Systemic barrier dysfunction in type 2 inflammation diseases: perspective in the skin, airways, and gastrointestinal tract

Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD. Atopic dermatitis. Nat Rev Dis Primers. 2018;4(1):1. https://doi.org/10.1038/s41572-018-0001-z.

Article  PubMed  Google Scholar 

Kim B, Rothenberg ME, Sun X, Bachert C, Artis D, Zaheer R, et al. Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms, and therapeutic targets in atopic diseases. J Allergy Clin Immunol. 2023. https://doi.org/10.1016/j.jaci.2023.08.017.

Article  PubMed  PubMed Central  Google Scholar 

Koyasu S, Moro K. Type 2 innate immune responses and the natural helper cell. Immunology. 2011;132(4):475–81. https://doi.org/10.1111/j.1365-2567.2011.03413.x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prescott J, Szeszko A. The emerging role of the type 2 inflammatory cascade in atopic diseases[J]. 2019.

Kenneth M, Casey W. Janeway's immuno biology 9th edition [M]. Taylor & Francis Group, LLC, Garland Science; 2017.

Schleimer RP, Berdnikovs S. Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases. J Allergy Clin Immunol. 2017;139(6):1752–61. https://doi.org/10.1016/j.jaci.2017.04.010.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Larsen SB, Cowley CJ, Fuchs E. Epithelial cells: liaisons of immunity. Curr Opin Immunol. 2020;62:45–53. https://doi.org/10.1016/j.coi.2019.11.004.

Article  CAS  PubMed  Google Scholar 

Georas SN, Rezaee F. Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation. J Allergy Clin Immunol. 2014;134(3):509–20. https://doi.org/10.1016/j.jaci.2014.05.049.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Izquierdo E, Rodriguez-Coira J, Delgado-Dolset MI, Gomez-Casado C, Barber D, Escribese MM. Epithelial barrier: protector and trigger of allergic disorders. J Investig Allergol Clin Immunol. 2022;32(2):81–96. https://doi.org/10.18176/jiaci.0779.

Article  CAS  PubMed  Google Scholar 

Schneeberger EE, Lynch RD. The tight junction: a multifunctional complex. Am J Physiol Cell Physiol. 2004;286(6):C1213–28. https://doi.org/10.1152/ajpcell.00558.2003.

Article  CAS  PubMed  Google Scholar 

Parron-Ballesteros J, Gordo RG, Lopez-Rodriguez JC, Olmo N, Villalba M, Batanero E, et al. Beyond allergic progression: from molecules to microbes as barrier modulators in the gut-lung axis functionality. Front Allergy. 2023;4:1093800. https://doi.org/10.3389/falgy.2023.1093800.

Article  PubMed  PubMed Central  Google Scholar 

Noda S, Krueger JG, Guttman-Yassky E. The translational revolution and use of biologics in patients with inflammatory skin diseases. J Allergy Clin Immunol. 2015;135(2):324–36. https://doi.org/10.1016/j.jaci.2014.11.015.

Article  CAS  PubMed  Google Scholar 

Kim B, Rothenberg ME, Sun X, Bachert C, Artis D, Zaheer R, et al. Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases. J Allergy Clin Immunol. 2023. https://doi.org/10.1016/j.jaci.2023.08.017.

Article  PubMed  PubMed Central  Google Scholar 

Hoy SM. Tezepelumab: first approval. Drugs. 2022;82(4):461–8. https://doi.org/10.1007/s40265-022-01679-2.

Article  CAS  PubMed  Google Scholar 

Akdis CA. Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions? Nat Rev Immunol. 2021;21(11):739–51. https://doi.org/10.1038/s41577-021-00538-7.

Article  CAS  PubMed  Google Scholar 

Lopez-Rodriguez JC, Gonzalez M, Bogas G, Mayorga C, Villalba M, Batanero E. Epithelial permeability to Ole e 1 is more dependent on the functional state of the bronchial epithelium than on the activity of Der p 1 protease acting as an adjuvant to the bystander allergen. J Investig Allergol Clin Immunol. 2021;31(4):343–6. https://doi.org/10.18176/jiaci.0603.

