Effect of controlled human infection on B cell subsets in individuals with different levels of malaria immunity

Geneva: World Health Organization. World malaria report 2024: addressing inequity in the global malaria response. [Internet]. Available from: https://www.wipo.int/amc/en/mediation/https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2023 (2024).

RTS S Clinical Trials Partnership (2015) Efficacy and safety of RTS, S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: Final results of a phase 3, individually randomised, controlled trial. The Lancet 386:31–45

Article  Google Scholar 

Datoo MS, Natama HM, Somé A, Bellamy D, Traoré O, Rouamba T et al (2022) Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical malaria after 2 years’ follow-up in children in Burkina Faso: a phase 1/2b randomised controlled trial. Lancet Infect Dis 22:1728–1736

Article  PubMed  CAS  Google Scholar 

Mordmüller B, Surat G, Lagler H, Chakravarty S, Ishizuka AS, Lalremruata A, Gmeiner M, Campo JJ, Esen M, Ruben AJ, Held J (2017) Sterile protection against human malaria by chemoattenuated PfSPZ vaccine. Nature 542(7642):445–449

Article  PubMed  PubMed Central  Google Scholar 

Mwakingwe-Omari A, Healy SA, Lane J, Cook DM, Kalhori S, Wyatt C et al (2021) Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity. Nature 595:289–294

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sulyok Z, Fendel R, Eder B, Lorenz FR, Kc N, Karnahl M et al (2021) Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial. Nat Commun 12:2518

Article  PubMed  PubMed Central  CAS  Google Scholar 

Moita D, Prudêncio M (2024) Whole-sporozoite malaria vaccines: where we are, where we are going. EMBO Mol Med. 16(10):2279–2289. https://doi.org/10.1038/s44321-024-00131-0

Stanisic DI, McCarthy JS, Good MF (2017) Controlled human malaria infection: applications, advances, and challenges. Infect Immun 86:479–496

Google Scholar 

Pierce SK, Miller LH (2009) World Malaria Day 2009: what malaria knows about the immune system that immunologists still do not. J Immunol 182:5171–5177

Article  PubMed  CAS  Google Scholar 

Ly A, Hansen DS (2019) Development of B cell memory in malaria. Front Immunol 10:435267

Article  Google Scholar 

Crompton PD, Kayala MA, Traore B, Kayentao K, Ongoiba A, Weiss GE et al (2010) A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray. Proc Natl Acad Sci U S A 107:6958–6963

Article  PubMed  PubMed Central  CAS  Google Scholar 

Akpogheneta OJ, Duah NO, Tetteh KKA, Dunyo S, Lanar DE, Pinder M et al (2008) Duration of naturally acquired antibody responses to blood-stage Plasmodium falciparum is age dependent and antigen specific. Infect Immun 76:1748–1755

Article  PubMed  PubMed Central  CAS  Google Scholar 

Weiss GE, Traore B, Kayentao K, Ongoiba A, Doumbo S, Doumtabe D et al (2010) The plasmodium falciparum-specific human memory b cell compartment expands gradually with repeated malaria infections. PLoS Pathog 6:1–13

Article  Google Scholar 

Amanna IJ, Carlson NE, Slifka MK (2007) Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med 357:1903–1915

Article  PubMed  CAS  Google Scholar 

Asito AS, Moormann AM, Kiprotich C, Ng’ang’a ZW, Ploutz-Snyder R, Rochford R (2008) Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children. Malar J 7:238

Article  PubMed  PubMed Central  Google Scholar 

Malaspina A, Moir S, Ho J, Wang W, Howell ML, O’Shea MA et al (2006) Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: correlation with increased IL-7. Proc Natl Acad Sci U S A 103:2262–2267

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cuss AK, Avery DT, Cannons JL, Yu LJ, Nichols KE, Shaw PJ et al (2006) Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity. J Immunol 176:1506–1516

Article  PubMed  CAS  Google Scholar 

Moir S, Ho J, Malaspina A, Wang W, Dipoto AC, Shea MAO et al (2008) Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. J Exp Med 205:1797–1805

