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Double negative T cells (CD4-/CD8-) are associated with Trypanosoma cruzi persistence in the mouse colon during chronic Chagas disease
IntroductionChagas disease (CD), caused by the blood borne parasite Trypanosoma cruzi, affects 6–8 million people primaril...
Multi-omics and experimental validation identify USP54 as a prognostic deubiquitinase promoting pancreatic ductal adenocarcinoma progression within the immune microenvironment
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a complex tumor ecosystem that contri...
Deciphering the interferon gene signature spectrum: association with the clinical heterogeneity of Sjögren’s disease
PurposeThis study aimed to identify interferon (IFN)-related key genes in patients with Sjögren’s Disease (SjD) and to elu...
Hepatitis C virus core protein-induced myeloid-derived suppressor cells promote hepatic fibrosis by regulating hepatic stellate cell function via TGF-β
Background and objectiveMyeloid-derived suppressor cells (MDSCs) constitute a population of cells with immunosuppressive f...
Multidimensional regulatory mechanisms and translational potential of epigenetic networks in the rheumatoid arthritis disease course
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis that may progress to irreversible jo...
Dual effects of JAK vs TNF inhibitors on osteoporosis, fractures and mortality in rheumatoid arthritis: a real-world cohort study
PurposeThis real-world study compared the effects of JAK inhibitors (JAKi) versus TNF inhibitors (TNFi) on bone health and...
Gut microbiota alliance to shape sceneries of familial Mediterranean fever: a scoping review detailing difference between children and adults
Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease worldwide and a key-model to illu...
Overcoming multidimensional immunotherapy resistance in PDAC: from microenvironment to clinic
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, with immunotherapy yielding
Case Report: A case of severe hypotension induced by nimotuzumab in a nasopharyngeal carcinoma patient
Nimotuzumab, a humanized immunoglobulin G1 monoclonal antibody, is mainly used in combination with radiotherapy for the tr...
[18F]-FDG-PET/CT detects subclinical optic nerve inflammation in giant cell arteritis
ObjectiveVision loss is a feared complication in giant cell arteritis (GCA). However, imaging data characterizing intraorb...
Intact lymph node homing and CD8+ T-cell priming abilities of Sprouty2-deficient dendritic cells
Sprouty2 (Spry2) acts as a modulator of the MAPK-ERK signaling pathway by exerting both positive and negative regulation i...
Correction: Long pentraxin 3 (PTX3) regulates IL-17A-mediated secondary immunity to Leishmania major infection in mice
Adding/removing text [ "In the published article, there was a mistake as we have missed including a sentence in the I...
Unraveling the indolence of papillary thyroid carcinoma: an exploratory study on B-cell subsets based on genetic predisposition and tumor immunity
BackgroundActive surveillance for low-risk papillary thyroid carcinoma (PTC) is hampered by the lack of reliable biomarker...
Incomplete B-cell reconstitution in ART-treated people living with HIV is associated with EBV-linked lymphoma progression
BackgroundDespite the widespread use of antiretroviral therapy (ART), people living with HIV continue to exhibit persisten...
Evaluation of the trypanocidal and immunomodulatory effects of LDT409, a cardanol derivative from cashew nut shell liquid
IntroductionChagas disease (CD), caused by Trypanosoma cruzi, is a neglected tropical illness with significant public heal...
Neuronal intranuclear inclusion disease with initial manifestation of intractable nausea and vomiting responsive to corticosteroids: a case report
Neuronal intranuclear inclusion disease (NIID) can initially present with gastrointestinal symptoms as the sole or primary...
Reinventing malaria control: hierarchical intervention strategies for African settings based on the microbiota-barrier-innate immunity axis
Malaria control is challenged by parasite drug resistance and inadequate vaccine protection. Although mosquito gut microbe...
Lymphocyte function inhibition and exhaustion in sepsis: mechanisms and applications
Sepsis is a life-threatening organ dysfunction syndrome caused by a dysregulated host response to infection and is charact...
Natural killer cell dysfunction in glioma: from immune evasion to immunotherapy
Natural killer (NK) cells, critical components of innate immunity, possess the ability to eliminate tumor cells without pr...
Combined use of Bumetanide and MGE cell transplantation alleviates neuropathic pain and its mechanism after spinal cord injury in mice
IntroductionNeuropathic pain (NP) after spinal cord injury (SCI) is intractable with limited efficacy of single treatments...
Anti-Mesothelin CAR-NK cells as a novel targeted therapy against cervical cancer
1 IntroductionTargeted therapy approaches are increasingly implemented in cancer therapy regimens, often complementing con...
Lysate of Parabacteroides distasonis prevents severe forms of experimental autoimmune encephalomyelitis by modulating the priming of T cell response
1 IntroductionMultiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), which is...
Pan-cancer analysis shows that BCAP31 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types
IntroductionThe prevalence and fatality rate of cancer is consistently rising, resulting in cancer being the second most p...
The histamine analogue clobenpropit modulates IRF7 phosphorylation and interferon production by targeting CXCR4 in systemic lupus erythematosus models
IntroductionSystemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by a variety of autoantibodie...
Impact of Janus kinase inhibitors and methotrexate on interstitial lung disease in rheumatoid arthritis patients
IntroductionRheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by chronic joint inflammation, a...
Retraction: Autoantibodies in renal diseases – clinical significance and recent developments in serological detection
Retraction: Autoantibodies in renal diseases – clinical significance and recent developments in serological detectionPleas...
C3 deficiency promotes pulmonary inflammation in AT1R-induced mouse model for systemic sclerosis
IntroductionSystemic sclerosis (SSc) is an autoimmune connective tissue disease with multiple organ involvements and heter...
Metformin improves Mycobacterium avium infection by strengthening macrophage antimicrobial functions
IntroductionNon-tuberculous mycobacterial (NTM) infections have emerged as significant public health concerns worldwide du...
Associations of NETs with inflammatory risk and clinical predictive value in large artery atherosclerosis stroke: a prospective cohort study
1 IntroductionIschemic stroke is the major cause of death and disability worldwide (1). The prevalence and the burden of i...
Deciphering ferroptosis in critical care: mechanisms, consequences, and therapeutic opportunities
1 IntroductionCritical illness, marked by organ-level pathophysiological disruptions, remains a significant global health ...
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