Article  CAS  PubMed  Google Scholar 

Sajjan U, Wang Q, Zhao Y, Gruenert DC, Hershenson MB. Rhinovirus disrupts the barrier function of polarized airway epithelial cells. Am J Respir Crit Care Med. 2008;178(12):1271–81. https://doi.org/10.1164/rccm.200801-136OC.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haahtela T. A biodiversity hypothesis. Allergy. 2019;74(8):1445–56. https://doi.org/10.1111/all.13763.

Article  PubMed  Google Scholar 

Hevia A, Milani C, Lopez P, Donado CD, Cuervo A, Gonzalez S, et al. Allergic patients with long-term asthma display low levels of Bifidobacterium adolescentis. PLoS ONE. 2016;11(2):e0147809. https://doi.org/10.1371/journal.pone.0147809.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pothoven KL, Schleimer RP. The barrier hypothesis and Oncostatin M: Restoration of epithelial barrier function as a novel therapeutic strategy for the treatment of type 2 inflammatory disease. Tissue Barriers. 2017;5(3):e1341367. https://doi.org/10.1080/21688370.2017.1341367.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xian M, Wawrzyniak P, Ruckert B, Duan S, Meng Y, Sokolowska M, et al. Anionic surfactants and commercial detergents decrease tight junction barrier integrity in human keratinocytes. J Allergy Clin Immunol. 2016;138(3):890-3 e9. https://doi.org/10.1016/j.jaci.2016.07.003.

Article  CAS  PubMed  Google Scholar 

Wang M, Tan G, Eljaszewicz A, Meng Y, Wawrzyniak P, Acharya S, et al. Laundry detergents and detergent residue after rinsing directly disrupt tight junction barrier integrity in human bronchial epithelial cells. J Allergy Clin Immunol. 2019;143(5):1892–903. https://doi.org/10.1016/j.jaci.2018.11.016.

Article  CAS  PubMed  Google Scholar 

Ogulur I, Pat Y, Aydin T, Yazici D, Ruckert B, Peng Y, et al. Gut epithelial barrier damage caused by dishwasher detergents and rinse aids. J Allergy Clin Immunol. 2023;151(2):469–84. https://doi.org/10.1016/j.jaci.2022.10.020.

Article  CAS  PubMed  Google Scholar 

Sandall AM, Cox SR, Lindsay JO, Gewirtz AT, Chassaing B, Rossi M, et al. Emulsifiers impact colonic length in mice and emulsifier restriction is feasible in people with Crohn’s disease. Nutrients. 2020;12(9). https://doi.org/10.3390/nu12092827.

Halmos EP, Mack A, Gibson PR. Review article: Emulsifiers in the food supply and implications for gastrointestinal disease. Aliment Pharmacol Ther. 2019;49(1):41–50. https://doi.org/10.1111/apt.15045.

Article  CAS  PubMed  Google Scholar 

Celebi Sozener Z, Ozbey Yucel U, Altiner S, Ozdel Ozturk B, Cerci P, Turk M, et al. The external exposome and allergies: from the perspective of the epithelial barrier hypothesis. Front Allergy. 2022;3:887672. https://doi.org/10.3389/falgy.2022.887672.

Article  PubMed  PubMed Central  Google Scholar 

Akdis CA, Arkwright PD, Bruggen MC, Busse W, Gadina M, Guttman-Yassky E, et al. Type 2 immunity in the skin and lungs. Allergy. 2020;75(7):1582–605. https://doi.org/10.1111/all.14318.

Article  CAS  PubMed  Google Scholar 

Hopp RJ. Hypersensitivity reactions: an everyday occurrence in pediatric allergy clinics. Pediatr Allergy Immunol Pulmonol. 2020;33(1):12–8. https://doi.org/10.1089/ped.2019.1109.

Article  PubMed  PubMed Central  Google Scholar 

Annunziato F, Romagnani C, Romagnani S. The 3 major types of innate and adaptive cell-mediated effector immunity. J Allergy Clin Immunol. 2015;135(3):626–35. https://doi.org/10.1016/j.jaci.2014.11.001.

Article  CAS  PubMed  Google Scholar 

Egholm C, Heeb LEM, Impellizzieri D, Boyman O. The regulatory effects of interleukin-4 receptor signaling on neutrophils in type 2 immune responses. Front Immunol. 2019;10:2507. https://doi.org/10.3389/fimmu.2019.02507.

Article 

Comments (0)

No login
gif