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Freedom of scientific inquiry: reclaiming space for controversy
Freedom of scientific inquiry: reclaiming space for controversy
No matter how small the possibility, or how inconvenient the topic, scientists must maintain the humility to acknowledge t...
CRISPR screen reveals regulators of age-associated CD8+ T cell dysfunction in cancer
A preprint by Chen et al. identifies Dusp5 and Zfp219 as regulators of age-associated T cell dysfunction in the tumour mic...
Immune regulation by erythroid cells: how erythroid progenitor cells and mature red blood cells shape immunity
Immune regulation by erythroid cells: how erythroid progenitor cells and mature red blood cells shape immunity
Once considered to be passive oxygen carriers, erythroid cells are now recognized as dynamic modulators of immune response...
T cell-derived extracellular vesicles promote antitumour immunity through horizontal gene transfer
T cell-derived extracellular vesicles promote antitumour immunity through horizontal gene transfer
Hu et al. report that activated T cells can enhance antigen processing and presentation in tumour cells and dendritic cell...
Comparative insights into the apoptosome, inflammasomes and PIDDosome
Comparative insights into the apoptosome, inflammasomes and PIDDosome
Caspase activation platforms such as the apoptosome, inflammasome and PIDDosome are central to cellular responses to stres...
Calibrating T cell responsiveness through interactions with self
Calibrating T cell responsiveness through interactions with self
During an immune response, T cells face one of the most consequential decisions of their lifespan upon recognitio...
Macrophages sample the living self
Macrophages sample the living self
Macrophages continuously ‘nibble’ healthy neighbouring cells, capturing minute amounts of cytosolic material t...
A role for CD8+ T cells in lupus nephritis
A role for CD8+ T cells in lupus nephritis
CD8+ T cells infiltrating the kidneys contribute to lupus nephritis by retaining cytotoxic functions despite appearing to ...
An inter-organ neuro–immuno–endocrine circuit for glucose homeostasis
A study in Science reports that intestinal innate lymphoid cells migrate to the pancreas in response to low blood glucose ...
Kidney immunology from pathophysiology to clinical translation
Kidney immunology from pathophysiology to clinical translation
Kidney diseases are widespread and represent a considerable medical, social and economic burden. However, there has been m...
Podoplanin mediates stromal–immune crosstalk in the lymph node
A preprint by Makris et al. shows that podoplanin is a key regulator of the functions of fibroblastic reticular cells in l...
Immune control of brain physiology
Immune control of brain physiology
The peripheral immune system communicates with the brain through complex anatomical routes involving the skull, the brain ...
Trained immunity in chronic inflammatory diseases and cancer
Trained immunity in chronic inflammatory diseases and cancer
A decade after the term ‘trained immunity’ (TRIM) was coined to reflect the long-lasting hyper-responsiveness ...
Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors
Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors
A recent Review in this journal by Comerford and McColl1 discussed how atypical chemokine receptors (ACKRs) have emerged a...
B cells in non-lymphoid tissues
B cells in non-lymphoid tissues
B cells have long been understood to be drivers of both humoral and cellular immunity. Recent advances underscore this imp...
Faulty mitochondria jump between tumours and T cells
Faulty mitochondria jump between tumours and T cells
To evade elimination by T cells, tumour cells transfer mutant mitochondria to T cells, which reprogrammes their metabolism...
Sleep deprivation whips up cytokine storm
A new mouse model of sleep deprivation reveals a potent pathway by which sleep-related changes in prostaglandin D2 in the ...
TCRs and AI: the future is now
A preprint by Fast et al. describes TAPIR, a computational tool for predicting TCR–pMHC interactions.
Adipose tissue maintains healthy joint fibroblasts via cortisol signalling
A preprint by Faust et al. determines mechanisms of crosstalk between adipocytes and fibroblasts in the joint relevant to ...
Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations
Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations
The approval of the first immune checkpoint inhibitors provided a paradigm shift for the treatment of malignancies across ...
Neonatal monocytes suppress adult TH17 cell responses in skin
A preprint by Dhariwala et al. reports that monocytes in the skin of newborn mice suppress microbiota-driven inflammatory ...
Brain regulatory T cells
Brain regulatory T cells
The brain, long thought to be isolated from the peripheral immune system, is increasingly recognized to be integrated into...
Author Correction: Protein kinases: drug targets for immunological disorders
Authors and AffiliationsDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Nationa...
Communicating science effectively in times of crisis: time for reflection
Communicating science effectively in times of crisis: time for reflection
Gary Koretzky served as president of the American Association of Immunologists (AAI) from 2021 to 2022. During this tenure...
Lipid metabolism extinguishes cGAS–STING-induced inflammation
Lipid metabolism extinguishes cGAS–STING-induced inflammation
Liver X receptor (LXR) signalling can inhibit the DNA-sensing cGAS–STING inflammatory pathway through degradation of...
Role of the microbiota in response to and recovery from cancer therapy
Role of the microbiota in response to and recovery from cancer therapy
Our understanding of how the microbiota affects the balance between response to and failure of cancer treatment by modulat...
Low serotonin linked to long COVID
Low serotonin linked to long COVID
A study shows that individuals with long COVID have low levels of serotonin, which explains the neurocognitive impairments...
Host IgM facilitates mating in Leishmania
The parasite Leishmania, which causes the debilitating disease leishmaniasis, is spread by sandflies and affects millions ...
Gut fungi have lasting effect on immune response to severe COVID-19
A study by Kusakabe et al. reports increased antibody responses to specific fungi in individuals with severe COVID-19, par...
NMDAR-directed CAAR T cells show promise for autoimmune encephalitis
N-methyl-d-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis. It is usually treated by un...
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