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SerpinB9 sustains CIITA to orchestrate MHC-II expression and Th1 differentiation in β-glucan-induced macrophages
SerpinB9 sustains CIITA to orchestrate MHC-II expression and Th1 differentiation in β-glucan-induced macrophages
Whole glucan particles (WGP) enhance macrophage immune function, while serine protease inhibitor B9 (SerpinB9)—a mol...
Seasonal pattern, global search trend, and public interest in arthritis from 2004 to 2022: an infodemiology study
Seasonal pattern, global search trend, and public interest in arthritis from 2004 to 2022: an infodemiology study
Arthritis is a common condition that causes articular cartilage damage, joint tissue destruction, and ligament involvement...
Disease activity and immune disbalance are key drivers of infections in patients with idiopathic inflammatory myopathies: results from the MYOTReCSZ cohort
Disease activity and immune disbalance are key drivers of infections in patients with idiopathic inflammatory myopathies: results from the MYOTReCSZ cohort
Patients with idiopathic inflammatory myopathies (IIM) are at increased risk for infections. Identifying clinical and immu...
Characterization of the neuromuscular manifestations in patients with IgG4-related disease: a systematic review
Characterization of the neuromuscular manifestations in patients with IgG4-related disease: a systematic review
Immunoglobulin G4-related disease (IgG4-RD) neurological involvement typically presents as pachymeningitis. However, there...
Dexmedetomidine protects against postoperative neurocognitive disorder by mitigating mitochondrial dysfunction through regulating the IP3R-GRP75-VDAC1 complex-mediated calcium transport
Dexmedetomidine protects against postoperative neurocognitive disorder by mitigating mitochondrial dysfunction through regulating the IP3R-GRP75-VDAC1 complex-mediated calcium transport
Dexmedetomidine (Dex), an α2 adrenergic receptor agonist, has been shown to exert protective effects against postoper...
History of cold urticaria research: from systematic studies of the 19th century to modern prospective strategies in clinical practice
History of cold urticaria research: from systematic studies of the 19th century to modern prospective strategies in clinical practice
This study aimed to determine the current prospective strategies for diagnosing and treating cold urticaria based on the h...
STAT6 inhibition stabilizes induced regulatory T cells and enhances their therapeutic potential in inflammatory bowel disease
STAT6 inhibition stabilizes induced regulatory T cells and enhances their therapeutic potential in inflammatory bowel disease
The development and stability of induced regulatory T cells (iTregs) are essential for their immunosuppressive function an...
Lactylation-related multigene signature in multiple myeloma: integrated prognostic stratification, immune landscape profiling, and therapeutic guidance
Lactylation-related multigene signature in multiple myeloma: integrated prognostic stratification, immune landscape profiling, and therapeutic guidance
Multiple myeloma (MM) is an incurable hematologic malignancy with high heterogeneity and poor prognosis. Lactylation, a no...
Macrophage migration inhibitory factor (MIF): a Janus-faced cytokine in viral pathogenesis and host defense
Macrophage migration inhibitory factor (MIF): a Janus-faced cytokine in viral pathogenesis and host defense
Macrophage migration inhibitory factor (MIF) is one of several pivotal cytokines that contribute to orchestrate immune reg...
Regulatory dynamics of Th17 lymphocytes in oral squamous cell carcinoma: immune modulation and emerging immunotherapies
Regulatory dynamics of Th17 lymphocytes in oral squamous cell carcinoma: immune modulation and emerging immunotherapies
With the rapid increase in the severity and mortality of OSCC, the potential for new and effective therapies has increased...
BECN1 activator peptide Tat-beclin 1 promotes ferroptosis via the BECN1-SLC7A11 axis to inhibit NSCLC progression
BECN1 activator peptide Tat-beclin 1 promotes ferroptosis via the BECN1-SLC7A11 axis to inhibit NSCLC progression
Non-small-cell lung cancer (NSCLC) is associated with high mortality. Beclin 1 (BECN1), an autophagy regulator, and ferrop...
Polymorphisms in and genes in rheumatoid arthritis: a Brazilian study and meta-analysis of susceptibility and TNFi response
Polymorphisms in and genes in rheumatoid arthritis: a Brazilian study and meta-analysis of susceptibility and TNFi response
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressiv...
MYC affects mitochondrial function in IgA nephropathy by promoting the degradation of MFN1 through HRD1
MYC affects mitochondrial function in IgA nephropathy by promoting the degradation of MFN1 through HRD1
IgA nephropathy is characterized by the deposition of IgA and complement C3 in the glomerular mesangial region. Recent res...
Deciphering macrophage dynamics and immune evasion strategies by the intracellular bacteria
Deciphering macrophage dynamics and immune evasion strategies by the intracellular bacteria
Macrophages are the constituents of the innate immune system that play an important role in the control of infections, pha...
Hypermethylation of lysosomal-associated genes and compromises lysosome function in patients with acute lymphoblastic leukemia
Hypermethylation of lysosomal-associated genes and compromises lysosome function in patients with acute lymphoblastic leukemia
DNA methylation plays a pivotal role in the pathogenesis of Acute Lymphocytic Leukemia (ALL), a hematological malignancy m...
