteristics, clinical outcome, and prognos...
A scholar of blood and beauty: remembering Prof. Jacques-Louis Binet (1932–2024)
A scholar of blood and beauty: remembering Prof. Jacques-Louis Binet (1932–2024)
Prof. Jacques-Louis Binet was born in Paris on May 1, 1932, and died there o...
Distinct stromal cell populations define the B-cell acute lymphoblastic leukemia microenvironment
Distinct stromal cell populations define the B-cell acute lymphoblastic leukemia microenvironment
The bone marrow microenvironment plays a critical role in B-cell acute lymphoblastic leukemia (B-ALL) progression, yet its...
Progressive T cell defects correlate with disease outcome in high-count monoclonal B-cell lymphocytosis
Progressive T cell defects correlate with disease outcome in high-count monoclonal B-cell lymphocytosis
Competing interests SAP: Research funding has been provided to the institution f...
Targeting p16INK4a-mediated cellular senescence as a therapeutic strategy for FLT3-ITD-driven acute myeloid leukemia
Targeting p16INK4a-mediated cellular senescence as a therapeutic strategy for FLT3-ITD-driven acute myeloid leukemia
Cellular senescence serves as a critical tumor-suppressive mechanism across various cancer types, yet its role in FLT3-ITD...
Germline Jak2-R1063H mutation interferes with normal hematopoietic development and increases risk of thrombosis and leukemic transformation
Germline Jak2-R1063H mutation interferes with normal hematopoietic development and increases risk of thrombosis and leukemic transformation
The acquired JAK2-V617F mutation plays a causal role in myeloproliferative neoplasms (MPN). Weakly activating JAK2 germlin...
Unraveling the molecular landscape of Erdheim–Chester disease: new insights from methylome and transcriptome integration
Unraveling the molecular landscape of Erdheim–Chester disease: new insights from methylome and transcriptome integration
Erdheim–Chester Disease (ECD) is a rare histiocytosis characterized by a wide spectrum of clinical manifestations. A...
Quality of life and life satisfaction in long-term survivors of acute myeloid leukemia
Quality of life and life satisfaction in long-term survivors of acute myeloid leukemia
We performed a questionnaire-based cross-sectional study to analyze Acute Myeloid Leukemia (AML) long-term survivor (LTS) ...
Profound sympathetic neuropathy in the bone marrow of patients with acute myeloid leukemia
Profound sympathetic neuropathy in the bone marrow of patients with acute myeloid leukemia
Acute myeloid leukemia (AML) is a malignancy with a poor prognosis. The expansion of leukemic cells is associated with the...
Luigi (Gino) Chieco-Bianchi: a man linking hematological and virological research
Luigi (Gino) Chieco-Bianchi: a man linking hematological and virological research
Credit: Courtesy of G. PizzoloLuigi Chieco Bianchi, called Gino by his friends, died in Padua on June 23rd 20...
ACOX1-mediated peroxisomal fatty acid oxidation contributes to metabolic reprogramming and survival in chronic lymphocytic leukemia
ACOX1-mediated peroxisomal fatty acid oxidation contributes to metabolic reprogramming and survival in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is still an incurable disease, with many patients developing resistance to conventional...
Predictors of early morbidity and mortality in newly diagnosed multiple myeloma: data from five randomized, controlled, phase III trials in 3700 patients
Predictors of early morbidity and mortality in newly diagnosed multiple myeloma: data from five randomized, controlled, phase III trials in 3700 patients
Early morbidity and mortality affect patient outcomes in multiple myeloma. Thus, we dissected the incidence and causes of ...
Development of osteonecrosis and improved survival in B-ALL: results of Children’s Oncology Group Trial AALL0232
Development of osteonecrosis and improved survival in B-ALL: results of Children’s Oncology Group Trial AALL0232
Osteonecrosis is a significant toxicity of acute lymphoblastic leukemia (ALL) therapy. In retrospective analyses, superior...
Real world analysis on the determinants of survival in primary plasma cell leukemia in the United States
Real world analysis on the determinants of survival in primary plasma cell leukemia in the United States
Gundesen MT, Lund T, Moeller HEH, Abildgaard N. Plasma cell leukemia: definition, presentation, and treatment. Curr Oncol ...
Cytokine-responsive T- and NK-cells portray SARS-CoV-2 vaccine-responders and infection in multiple myeloma patients
Cytokine-responsive T- and NK-cells portray SARS-CoV-2 vaccine-responders and infection in multiple myeloma patients
Patients with multiple myeloma (MM) routinely receive mRNA-based vaccines to reduce COVID-19-related mortality. However, w...
Correction: Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
Acute myeloid leukemia (AML) is a diverse hematological cancer characterized by uncontrolled proliferation of myeloid blas...
RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment
RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment
The fate of leukaemia stem cells (LSCs) is determined by both their inherent mechanisms and crosstalk with their niches. A...
Correction to: MARCKS regulates tonic and chronic active B cell receptor signaling
Author notesThese authors contributed equally: Chenguang Xu, Yan FangAuthors and AffiliationsMOE Key Laboratory of Protein...
Chronic lymphocytic leukemia patient-derived xenografts recapitulate clonal evolution to Richter transformation
Chronic lymphocytic leukemia patient-derived xenografts recapitulate clonal evolution to Richter transformation
Chronic lymphocytic leukemia (CLL) is a B-cell neoplasm with a heterogeneous clinical behavior. In 5–10% of patients...
Genomic DNA-based measurable residual disease monitoring in pediatric acute myeloid leukemia: unselected consecutive cohort study
Genomic DNA-based measurable residual disease monitoring in pediatric acute myeloid leukemia: unselected consecutive cohort study
Measurable residual disease (MRD) monitoring in childhood acute myeloid leukemia (AML) is used to assess response to treat...
A positive feedback loop regulation between NOTCH1 and USP11 in T-cell leukemia
A positive feedback loop regulation between NOTCH1 and USP11 in T-cell leukemia
NOTCH1 is a transmembrane receptor in a highly conserved signaling pathway that controls cell fate decisions in various or...
Prognostic implications of CD9 in childhood acute lymphoblastic leukemia: insights from a nationwide multicenter study in China
Prognostic implications of CD9 in childhood acute lymphoblastic leukemia: insights from a nationwide multicenter study in China
The outcomes of children with acute lymphoblastic leukemia (ALL) have been incrementally improved with risk-directed chemo...
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