https://www.nobelprize.org/prizes/medicine/2018/press-release/
Buchbinder, E. I., & Desai, A. (2016). CTLA-4 and PD-1 pathways: Similarities, differences, and implications of their inhibition. American Journal Of Clinical Oncology, 39(1), 98–106. https://doi.org/10.1097/COC.0000000000000239
Article PubMed PubMed Central CAS Google Scholar
Lu, L., Zhan, M., Li, X. Y., Zhang, H., Dauphars, D. J., Jiang, J., Yin, H., Li, S. Y., Luo, S., Li, Y., & He, Y. W. (2022). Clinically approved combination immunotherapy: Current status, limitations, and future perspective. Curr Res Immunol, 3, 118–127. https://doi.org/10.1016/j.crimmu.2022.05.003
Article PubMed PubMed Central CAS Google Scholar
Mittendorf, E. A., Burgers, F., Haanen, J., & Cascone, T. (2022). Neoadjuvant immunotherapy: Leveraging the immune system to treat early-stage disease. American Society of Clinical Oncology Educational Book, 42, 1–15. https://doi.org/10.1200/EDBK_349411
Jin, Y., Wei, J., Weng, Y., Feng, J., Xu, Z., Wang, P., Cui, X., Chen, X., Wang, J., & Peng, M. (2022). Adjuvant therapy with PD1/PDL1 inhibitors for human cancers: A systematic review and meta-analysis. Frontiers In Oncology, 12, 732814. https://doi.org/10.3389/fonc.2022.732814
Article PubMed PubMed Central CAS Google Scholar
Cercek, A., Lumish, M., Sinopoli, J., Weiss, J., Shia, J., Lamendola-Essel, M., El Dika, I. H., Segal, N., Shcherba, M., Sugarman, R., Stadler, Z., Yaeger, R., Smith, J. J., Rousseau, B., Argiles, G., Patel, M., Desai, A., Saltz, L. B., Widmar, M., … Diaz, L. A., Jr. (2022). PD-1 Blockade in mismatch repair-deficient, locally advanced rectal cancer. New England Journal Of Medicine, 386(25), 2363–2376. https://doi.org/10.1056/NEJMoa2201445
Article PubMed CAS Google Scholar
Goodman, A. M., Piccioni, D., Kato, S., Boichard, A., Wang, H. Y., Frampton, G., Lippman, S. M., Connelly, C., Fabrizio, D., Miller, V., Sicklick, J. K., & Kurzrock, R. (2018). Prevalence of PDL1 amplification and preliminary response to immune checkpoint blockade in solid tumors. JAMA Oncology, 4(9), 1237–1244. https://doi.org/10.1001/jamaoncol.2018.1701
Article PubMed PubMed Central Google Scholar
Goodman, A. M., Kato, S., Bazhenova, L., Patel, S. P., Frampton, G. M., Miller, V., Stephens, P. J., Daniels, G. A., & Kurzrock, R. (2017). Tumor mutational burden as an independent predictor of response to immunotherapy in diverse cancers. Molecular Cancer Therapeutics, 16(11), 2598–2608. https://doi.org/10.1158/1535-7163.MCT-17-0386
Article PubMed PubMed Central CAS Google Scholar
Patel, S. P., & Kurzrock, R. (2015). PD-L1 Expression as a predictive biomarker in cancer immunotherapy. Molecular Cancer Therapeutics, 14(4), 847–856. https://doi.org/10.1158/1535-7163.MCT-14-0983
Article PubMed CAS Google Scholar
Bevins, N. J., Okamura, R., Montesion, M., Adashek, J. J., Goodman, A. M., & Kurzrock, R. (2022). Tumor infiltrating lymphocyte expression of PD-1 predicts response to anti-PD-1/PD-L1 immunotherapy. J Immunother Precis Oncol, 5(4), 90–97. https://doi.org/10.36401/JIPO-22-9
Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., Leming, P. D., Spigel, D. R., Antonia, S. J., Horn, L., Drake, C. G., Pardoll, D. M., Chen, L., Sharfman, W. H., Anders, R. A., … Sznol, M. (2012). Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. New England Journal Of Medicine, 366(26), 2443–2454. https://doi.org/10.1056/NEJMoa1200690