RNA-based cancer vaccines: mechanisms, clinical progress, and translational challenges
RNA-based cancer vaccines: mechanisms, clinical progress, and translational challenges
Recent advancements in vaccine technology have led to the development of RNA-based vaccines, including mRNA, circular RNA,...
Prevalence, incidence, and mortality of autoimmune diseases among adolescents and young adults in Mexico: an analysis based on the global burden of disease study 2021
Prevalence, incidence, and mortality of autoimmune diseases among adolescents and young adults in Mexico: an analysis based on the global burden of disease study 2021
This nationwide analysis quantified the contemporary and future burden of six autoimmune diseases (ADs)—rheumatoid a...
Macrophage-derived exosomes in autoimmune diseases: mechanistic insights and therapeutic implications
Macrophage-derived exosomes in autoimmune diseases: mechanistic insights and therapeutic implications
Autoimmune diseases are characterized by an aberrant immune response that targets the body’s own tissues, resulting ...
A comprehensive analysis of scRNA-Seq and RNA-Seq unveils B cell immune suppression in the AAV-loaded brain
A comprehensive analysis of scRNA-Seq and RNA-Seq unveils B cell immune suppression in the AAV-loaded brain
The use of AAV vectors for in vivo gene therapy has demonstrated the potential to permanently correct genetic diseases by ...
Deciphering autoimmune susceptibility: a meta-analysis of gene variants
Deciphering autoimmune susceptibility: a meta-analysis of gene variants
Autoimmune disorders are intricate conditions where the immune system directs its attack towards the body’s tissues....
Systemic barrier dysfunction in type 2 inflammation diseases: perspective in the skin, airways, and gastrointestinal tract
Systemic barrier dysfunction in type 2 inflammation diseases: perspective in the skin, airways, and gastrointestinal tract
The epithelial barrier in different organs is the first line of defense against environmental insults and allergens, with ...
A novel loss of function mutation in the gene in a patient diagnosed with Hodgkin’s lymphoma
A novel loss of function mutation in the gene in a patient diagnosed with Hodgkin’s lymphoma
Kane LP. T cell Ig and mucin domain proteins and immunity. J Immunol Baltim Md 1950. 2010;184(6):2743–9.CAS  ...
Immunoenhancing of the anti-cancer therapy and anti-oxidative stress by co-administration of granulocyte-colony stimulating factor-mobilized stem cells or cells derived from bone marrow and/or spleen plus vaccination with chemotherapeutic cyclophosphamide
Immunoenhancing of the anti-cancer therapy and anti-oxidative stress by co-administration of granulocyte-colony stimulating factor-mobilized stem cells or cells derived from bone marrow and/or spleen plus vaccination with chemotherapeutic cyclophosphamide
The combination of immunotherapy and chemotherapy, referred to as chemo-immunotherapy, represents a promising regimen for ...
α-Amanitin aggravates hepatic injury by activating oxidative stress and mitophagy via peroxiredoxin 6 inhibition
α-Amanitin aggravates hepatic injury by activating oxidative stress and mitophagy via peroxiredoxin 6 inhibition
Mushroom poisoning is mainly caused by α-amanitin (α-AMA), and there is currently no effective drug to treat ...
Pivotal epitopes for islet antigen-specific CD8 T cell detection improve classification of suspected type 1 diabetes with the HLA-A*0201 allele
Pivotal epitopes for islet antigen-specific CD8 T cell detection improve classification of suspected type 1 diabetes with the HLA-A*0201 allele
A proportion of patients with new-onset diabetes share similar symptoms with type 1 diabetes (T1D) patients but they are n...
Clinical management of autoimmune liver diseases: juncture, opportunities, and challenges ahead
Clinical management of autoimmune liver diseases: juncture, opportunities, and challenges ahead
The three major autoimmune liver diseases are autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary s...
Phenotypic characterization of tumor associated macrophages and circulating monocytes in patients with Urothelial carcinoma of bladder
Phenotypic characterization of tumor associated macrophages and circulating monocytes in patients with Urothelial carcinoma of bladder
Targeting immune checkpoints has shown clinical efficacy in Urothelial carcinoma of bladder (UBC); however, a substantial ...
HBx/WDR5 enhances IGF-1 transcription in hepatocellular carcinoma cells and promotes recruitment, infiltration, and activity of Treg cells
HBx/WDR5 enhances IGF-1 transcription in hepatocellular carcinoma cells and promotes recruitment, infiltration, and activity of Treg cells
HBV X protein (HBx), the smallest open reading frame in the hepatitis B virus (HBV) genome, can promote hepatocellular car...
Role of basophils and type 2 inflammation in bullous pemphigoid pathophysiology: a comparative study of blood and blister fluid
Role of basophils and type 2 inflammation in bullous pemphigoid pathophysiology: a comparative study of blood and blister fluid
Bullous pemphigoid (BP) is an autoimmune disease characterized by blister formation and inflammatory cell infiltration. In...
Comparison of artificial intelligence applications and commercial system performances using selected ANA IIF images
Comparison of artificial intelligence applications and commercial system performances using selected ANA IIF images
Accurate and accessible classification of anti-nuclear antibodies (ANA) through indirect immunofluorescence (IIF) imaging ...
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