SCI Abstract

search
+
Deferiprone inhibits virulence and biofilm formation in
Deferiprone inhibits virulence and biofilm formation in
Burkholderia cenocepacia, an opportunistic pathogen, poses a significant threat to human health, necessitating the discove...
CRISPR/Cas9-mediated deletion of a kinetoplast-associated gene attenuates virulence in parasites
CRISPR/Cas9-mediated deletion of a kinetoplast-associated gene attenuates virulence in parasites
We employed a CRISPR/Cas9 technique in Leishmania major to evaluate its efficiency in editing a kDNA-associated gene, the ...
Interleukin-6 overexpression and elevated granulocyte-to-lymphocyte ratio indicate hepatic stress in experimental group a Streptococcus sepsis
Interleukin-6 overexpression and elevated granulocyte-to-lymphocyte ratio indicate hepatic stress in experimental group a Streptococcus sepsis
Group A Streptococcus (GAS) is a pathogen that is capable of colonizing various infection sites and can potentially elicit...
Mechanistic insights into interaction facilitating UV-induced DNA damage repair in
Mechanistic insights into interaction facilitating UV-induced DNA damage repair in
Leishmania donovani is the causative agent of the fatal visceral leishmaniasis (VL) disease in humans in the tropical regi...
Profiling the nasopharyngeal Microbiome in patients with community-acquired pneumonia caused by : diagnostic challenges and ecological insights
Profiling the nasopharyngeal Microbiome in patients with community-acquired pneumonia caused by : diagnostic challenges and ecological insights
Community-acquired pneumonia (CAP) is a significant health threat for adults. Although conjugate vaccines have reduced pne...
Impact of vancomycin and on the secretome and pathogenicity of
Impact of vancomycin and on the secretome and pathogenicity of
Clostridium innocuum, a member of the human gut microbiome with intrinsic resistance to vancomycin, has been increasingly ...
Impact of colonization and skin abscesses on formation of human anti-αGal antibodies
Impact of colonization and skin abscesses on formation of human anti-αGal antibodies
IgG antibodies against terminal galactose-α-1,3-galactose (anti-αGal antibodies) are naturally occurring in huma...
Complement C5a promotes human retinal pigment epithelial cell viability and migration through SLC38A1-mediated glutamine metabolism
Complement C5a promotes human retinal pigment epithelial cell viability and migration through SLC38A1-mediated glutamine metabolism
The pathological basis of many visual disorders involves the abnormal viability and migration of retinal pigment epitheliu...
Regulatory T cells suppress TLR9-induced formation of intrahepatic myeloid-cell aggregates for T cell population expansion in liver
Regulatory T cells suppress TLR9-induced formation of intrahepatic myeloid-cell aggregates for T cell population expansion in liver
Toll-like receptor (TLR) 9 ligand has been reported to induce the formation of intrahepatic myeloid-cell aggregates for T ...
Streptococcal pyrogenic exotoxin a induces regulatory T cells via TNF-α-TNFR2 signaling
Streptococcal pyrogenic exotoxin a induces regulatory T cells via TNF-α-TNFR2 signaling
Bacterial superantigens are potent immune activators that trigger T cell proliferation and intensive release of cytokines,...
Targeting the STAT3/ACLY axis attenuates pulmonary inflammation but delays clearance via citrate metabolism
Targeting the STAT3/ACLY axis attenuates pulmonary inflammation but delays clearance via citrate metabolism
Airway epithelial cells play a pivotal role in the early host response to Mycoplasma pneumoniae colonization. Our previous...
Adaptation and validation of a gastrointestinal panel to detect diarrheal virus pathogens on a high-throughput qPCR system
Adaptation and validation of a gastrointestinal panel to detect diarrheal virus pathogens on a high-throughput qPCR system
With around 2 billion cases each year, infectious gastroenteritis remains a worldwide health problem. A major cau...
Long-lasting IgM and declining IgG levels: a serologic 5-year follow-up study in healthy blood donors infected with hepatitis E virus
Long-lasting IgM and declining IgG levels: a serologic 5-year follow-up study in healthy blood donors infected with hepatitis E virus
Hepatitis E virus (HEV) has attracted increasing attention in transfusion medicine in recent years. Mandatory testing regi...
Severe enterovirus A71 pathogenesis and immune responses in human nucleolin transgenic mice
Severe enterovirus A71 pathogenesis and immune responses in human nucleolin transgenic mice
Enterovirus A71 (EV-A71) infection is known to cause hand-foot-mouth disease, which may develop severe symptoms such as en...
Cytokine-mediated inhibition of adherence and invasion into nonphagocytic cells
Cytokine-mediated inhibition of adherence and invasion into nonphagocytic cells
Staphylococcus aureus is a major pathogen responsible for a wide range of infections, from minor skin diseases to life-thr...
