SCI Abstract

search
+
pyruvate kinase and mitochondrial processing protease: Two novel vaccine candidates, selected via a seroproteomic approach, trigger a protective immune response against murine cutaneous leishmaniasis
pyruvate kinase and mitochondrial processing protease: Two novel vaccine candidates, selected via a seroproteomic approach, trigger a protective immune response against murine cutaneous leishmaniasis
American tegumentary leishmaniasis (ATL) is a neglected tropical disease that affects millions of people worldwide, for wh...
Regulated expression of galectins 1 and 3 IS associated with dysregulated T cell responses in pulmonary and pleural tuberculosis
Regulated expression of galectins 1 and 3 IS associated with dysregulated T cell responses in pulmonary and pleural tuberculosis
Galectins exert a wide range of effects on immune cells in acute and chronic pathologies, although their effects are less ...
A new bactericidal chlorinated derivative containing 2-aminooxazole potentiates antibacterial action of colistin against multidrug-resistant
A new bactericidal chlorinated derivative containing 2-aminooxazole potentiates antibacterial action of colistin against multidrug-resistant
This comprehensive study provides insight into the antibacterial action of a recently published 2-chloro-N-(oxazol-2-yl)is...
Therapeutic potential of PMC204 membrane vesicles against drug-resistant
Therapeutic potential of PMC204 membrane vesicles against drug-resistant
Tuberculosis remains a severe global health threat, exacerbated by the rising prevalence of multidrug-resistant (MDR) and ...
Diagnostic performance of circulating microRNA signatures for differentiating tuberculosis disease from tuberculosis infection
Diagnostic performance of circulating microRNA signatures for differentiating tuberculosis disease from tuberculosis infection
As regulators of innate and adaptive immunity, microRNAs (miRNAs) could aid in the discrimination between tuberculosis dis...
Effect of controlled human infection on B cell subsets in individuals with different levels of malaria immunity
Effect of controlled human infection on B cell subsets in individuals with different levels of malaria immunity
Continuous exposure to Plasmodium falciparum (Pf) has been associated with alterations in B cells. We investigated the eff...
Characterizing tuberculous meningitis in a South African pediatric cohort using GCxGC-TOFMS metabolomics
Characterizing tuberculous meningitis in a South African pediatric cohort using GCxGC-TOFMS metabolomics
The objective of this study was to characterize the metabolic profile of tuberculous meningitis (TBM) in the cerebrospinal...
or not? Beyond MALDI-TOF in the frontier of diversity
or not? Beyond MALDI-TOF in the frontier of diversity
Advanced platforms, such as whole genome sequencing (WGS), should be employed to enhance and refine microbial identificati...
Microbiome therapeutic PMC101 inhibits the translocation of carbapenem-resistant while enhancing eubiosis in antibiotic-induced dysbiosis mice
Microbiome therapeutic PMC101 inhibits the translocation of carbapenem-resistant while enhancing eubiosis in antibiotic-induced dysbiosis mice
Carbapenem-resistant Enterobacteriaceae (CRE), known for their extensive antibiotic resistance, pose a severe global medic...
Furamidine enhances IL-23-mediated autophagic response through IL-23R-TYK2-STAT3-dependent regulation of intracellular Ca²⁺ level to facilitate mycobacterial clearance in human macrophages
Furamidine enhances IL-23-mediated autophagic response through IL-23R-TYK2-STAT3-dependent regulation of intracellular Ca²⁺ level to facilitate mycobacterial clearance in human macrophages
Mycobacterium tuberculosis (M. tb), the etiological agent of tuberculosis (TB), subverts host immune responses to establis...
YopP modulates bacterial virulence and systemic dissemination in Peyer´s patches during murine infection
YopP modulates bacterial virulence and systemic dissemination in Peyer´s patches during murine infection
Yersinia enterocolitica (Ye) typically causes gastroenteritis and mesenteric lymphadenitis and can also spread extra-intes...
Commensal induce activation of monocytes via TLR2/CD14 signalling in whole blood
Commensal induce activation of monocytes via TLR2/CD14 signalling in whole blood
Myeloid cells, such as monocytes, are central in the immune response to infections. However, limited knowledge exists rega...
Genotypic investigation of in patients with relapsing leprosy in Mato Grosso, Brazil
Genotypic investigation of in patients with relapsing leprosy in Mato Grosso, Brazil
Leprosy is a chronic disease that leads to significant neurological damage and disabilities. Drug resistance is a major ch...
A comprehensive multi-epitope recombinant protein strategy for accurate serological detection of infection
A comprehensive multi-epitope recombinant protein strategy for accurate serological detection of infection
Toxoplasma gondii is a globally prevalent zoonotic parasite responsible for toxoplasmosis. Accurate serological diagnosis ...
The role of ciliary function in airway epithelial defense against
The role of ciliary function in airway epithelial defense against
Respiratory cilia play a crucial role in clearing pathogens from the airway, and understanding how Pseudomonas aeruginosa ...
