Spits H, Mjosberg J. Heterogeneity of type 2 innate lymphoid cells. Nat Rev Immunol. 2022;22:701–12. https://doi.org/10.1038/s41577-022-00704-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Serafini N, Vosshenrich CA, Di Santo JP. Transcriptional regulation of innate lymphoid cell fate. Nat Rev Immunol. 2015;15:415–28. https://doi.org/10.1038/nri3855.

Article  CAS  PubMed  Google Scholar 

von Moltke J, Ji M, Liang HE, Locksley RM. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature. 2016;529:221–5. https://doi.org/10.1038/nature16161.

Article  CAS  Google Scholar 

Xu H, Ding J, Porter CBM, Wallrapp A, Tabaka M, Ma S, et al. Transcriptional atlas of intestinal immune cells reveals that neuropeptide alpha-CGRP modulates group 2 innate lymphoid cell responses. Immunity. 2019;51:696–708.e699. https://doi.org/10.1016/j.immuni.2019.09.004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, et al. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017;549:351–6. https://doi.org/10.1038/nature24029.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao Y, Li Y, Wang X, Liu S, Zhang Y, Liu G, et al. Dopamine inhibits group 2 innate lymphoid cell-driven allergic lung inflammation by dampening mitochondrial activity. Immunity. 2023;56:320–35.e329. https://doi.org/10.1016/j.immuni.2022.12.017.

Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, et al. Pulmonary neuroendocrine cells amplify allergic asthma responses. Science. 2018;360. https://doi.org/10.1126/science.aan8546.

Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, et al. Silencing nociceptor neurons reduces allergic airway inflammation. Neuron. 2015;87:341–54. https://doi.org/10.1016/j.neuron.2015.06.007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Laffont S, Blanquart E, Savignac M, Cenac C, Laverny G, Metzger D, et al. Androgen signaling negatively controls group 2 innate lymphoid cells. J Exp Med. 2017;214:1581–92. https://doi.org/10.1084/jem.20161807.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu G, Chen Y, Wang Y, Deng X, Xiao Q, Zhang L, et al. Angiotensin II enhances group 2 innate lymphoid cell responses via AT1a during airway inflammation. J Exp Med.2022;219. https://doi.org/10.1084/jem.20211001.

Cui W, Nagano Y, Morita S, Tanoue T, Yamane H, Ishikawa K, et al. Diet-mediated constitutive induction of novel IL-4+ ILC2 cells maintains intestinal homeostasis in mice. J Exp Med. 2023;220. https://doi.org/10.1084/jem.20221773.

Hodge SH, Krauss MZ, Kaymak I, King JI, Howden AJM, Panic G, et al. Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses. J Exp Med. 2023;220. https://doi.org/10.1084/jem.20221073.

Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, et al. Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit. Immunity. 2018;49:33–41.e37. https://doi.org/10.1016/j.immuni.2018.06.016.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schneider C, O’Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, et al. A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling. Cell. 2018;174:271–84.e214. https://doi.org/10.1016/j.cell.2018.05.014.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, et al. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013;502:245–8. https://doi.org/10.1038/nature12526.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lei AH, Xiao Q, Liu GY, Shi K, Yang Q, Li X, et al. ICAM-1 controls development and function of ILC2. J Exp Med. 2018;215:2157–74. https://doi.org/10.1084/jem.20172359.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tamari M, Del Bel KL, Ver Heul AM, Zamidar L, Orimo K, Hoshi M, et al. Sensory neurons promote immune homeostasis in the lung. Cell. 2024;187:44–61.e17. https://doi.org/10.1016/j.cell.2023.11.027.

Article  CAS  PubMed  Google Scholar 

Liu GY, Wang Y, Yi XF, Wang JY, Zhang J, Feng XX, et al. BACH2 drives the development and function of group 2 innate lymphoid cells. Sci Adv. 2025;11. https://doi.org/10.1126/sciadv.ads4323.

Zang Y, Liu S, Rao Z, Wang Y, Zhang B, Li H, et al. Retinoid X receptor gamma dictates the activation threshold of group 2 innate lymphoid cells and limits type 2 inflammation in the small intestine. Immunity. 2023;56:2542–2554.e2547. https://doi.org/10.1016/j.immuni.2023.08.019.

Article  CAS  PubMed  Google Scholar 

Monticelli LA, Osborne LC, Noti M, Tran SV, Zaiss DM, Artis D. IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions. Proc Natl Acad Sci USA. 2015;112:10762–7. https://doi.org/10.1073/pnas.1509070112.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Uddin J, Yano H, Parkhurst CN, Zhang W, Ahmed A, Ribeiro de Godoy V, et al. CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation. Nature Immunology. 2025;26:1516–26. https://doi.org/10.1038/s41590-025-02243-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zaiss DMW, Pearce EJ, Artis D, McKenzie ANJ, Klose CSN. Cooperation of ILC2s and T(H)2 cells in the expulsion of intestinal helminth parasites. Nat Rev Immunol. 2023. https://doi.org/10.1038/s41577-023-00942-1.

Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TK, et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature. 2010;464:1367–70. https://doi.org/10.1038/nature08900.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKenzie GJ, Fallon PG, Emson CL, Grencis RK, McKenzie AN. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J Exp Med. 1999;189:1565–72. https://doi.org/10.1084/jem.189.10.1565.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Madden KB, Whitman L, Sullivan C, Gause WC, Urban JF Jr., Katona IM, et al. Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function. J Immunol. 2002;169:4417–22. https://doi.org/10.4049/jimmunol.169.8.4417.

Article  CAS  PubMed  Google Scholar 

Hasnain SZ, Evans CM, Roy M, Gallagher AL, Kindrachuk KN, Barron L, et al. Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med. 2011;208:893–900. https://doi.org/10.1084/jem.20102057.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arifuzzaman M, Won TH, Yano H, Uddin J, Emanuel ER, Hu E, et al. Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation. J Exp Med. 2024;221. https://doi.org/10.1084/jem.20232148.

Tsou AM, Yano H, Parkhurst CN, Mahlakõiv T, Chu C, Zhang W, et al. Neuropeptide regulation of nonredundant ILC2 responses at barrier surfaces. Nature. 2022;611:787–93. https://doi.org/10.1038/s41586-022-05297-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu G, Huang H, Wang Y, Han Y, Wang J, Shi M, et al. ILC2 instructs neural stem and progenitor cells to potentiate neurorepair after stroke. Neuron. 2025. https://doi.org/10.1016/j.neuron.2025.03.014.

Lei G, Zhuang L, Gan B. Targeting ferroptosis as a vulnerability in cancer. Nat Rev Cancer. 2022;22:381–96. https://doi.org/10.1038/s41568-022-00459-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22:266–82. https://doi.org/10.1038/s41580-020-00324-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Zeh HJ, Kang R, Kroemer G, Tang D. Cell death in pancreatic cancer: from pathogenesis to therapy. Nat Rev Gastroenterol Hepatol. 2021;18:804–23. https://doi.org/10.1038/s41575-021-00486-6.

Article  PubMed  Google Scholar 

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156:317–31. https://doi.org/10.1016/j.cell.2013.12.010.