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Gasdermin E-mediated lysosome-pore formation curbs pancreatic ductal adenocarcinoma via IFN-γ/IFN-β/TGF-β cocktail mRNA-LNP
Gasdermin E-mediated lysosome-pore formation curbs pancreatic ductal adenocarcinoma via IFN-γ/IFN-β/TGF-β cocktail mRNA-LNP
Despite the pleiotropic capacities of cytokines in modulating cell behaviors, their therapeutic application in cancer rema...
Melanosomes support immune evasion in melanoma
Melanosomes support immune evasion in melanoma
LG is grateful to the William Guy Forbeck Research Foundation (Carbondale, CO) for fostering the dissemination of knowledg...
GPX4-dependent ferroptosis governs ILC2 homeostasis and colitis progression
GPX4-dependent ferroptosis governs ILC2 homeostasis and colitis progression
The critical role of group 2 innate lymphoid cells (ILC2s) in host defense and mucosal inflammation has been well establis...
Author Correction: NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology
Author Correction: NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology
These authors contributed equally: Xiaolong He, Weijun Yang, Zhijie Zeng, Yi Wei.Department of Microbiology, Guangdong Pro...
B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8+ T-cell response
B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8+ T-cell response
Natural killer and CD8+ T cells are critical in the elimination of blood-borne viruses such as cytomegalovirus (CMV); howe...
Tofacitinib repairs inflammation and mitochondrial dysregulation in GM-CSF-reprogrammed RA macrophages
Tofacitinib repairs inflammation and mitochondrial dysregulation in GM-CSF-reprogrammed RA macrophages
Rheumatoid arthritis (RA) exhibits heterogeneous endotypes, complicating treatment strategies. GM-CSF and GM-CSFRα ar...
Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing
Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing
Cytotoxic T lymphocytes (CTLs) eliminate target cells by forming immunological synapses and releasing effector molecules, ...
Oncolytic virus M1 reinvigorates CD8+ T-cell immunity against glioblastoma through B-cell-dependent antigen cross-presentation in the spleen
Oncolytic virus M1 reinvigorates CD8+ T-cell immunity against glioblastoma through B-cell-dependent antigen cross-presentation in the spleen
Glioblastoma multiforme (GBM) is a lethal primary brain cancer with limited treatment options. Systemic and local immunosu...
Author Correction: Three macrophage subsets are identified in the uterus during early human pregnancy
Author Correction: Three macrophage subsets are identified in the uterus during early human pregnancy
In the published version of Fig. 2b and Fig. 6d, the same HMOX1 western blot...
Eliciting antitumor immunity via therapeutic cancer vaccines
Eliciting antitumor immunity via therapeutic cancer vaccines
Therapeutic cancer vaccines aim to expand and activate antigen-specific T cells for the targeted elimination of cancer cel...
Cholesterol promotes autoimmune pathology through T follicular helper cells
Cholesterol promotes autoimmune pathology through T follicular helper cells
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease character...
Monocyte-derived TGF-β shapes memory CD8+ T cells
Monocyte-derived TGF-β shapes memory CD8+ T cells
Sun L, Zhang C, Jiao A, Su Y, Zhang T, Wang Q, et al. CCR2+ monocytes promote memory CD8+ T-cell differentiation via membr...
Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy
Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy
T cells often acquire diverse phenotypes and functional states following activation. CD4+ T cells are traditionally classi...
IL-17-secreting γδ T-cell-driven Siglec-F+ neutrophils mediate lung pathology in emphysema
IL-17-secreting γδ T-cell-driven Siglec-F+ neutrophils mediate lung pathology in emphysema
Mills KHG. IL-17 and IL-17-producing cells in protection versus pathology. Nat Rev Immunol. 2023;23:38–54.CAS  PubMed ...
CD8+GZMK+CD27+CCR7+ T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells
CD8+GZMK+CD27+CCR7+ T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells
Splenic sympathetic activity critically modulates peripheral immunity after ischemic stroke, thus intervention in spleen s...
The role of exosomes in immunopathology and potential therapeutic implications
The role of exosomes in immunopathology and potential therapeutic implications
Extracellular vesicles (EVs), including exosomes, ectosomes, and apoptotic bodies, are released by various cells. Among th...
Author Correction: Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Author Correction: Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Author notesThese authors contributed equally: Hanhui Zhong, Jingjing Ji, Jinling Zhuang.Authors and AffiliationsThe Depar...
Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance
Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance
Marginal zone (MZ) B cells, which are splenic innate-like B cells that rapidly secrete antibodies (Abs) against b...
gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity
gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity
Apart from mediating viral entry, the function of the free HIV-1 envelope protein (gp120) has yet to be elucidated. Our gr...
Development of NK cell-based cancer immunotherapies through receptor engineering
Development of NK cell-based cancer immunotherapies through receptor engineering
Natural killer (NK) cell-based immunotherapies are attracting increasing interest in the field of cancer treatment. Early ...
Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2
Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2
The overexpression of sialic acids on glycans, called hypersialylation, is a common alteration found in cancer cells. Sial...
Neutrophils in the tumor microenvironment – when a company becomes a crowd
Neutrophils in the tumor microenvironment – when a company becomes a crowd
Traditionally, neutrophils are perceived as terminally differentiated cells with defined functions an...
Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Mucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the major interfaces between the...
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Acetaldehyde dehydrogenase 2 (ALDH2) mutations are commonly found in a subgroup of the Asian population. However, the role...
The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation
The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation
The main challenges in the use of immune checkpoint inhibitors (ICIs) are ascribed to the immunosuppressive tumor microenv...
Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment
Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment
A highly immunosuppressive tumor microenvironment (TME) and the presence of the blood‒brain barrier are the two majo...
Interleukin-10 multitasking in allergic airway inflammation
Interleukin-10 multitasking in allergic airway inflammation
Papi A, Brightling C, Pedersen SE, Reddel HK. Asthma. Lancet. 2018;391:783–800.Article  PubMed  ...
A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells
A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells
Functional Tregs play a key role in tumor development and progression, representing a major barrier to anticancer immunity...
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a rare autosomal recessive disorder char...
Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis
Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis
Inflammasomes are important sentinels of innate immune defense; they sense pathogens and induce the cell death of infected...
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