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Glutaminase activity maintains NK cell cytotoxicity through metabolic regulation of effector function
Glutaminase activity maintains NK cell cytotoxicity through metabolic regulation of effector function
Natural killer (NK) cells are responsible for monitoring and eliminating malignant or virus-infected cells. To become acti...
Lack of phospho-eIF4E worsens experimental colitis by inhibiting Treg suppressive activity
Lack of phospho-eIF4E worsens experimental colitis by inhibiting Treg suppressive activity
Phosphorylation of eIF4E by MNK1/2 modulates protein synthesis by controlling the translation of specific mRNAs. Immune ce...
Correction: Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis
Correction: Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Contribution of brain pericytes to neuroinflammation following repetitive head trauma
Contribution of brain pericytes to neuroinflammation following repetitive head trauma
Neuroinflammation is a prominent pathological hallmark of traumatic brain injury (TBI) and glia cells have been widely cha...
Prehospital pulse-dose glucocorticoid on index of microvascular resistance in patients with ST-segment elevation myocardial infarction: a sub-study of the PULSE-MI trial
Prehospital pulse-dose glucocorticoid on index of microvascular resistance in patients with ST-segment elevation myocardial infarction: a sub-study of the PULSE-MI trial
Microvascular injury in patients with ST-segment elevation myocardial infarction (STEMI) occurs in up to 50%, yet no thera...
Semaphorin 7a is protective through immune modulation during acetaminophen-induced liver injury
Semaphorin 7a is protective through immune modulation during acetaminophen-induced liver injury
Acetaminophen (APAP) induced acute liver injury (ALI), the leading cause acute liver failure in the western world, has lim...
Retraction Note: Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats
Retraction Note: Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases
Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases
Smoking, alcohol abuse, and hypertension are – among others, potential risk factors for cardiovascular diseases. The...
SARS-CoV-2 infection as a model to study the effect of cinnamaldehyde as adjuvant therapy for viral pneumonia
SARS-CoV-2 infection as a model to study the effect of cinnamaldehyde as adjuvant therapy for viral pneumonia
The recent pandemic outbursts, due to SARS-CoV-2, have highlighted once more the central role of the inflammatory process ...
Lipid from electronic cigarette-aerosol both with and without nicotine induced pro-inflammatory macrophage polarization and disrupted phagocytosis
Lipid from electronic cigarette-aerosol both with and without nicotine induced pro-inflammatory macrophage polarization and disrupted phagocytosis
Clinical cases and experimental evidence revealed that electronic cigarettes (ECIG) induce serious adverse health effects,...
Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway
Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway
Soluble Epoxide Hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids and critically affects airway infl...
The TFPI2–PPARγ axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic mice
The TFPI2–PPARγ axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic mice
Diabetes mellitus is one of the causes of poor ventricular remodelling and poor cardiac recovery after myocardial infarcti...
Sodium butyrate alleviates R97-116 peptide-induced myasthenia gravis in mice by improving the gut microbiota and modulating immune response
Sodium butyrate alleviates R97-116 peptide-induced myasthenia gravis in mice by improving the gut microbiota and modulating immune response
Fermented butyrate exhibits an anti-inflammatory response to maintain immune homeostasis within the gut. However, the effe...
Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation
Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation
Hendra virus is an emerging virus with a geographically broad host reservoir. In humans, Hendra virus causes excessive inf...
IgG immune complex-induced acute lung injury is ameliorated by cAMP via down-regulation of C/EBP- and AP-1-mediated transcriptions
IgG immune complex-induced acute lung injury is ameliorated by cAMP via down-regulation of C/EBP- and AP-1-mediated transcriptions
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) are life threatening pulmonar...
Towards clinical application of GlycA and GlycB for early detection of inflammation associated with (pre)diabetes and cardiovascular disease: recent evidence and updates
Towards clinical application of GlycA and GlycB for early detection of inflammation associated with (pre)diabetes and cardiovascular disease: recent evidence and updates
Cardiometabolic diseases are associated with low-grade inflammation early in life and persists into old age. The long late...
