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Using ultrasound and microbubble to enhance the effects of conventional cancer therapies in clinical settings
Using ultrasound and microbubble to enhance the effects of conventional cancer therapies in clinical settings
It has been demonstrated in preclinical research that the administration of microbubbles with ultrasound can augment the p...
VCAM-1 as a common biomarker in inflammatory bowel disease and colorectal cancer: unveiling the dual anti-inflammatory and anti-cancer capacities of anti-VCAM-1 therapies
VCAM-1 as a common biomarker in inflammatory bowel disease and colorectal cancer: unveiling the dual anti-inflammatory and anti-cancer capacities of anti-VCAM-1 therapies
Vascular cell adhesion molecule (VCAM)-1 has garnered significant research attention due to its potential as a disease bio...
Prostate cancer-specific proinflammatory cytokines and chemokines impact on cancer stem cell development, lineage plasticity and heterogeneity in an Ancestral/racially diverse population: review
Prostate cancer-specific proinflammatory cytokines and chemokines impact on cancer stem cell development, lineage plasticity and heterogeneity in an Ancestral/racially diverse population: review
Since 1976, Surveillance Epidemiology End Results (SEER) began collecting ethnicity data for the National Cancer Institute...
Microbiota and cancer: unraveling the significant influence of microbial communities on cancer treatment
Microbiota and cancer: unraveling the significant influence of microbial communities on cancer treatment
Lee, J. Y., Bays, D. J., Savage, H. P., & Baumler, A. J. (2024). The human gut microbiome in health and disease: Time ...
Lessons learned from a decade of immune checkpoint inhibition: The good, the bad, and the ugly
Lessons learned from a decade of immune checkpoint inhibition: The good, the bad, and the ugly
Discovering the brakes/checkpoints that cancer places on the immune system to prevent being eradicated led to the 2018 Nob...
Microenvironment matters: insights from the FOSTER consortium on microenvironment-driven approaches to osteosarcoma therapy
Microenvironment matters: insights from the FOSTER consortium on microenvironment-driven approaches to osteosarcoma therapy
Osteosarcoma (OS), a prevalent malignant bone tumor, has seen limited progress in treatment efficacy and patient outcomes ...
State-of-the-art of multidisciplinary approach of bone metastasis-directed therapy: review and challenging questions for preparation of a GEMO practice guidelines
State-of-the-art of multidisciplinary approach of bone metastasis-directed therapy: review and challenging questions for preparation of a GEMO practice guidelines
Bone is a common secondary site of dissemination during the course of cancer. Bone metastases (BM) can be associated with ...
Tumor heterogeneity in retinoblastoma: a literature review
Tumor heterogeneity in retinoblastoma: a literature review
Tumor heterogeneity, characterized by the presence of diverse cell populations within a tumor, is a key feature of the com...
CAR T-cells for acute leukemias in children: current status, challenges, and future directions
CAR T-cells for acute leukemias in children: current status, challenges, and future directions
CAR T-cells therapy is seen as one of the most promising immunotherapies for leukemias, since targeting CD19 has revolutio...
Lactate metabolism and lactylation in breast cancer: mechanisms and implications
Lactate metabolism and lactylation in breast cancer: mechanisms and implications
As the end-product of glycolysis, lactate serves as a regulator of protein lactylation in addition to being an energy subs...
Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy
Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy
In recent years, increasing evidence has shown that metals play important roles in both innate and adaptive immunity. An e...
Molecular mechanisms of metastatic peritoneal dissemination in gastric adenocarcinoma
Molecular mechanisms of metastatic peritoneal dissemination in gastric adenocarcinoma
Peritoneal dissemination portends a dismal prognosis in patients with gastric adenocarcinoma in the context of limited eff...
Nanomaterials in cancer starvation therapy: pioneering advances, therapeutic potential, and clinical challenges
Nanomaterials in cancer starvation therapy: pioneering advances, therapeutic potential, and clinical challenges
Gaining significant attention in recent years, starvation therapy based on the blocking nutrients supply to cancer cells v...
