Abolghasemi M, Mahjoub S. Long noncoding RNAs as a piece of polycystic ovary syndrome puzzle. Mol Biol Rep. 2021;48(4):3845–51.

Article  CAS  PubMed  Google Scholar 

Balen AH, Morley LC, Misso M, Franks S, Legro RS, Wijeyaratne CN, et al. The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance. Hum Reprod Update. 2016;22(6):687–708.

Article  PubMed  Google Scholar 

Belani M, Deo A, Shah P, Banker M, Singal P, Gupta S. Differential insulin and steroidogenic signaling in insulin resistant and non-insulin resistant human luteinized granulosa cells-A study in PCOS patients. J Steroid Biochem Mol Biol. 2018;178:283–92.

Article  CAS  PubMed  Google Scholar 

Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod. 2016;31(12):2841–55.

Article  PubMed  Google Scholar 

Che Q, Liu M, Zhang D, Lu Y, Xu J, Lu X, et al. Long noncoding RNA HUPCOS promotes follicular fluid androgen excess in PCOS patients via aromatase inhibition. J Clin Endocrinol Metab. 2020;105(4):dgaa060. https://doi.org/10.1210/clinem/dgaa060.

Chen Z, Liu L, Xi X, Burn M, Karakaya C, Kallen AN. Aberrant H19 Expression Disrupts Ovarian Cyp17 and Testosterone Production and Is Associated with Polycystic Ovary Syndrome in Women. Reprod Sci. 2022;29(4):1357–67.

Article  PubMed  Google Scholar 

Chiaffarino F, Cipriani S, Dalmartello M, Ricci E, Esposito G, Fedele F, et al. Prevalence of polycystic ovary syndrome in European countries and USA: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2022;279:159–70.

Article  PubMed  Google Scholar 

Cozzolino M, Herraiz S, Titus S, Roberts L, Romeu M, Peinado I, et al. Transcriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response. Hum Reprod. 2022;37(6):1274–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dewailly D, Robin G, Peigne M, Decanter C, Pigny P, Catteau-Jonard S. Interactions between androgens, FSH, anti-Müllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary. Hum Reprod Update. 2016;22(6):709–24.

Article  CAS  PubMed  Google Scholar 

Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018;14(5):270–84.

Article  PubMed  Google Scholar 

Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, et al. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril. 2012;97(1):28-38.e25.

Article  PubMed  Google Scholar 

Franks S, Stark J, Hardy K. Follicle dynamics and anovulation in polycystic ovary syndrome. Hum Reprod Update. 2008;14(4):367–78.

Article  CAS  PubMed  Google Scholar 

Gebert M, Heimbucher J, Gsell VK, Keimer K, Dillinger AE, Tamm ER. Induced Attenuation of Scleral TGF-β Signaling in Mutant Mice Increases Susceptibility to IOP-Induced Optic Nerve Damage. Invest Ophthalmol vis Sci. 2024;65(1):48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geng X, Zhao J, Huang J, Li S, Chu W, Wang WS, et al. lnc-MAP3K13-7:1 Inhibits Ovarian GC Proliferation in PCOS via DNMT1 Downregulation-Mediated CDKN1A Promoter Hypomethylation. Mol Ther. 2021;29(3):1279–93.

Article  CAS  PubMed  Google Scholar 

Gong TT, Liu FH, Xiao Q, Li YZ, Wei YF, Xu HL, et al. SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation. Commun Biol. 2024;7(1):67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E. American association of clinical endocrinologists, american college of endocrinology, and androgen excess and PCOS society disease state clinical review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome–part 1. Endocr Pract. 2015;21(11):1291–300.

Article  PubMed  Google Scholar 

Granados-Aparici S, Yang Q, Clarke HJ. SMAD4 promotes somatic-germline contact during murine oocyte growth. Elife. 2024;13.

Hou N, Guo Z, Zhao G, Jia G, Luo B, Shen X, et al. Inhibition of microRNA-21-3p suppresses proliferation as well as invasion and induces apoptosis by targeting RNA-binding protein with multiple splicing through Smad4/extra cellular signal-regulated protein kinase signalling pathway in human colorectal cancer HCT116 cells. Clin Exp Pharmacol Physiol. 2018;45(7):729–41.