Advances in the study of macrophage polarization in inflammatory immune skin diseases
Advances in the study of macrophage polarization in inflammatory immune skin diseases
When exposed to various microenvironmental stimuli, macrophages are highly plastic and primarily polarized into the pro-in...
Genome-wide identification and functional analysis of dysregulated alternative splicing profiles in sepsis
Genome-wide identification and functional analysis of dysregulated alternative splicing profiles in sepsis
An increasing body of evidence now shows that the long-term mortality of patients with sepsis are associated with various ...
Inhibition of COX-2 signaling favors E. coli during urinary tract infection
Inhibition of COX-2 signaling favors E. coli during urinary tract infection
To avoid the overuse of antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), acting via cyclooxygenase (COX) inhib...
Effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress
Effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress
The strong perioperative stress response caused by surgical anesthesia can significantly suppress immune function, and the...
Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis
Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis
Ferroptosis in alveolar and bronchial epithelial cells is one of the main mechanisms underlying the development of chronic...
Correction: Analysis of AT7519 as a pro-resolution compound in an acetaminophen-induced mouse model of acute inflammation by UPLC-MS/MS
Correction: Analysis of AT7519 as a pro-resolution compound in an acetaminophen-induced mouse model of acute inflammation by UPLC-MS/MS
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Air pollution induces pyroptosis of human monocytes through activation of inflammasomes and Caspase-3-dependent pathways
Air pollution induces pyroptosis of human monocytes through activation of inflammasomes and Caspase-3-dependent pathways
According to the World Health Organization (WHO), air pollution is one of the most serious threats for our planet. Despite...
Finding the priority and cluster of inflammatory biomarkers for infectious preterm birth: a systematic review
Finding the priority and cluster of inflammatory biomarkers for infectious preterm birth: a systematic review
Infectious preterm birth (PTB) is one of the most important causes of perinatal death. It is difficult to find reliable bi...
Inhibition of GSK3β activity alleviates acute liver failure via suppressing multiple programmed cell death
Inhibition of GSK3β activity alleviates acute liver failure via suppressing multiple programmed cell death
Acute liver failure (ALF) is one of the most common life-threatening diseases in adults without previous liver disease. Gl...
The occurrence and development of radiation-induced lung injury after interstitial brachytherapy and stereotactic radiotherapy in SD rats
The occurrence and development of radiation-induced lung injury after interstitial brachytherapy and stereotactic radiotherapy in SD rats
To compare the severity of radiation-induced lung injury (RILI) after the right lung of SD rats received interstitial brac...
Stem cell-derived brainstem mouse astrocytes obtain a neurotoxic phenotype in vitro upon neuroinflammation
Stem cell-derived brainstem mouse astrocytes obtain a neurotoxic phenotype in vitro upon neuroinflammation
Astrocytes respond to injury and disease through a process known as reactive astrogliosis, of which inflammatory signaling...
Ischemic stroke-related gene expression profiles across species: a meta-analysis
Ischemic stroke-related gene expression profiles across species: a meta-analysis
Stroke patients are often left with permanent disabilities with no regenerative treatment options. Unbiased RNA sequencing...
Analysis of AT7519 as a pro-resolution compound in an acetaminophen-induced mouse model of acute inflammation by UPLC-MS/MS
Analysis of AT7519 as a pro-resolution compound in an acetaminophen-induced mouse model of acute inflammation by UPLC-MS/MS
Uncontrolled inflammation contributes to the progression of organ damage in acute conditions, such as acetaminophen-induce...
Identification and validation of biomarkers related to Th1 cell infiltration in neuropathic pain
Identification and validation of biomarkers related to Th1 cell infiltration in neuropathic pain
Neuropathic pain (NP) is a widespread chronic pain with a prevalence of 6.9–10% in the general population, severely ...
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