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Lymphatic metastasis in pancreatic cancer: from bedside to bench and back
Lymphatic metastasis in pancreatic cancer: from bedside to bench and back
Pancreatic cancer is an extremely aggressive and lethal malignant cancer; almost half of the patients have distant metasta...
Functions and clinical implications of the liver microenvironment in hepatic uveal melanoma metastases
Functions and clinical implications of the liver microenvironment in hepatic uveal melanoma metastases
Uveal melanoma (UM) is an aggressive intraocular malignancy in adults arising from the melanocytes of the uveal tract. Whi...
Towards a personalized utilization of stereotactic body radiotherapy for the management of liver metastases in solid tumors
Towards a personalized utilization of stereotactic body radiotherapy for the management of liver metastases in solid tumors
The presence of liver metastases in solid tumors is associated with poor prognosis. This adverse impact on patient outcome...
Influence of genetic polymorphisms on gefitinib pharmacokinetics and adverse drug reactions in non-small cell lung cancer patients
Influence of genetic polymorphisms on gefitinib pharmacokinetics and adverse drug reactions in non-small cell lung cancer patients
Gefitinib is a first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) used in the treatm...
Combining radiotherapy and immune checkpoint inhibitors in metastatic cancers: a 25-year review of safety outcomes by the ENRSO Group
Combining radiotherapy and immune checkpoint inhibitors in metastatic cancers: a 25-year review of safety outcomes by the ENRSO Group
This scoping review evaluates the safety and feasibility of combining immune checkpoint inhibitors (ICIs) with radiotherap...
The intricate interplay between circadian rhythm, androgen signaling, hormone therapy, and cellular senescence in prostate cancer
The intricate interplay between circadian rhythm, androgen signaling, hormone therapy, and cellular senescence in prostate cancer
Prostate cancer (PCa) is the second most diagnosed cancer and the fifth leading cause of cancer death among men worldwide....
Advancing small cell lung cancer metastasis research: innovations in preclinical mouse models
Advancing small cell lung cancer metastasis research: innovations in preclinical mouse models
Small cell lung cancer (SCLC) represents one of the most aggressive malignancies, featured with its extraordinary metastat...
Recent advances and treatment strategies in liver metastasis of pancreatic neuroendocrine tumors
Recent advances and treatment strategies in liver metastasis of pancreatic neuroendocrine tumors
Pancreatic neuroendocrine tumors (pNETs) are characterized by significant spatial and temporal heterogeneity, exhibiting a...
Spatial omics: applications and utility in profiling the tumor microenvironment
Spatial omics: applications and utility in profiling the tumor microenvironment
Spatial transcriptomics has emerged as a transformative technology in biomedical research, offering unprecedented insights...
Circulating tumour cells and circulating tumour DNA in head and neck cancer: from molecular insights to clinical impact
Circulating tumour cells and circulating tumour DNA in head and neck cancer: from molecular insights to clinical impact
Head and neck squamous cell cancers (HNSCC) are a clinically and biologically diverse group of malignancies with limited t...
Ferroptosis at the intersection of radiotherapy and immunotherapy
Ferroptosis at the intersection of radiotherapy and immunotherapy
Immunotherapy and radiotherapy are widely used in the treatments of various cancers. However, their application remains li...
Alternate actions of CDK4/6 inhibitors beyond cell cycle blockade: unexplored roles in therapy resistance 
Alternate actions of CDK4/6 inhibitors beyond cell cycle blockade: unexplored roles in therapy resistance 
Cell cycle dysregulation and the aberrant activation of cyclin-dependent kinases (CDKs) lead to uncontrolled cell prolifer...
One-carbon metabolism in cancer: moonlighting functions of metabolic enzymes and anti-tumor therapy
One-carbon metabolism in cancer: moonlighting functions of metabolic enzymes and anti-tumor therapy
One-carbon (1C) metabolism is a central metabolic network that supports nucleotide biosynthesis, amino acid metabolism, an...
Thrombocytosis in cancer patients: when more is not better—in fact, the opposite
Thrombocytosis in cancer patients: when more is not better—in fact, the opposite
Platelets are key elements of hemostasis which play an important role in pathological processes, especially in the context...
The dual fate of DYRK2 in cancer: balancing the light and dark side of tumorigenesis
The dual fate of DYRK2 in cancer: balancing the light and dark side of tumorigenesis
Dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) is emerging as a pivotal player in cancer biology due...
