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Zebularine showed anti-tumor efficacy in clear cell renal cell carcinoma
1 IntroductionClear cell renal cell carcinoma (ccRCC) constitutes approximately 70%–80% of renal cell carcinoma (RCC) and ...
Case report: Aumolertinib plus gumarontinib in a patient with EGFR mutated non-small-cell lung cancer harboring acquired MET amplification following progression on afatinib plus crizotinib
BackgroundEpidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) represent the standard therapeutic modal...
Current usage of inclisiran for cardiovascular diseases: overview of current clinical trials
IntroductionCardiovascular disease (CVD) is a health concern globally contributing significantly to illness and death on a...
COL7A1 indicates crucial potential as a basal membrane-related prognostic biomarker and therapeutic target in lung adenocarcinoma
1 IntroductionLung adenocarcinoma (LUAD) constitutes the most prevalent histological subtype among Non-small-cell lung can...
Editorial: Lung microbiome in health and disease
In lung carcinogenesis, Zhai et al describes the interplay between bacteria and their metabolites in different early-stage...
Methamphetamine self-administration causes neuronal dysfunction in rat medial prefrontal cortex in a sex-specific and withdrawal time-dependent manner
IntroductionAccording to the United Nations Office on Drugs and Crime (UNODC, 2021), amphetamine-type stimulants, includin...
Model-guided development of pharmacokinetic/pharmacodynamic cut-offs and evaluation of sitafloxacin dosing regimens against target pathogens
1 IntroductionAntimicrobial susceptibility clinical breakpoints are among the most important components of antimicrobial p...
Phytochemical synergies in BK002: advanced molecular docking insights for targeted prostate cancer therapy
1 Introduction1.1 Chronic inflammation and cancer: a complex interrelationshipThe established link between chronic inflamm...
A double-layer PLGA/CoI-MeHA tissue engineering scaffold for urethral reconstruction
1 IntroductionFactors leading to urethral injury include malformations, inflammation, and trauma, which can often lead to ...
Neurotoxicity mechanisms and clinical implications of six common recreational drugs
1 IntroductionThe global increase in recreational drug use continues to pose significant challenges to public health and s...
Corrigendum: Apigenin protects against ischemic stroke by increasing DNA repair
Apigenin protects against ischemic stroke by increasing DNA repairNiu Ping1, Kuiyang Zuo3, Jiahan Cai4, Chunshu Rong1, Ziq...
Regulatory role and therapeutic prospect of lactate modification in cancer
1 IntroductionPTMs of proteins involve covalent modifications on the protein backbone or amino acid side chains, thereby i...
Contribution and expression of renal drug transporters in renal cell carcinoma
1 IntroductionKidney cancer is a relatively common type of cancer, accounting for approximately 3%–5% of all malignancies ...
Psychological repercussions of PM air pollution in human aging: a comprehensive review of urban and rural environments
1 IntroductionAmbient pollution, both indoors and outdoors, and its impact on population health represent some of the most...
A limited sampling strategy for estimating busulfan exposure in pediatric hematopoietic stem cell transplantation
1 IntroductionBusulfan (Bu) is an alkylating agent used in chemotherapy regimens alongside drugs such as cyclophosphamide ...
Impact of the national health insurance coverage policy on mecapegfilgrastim utilization for chemoradiotherapy-induced neutropenia in cancer patients in China: a retrospective real-world analysis
1 IntroductionCancer has become the leading cause of death globally (Bray et al., 2021). According to the International Ag...
Comparison of the effects of perioperative fentanyl and morphine use on the short-term prognosis of patients with cardiac surgery in the ICU
IntroductionCardiac surgery is one of the treatments of adult heart diseases, which can reduce the mortality of patients (...
Association between GLP-1 RAs and DPP-4 inhibitors with biliary disorders: pharmacovigilance analysis
1 IntroductionDiabetes, a significant global health challenge, is anticipated to reach $1.054 trillion in healthcare costs...
Editorial: Disease-on-a-chip: from point-of-care to personalized medicine
Editorial: Disease-on-a-chip: from point-of-care to personalized medicine
Miniaturization has played a pivotal role in driving innovation in microfluidic devices, particularly in their application...
Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone
Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone
Progesterone has been shown to have neuroprotective capabilities against a wide range of nervous system injuries, however ...
Drug repositioning in thyroid cancer treatment: the intriguing case of anti-diabetic drugs
Drug repositioning in thyroid cancer treatment: the intriguing case of anti-diabetic drugs
Cancer represents the main cause of death worldwide. Thyroid cancer (TC) shows an overall good rate of survival, however t...
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis
Background: A traumatic spinal cord injury (TSCI) can lead to severe nerve damage and disability. Cell transplantation the...
From the CONSORT to the ConPhyMP statement and beyond—how to ascertain best practice
From the CONSORT to the ConPhyMP statement and beyond—how to ascertain best practice
With the implementation of the ConPhyMP reporting tool as an element of peer review in Frontiers in Pharmacology, Section ...
A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects
A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects
Purpose: HSK16149 is a novel, potent gamma-aminobutyric acid (GABA) analog for the treatment of neuropathic pain. This stu...
Psoriasis comorbid with atherosclerosis meets in lipid metabolism
Psoriasis comorbid with atherosclerosis meets in lipid metabolism
Psoriasis (PSO) is a common skin disease affecting approximately 1%–3% of the population, and the incidence rate is increa...
Case report: SAF-189s is a potent inhibitor in a lorlatinib-resistant NSCLC patient with acquired compound mutations ALK L1196M and D1203N
Case report: SAF-189s is a potent inhibitor in a lorlatinib-resistant NSCLC patient with acquired compound mutations ALK L1196M and D1203N
Acquired anaplastic lymphoma kinase (ALK) mutation is the major resistant mechanism to ALK tyrosine kinase inhibitors (TKI...
Herbal formulas for detoxification and dredging collaterals in treating carotid atherosclerosis: a systematic review and meta-analysis
Herbal formulas for detoxification and dredging collaterals in treating carotid atherosclerosis: a systematic review and meta-analysis
Objective: To systematically evaluate the efficacy and safety of the Chinese medicine detoxification and dredging collater...
Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial
Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial
Introduction: Poor adherence to pharmacological treatment is frequent in people with severe mental disorders and it often ...
Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing
Preventative and therapeutic potential of tocotrienols on musculoskeletal diseases in ageing
Musculoskeletal health is paramount in an ageing population susceptible to conditions such as osteoporosis, arthritis and ...
Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium
Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium
Introduction: Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) prote...
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