A novel TamA + LtgC bivalent vaccine induces potent immunogenic and bactericidal antibodies against
A novel TamA + LtgC bivalent vaccine induces potent immunogenic and bactericidal antibodies against
Development of an effective vaccine against Neisseria gonorrhoeae comes with unique challenges. After five decades of rese...
Isohemagglutinins exhibit synergistic polyreactivity toward surface antigens: implications for broad-spectrum reactivity of human antibodies
Isohemagglutinins exhibit synergistic polyreactivity toward surface antigens: implications for broad-spectrum reactivity of human antibodies
Synergistic polyreactivity of antibodies—where distinct oligo- or polyreactive clones combine to enable broad-spectr...
A potent protein vaccines OmpW induces strong protective immunity against in a mouse model
A potent protein vaccines OmpW induces strong protective immunity against in a mouse model
Klebsiella pneumoniae causes severe respiratory-associated infections in healthy individuals, and widespread antibiotic re...
Characterization of outer membrane vesicles from and their role in the dissemination of carbapenem resistance
Characterization of outer membrane vesicles from and their role in the dissemination of carbapenem resistance
Species outside the Acinetobacter calcoaceticus–baumannii (Acb) complex have recently emerged as new clinically rele...
The 2′-α-Fluoro,2′-β-Bromo uridine phosphoramidate prodrug (2-BFU) reduces dengue virus replication and attenuates infection-induced thrombocytopenia
The 2′-α-Fluoro,2′-β-Bromo uridine phosphoramidate prodrug (2-BFU) reduces dengue virus replication and attenuates infection-induced thrombocytopenia
Dengue virus (DENV) infection remains a major global health concern, with clinical manifestations ranging from mild febril...
Deferiprone inhibits virulence and biofilm formation in
Deferiprone inhibits virulence and biofilm formation in
Burkholderia cenocepacia, an opportunistic pathogen, poses a significant threat to human health, necessitating the discove...
CRISPR/Cas9-mediated deletion of a kinetoplast-associated gene attenuates virulence in parasites
CRISPR/Cas9-mediated deletion of a kinetoplast-associated gene attenuates virulence in parasites
We employed a CRISPR/Cas9 technique in Leishmania major to evaluate its efficiency in editing a kDNA-associated gene, the ...
Interleukin-6 overexpression and elevated granulocyte-to-lymphocyte ratio indicate hepatic stress in experimental group a Streptococcus sepsis
Interleukin-6 overexpression and elevated granulocyte-to-lymphocyte ratio indicate hepatic stress in experimental group a Streptococcus sepsis
Group A Streptococcus (GAS) is a pathogen that is capable of colonizing various infection sites and can potentially elicit...
Mechanistic insights into interaction facilitating UV-induced DNA damage repair in
Mechanistic insights into interaction facilitating UV-induced DNA damage repair in
Leishmania donovani is the causative agent of the fatal visceral leishmaniasis (VL) disease in humans in the tropical regi...
Profiling the nasopharyngeal Microbiome in patients with community-acquired pneumonia caused by : diagnostic challenges and ecological insights
Profiling the nasopharyngeal Microbiome in patients with community-acquired pneumonia caused by : diagnostic challenges and ecological insights
Community-acquired pneumonia (CAP) is a significant health threat for adults. Although conjugate vaccines have reduced pne...
Impact of vancomycin and on the secretome and pathogenicity of
Impact of vancomycin and on the secretome and pathogenicity of
Clostridium innocuum, a member of the human gut microbiome with intrinsic resistance to vancomycin, has been increasingly ...
Impact of colonization and skin abscesses on formation of human anti-αGal antibodies
Impact of colonization and skin abscesses on formation of human anti-αGal antibodies
IgG antibodies against terminal galactose-α-1,3-galactose (anti-αGal antibodies) are naturally occurring in huma...
Complement C5a promotes human retinal pigment epithelial cell viability and migration through SLC38A1-mediated glutamine metabolism
Complement C5a promotes human retinal pigment epithelial cell viability and migration through SLC38A1-mediated glutamine metabolism
The pathological basis of many visual disorders involves the abnormal viability and migration of retinal pigment epitheliu...
Regulatory T cells suppress TLR9-induced formation of intrahepatic myeloid-cell aggregates for T cell population expansion in liver
Regulatory T cells suppress TLR9-induced formation of intrahepatic myeloid-cell aggregates for T cell population expansion in liver
Toll-like receptor (TLR) 9 ligand has been reported to induce the formation of intrahepatic myeloid-cell aggregates for T ...
Streptococcal pyrogenic exotoxin a induces regulatory T cells via TNF-α-TNFR2 signaling
Streptococcal pyrogenic exotoxin a induces regulatory T cells via TNF-α-TNFR2 signaling
Bacterial superantigens are potent immune activators that trigger T cell proliferation and intensive release of cytokines,...
Load More
format_indent_increase