Article  CAS  PubMed  Google Scholar 

Huang J, Zhao J, Geng X, Chu W, Li S, Chen ZJ, et al. Long non-coding RNA lnc-CCNL1-3:1 promotes granulosa cell apoptosis and suppresses glucose uptake in women with polycystic ovary syndrome. Mol Ther Nucleic Acids. 2021;23:614–28.

Article  CAS  PubMed  Google Scholar 

Jiao J, Shi B, Wang T, Fang Y, Cao T, Zhou Y, et al. Characterization of long non-coding RNA and messenger RNA profiles in follicular fluid from mature and immature ovarian follicles of healthy women and women with polycystic ovary syndrome. Hum Reprod. 2018;33(9):1735–48.

Article  CAS  PubMed  Google Scholar 

Joham AE, Norman RJ, Stener-Victorin E, Legro RS, Franks S, Moran LJ, et al. Polycystic ovary syndrome. Lancet Diabetes Endocrinol. 2022;10(9):668–80.

Article  CAS  PubMed  Google Scholar 

Kian M, Hosseini E, Abdizadeh T, Langaee T, Khajouei A, Ghasemi S. Molecular docking and mouse modeling suggest CMKLR1 and INSR as targets for improving PCOS phenotypes by minocycline. Excli j. 2022;21:400–14.

PubMed  PubMed Central  Google Scholar 

Li Q. Inhibitory SMADs: potential regulators of ovarian function. Biol Reprod. 2015;92(2):50.

Article  PubMed  Google Scholar 

Li X, Tripurani SK, James R, Pangas SA. Minimal fertility defects in mice deficient in oocyte-expressed Smad4. Biol Reprod. 2012;86(1):1–6.

Article  PubMed  Google Scholar 

Lin H, Xing W, Li Y, Xie Y, Tang X, Zhang Q. Downregulation of serum long noncoding RNA GAS5 may contribute to insulin resistance in PCOS patients. Gynecol Endocrinol. 2018;34(9):784–8.

Article  CAS  PubMed  Google Scholar 

Liu Z, Hao C, Song D, Zhang N, Bao H, Qu Q. Androgen Receptor Coregulator CTBP1-AS Is Associated With Polycystic Ovary Syndrome in Chinese Women: A Preliminary Study. Reprod Sci. 2015;22(7):829–37.

Article  PubMed  PubMed Central  Google Scholar 

Liu L, Kryvokhyzha D, Rippe C, Jacob A, Borreguero-Muñoz A, Stenkula KG, et al. Myocardin regulates exon usage in smooth muscle cells through induction of splicing regulatory factors. Cell Mol Life Sci. 2022;79(8):459.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Livadas S, Yildiz BO, Mastorakos G, Gambineri A, Pignatelli D, Giorgino F, et al. European survey of diagnosis and management of the polycystic ovary syndrome: full report on the ESE PCOS Special Interest Group’s 2023 Questionnaire. Eur J Endocrinol. 2024;191(2):134–43.

Article  PubMed  Google Scholar 

Luo X, Dong Y, Zheng H, Zhou X, Rong L, Liu X, et al. CAPN2 correlates with insulin resistance states in PCOS as evidenced by multi-dataset analysis. J Ovarian Res. 2024;17(1):79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moghetti P, Tosi F. Insulin resistance and PCOS: chicken or egg? J Endocrinol Invest. 2021;44(2):233–44.

Article  CAS  PubMed  Google Scholar 

Paixão L, Ramos RB, Lavarda A, Morsh DM, Spritzer PM. Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review. Reprod Biol Endocrinol. 2017;15(1):12.

Article  PubMed  PubMed Central  Google Scholar 

Panghiyangani R, Soeharso P, DA Andrijono S, Wiweko B, Kurniati M, et al. CYP19A1 Gene Expression in Patients with Polycystic Ovarian Syndrome. J Hum Reprod Sci. 2020;13(2):100–3.

Article  CAS  PubMed  PubMed Central