Article PubMed CAS Google Scholar
Le, D. T., Durham, J. N., Smith, K. N., Wang, H., Bartlett, B. R., Aulakh, L. K., Lu, S., Kemberling, H., Wilt, C., Luber, B. S., Wong, F., Azad, N. S., Rucki, A. A., Laheru, D., Donehower, R., Zaheer, A., Fisher, G. A., Crocenzi, T. S., Lee, J. J., … Diaz, L. A., Jr. (2017). Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science, 357(6349), 409–413. https://doi.org/10.1126/science.aan6733
Article PubMed PubMed Central CAS Google Scholar
Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., Biedrzycki, B., Donehower, R. C., Zaheer, A., Fisher, G. A., Crocenzi, T. S., Lee, J. J., Duffy, S. M., Goldberg, R. M., de la Chapelle, A., … Diaz, L. A., Jr. (2015). PD-1 Blockade in tumors with mismatch-repair deficiency. New England Journal Of Medicine, 372(26), 2509–2520. https://doi.org/10.1056/NEJMoa1500596
Article PubMed CAS Google Scholar
Jardim, D. L., Goodman, A., de Melo Gagliato, D., & Kurzrock, R. (2021). The challenges of tumor mutational burden as an immunotherapy biomarker. Cancer Cell, 39(2), 154–173. https://doi.org/10.1016/j.ccell.2020.10.001
Article PubMed CAS Google Scholar
Thompson, J. A., Schneider, B. J., Brahmer, J., Achufusi, A., Armand, P., Berkenstock, M. K., Bhatia, S., Budde, L. E., Chokshi, S., Davies, M., Elshoury, A., Gesthalter, Y., Hegde, A., Jain, M., Kaffenberger, B. H., Lechner, M. G., Li, T., Marr, A., McGettigan, S., McPherson, J., Medina, T., Mohindra, N. A., Olszanski, A. J., Oluwole, O., Patel, S. P., Patil, P., Reddy, S., Ryder, M., Santomasso, B., Shofer, S., Sosman, J. A., Wang, Y., Zaha, V. G., Lyons, M., Dwyer, M., & Hang, L. (2022). Management of immunotherapy-related toxicities, Version 1.2022, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network, 20(4), 387–405. https://doi.org/10.6004/jnccn.2022.0020
Larkin, J., Chiarion-Sileni, V., Gonzalez, R., Grob, J. J., Rutkowski, P., Lao, C. D., Cowey, C. L., Schadendorf, D., Wagstaff, J., Dummer, R., Ferrucci, P. F., Smylie, M., Hogg, D., Hill, A., Marquez-Rodas, I., Haanen, J., Guidoboni, M., Maio, M., Schoffski, P., … Wolchok, J. D. (2019). Five-year survival with combined nivolumab and ipilimumab in advanced melanoma. New England Journal Of Medicine, 381(16), 1535–1546. https://doi.org/10.1056/NEJMoa1910836
Article PubMed CAS Google Scholar
Petrelli, F., Signorelli, D., Ghidini, M., Ghidini, A., Pizzutilo, E. G., Ruggieri, L., Cabiddu, M., Borgonovo, K., Dognini, G., Brighenti, M., De Toma, A., Rijavec, E., Garassino, M. C., Grossi, F., & Tomasello, G. (2020). Association of steroids use with survival in patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis. Cancers (Basel), 12(3). https://doi.org/10.3390/cancers12030546
Renner, A., Burotto, M., & Rojas, C. (2019). Immune checkpoint inhibitor dosing: Can we go lower without compromising clinical efficacy? J Glob Oncol, 5, 1–5. https://doi.org/10.1200/JGO.19.00142
Champiat, S., Dercle, L., Ammari, S., Massard, C., Hollebecque, A., Postel-Vinay, S., Chaput, N., Eggermont, A., Marabelle, A., Soria, J. C., & Ferte, C. (2017). Hyperprogressive disease is a new pattern of progression in cancer patients treated by anti-PD-1/PD-L1. Clinical Cancer Research, 23(8), 1920–1928. https://doi.org/10.1158/1078-0432.CCR-16-1741
