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Allelopathic effects of four spontaneous plants from arid regions on the germination and growth of selected weeds and crops
The study investigates the allelopathic potential of the aqueous extracts of four plants species; Cleome arabica L., Diplo...
Polyphyllin B induces ferroptosis in triple-negative breast cancer by inactivating NRF2
BackgroundTriple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC) and lacks effective tr...
Cost-utility analysis of add-on ezetimibe to moderate-intensity statin versus moderate-intensity statin alone for secondary prevention in patients with acute coronary syndrome intolerant to high-intensity statin therapy in Thailand
BackgroundAlthough high-intensity statin therapy is recommended for the secondary prevention of acute coronary syndrome (A...
Predicting affinity and potency of new psychoactive substances at cannabinoid 1 receptor with explainable artificial intelligence
Introduction Binding affinity and functional potency are two distinct but pharmacologically related properties in ligand-r...
Incidence and risk factors of venous and arterial thromboembolism events in lung cancer patients treated with immune checkpoint inhibitors
BackgroundThromboembolism (TE), which comprises venous thromboembolism (VTE) and arterial thromboembolism (ATE), represent...
Original research a real-world study of adverse events of nafamostat mesylate and sodium citrate based on the world health organization-VigiAccess database
AimsWhile nafamostat mesylate (NM) and sodium citrate serve as commonly used extracorporeal anticoagulants in clinical pra...
A rationally designed 18-amino acid peptide with potential as GLP-1 receptor agonist
IntroductionDiabetes mellitus (DM) is a multifaceted disease etiologically characterised by dysregulation in glucose homeo...
Association between terbutaline sulfate plus ambroxol hydrochloride and clinical outcomes, pulmonary function, and inflammatory biomarkers in elderly patients with acute exacerbation of chronic obstructive pulmonary disease
BackgroundAcute exacerbations of chronic obstructive pulmonary disease (AECOPD) are characterized by airflow limitation an...
Alkaloids from Fritillariae Cirrhosae Bulbus - progress on their pharmacological activities
Fritillariae Cirrhosae Bulbus is a valuable and authentic medicinal material widely used in traditional Chinese medicine t...
Dual BAFF/APRIL inhibition with telitacicept in systemic lupus erythematosus and IgA nephropathy: pharmacological rationale, clinical efficacy, and safety on female fertility preservation
BackgroundSystemic lupus erythematosus (SLE) and IgA nephropathy (IgAN) are immune-mediated renal disorders characterized ...
Adverse neurological events associated with bispecific T cell engagers in oncology: a real-world study
BackgroundWith the increasing use of bispecific T cell engagers (BiTEs) in anti-tumor immunotherapy, the associated advers...
Real-world evaluation of attention deficit hyperactivity disorder symptoms and side effects in patients prescribed serdexmethylphenidate/dexmethylphenidate or other stimulants
BackgroundSerdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) (Azstarys®) is an FDA-approved treatment for ADHD in patien...
Thrombocytopenia and anemia associated with piperacillin-tazobactam: integrating clinical case series with FAERS disproportionality analysis
BackgroundPiperacillin-tazobactam (TZP) is a commonly used broad-spectrum antibiotic in clinical practice; however, its ha...
Factors associated with non-adherence to antihypertensive therapy and blood pressure control in Iraq
Background/ObjectivesHypertension is a major global public health concern, affecting approximately 1.28 billion people wor...
Hydroxysafflor yellow a attenuates oxygen-glucose deprivation/ reoxygenation induced endothelial pyroptosis via PARP-1/NLRP3 pathway
IntroductionDysfunction of brain microvascular endothelial cells (BMECs) induced by oxidative stress represents a critical...
Pretreatment of trans-ferulic acid improved neurotoxicity in a thioacetamide-induced hepatic encephalopathy rat model; participation of the MAPK/NF-κb signaling pathway
AimTrans-ferulic acid (TFA), a naturally occurring phenolic compound, has attracted significant attention due to its stron...
Adjuvant therapeutic effects and mechanisms of Yinchenhao decoction in obstructive jaundice: a narrative review
Yinchenhao Decoction (YCHD) is a classic traditional Chinese medicine (TCM) formula composed of three botanical drugs: Art...
Angiotensin II type 1 and type 2 receptors modulate TWIK1 channel expression and pain sensitivity in a rat model of neuropathic pain
BackgroundThe renin–angiotensin system (RAS) contributes to inflammatory and neuropathic pain, but whether its primary rec...
A narrative review of PCSK9 inhibitors: from evolocumab to novel discoveries
The application of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors represents a crucial milestone in the ...
Efficacy and safety of anisodine hydrobromide injection in acute ischemic stroke—a multicenter real-world observational study
ObjectiveTo evaluate the efficacy and safety of anisodine hydrobromide injection in patients with acute ischemic stroke in...
Zebularine showed anti-tumor efficacy in clear cell renal cell carcinoma
1 IntroductionClear cell renal cell carcinoma (ccRCC) constitutes approximately 70%–80% of renal cell carcinoma (RCC) and ...
Case report: Aumolertinib plus gumarontinib in a patient with EGFR mutated non-small-cell lung cancer harboring acquired MET amplification following progression on afatinib plus crizotinib
BackgroundEpidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) represent the standard therapeutic modal...
Current usage of inclisiran for cardiovascular diseases: overview of current clinical trials
IntroductionCardiovascular disease (CVD) is a health concern globally contributing significantly to illness and death on a...
COL7A1 indicates crucial potential as a basal membrane-related prognostic biomarker and therapeutic target in lung adenocarcinoma
1 IntroductionLung adenocarcinoma (LUAD) constitutes the most prevalent histological subtype among Non-small-cell lung can...
Editorial: Lung microbiome in health and disease
In lung carcinogenesis, Zhai et al describes the interplay between bacteria and their metabolites in different early-stage...
Methamphetamine self-administration causes neuronal dysfunction in rat medial prefrontal cortex in a sex-specific and withdrawal time-dependent manner
IntroductionAccording to the United Nations Office on Drugs and Crime (UNODC, 2021), amphetamine-type stimulants, includin...
Model-guided development of pharmacokinetic/pharmacodynamic cut-offs and evaluation of sitafloxacin dosing regimens against target pathogens
1 IntroductionAntimicrobial susceptibility clinical breakpoints are among the most important components of antimicrobial p...
Phytochemical synergies in BK002: advanced molecular docking insights for targeted prostate cancer therapy
1 Introduction1.1 Chronic inflammation and cancer: a complex interrelationshipThe established link between chronic inflamm...
A double-layer PLGA/CoI-MeHA tissue engineering scaffold for urethral reconstruction
1 IntroductionFactors leading to urethral injury include malformations, inflammation, and trauma, which can often lead to ...
Neurotoxicity mechanisms and clinical implications of six common recreational drugs
1 IntroductionThe global increase in recreational drug use continues to pose significant challenges to public health and s...
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