Synergistic activity of fosfomycin and flucloxacillin against methicillin-susceptible and methicillin-resistant in vitro and in vivo assessment
Synergistic activity of fosfomycin and flucloxacillin against methicillin-susceptible and methicillin-resistant in vitro and in vivo assessment
Fosfomycin (FOF) exhibits broad-spectrum antimicrobial activity, and is mainly used in combination therapy. Previous in vi...
Fighting biofilm: bacteriophages eliminate biofilm formed by multidrug-resistant on urological catheters
Fighting biofilm: bacteriophages eliminate biofilm formed by multidrug-resistant on urological catheters
The Enterobacter cloacae complex (ECC) is a prevalent nosocomial pathogen associated with various human infections, which ...
Short- and long-term impact of aseptic bathing strategies on the skin microbiome in ICU patients
Short- and long-term impact of aseptic bathing strategies on the skin microbiome in ICU patients
Bathing strategies with antiseptic agents, such as Chlorhexidine and Octenidine, have been widely adopted to mitigate infe...
Effects of acetate-producing Blautia wexlerae on oxidative stress and NLRP3 inflammasome in obesity-associated male infertility
Effects of acetate-producing Blautia wexlerae on oxidative stress and NLRP3 inflammasome in obesity-associated male infertility
Background: Obesity-associated male infertility is a common complication of obesity and has been increasing in prevalence....
Serotype distribution, antibiotic resistance, multilocus sequence typing, and virulence factors of invasive and non-invasive Streptococcus pneumoniae in Northeast China from 2000 to 2021
Serotype distribution, antibiotic resistance, multilocus sequence typing, and virulence factors of invasive and non-invasive Streptococcus pneumoniae in Northeast China from 2000 to 2021
Streptococcus pneumoniae infection is a major public health concern with high morbidity and mortality rates. This study ai...
Alteration of β-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence
Alteration of β-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence
Candida auris is an emerging pathogenic yeast that has been categorized as a global public health threat and a critical pr...
Exploring the potential of Lactocaseibacillus rhamnosus PMC203 in inducing autophagy to reduce the burden of Mycobacterium tuberculosis
Exploring the potential of Lactocaseibacillus rhamnosus PMC203 in inducing autophagy to reduce the burden of Mycobacterium tuberculosis
Mycobacterium tuberculosis, a lethal pathogen in human history, causes millions of deaths annually, which demands the deve...
Identification of homologs of the Chlamydia trachomatis effector CteG reveals a family of Chlamydiaceae type III secreted proteins that can be delivered into host cells
Identification of homologs of the Chlamydia trachomatis effector CteG reveals a family of Chlamydiaceae type III secreted proteins that can be delivered into host cells
Chlamydiae are a large group of obligate endosymbionts of eukaryotes that includes the Chlamydiaceae family, comprising se...
Repurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis
Repurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis
Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, an intracellular pathogen with a high mort...
Carl Flügge, one of the last holistic hygienists and discoverer of droplet transmission of infectious diseases
Carl Flügge, one of the last holistic hygienists and discoverer of droplet transmission of infectious diseases
Carl Flügge is best known for the promotion of studies demonstrating the transmission of all manner of infections, bu...
Analytical and clinical evaluation of a novel real-time PCR-based detection kit for Mpox virus
Analytical and clinical evaluation of a novel real-time PCR-based detection kit for Mpox virus
Outbreaks of emerging diseases, like Mpox in 2022, pose unprecedented challenges to global healthcare systems. Although Mp...
Exploration of compounds to inhibit the Panton-Valentine leukocidin of Staphylococcus aureus
Exploration of compounds to inhibit the Panton-Valentine leukocidin of Staphylococcus aureus
The Panton-Valentine leukocidin (PVL) of Staphylococcus aureus is associated with necrotizing infections. After binding to...
Cellular immunity to nucleoproteins (NP) of Crimean-Congo hemorrhagic fever virus (CCHFV) and Hazara Virus (HAZV)
Cellular immunity to nucleoproteins (NP) of Crimean-Congo hemorrhagic fever virus (CCHFV) and Hazara Virus (HAZV)
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a globally significant vector-borne pathogen with no internationally-lice...
Trivalent outer membrane vesicles-based combination vaccine candidate induces protective immunity against Campylobacter and invasive non-typhoidal Salmonella in adult mice
Trivalent outer membrane vesicles-based combination vaccine candidate induces protective immunity against Campylobacter and invasive non-typhoidal Salmonella in adult mice
Campylobacter and invasive non-typhoidal Salmonella (iNTS) are among the most common causative agents of gastroenteritis w...
A plant-based oligomeric CD2v extracellular domain antigen exhibits equivalent immunogenicity to the live attenuated vaccine ASFV-G-∆I177L
A plant-based oligomeric CD2v extracellular domain antigen exhibits equivalent immunogenicity to the live attenuated vaccine ASFV-G-∆I177L
African swine fever (ASF), caused by the African swine fever virus (ASFV), is a deadly, highly contagious disease in both ...
Load More
format_indent_increase