Article PubMed CAS Google Scholar
Kato, S., Goodman, A., Walavalkar, V., Barkauskas, D. A., Sharabi, A., & Kurzrock, R. (2017). Hyperprogressors after immunotherapy: Analysis of genomic alterations associated with accelerated growth rate. Clinical Cancer Research, 23(15), 4242–4250. https://doi.org/10.1158/1078-0432.CCR-16-3133
Article PubMed PubMed Central CAS Google Scholar
Adashek, J. J., Subbiah, I. M., Matos, I., Garralda, E., Menta, A. K., Ganeshan, D. M., & Subbiah, V. (2020). Hyperprogression and immunotherapy: Fact, fiction, or alternative fact? Trends Cancer, 6(3), 181–191. https://doi.org/10.1016/j.trecan.2020.01.005
Article PubMed PubMed Central CAS Google Scholar
Adashek, J. J., Kato, S., Ferrara, R., Lo Russo, G., & Kurzrock, R. (2020). Hyperprogression and immune checkpoint inhibitors: Hype or progress? The Oncologist, 25(2), 94–98. https://doi.org/10.1634/theoncologist.2019-0636
Wolchok, J. D., Chiarion-Sileni, V., Gonzalez, R., Grob, J. J., Rutkowski, P., Lao, C. D., Cowey, C. L., Schadendorf, D., Wagstaff, J., Dummer, R., Ferrucci, P. F., Smylie, M., Butler, M. O., Hill, A., Marquez-Rodas, I., Haanen, J., Guidoboni, M., Maio, M., Schoffski, P., … Hodi, F. S. (2022). Long-term outcomes with nivolumab plus ipilimumab or nivolumab alone versus ipilimumab in patients with advanced melanoma. Journal Of Clinical Oncology, 40(2), 127–137. https://doi.org/10.1200/JCO.21.02229
Article PubMed CAS Google Scholar
Motzer, R. J., McDermott, D. F., Escudier, B., Burotto, M., Choueiri, T. K., Hammers, H. J., Barthelemy, P., Plimack, E. R., Porta, C., George, S., Powles, T., Donskov, F., Gurney, H., Kollmannsberger, C. K., Grimm, M. O., Barrios, C., Tomita, Y., Castellano, D., Grunwald, V., … Tannir, N. M. (2022). Conditional survival and long-term efficacy with nivolumab plus ipilimumab versus sunitinib in patients with advanced renal cell carcinoma. Cancer, 128(11), 2085–2097. https://doi.org/10.1002/cncr.34180
Article PubMed CAS Google Scholar
Brahmer, J. R., Lee, J. S., Ciuleanu, T. E., Bernabe Caro, R., Nishio, M., Urban, L., Audigier-Valette, C., Lupinacci, L., Sangha, R., Pluzanski, A., Burgers, J., Mahave, M., Ahmed, S., Schoenfeld, A. J., Paz-Ares, L. G., Reck, M., Borghaei, H., O’Byrne, K. J., Gupta, R. G., … Ramalingam, S. S. (2023). Five-year survival outcomes with nivolumab plus ipilimumab versus chemotherapy as first-line treatment for metastatic non-small-cell lung cancer in CheckMate 227. Journal Of Clinical Oncology, 41(6), 1200–1212. https://doi.org/10.1200/JCO.22.01503
Article PubMed CAS Google Scholar
Andre, T., Berton, D., Curigliano, G., Sabatier, R., Tinker, A. V., Oaknin, A., Ellard, S., de Braud, F., Arkenau, H. T., Trigo, J., Gravina, A., Kristeleit, R., Moreno, V., Abdeddaim, C., Vano, Y. A., Samouelian, V., Miller, R., Boni, V., Torres, A. A., … Banerjee, S. (2023). Antitumor activity and safety of dostarlimab monotherapy in patients with mismatch repair deficient solid tumors: A nonrandomized controlled trial. JAMA Network Open, 6(11), e2341165. https://doi.org/10.1001/jamanetworkopen.2023.41165
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