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Phase change nanodroplets: Challenges and clinical potential

Dual-driven by regulatory science and policy reconstruction: Traditional Chinese medicine (TCM) new drugs accelerate development—A critical review of highlights in registration and regulation of TCM and natural medicine new drugs in China (2021–2025)

Acta Pharmaceutica Sinica B

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Exendin-4 alleviates anxiety-like behaviors in chronic restraint stress mice via regulating BLA GLP-1R/BDNF signaling

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Glutaminolysis inhibition boosts cuproptosis to eliminate breast cancer stem cells

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Inhaled collagenase I liposomes reverse pulmonary fibrosis via local collagen degradation

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Universal off-the-shelf TGF-β1-knockout whole-tumor cell vaccine overcomes immunotherapy resistance in pMMR/MSS tumors

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Double coordination-driven Fe–DOX synergy enhances ferroptosis and immunogenic cancer therapy

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Hepatokine FGL1 drives endothelial injury and atherogenesis via integrin β1-mediated endothelial–mesenchymal transition

Acta Pharmaceutica Sinica B

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Neutralizing dentin sialophosphoprotein facilitates tumor vascular normalization in colorectal cancer by blocking the crosstalk between tumor cells and endothelial cells

Acta Pharmaceutica Sinica B

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Novel circUnc79 regulates morphine-induced reward memory via the miR-149-3p/EAAT2 axis and glutamatergic plasticity

Acta Pharmaceutica Sinica B

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IFI30 reprograms glioblastoma-associated macrophage and induces immune evasion by MAFF/PTGS2 pathway

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Tuning protein corona on nucleic acid nanodrugs for targeted delivery

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Sequential mRNA vaccine-enabled quadruple therapy induces functional cure of HBV in rAAV8-1.3HBV carrier mice

Acta Pharmaceutica Sinica B

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Learn from nature, surpass nature: Bionic immune cell engineering—A new paradigm for unlocking the dual “delivery-activation” code in cancer therapy

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Cytoplasmic relocation of nuclear Ku70 by Bruceine A augments cGAS–STING pathway-mediated anti-tumor immunity

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Dual-modal tumor-selective Benzofuran tracer integrating real-time imaging and anticancer effects

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Antihypertensive drug-induced liver injury is rare, but strongly associated with HLA-B*35:01

Acta Pharmaceutica Sinica B

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Emerging organoids and organoids-on-chip platforms for translational development of antibody‒drug conjugates and next-generation bioconjugates

Acta Pharmaceutica Sinica B

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Rhynchophylline rewires DLAT lipoylation via conformational control to reverse mitochondrial bioenergetic collapse against dopaminergic neuronal injury

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Nanobodies targeting SARS-CoV-2 variants

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Pathology-directed drug delivery strategies: How to overcome blood–brain barrier for the treatment of brain diseases

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Engineered cyclic peptide targeting ITGA5 disrupts tumor-stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma

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Immunocyte reprogramming empowers live-cell drug delivery: Mechanistic insights, delivery strategies, and clinical perspectives

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Photoimmunological hydrogel vaccine creates a supportive immune niche to promote antigen cross-presentation cascade and cancer-immunity cycle progression

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Targeting glial cells: Unveiling the neuroprotective mechanisms of Ginseng in the brain microenvironment

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Palmitoylation of Tfr1 enhances platelet ferroptosis and liver injury in heat stroke

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REEP6 promotes colorectal cancer glycolysis and tumorigenesis through PRMT5-mediated PGAM1 arginine methylation

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Interleukin 12-tethered nano-aluminum adjuvant orchestrates environmental immunomodulation to empower cytotoxic T cells against solid tumors

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Gambogenic acid ameliorates inflammation by inhibiting HK1-mediated Warburg effect and NLRP3 inflammasome activation in sepsis

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Progress in peptide and protein therapeutics: Challenges and strategies

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