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Developing a vaccine strategy to prevent the progression of pulmonary fibrosis
Developing a vaccine strategy to prevent the progression of pulmonary fibrosis
Pulmonary fibrosis is an incurable chronic, progressive disease characterized by the emergence of fibrosis-specific cells,...
Author Correction: Chemokine-defined macrophage niches establish spatial organization of tumor immunity
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 ...
ROS breaks the cofilin lock on NLRP3
ROS breaks the cofilin lock on NLRP3
How reactive oxygen species (ROS) contribute to NLRP3 inflammasome activity has been debated. Findings now show that cofil...
BLIMP1 tunes germinal center B cell responses to limit clonal dominance
BLIMP1 tunes germinal center B cell responses to limit clonal dominance
The plasma cell transcription factor BLIMP1 unexpectedly functions in germinal center B cells as a signaling-induced gatek...
Astrocyte-driven immunosuppression in the brain tumor microenvironment
Astrocyte-driven immunosuppression in the brain tumor microenvironment
Brain tumors are among the most lethal cancers, with limited success from emerging immunotherapies, largely due to the res...
IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma
IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma
Allergic asthma is driven by type 2 immune responses, including type 2 innate lymphoid cells (ILC2s). Although ILC2s are a...
A spatially coordinated keratinocyte–fibroblast circuit recruits MMP9⁺ myeloid cells to drive type I interferon-driven inflammation in photosensitive autoimmunity
A spatially coordinated keratinocyte–fibroblast circuit recruits MMP9⁺ myeloid cells to drive type I interferon-driven inflammation in photosensitive autoimmunity
Photosensitivity is central to cutaneous lupus erythematosus and dermatomyositis (DM), but the mechanisms linking UVB expo...
Kupffer cell calibration of T cell responses via VSIG4–CD5 interaction promotes tumor evasion
Kupffer cell calibration of T cell responses via VSIG4–CD5 interaction promotes tumor evasion
Liver metastases can resist T cell immunotherapies, indicating an adaptation of metastatic tumors toward reduced immunogen...
Publisher Correction: TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
The pre-T cell receptor as a tumor immunotherapy target in T cell leukemia
The pre-T cell receptor as a tumor immunotherapy target in T cell leukemia
The pre-T cell receptor is essential for T cell development. It is also an emerging immunotherapy target.
Type A cholesterol-dependent cytolysins translocate to the trans-Golgi network for NLRP3 inflammasome activation
Type A cholesterol-dependent cytolysins translocate to the trans-Golgi network for NLRP3 inflammasome activation
Cholesterol-dependent cytolysins (CDCs) constitute the largest group of pore-forming toxins and serve as critical virulenc...
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis
Crohn’s disease pathology is modeled in TNFΔARE+/− mice that overproduce tumor necrosis factor (TNF) to d...
Bacterial toxins rewire the trans-Golgi network to activate the inflammatory response
Bacterial toxins rewire the trans-Golgi network to activate the inflammatory response
Cholesterol-dependent cytolysins produced by diverse bacterial pathogens are internalized by host cells and translocate to...
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity
CD4+ T follicular helper (TFH) cells support tailored B cell responses against multiple classes of pathogens. To reveal ho...
T cells engineered to target a shared β-catenin mutation eradicate solid tumors in mice
T cells engineered to target a shared β-catenin mutation eradicate solid tumors in mice
We identified T cell receptors (TCRs) targeting antigenic peptides that contain a shared β-catenin mutation (CTNNB1S3...
Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration
Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration
Interleukin-18 (IL-18) is an acute-phase proinflammatory molecule crucial for mediating viral clearance by activating T he...
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption
These authors contributed equally: Susan Pereira Ribeiro, Zachary Strongin.Deceased: Timothy Hoang.These authors jointly s...
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy
In an unbiased high-throughput screen of 800 kinase inhibitors, we identified a cocktail of kinase inhibitors that increas...
Intestinal microbiome metabolites control sepsis outcome
Intestinal microbiome metabolites control sepsis outcome
Sepsis results from a dysregulated immune response to infection. A study now shows that gut microbiota-derived metabolites...
IRE1α–XBP1 moonlighting to restrict leukemia
IRE1α–XBP1 moonlighting to restrict leukemia
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by repressing pro-leukemogenic programs, independ...
Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2
Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2
Viral variant and host vaccination status impact infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-...
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Maturation of conventional dendritic cells (cDCs) is crucial for maintaining tolerogenic safeguards against auto-immunity ...
ImmunOctoberfest reloaded
ImmunOctoberfest reloaded
On 23–26 September 2024, the second ImmunOctoberfest conference took place in Raitenhaslach, Germany, and brought to...
NIAID workshop on infections and autoimmune diseases
NIAID workshop on infections and autoimmune diseases
On 11–12 September 2024, the National Institute of Allergy and Infectious Diseases (NIAID) convened experts to discu...
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation
The nature of activation signals is essential in determining T cell subset differentiation; however, the features that det...
The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes
The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes
Intestinal intraepithelial lymphocytes (IELs) exhibit prompt innate-like responses to microenvironmental cues and require ...
Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function
Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function
Spleen marginal zone (MZ) B cells are important for antibody responses against blood-borne antigens. The signals they use ...
Publisher Correction: CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides
John DaviesPresent address: Department of Safety Assessment, Genentech, Inc., San Francisco, CA, USAChristian S. HinrichsP...
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hybrid immunity is more protective than vaccination or previo...
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
Bacille Calmette–Guérin (BCG) vaccination can confer nonspecific protection against heterologous pathogens. How...
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