The diverse roles of Hox proteins in the regulation of the cell cycle and their therapeutic value in cancer treatment
The diverse roles of Hox proteins in the regulation of the cell cycle and their therapeutic value in cancer treatment
Tissue morphogenesis and homeostasis occur at the interface of a fine coordination between cell cycle and differentiation ...
Engineered bone matrix models for understanding breast cancer skeletal metastasis
Engineered bone matrix models for understanding breast cancer skeletal metastasis
Bone is the most common site of metastasis in patients with advanced breast cancer and serves as a reservoir from which se...
The impact of genomic ancestry on tumor genomics in head and neck squamous cell carcinoma
The impact of genomic ancestry on tumor genomics in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) exhibits significant survival disparities by ancestry. This review explores ...
PD-L1 subpopulations of metastatic urothelial carcinoma demonstrate heterogeneity to chemotherapy: an integrated analysis of digitized trial results
PD-L1 subpopulations of metastatic urothelial carcinoma demonstrate heterogeneity to chemotherapy: an integrated analysis of digitized trial results
Efforts to translate advances in immunology into anti-cancer immunotherapies have progressed rapidly in recent years. Six ...
Using ultrasound and microbubble to enhance the effects of conventional cancer therapies in clinical settings
Using ultrasound and microbubble to enhance the effects of conventional cancer therapies in clinical settings
It has been demonstrated in preclinical research that the administration of microbubbles with ultrasound can augment the p...
VCAM-1 as a common biomarker in inflammatory bowel disease and colorectal cancer: unveiling the dual anti-inflammatory and anti-cancer capacities of anti-VCAM-1 therapies
VCAM-1 as a common biomarker in inflammatory bowel disease and colorectal cancer: unveiling the dual anti-inflammatory and anti-cancer capacities of anti-VCAM-1 therapies
Vascular cell adhesion molecule (VCAM)-1 has garnered significant research attention due to its potential as a disease bio...
Prostate cancer-specific proinflammatory cytokines and chemokines impact on cancer stem cell development, lineage plasticity and heterogeneity in an Ancestral/racially diverse population: review
Prostate cancer-specific proinflammatory cytokines and chemokines impact on cancer stem cell development, lineage plasticity and heterogeneity in an Ancestral/racially diverse population: review
Since 1976, Surveillance Epidemiology End Results (SEER) began collecting ethnicity data for the National Cancer Institute...
Microbiota and cancer: unraveling the significant influence of microbial communities on cancer treatment
Microbiota and cancer: unraveling the significant influence of microbial communities on cancer treatment
Lee, J. Y., Bays, D. J., Savage, H. P., & Baumler, A. J. (2024). The human gut microbiome in health and disease: Time ...
Lessons learned from a decade of immune checkpoint inhibition: The good, the bad, and the ugly
Lessons learned from a decade of immune checkpoint inhibition: The good, the bad, and the ugly
Discovering the brakes/checkpoints that cancer places on the immune system to prevent being eradicated led to the 2018 Nob...
Microenvironment matters: insights from the FOSTER consortium on microenvironment-driven approaches to osteosarcoma therapy
Microenvironment matters: insights from the FOSTER consortium on microenvironment-driven approaches to osteosarcoma therapy
Osteosarcoma (OS), a prevalent malignant bone tumor, has seen limited progress in treatment efficacy and patient outcomes ...
State-of-the-art of multidisciplinary approach of bone metastasis-directed therapy: review and challenging questions for preparation of a GEMO practice guidelines
State-of-the-art of multidisciplinary approach of bone metastasis-directed therapy: review and challenging questions for preparation of a GEMO practice guidelines
Bone is a common secondary site of dissemination during the course of cancer. Bone metastases (BM) can be associated with ...
Tumor heterogeneity in retinoblastoma: a literature review
Tumor heterogeneity in retinoblastoma: a literature review
Tumor heterogeneity, characterized by the presence of diverse cell populations within a tumor, is a key feature of the com...
CAR T-cells for acute leukemias in children: current status, challenges, and future directions
CAR T-cells for acute leukemias in children: current status, challenges, and future directions
CAR T-cells therapy is seen as one of the most promising immunotherapies for leukemias, since targeting CD19 has revolutio...
Lactate metabolism and lactylation in breast cancer: mechanisms and implications
Lactate metabolism and lactylation in breast cancer: mechanisms and implications
As the end-product of glycolysis, lactate serves as a regulator of protein lactylation in addition to being an energy subs...
Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy
Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy
In recent years, increasing evidence has shown that metals play important roles in both innate and adaptive immunity. An e...
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