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Author Correction: Three macrophage subsets are identified in the uterus during early human pregnancy
Author Correction: Three macrophage subsets are identified in the uterus during early human pregnancy
In the published version of Fig. 2b and Fig. 6d, the same HMOX1 western blot...
Eliciting antitumor immunity via therapeutic cancer vaccines
Eliciting antitumor immunity via therapeutic cancer vaccines
Therapeutic cancer vaccines aim to expand and activate antigen-specific T cells for the targeted elimination of cancer cel...
Cholesterol promotes autoimmune pathology through T follicular helper cells
Cholesterol promotes autoimmune pathology through T follicular helper cells
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease character...
Monocyte-derived TGF-β shapes memory CD8+ T cells
Monocyte-derived TGF-β shapes memory CD8+ T cells
Sun L, Zhang C, Jiao A, Su Y, Zhang T, Wang Q, et al. CCR2+ monocytes promote memory CD8+ T-cell differentiation via membr...
Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy
Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy
T cells often acquire diverse phenotypes and functional states following activation. CD4+ T cells are traditionally classi...
IL-17-secreting γδ T-cell-driven Siglec-F+ neutrophils mediate lung pathology in emphysema
IL-17-secreting γδ T-cell-driven Siglec-F+ neutrophils mediate lung pathology in emphysema
Mills KHG. IL-17 and IL-17-producing cells in protection versus pathology. Nat Rev Immunol. 2023;23:38–54.CAS  PubMed ...
CD8+GZMK+CD27+CCR7+ T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells
CD8+GZMK+CD27+CCR7+ T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells
Splenic sympathetic activity critically modulates peripheral immunity after ischemic stroke, thus intervention in spleen s...
The role of exosomes in immunopathology and potential therapeutic implications
The role of exosomes in immunopathology and potential therapeutic implications
Extracellular vesicles (EVs), including exosomes, ectosomes, and apoptotic bodies, are released by various cells. Among th...
Author Correction: Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Author Correction: Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Author notesThese authors contributed equally: Hanhui Zhong, Jingjing Ji, Jinling Zhuang.Authors and AffiliationsThe Depar...
Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance
Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance
Marginal zone (MZ) B cells, which are splenic innate-like B cells that rapidly secrete antibodies (Abs) against b...
gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity
gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity
Apart from mediating viral entry, the function of the free HIV-1 envelope protein (gp120) has yet to be elucidated. Our gr...
Development of NK cell-based cancer immunotherapies through receptor engineering
Development of NK cell-based cancer immunotherapies through receptor engineering
Natural killer (NK) cell-based immunotherapies are attracting increasing interest in the field of cancer treatment. Early ...
Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2
Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2
The overexpression of sialic acids on glycans, called hypersialylation, is a common alteration found in cancer cells. Sial...
Neutrophils in the tumor microenvironment – when a company becomes a crowd
Neutrophils in the tumor microenvironment – when a company becomes a crowd
Traditionally, neutrophils are perceived as terminally differentiated cells with defined functions an...
Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Mucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the major interfaces between the...
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Acetaldehyde dehydrogenase 2 (ALDH2) mutations are commonly found in a subgroup of the Asian population. However, the role...
The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation
The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation
The main challenges in the use of immune checkpoint inhibitors (ICIs) are ascribed to the immunosuppressive tumor microenv...
Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment
Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment
A highly immunosuppressive tumor microenvironment (TME) and the presence of the blood‒brain barrier are the two majo...
Interleukin-10 multitasking in allergic airway inflammation
Interleukin-10 multitasking in allergic airway inflammation
Papi A, Brightling C, Pedersen SE, Reddel HK. Asthma. Lancet. 2018;391:783–800.Article  PubMed  ...
A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells
A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells
Functional Tregs play a key role in tumor development and progression, representing a major barrier to anticancer immunity...
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a rare autosomal recessive disorder char...
Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis
Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis
Inflammasomes are important sentinels of innate immune defense; they sense pathogens and induce the cell death of infected...
Microglia out of place—mapping macrophages across the developing human body
Microglia out of place—mapping macrophages across the developing human body
Macrophages (MΦs) are versatile cells found in every organ. Throughout the body, they work tirelessly...
SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”
SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of immunity. Knowledge about this ...
Insm1 regulates mTEC development and immune tolerance
Insm1 regulates mTEC development and immune tolerance
The expression of self-antigens in medullary thymic epithelial cells (mTECs) is essential for the establishment of immune ...
CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation
CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation
The G protein-coupled receptor ADGRE5 (CD97) binds to various metabolites that play crucial regulatory roles in metabolism...
The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARγ
The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARγ
Cytokine storms are crucial in the development of various inflammatory diseases, including sepsis and autoimmune disorders...
Author Correction: MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages
These authors contributed equally: Jingjing Cao, Lili Ji, Yanxia Zhan.Department of Hematology, Zhongshan Hospital, Fudan ...
New insights into the role of the immune inhibitory receptor VSTM1 in autoimmune disease
New insights into the role of the immune inhibitory receptor VSTM1 in autoimmune disease
Olde Nordkamp MJ, Koeleman BP, Meyaard L. Do inhibitory immune receptors play a role in the etiology of autoimmune disease...
Mitochondrial DNA-triggered innate immune response: mechanisms and diseases
Mitochondrial DNA-triggered innate immune response: mechanisms and diseases
Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from mitochondria into the cytosol. The relea...
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