These authors contributed equally: Susan Pereira Ribeiro, Zachary Strongin.

Deceased: Timothy Hoang.

These authors jointly supervised this work: Mirko Paiardini, Rafick P. Sekaly.

Pathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA

Susan Pereira Ribeiro, Hugo Soudeyns, Felipe ten-Caten, Khader Ghneim, Gabriela Pacheco Sanchez, Giuliana Xavier de Medeiros, Perla Mariana Del Rio Estrada, Guido Silvestri, Mirko Paiardini & Rafick P. Sekaly

Emory Vaccine Center, Atlanta, GA, USA

Susan Pereira Ribeiro & Rafick P. Sekaly

Winship Cancer Institute of Emory University, Atlanta, GA, USA

Susan Pereira Ribeiro & Rafick P. Sekaly

Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA

Zachary Strongin, Timothy Hoang, Kevin Nguyen, Justin Harper, Sherrie Jean, Chelsea Wallace, Guido Silvestri & Mirko Paiardini

Viral Immunopathology Unit, Centre de recherche Azrieli du CHU Sainte-Justine, Montreal, Québec, Canada

Hugo Soudeyns

Department of Microbiology, Infectiology and Immunology and Department of Pediatrics, Faculty of Medicine, Université de Montréal, Montreal, Québec, Canada

Hugo Soudeyns

Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

Perla Mariana Del Rio Estrada

RPM Bioinfo Solutions, Blainville, Québec, Canada

Adam-Nicolas Pelletier

Becton Dickinson, San Jose, CA, USA

Robert Balderas

AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA

Jeffrey D. Lifson

Department of Discovery Biologics, Merck & Co. Inc., South San Francisco, CA, USA

Gopalan Raghunathan & Daniel M. Gorman

Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co. Inc., South San Francisco, CA, USA

Eric Rimmer & Cinthia V. Pastuskovas

Department of Quantitative Biosciences, Merck & Co. Inc., Rahway, NJ, USA

Guoxin Wu, Bonnie J. Howell & Daria J. Hazuda

Department of Discovery Oncology, Merck & Co. Inc., Boston, MA, USA

Luca Micci

Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA

Ruy M. Ribeiro

Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR, USA

Chi Ngai Chan & Jacob D. Estes

Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA

Chi Ngai Chan & Jacob D. Estes