Mills KHG. IL-17 and IL-17-producing cells in protection versus pathology. Nat Rev Immunol. 2023;23:38–54.

CAS  PubMed  Google Scholar 

Hong J, Kang MH, Lee J, Cha MS, Bae YS, Kim HY, et al. γδ(+) T-cell-derived IL-17A stimulates airway epithelial/stromal cells to secrete G-CSF, promoting lung-specific pathogenic Siglec-F(+) neutrophil development in PPE-induced emphysema. Cell Mol Immunol. 2025;22:791–805.

CAS  PubMed  PubMed Central  Google Scholar 

Le Rouzic O, Pichavant M, Frealle E, Guillon A, Si-Tahar M, Gosset P. Th17 cytokines: novel potential therapeutic targets for COPD pathogenesis and exacerbations. Eur Respir J. 2017;50:1602434.

PubMed  Google Scholar 

Kurimoto E, Miyahara N, Kanehiro A, Waseda K, Taniguchi A, Ikeda G, et al. IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice. Respir Res. 2013;14:5.

CAS  PubMed  PubMed Central  Google Scholar 

Fujii U, Miyahara N, Taniguchi A, Waseda K, Morichika D, Kurimoto E, et al. IL-23 Is essential for the development of elastase-induced pulmonary inflammation and emphysema. Am J Respir Cell Mol Biol. 2016;55:697–707.

CAS  PubMed  Google Scholar 

Matsui M, Nagakubo D, Satooka H, Hirata T. A novel Siglec-F(+) neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model. Biochem Biophys Res Commun. 2020;526:599–606.

CAS  PubMed  Google Scholar 

Borkner L, Curham LM, Wilk MM, Moran B, Mills KHG. IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F(+) neutrophils. Mucosal Immunol. 2021;14:1183–202.

CAS  PubMed  PubMed Central  Google Scholar 

McGinley AM, Sutton CE, Edwards SC, Leane CM, DeCourcey J, Teijeiro A, et al. Interleukin-17A serves a priming role in autoimmunity by recruiting IL-1β-producing myeloid cells that promote pathogenic T Cells. Immunity. 2020;52:342–.e346.

CAS  PubMed  Google Scholar 

Fukuzaki S, Righetti RF, Santos TMD, Camargo LDN, Aristóteles L, Souza FCR, et al. Preventive and therapeutic effect of anti-IL-17 in an experimental model of elastase-induced lung injury in C57Bl6 mice. Am J Physiol Cell Physiol. 2021;320:C341–c354.

CAS  PubMed  Google Scholar 

Voss M, Wolf L, Kamyschnikow A, Wonnenberg B, Honecker A, Herr C, et al. Il-17A contributes to maintenance of pulmonary homeostasis in a murine model of cigarette smoke-induced emphysema. Am J Physiol Lung Cell Mol Physiol. 2015;309:L188–195.

CAS  PubMed  Google Scholar 

Eich A, Urban V, Jutel M, Vlcek J, Shim JJ, Trofimov VI, et al. A randomized, Placebo-controlled Phase 2 Trial of CNTO 6785 in chronic obstructive pulmonary disease. Copd. 2017;14:476–83.

PubMed  Google Scholar 

Gamell C, Bankovacki A, Scalzo-Inguanti K, Sedgmen B, Alhamdoosh M, Gail E, et al. CSL324, a granulocyte colony-stimulating factor receptor antagonist, blocks neutrophil migration markers that are upregulated in hidradenitis suppurativa. Br J Dermatol. 2023;188:636–48.

CAS  PubMed  Google Scholar