Novel immunotherapy for gastric cancer: targeting the CD47–SIRPα axis
Novel immunotherapy for gastric cancer: targeting the CD47–SIRPα axis
Gastric cancer (GC) represents a significant global health challenge, with limited therapeutic options and poor outcomes. ...
The invadosome of stem-like cancer cells: metastasis machinery and targetable vulnerability
The invadosome of stem-like cancer cells: metastasis machinery and targetable vulnerability
Despite recent advances in targeted and immuno-therapy, metastasis still kills most cancer patients. Overcoming cancer met...
Opioid use and the risk of cancer incidence and mortality: a systematic review
Opioid use and the risk of cancer incidence and mortality: a systematic review
There is abundant but discrepant scientific literature reporting an effect of opioids on the course of cancer. The Interna...
Role of PLK4 inhibition in cancer therapy
Role of PLK4 inhibition in cancer therapy
Genomic instability is a hallmark of cancer and is associated with tumor progression and therapeutic resistance. Centriole...
Shaping the battlefield: and tumor mutations’ role on the immune microenvironment and immunotherapy responses in lung cancer
Shaping the battlefield: and tumor mutations’ role on the immune microenvironment and immunotherapy responses in lung cancer
The two most common and mutually exclusive driver mutations in non-small cell lung cancer affect EGFR and KRAS oncogenes. ...
Prospects and limitations of NK cell adoptive therapy in clinical applications
Prospects and limitations of NK cell adoptive therapy in clinical applications
During the last three decades, there has been substantial advancement in comprehending the chemical attributes and roles o...
Tissue-agnostic biomarkers in solid tumors: current approvals and emerging candidates
Tissue-agnostic biomarkers in solid tumors: current approvals and emerging candidates
The landscape of cancer treatment has shifted from histology-specific to tissue-agnostic approaches, targeting molecular a...
Biography—Mathieu Boissan, Pharm.D., Ph.D
Biography—Mathieu Boissan, Pharm.D., Ph.D
Mathieu Boissan, Pharm.D., Ph.D.Mathieu Boissan, Pharm.D., Ph.D. is a cellular biolo...
Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments
Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments
Colorectal cancer is the third most common and the second deadliest cancer worldwide. To date, colorectal cancer becomes o...
Glucocorticoid receptor: a harmonizer of cellular plasticity in breast cancer—directs the road towards therapy resistance, metastatic progression and recurrence
Glucocorticoid receptor: a harmonizer of cellular plasticity in breast cancer—directs the road towards therapy resistance, metastatic progression and recurrence
Recent therapeutic advances have significantly uplifted the quality of life in breast cancer patients, yet several impedim...
Targeting the key players of phenotypic plasticity in cancer cells by phytochemicals
Targeting the key players of phenotypic plasticity in cancer cells by phytochemicals
Plasticity of phenotypic traits refers to an organism’s ability to change in response to environmental stimuli. As a...
PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases
PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases
We describe here the molecular basis of the complex formation of PRUNE1 with the tumor metastasis suppressors NME1 and NME...
UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect
UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect
Pancreatic cancer has an exaggerated dependence on mitochondrial metabolism, but methods to specifically target the mitoch...
Deciphering cellular plasticity in pancreatic cancer for effective treatments
Deciphering cellular plasticity in pancreatic cancer for effective treatments
Cellular plasticity and therapy resistance are critical features of pancreatic cancer, a highly aggressive and fatal disea...
The emerging roles of histone demethylases in cancers
The emerging roles of histone demethylases in cancers
Modulation of histone methylation status is regarded as an important mechanism of epigenetic regulation and has substantia...
Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response
Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response
Epithelial-mesenchymal transition (EMT) is a complicated molecular process that governs cellular shape and function change...
Epigenetic reprogramming of T cells: unlocking new avenues for cancer immunotherapy
Epigenetic reprogramming of T cells: unlocking new avenues for cancer immunotherapy
T cells, a key component of cancer immunotherapy, undergo a variety of histone modifications and DNA methylation changes s...
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