Pivotal epitopes for islet antigen-specific CD8 T cell detection improve classification of suspected type 1 diabetes with the HLA-A*0201 allele

Quattrin T, Mastrandrea LD, Walker LSK. Type 1 diabetes. Lancet. 2023;401:2149. https://doi.org/10.1016/S0140-6736(23)00223-4.

Article  CAS  PubMed  Google Scholar 

Phillip M, Achenbach P, Addala A, et al. Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes. Diabetes Care. 2024;47(8):1276–98. https://doi.org/10.2337/dci24-0042.

Article  CAS  PubMed  Google Scholar 

Yang L, Luo S, Huang G, et al. The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese. Diabetes Metab Res Rev. 2010;26(7):579–84. https://doi.org/10.1002/dmrr.1128.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ludvigsson J, Carlsson A, Deli A, et al. Decline of C-peptide during the first year after diagnosis of Type 1 diabetes in children and adolescents. Res Support, NIH, Extramural Res Support, Non-US Gov’t Diabetes Res Clin Pract. 2013;100(2):203–9. https://doi.org/10.1016/j.diabres.2013.03.003.

Article  CAS  PubMed  Google Scholar 

Wiedeman AE, Muir VS, Rosasco MG, et al. Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression. J Clin Invest. 2020;130(1):480–90. https://doi.org/10.1172/JCI126595.

Article  CAS  PubMed  Google Scholar 

Katsarou A, Gudbjornsdottir S, Rawshani A, et al. Type 1 diabetes mellitus. Nat Rev Dis Primers. 2017;3:17016. https://doi.org/10.1038/nrdp.2017.16.

Article  PubMed  Google Scholar 

Mallone R, Roep BO. Biomarkers for immune intervention trials in type 1 diabetes. Research Support, Non-U.S. Gov’t Review. Clin Immunol. 2013;149(3):286–96. https://doi.org/10.1016/j.clim.2013.02.009.

Article  CAS  PubMed  Google Scholar 

Wu X, Xu X, Gu R, et al. Prediction of HLA class I-restricted T-cell epitopes of islet autoantigen combined with binding and dissociation assays. Research Support, Non-U.S. Gov’t. Autoimmunity. 2012;45(2):176–85. https://doi.org/10.3109/08916934.2011.622014.

Article  CAS  PubMed  Google Scholar 

Martinuzzi E, Novelli G, Scotto M, et al. The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment. Diabetes. 2008;57(5):1312–20. https://doi.org/10.2337/db07-1594.

Article  CAS  PubMed  Google Scholar 

Blancou P, Mallone R, Martinuzzi E, et al. Immunization of HLA Class I Transgenic mice identifies autoantigenic epitopes eliciting dominant responses in Type 1 diabetes patients. J Immunol. 2007;178(11):7458–66. https://doi.org/10.4049/jimmunol.178.11.7458

Article  PubMed  Google Scholar 

Luce S, Lemonnier F, Briand JP, et al. Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes. Diabetes. 2011;60(12):3289–99. https://doi.org/10.2337/db11-0270.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Toma A, Laika T, Haddouk S, et al. Recognition of human proinsulin leader sequence by class I-restricted T-cells in HLA-A*0201 transgenic mice and in human type 1 diabetes. Diabetes. 2009;58(2):394–402. https://doi.org/10.2337/db08-0599.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Skowera A, Ellis RJ, Varela-Calvino R, et al. CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope Research Support, Non-U.S. Gov’t. J Clin Investig. 2008;118(10):3390–402. https://doi.org/10.1172/JCI35449.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mallone R, Scotto M, Janicki CN, et al. Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop report-HLA Class I tetramer validation initiative. Diabetes Metab Res Rev. 2011;27(8):720–6. https://doi.org/10.1002/dmrr.1243.

Article  CAS  PubMed  Google Scholar 

Toma A, Haddouk S, Briand JP, et al. Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients. Proc Natl Acad Sci USA. 2005;102(30):10581–6. https://doi.org/10.1073/pnas.0504230102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pinkse GG, Tysma OH, Bergen CA, et al. Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci USA. 2005;102(51):18425–30. https://doi.org/10.1073/pnas.0508621102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Panina-Bordignon P, Lang R, van Endert PM, et al. Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes. J Exp Med. 1995;181(5):1923–7. https://doi.org/10.1084/jem.181.5.1923

Article  CAS  PubMed  Google Scholar 

Ouyang Q, Standifer NE, Qin H, et al. Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes. Diabetes. 2006;55(11):3068–74. https://doi.org/10.2337/db06-0065.

Article  CAS  PubMed  Google Scholar 

Standifer NE, Ouyang Q, Panagiotopoulos C, et al. Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t. Diabetes. 2006;55(11):3061–7. https://doi.org/10.2337/db06-0066.

Article  CAS  PubMed  Google Scholar 

Panagiotopoulos C, Qin H, Tan R, Verchere CB. Identification of a beta-cell-specific HLA class I restricted epitope in type 1 diabetes. Diabetes. 2003;52(11):2647–51. https://doi.org/10.2337/diabetes.52.11.2647

Article  CAS  PubMed  Google Scholar 

Scotto M, Afonso G, Larger E, et al. Zinc transporter (ZnT)8(186–194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients. Diabetologia. 2012;55(7):2026–31. https://doi.org/10.1007/s00125-012-2543-z.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Enee E, Kratzer R, Arnoux JB, et al. ZnT8 is a major CD8+ T cell-recognized autoantigen in pediatric type 1 diabetes. Diabetes. 2012;61(7):1779–84. https://doi.org/10.2337/db12-0071.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu X, Gu Y, Bian L, et al. Characterization of immune response to novel HLA-A2-restricted epitopes from zinc transporter 8 in type 1 diabetes. Vaccine. 2016;34(6):854–62. https://doi.org/10.1016/j.vaccine.2015.10.108.

Article  CAS  PubMed  Google Scholar 

Paul M, Badal D, Jacob N, et al. Pathophysiological characteristics of preproinsulin-specific CD8+ T cells in subjects with juvenile-onset and adult-onset type 1 diabetes: A 1-year follow-up study. Pediatric Diabetes. 2017;19:68. https://doi.org/10.1111/pedi.12536.

Article  CAS  PubMed  Google Scholar 

Unger WW, Velthuis J, Abreu JR, et al. Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers. J Autoimmun. 2011;37(3):151–9. https://doi.org/10.1016/j.jaut.2011.05.012.

Article  CAS  PubMed  Google Scholar 

van Lummel M, Duinkerken G, van Veelen PA, et al. Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes. Diabetes. 2014;63(1):237–47. https://doi.org/10.2337/db12-1214.

Article  CAS  PubMed  Google Scholar 

Arif S, Tree TI, Astill TP, et al. Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Investig. 2004;113(3):451–63. https://doi.org/10.1172/jci19585.

Article  CAS  PubMed 

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