Oliveira GA-O, Wu CA-O (2023) Dynamics and specificities of T cells in cancer immunotherapy. Nat Rev Cancer, 23, 295–316.
Puig-Saus CA-O, Sennino B, Peng S et al. (2023) Neoantigen-targeted CD8(+) T cell responses with PD-1 blockade therapy. Nature, 615, 697–704.
Rojas LA-O, Sethna Z, Soares KA-OX et al. (2023) Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer. Nature, 618, 144–150.
Schenkel JA-O, Pauken KA-O. (2023) Localization, tissue biology and T cell state - implications for cancer immunotherapy. Nat Rev Immunol, 23, 807–823.
Park, J., Hsueh, P.-C., Li, Z., & Ho, P.-C. (2023). Microenvironment-driven metabolic adaptations guiding CD8+ T cell anti-tumor immunity. Immunity, 56, 32–42.
Arner, E. N., & Rathmell, J. C. (2023). Metabolic programming and immune suppression in the tumor microenvironment. Cancer Cell, 41, 421–433.
Article PubMed PubMed Central Google Scholar
Liao, P., Chang, N., Xu, B., et al. (2022). Amino acid metabolism: Challenges and opportunities for the therapeutic treatment of leukemia and lymphoma. Immunology & Cell Biology, 100, 507–528.
Kao, K.-C., Vilbois, S., Tsai, C.-H., & Ho, P.-C. (2022). Metabolic communication in the tumour–immune microenvironment. Nature Cell Biology, 24, 1574–1583.
Hong, Y., Walling, B. L., Kim, H. R., et al. (2023). ST3GAL1 and betaII-spectrin pathways control CAR T cell migration to target tumors. Nature Immunology, 24, 1007–1019.
Article PubMed PubMed Central Google Scholar
Hickman, A., Koetsier, J., Kurtanich, T., et al. (2022). LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade. The Journal of Clinical Investigation, 132, e154152.
Article PubMed PubMed Central Google Scholar
Haake, M., Haack, B., Schafer, T., et al. (2023). Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment. Nature Communications, 14, 4253.
Article PubMed PubMed Central Google Scholar
DeGrendele HC, Kosfiszer M Fau - Estess P, Estess P Fau - Siegelman MH, Siegelman MH. (1997) CD44 activation and associated primary adhesion is inducible via T cell receptor stimulation. J Immunol, 159, 2549–2553.
Ong, S. T., Ng, A. S., Ng, X. R., et al. (2019). Extracellular K+Dampens T cell functions: Implications for immune suppression in the tumor microenvironment. Bioelectricity, 1, 169–179.
Article PubMed PubMed Central Google Scholar
Gurusamy, D., Clever, D., Eil, R., & Restifo, N. P. (2017). Novel “Elements” of Immune Suppression within the Tumor Microenvironment. Cancer Immunology Research, 5, 426–433.
Article PubMed PubMed Central Google Scholar
Hrvat A, Schmidt M, Wagner B et al. (2023) Electrolyte imbalance causes suppression of NK and T cell effector function in malignant ascites. Journal of Experimental & Clinical Cancer Research, 42.
Heim, L., Friedrich, J., Engelhardt, M., et al. (2018). NFATc1 Promotes Antitumoral Effector Functions and Memory CD8(+) T-cell differentiation during non-small cell lung cancer development. Cancer Research, 78, 3619–3633.
Tanaka Y, Nakao A, Miyake Y et al. (2021) Small molecule inhibitors targeting nuclear factor kappaB activation markedly reduce expression of interleukin-2, but not interferon-gamma, induced by phorbol esters and calcium ionophores. Int J Mol Sci 22.
Cronin, S. J. F., Seehus, C., Weidinger, A., et al. (2018). The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature, 563, 564–568.
Article PubMed PubMed Central Google Scholar
Ho, P. C., Bihuniak, J. D., Macintyre, A. N., et al. (2015). phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T Cell responses. Cell, 162, 1217–1228.
Article PubMed PubMed Central Google Scholar
Nath, A., Pal, R., Singh, L. M., et al. (2018). Gold-manganese oxide nanocomposite suppresses hypoxia and augments pro-inflammatory cytokines in tumor associated macrophages. International Immunopharmacology, 57, 157–164.
Ravell, J. C., Chauvin, S. D., He, T., & Lenardo, M. (2020). An Update on XMEN Disease. Journal of Clinical Immunology, 40, 671–681.
