SCI Abstract

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Pathology-directed drug delivery strategies: How to overcome blood–brain barrier for the treatment of brain diseases
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Engineered cyclic peptide targeting ITGA5 disrupts tumor-stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma
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Immunocyte reprogramming empowers live-cell drug delivery: Mechanistic insights, delivery strategies, and clinical perspectives
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Photoimmunological hydrogel vaccine creates a supportive immune niche to promote antigen cross-presentation cascade and cancer-immunity cycle progression
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Targeting glial cells: Unveiling the neuroprotective mechanisms of Ginseng in the brain microenvironment
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Palmitoylation of Tfr1 enhances platelet ferroptosis and liver injury in heat stroke
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REEP6 promotes colorectal cancer glycolysis and tumorigenesis through PRMT5-mediated PGAM1 arginine methylation
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Interleukin 12-tethered nano-aluminum adjuvant orchestrates environmental immunomodulation to empower cytotoxic T cells against solid tumors
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Gambogenic acid ameliorates inflammation by inhibiting HK1-mediated Warburg effect and NLRP3 inflammasome activation in sepsis
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Progress in peptide and protein therapeutics: Challenges and strategies
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Structure-guided design of picomolar-level macrocyclic TRPC5 channel inhibitors with antidepressant activity
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Fluorescence bioimaging of drug nanocarriers based on Förster resonance energy transfer, aggregation-induced emission and aggregation-caused quenching
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Probiotic living microneedles designed by interbacterial competition for accelerated infected wound healing
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Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies
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Omics-based large language models: A new engine for drug discovery innovation
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FAP-targeted radionuclide therapy induces ferroptosis in cancer-associated fibroblasts via disrupting iron homeostasis and redox balance
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In situ rewiring TAMs as annihilators by “Spark-Relay” nanoinitiator with flexible reactant ratio for amplifying solid tumor immunotherapy
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DHL-11, a novel prieurianin-type limonoid isolated from Munronia henryi, targeting IMPDH2 to inhibit triple-negative breast cancer
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LSD1 inhibition sensitizes anti-PD1 blockade immunotherapy by inhibiting the long-range attack of tumor-derived extracellular vesicles
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Computational approaches to druggable site identification: Current status and future perspective
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Marine-derived new peptaibols with antibacterial activities by targeting bacterial membrane phospholipids
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Anti-SARS-CoV-2 prodrug ATV006 has broad-spectrum antiviral activity against human and animal coronaviruses
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Targeting copper homeostasis: Akkermansia-derived OMVs co-deliver Atox1 siRNA and Elesclomol for cancer therapy
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Editorial of Virtual Special Issue: The Development of Antiviral Drug Discovery
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Silencing PTPN2 with nanoparticle-delivered small interfering RNA remodels tumor microenvironment to sensitize immunotherapy in hepatocellular carcinoma
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The neuroscience of cancer: Focus on neuropeptidergic systems
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Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines
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PROTAC-loaded nanocapsules degrading BRD4 for radio-chemotherapy sensitization in glioblastoma
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Submicron-sized superantigen biomimetic liposomes with highly efficient pulmonary accumulation to remodel local immune microenvironment for cancer chemoimmunotherapy
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Skin as an autonomous immune organ: antibody production and host protection
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