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Publisher Correction: TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
The pre-T cell receptor as a tumor immunotherapy target in T cell leukemia
The pre-T cell receptor as a tumor immunotherapy target in T cell leukemia
The pre-T cell receptor is essential for T cell development. It is also an emerging immunotherapy target.
Type A cholesterol-dependent cytolysins translocate to the trans-Golgi network for NLRP3 inflammasome activation
Type A cholesterol-dependent cytolysins translocate to the trans-Golgi network for NLRP3 inflammasome activation
Cholesterol-dependent cytolysins (CDCs) constitute the largest group of pore-forming toxins and serve as critical virulenc...
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis
Crohn’s disease pathology is modeled in TNFΔARE+/− mice that overproduce tumor necrosis factor (TNF) to d...
Bacterial toxins rewire the trans-Golgi network to activate the inflammatory response
Bacterial toxins rewire the trans-Golgi network to activate the inflammatory response
Cholesterol-dependent cytolysins produced by diverse bacterial pathogens are internalized by host cells and translocate to...
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity
CD4+ T follicular helper (TFH) cells support tailored B cell responses against multiple classes of pathogens. To reveal ho...
T cells engineered to target a shared β-catenin mutation eradicate solid tumors in mice
T cells engineered to target a shared β-catenin mutation eradicate solid tumors in mice
We identified T cell receptors (TCRs) targeting antigenic peptides that contain a shared β-catenin mutation (CTNNB1S3...
Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration
Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration
Interleukin-18 (IL-18) is an acute-phase proinflammatory molecule crucial for mediating viral clearance by activating T he...
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption
These authors contributed equally: Susan Pereira Ribeiro, Zachary Strongin.Deceased: Timothy Hoang.These authors jointly s...
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy
In an unbiased high-throughput screen of 800 kinase inhibitors, we identified a cocktail of kinase inhibitors that increas...
Intestinal microbiome metabolites control sepsis outcome
Intestinal microbiome metabolites control sepsis outcome
Sepsis results from a dysregulated immune response to infection. A study now shows that gut microbiota-derived metabolites...
IRE1α–XBP1 moonlighting to restrict leukemia
IRE1α–XBP1 moonlighting to restrict leukemia
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by repressing pro-leukemogenic programs, independ...
Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2
Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2
Viral variant and host vaccination status impact infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-...
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Maturation of conventional dendritic cells (cDCs) is crucial for maintaining tolerogenic safeguards against auto-immunity ...
ImmunOctoberfest reloaded
ImmunOctoberfest reloaded
On 23–26 September 2024, the second ImmunOctoberfest conference took place in Raitenhaslach, Germany, and brought to...
NIAID workshop on infections and autoimmune diseases
NIAID workshop on infections and autoimmune diseases
On 11–12 September 2024, the National Institute of Allergy and Infectious Diseases (NIAID) convened experts to discu...
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation
The nature of activation signals is essential in determining T cell subset differentiation; however, the features that det...
The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes
The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes
Intestinal intraepithelial lymphocytes (IELs) exhibit prompt innate-like responses to microenvironmental cues and require ...
Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function
Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function
Spleen marginal zone (MZ) B cells are important for antibody responses against blood-borne antigens. The signals they use ...
Publisher Correction: CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides
John DaviesPresent address: Department of Safety Assessment, Genentech, Inc., San Francisco, CA, USAChristian S. HinrichsP...
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hybrid immunity is more protective than vaccination or previo...
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
Bacille Calmette–Guérin (BCG) vaccination can confer nonspecific protection against heterologous pathogens. How...
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms
Author notesWen ZhouPresent address: BillionToOne, Menlo Park, CA, USAFan GaoPresent address: Lyterian Therapeutics, South...
Severe dengue progression beyond enhancement
Severe dengue progression beyond enhancement
The immune response to dengue virus infection is a well-coordinated balancing act. New research shows that an imbalanced r...
Cancer immunology leads the way
Cancer immunology research is diverse, uses cutting-edge technologies and continues to excite with its constantly evolving...
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells
Few cancers can be targeted efficiently by engineered T cell strategies. Here, we show that γδ T cell antigen re...
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
Annotation of immunologic gene function in vivo typically requires the generation of knockout mice, which is time consumin...
A second-generation M1-polarized CAR macrophage with antitumor efficacy
A second-generation M1-polarized CAR macrophage with antitumor efficacy
Chimeric antigen receptor (CAR) T cell therapies have successfully treated hematological malignancies. Macrophages have al...
The immunometabolic ecosystem in cancer
The immunometabolic ecosystem in cancer
Our increased understanding of how key metabolic pathways are activated and regulated in malignant cells has identified me...
Forks in the road for CAR T and CAR NK cell cancer therapies
Forks in the road for CAR T and CAR NK cell cancer therapies
The advent of chimeric antigen receptor (CAR) T cell therapy has resulted in unprecedented long-term clearance of relapse/...
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