Article PubMed PubMed Central Google Scholar
Brault, J., Meis, R. J., Li, L., et al. (2021). MAGT1 messenger RNA-corrected autologous T and natural killer cells for potential cell therapy in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia disease. Cytotherapy, 23, 203–210.
Sang, L. J., Ju, H. Q., Liu, G. P., et al. (2018). LncRNA CamK-A regulates Ca(2+)-signaling-mediated tumor microenvironment remodeling. Molecular Cell, 72(71–83), e77.
Sun J-L, Zhang N-P, Xu R-C et al. (2021) Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages. Journal of Translational Medicine 19.
Sapkota, M., & Knoell, D. L. (2018). Essential role of zinc and zinc transporters in myeloid cell function and host defense against infection. Journal of Immunology Research, 2018, 4315140.
Article PubMed PubMed Central Google Scholar
Sun, X., Zhang, Y., Li, J., et al. (2021). Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy. Nature Nanotechnology, 16, 1260–1270.
Article PubMed PubMed Central Google Scholar
Lotscher, J., Marti, I. L. A. A., Kirchhammer, N., et al. (2022). Magnesium sensing via LFA-1 regulates CD8(+) T cell effector function. Cell, 185(585–602), e529.
Cheng F, Peng G, Lu Y et al. (2022) Relationship between copper and immunity: The potential role of copper in tumor immunity. Frontiers in Oncology 12.
Chen S, Cui W, Chi Z et al. (2022) Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1. Cell Metabolism 34, 1843–1859.e1811.
Sharma, G., Sharma, A., Kim, I., et al. (2024). A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron. Nature Immunology, 25, 790–801.
Trebak, M., & Kinet, J. P. (2019). Calcium signalling in T cells. Nature Reviews Immunology, 19, 154–169.
Article PubMed PubMed Central Google Scholar
Go CA-O, Hooper R, Aronson MA-O et al. (2019) The Ca(2+) export pump PMCA clears near-membrane Ca(2+) to facilitate store-operated Ca(2+) entry and NFAT activation. Sci Signal 12, eaaw2627.
Byun, J.-K., Park, M., Lee, S., et al. (2020). Inhibition of glutamine utilization synergizes with immune checkpoint inhibitor to promote antitumor immunity. Molecular Cell, 80, 592-606.e598.
Rosencrans, W. M., Aguilella, V. M., Rostovtseva, T. K., & Bezrukov, S. M. (2021). alpha-Synuclein emerges as a potent regulator of VDAC-facilitated calcium transport. Cell Calcium, 95, 102355.
Article PubMed PubMed Central Google Scholar
Acharya, T. K., Kumar, S., Rokade, T. P., et al. (2023). TRPV4 regulates mitochondrial Ca(2+)-status and physiology in primary murine T cells based on their immunological state. Life Sciences, 318, 121493.
Fan, M., Zhang, J., Tsai, C. W., et al. (2020). Structure and mechanism of the mitochondrial Ca(2+) uniporter holocomplex. Nature, 582, 129–133.
Article PubMed PubMed Central Google Scholar
Lewis, R. S. (2007). The molecular choreography of a store-operated calcium channel. Nature, 446, 284–287.
Garbincius JA-O, Elrod JA-O. (2022) Mitochondrial calcium exchange in physiology and disease. Physiol Rev 102, 893–992.
Luchsinger, L. L., de Almeida, M. J., Corrigan, D. J., et al. (2016). Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential. Nature, 529, 528–531.
Article PubMed PubMed Central Google Scholar
Peng, W., Wong, Y. C., & Krainc, D. (2020). Mitochondria-lysosome contacts regulate mitochondrial Ca(2+) dynamics via lysosomal TRPML1. Proc Natl Acad Sci U S A, 117, 19266–19275.
Article PubMed PubMed Central Google Scholar
Chen, D., Xie, J., Fiskesund, R., et al. (2018). Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype. Nature Communications, 9, 873.
Article PubMed PubMed Central Google Scholar
Gawne, P., Man, F., Fonslet, J., et al. (2018). Manganese-52: Applications in cell radiolabelling and liposomal nanomedicine PET imaging using oxine (8-hydroxyquinoline) as an ionophore. Dalton Transactions, 47, 9283–9293.
Mercadante, C. J., Prajapati, M., Conboy, H. L., et al. (2019). Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity. The Journal of Clinical Investigation, 129, 5442–5461.
Article PubMed PubMed Central Google Scholar
Choi, E. K., Nguyen, T. T., Iwase, S., & Seo, Y. A. (2019). Ferroportin disease mutations influence manganese accumulation and cytotoxicity. The FASEB Journal, 33, 2228–2240.
Comments (0)