Kane LP. T cell Ig and mucin domain proteins and immunity. J Immunol Baltim Md 1950. 2010;184(6):2743–9.

CAS  Google Scholar 

Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature. 2002;415(6871):536–41.

Article  PubMed  CAS  Google Scholar 

Koguchi K, Anderson DE, Yang L, O’Connor KC, Kuchroo VK, Hafler DA. Dysregulated T cell expression of TIM3 in multiple sclerosis. J Exp Med. 2006;203(6):1413.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yang L, Anderson DE, Kuchroo J, Hafler DA. Lack of TIM-3 immunoregulation in multiple sclerosis. J Immunol Baltim Md 1950. 2008;180(7):4409–14.

CAS  Google Scholar 

Sánchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, et al. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol. 2003;4(11):1093–101.

Article  PubMed  Google Scholar 

Xie Y. The immune contexture and cancer therapy aspects of the TIM-3 checkpoint pathway. E3S Web Conf. 2021;271:02021.

Article  CAS  Google Scholar 

Sabatos CA, Chakravarti S, Cha E, Schubart A, Sánchez-Fueyo A, Zheng XX, et al. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol. 2003;4(11):1102–10.

Article  PubMed  CAS  Google Scholar 

Shen P, Yue R, Tang J, Si H, Shen L, Guo C, et al. Preferential Tim-3 expression on Treg and CD8(+) T cells, supported by tumor-associated macrophages, is associated with worse prognosis in gastric cancer. Am J Transl Res. 2016;8(8):3419–28.

PubMed  PubMed Central  CAS  Google Scholar 

Das M, Zhu C, Kuchroo VK. Tim-3 and its role in regulating anti-tumor immunity. Immunol Rev. 2017;276(1):97–111.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu JF, Wu L, Yang LL, Deng WW, Mao L, Wu H, et al. Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer. J Exp Clin Cancer Res CR. 2018;37:44.

Article  PubMed  Google Scholar 

Gayden T, Sepulveda FE, Khuong-Quang DA, Pratt J, Valera ET, Garrigue A, et al. Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome. Nat Genet. 2018;50(12):1650–7.

Article  PubMed  CAS  Google Scholar 

Chaweephisal P, Sosothikul D, Polprasert C, Wananukul S, Seksarn P. Subcutaneous panniculitis-like T-cell lymphoma with hemophagocytic lymphohistiocytosis syndrome in children and its essential role of HAVCR2 gene mutation analysis. J Pediatr Hematol Oncol. 2021;43(1):e80–4.

Article  PubMed  CAS  Google Scholar 

Wolf Y, Anderson AC, Kuchroo VK. TIM3 comes of age as an inhibitory receptor. Nat Rev Immunol. 2020;20(3):173–85.

Article  PubMed  CAS  Google Scholar 

Giovannone N, Liang J, Antonopoulos A, Geddes Sweeney J, King SL, Pochebit SM, et al. Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans. Nat Commun. 2018;9(1):3287.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cao A, Alluqmani N, Buhari FHM, Wasim L, Smith LK, Quaile AT, et al. Galectin-9 binds IgM-BCR to regulate B cell signaling. Nat Commun. 2018;9(1):3288.

Article  PubMed  PubMed Central  Google Scholar 

Gibson JF, Alpdogan O, Subtil A, Girardi M, Wilson LD, Roberts K, Foss F. Hematopoietic stem cell transplantation for primary cutaneous γδ T-cell lymphoma and refractory subcutaneous panniculitis-like T-cell lymphoma. J Am Acad Dermatol. 2015;72(6):1010-5.e5. https://doi.org/10.1016/j.jaad.2015.01.003.

Article  PubMed  Google Scholar 

Weng Wen-Kai, Iragavarapu Chaitanya, Weng Gavin M, Hoppe Richard T, Hiniker Susan, Khodadoust Michael S, Kim Youn H. Long-term remission with allogeneic transplant in patients with refractory/relapsed cutaneous cytotoxic T-cell lymphoma. Blood Neoplasia. 2024;1(2):100007.

Article  Google Scholar 

Wegehaupt O, Groß M, Wehr C, Marks R, Schmitt-Graeff A, Uhl M, Lorenz M, Schwarz K, Kratz C, Niemeyer C, Ehl S. TIM-3 deficiency presenting with two clonally unrelated episodes of mesenteric and subcutaneous panniculitis-like T-cell lymphoma and hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2020;67(6):e28302. https://doi.org/10.1002/pbc.28302.

Article  PubMed  Google Scholar