Article  PubMed  PubMed Central  CAS  Google Scholar 

Weiss GE, Crompton PD, Li S, Walsh LA, Moir S, Traore B et al (2009) Atypical memory B cells are greatly expanded in individuals living in a malaria-endemic area. J Immunol 183:2176–2182

Article  PubMed  CAS  Google Scholar 

Weiss GE, Clark EH, Li S, Traore B, Kayentao K, Ongoiba A et al (2011) A positive correlation between atypical memory B cells and Plasmodium falciparum transmission intensity in cross-sectional studies in Peru and Mali. PLoS ONE 6:e15983

Article  PubMed  PubMed Central  CAS  Google Scholar 

Illingworth J, Butler NS, Roetynck S, Mwacharo J, Pierce SK, Bejon P et al (2013) Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion. J Immunol 190:1038–1047

Article  PubMed  CAS  Google Scholar 

Subramaniam KS, Skinner J, Ivan E, Mutimura E, Kim RS, Feintuch CM et al (2015) HIV malaria co-infection is associated with atypical memory B cell expansion and a reduced antibody response to a broad array of Plasmodium falciparum antigens in Rwandan adults. PLoS ONE. https://doi.org/10.1371/journal.pone.0124412

Article  PubMed  PubMed Central  Google Scholar 

Girma T, Tsegaye A, Desta K, Ayalew S, Tamene W, Zewdie M et al (2023) Phenotypic characterization of peripheral B cells in Mycobacterium tuberculosis infection and disease in Addis Ababa, Ethiopia. Tuberculosis. https://doi.org/10.1016/j.tube.2023.102329

Article  PubMed  Google Scholar 

Requena P, Campo JJ, Umbers AJ, Ome M, Wangnapi R, Barrios D et al (2014) Pregnancy and malaria exposure are associated with changes in the B cell pool and in plasma eotaxin levels. J Immunol 193:2971–2983

Article  PubMed  CAS  Google Scholar 

Sutton HJ, Aye R, Idris AH, Vistein R, Nduati E, Kai O et al (2021) Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans. Cell Rep 34:108684

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sullivan RT, Kim CC, Fontana MF, Feeney ME, Jagannathan P, Boyle MJ et al (2015) FCRL5 delineates functionally impaired memory B cells associated with Plasmodium falciparum exposure. PLoS Pathog. https://doi.org/10.1371/journal.ppat.1004894

Article  PubMed  PubMed Central  Google Scholar 

Ambegaonkar AA, Kwak K, Sohn H, Manzella-Lapeira J, Brzostowski J, Pierce SK (2020) Expression of inhibitory receptors by B cells in chronic human infectious diseases restricts responses to membrane-associated antigens. Sci Adv. https://doi.org/10.1126/sciadv.aba6493

Article  PubMed  PubMed Central  Google Scholar 

Muellenbeck MF, Ueberheide B, Amulic B, Epp A, Fenyo D, Busse CE et al (2013) Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies. J Exp Med 210(2):389–399

Article  PubMed  PubMed Central  CAS  Google Scholar 

Scholzen A, Teirlinck AC, Bijker EM, Roestenberg M, Hermsen CC, Hoffman SL et al (2014) BAFF and BAFF receptor levels correlate with B cell subset activation and redistribution in controlled human malaria infection. J Immunol 192(8):3719–3729

Article  PubMed  CAS  Google Scholar 

Dobaño C, Bardají A, Arévalo-Herrera M, Martínez-Espinosa FE, Bôtto-Menezes C, Padilla N et al (2020) Cytokine signatures of plasmodium vivax infection during pregnancy and delivery outcomes. PLoS Negl Trop Dis 14:1–17

Article  Google Scholar 

Aguilar R, Campo JJ, Chicuecue S, Cisteró P, Català A, Luis L et al (2019) Changing plasma cytokine, chemokine and growth factor profiles upon differing malaria transmission intensities. Malar J. https://doi.org/10.1186/s12936-019-3038-x

Article  PubMed  PubMed Central 

Comments (0)

No login
gif