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Annexin A1-FPR1 Interaction in dendritic cells promotes immune microenvironment modulation in Thyroid Cancer
Annexin A1-FPR1 Interaction in dendritic cells promotes immune microenvironment modulation in Thyroid Cancer
Thyroid cancer (THCA) is profoundly influenced by its immune microenvironment, with dendritic cells (DCs) serving as key m...
Loss of YTHDF1 suppresses the progression of malignant rhabdoid tumor of the kidney by regulating Glutathione S-transferase Mu 2 (GSTM2)
Loss of YTHDF1 suppresses the progression of malignant rhabdoid tumor of the kidney by regulating Glutathione S-transferase Mu 2 (GSTM2)
Malignant rhabdoid tumor of the kidney (MRTK) is a rare renal tumor with poor prognosis. While germline mutations of SMARC...
Dissecting the METTL3/STC2 axis in colorectal cancer: implications for drug resistance and metastasis
Dissecting the METTL3/STC2 axis in colorectal cancer: implications for drug resistance and metastasis
In recent years, the role of epigenetic modifications, especially N6-methyladenosine (m6A) modifications, in the occurrenc...
Correction to: Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue
Correction to: Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
SENP3 alleviates osteoporosis via promoting SIRT3 transcription through the increase of DLX2 stability via SUMO2/3
SENP3 alleviates osteoporosis via promoting SIRT3 transcription through the increase of DLX2 stability via SUMO2/3
Recent studies have indicated a close relationship between SENP3 and osteoporosis. However, the detailed molecular mechani...
Oral squamous cell carcinoma: Insights into cellular heterogeneity, drug resistance, and evolutionary trajectories
Oral squamous cell carcinoma: Insights into cellular heterogeneity, drug resistance, and evolutionary trajectories
Oral squamous cell carcinoma (OSCC) can lead to metastasis and high mortality rates known for its aggressive and invasive ...
NFATC2/SERPINE1/JAK3/STAT3 signaling feedback loop in gastric cancer: immune evasion and anti-PD-1 resistance
NFATC2/SERPINE1/JAK3/STAT3 signaling feedback loop in gastric cancer: immune evasion and anti-PD-1 resistance
This research investigates how the SERPINE1-associated tumor microenvironment influences anti-PD-1 treatment response in g...
GelMA hydrogel-loaded extracellular vesicles derived from keratinocytes promote skin microvasculature regeneration and wound healing in diabetic mice through activation of the PDGF-induced PI3K/AKT pathway
GelMA hydrogel-loaded extracellular vesicles derived from keratinocytes promote skin microvasculature regeneration and wound healing in diabetic mice through activation of the PDGF-induced PI3K/AKT pathway
This study explores how extracellular vesicles (EVs) derived from keratinocytes cultured in Gelatin Methacryloyl (GelMA) h...
From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics
From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics
The brain growth spurt (BGS) represents a pivotal window in neurodevelopment, defined by rapid neurogenesis, heightened sy...
Single-cell spatial proteomics of non-relapse small cell lung cancer identifies tumor microenvironment determinants of survival
Single-cell spatial proteomics of non-relapse small cell lung cancer identifies tumor microenvironment determinants of survival
Small cell lung cancer (SCLC) is characterized by high malignancy and early propensity for metastasis, and modest response...
The role of lncRNA in androgen metabolism and follicle growth arrest in polycystic ovary syndrome
The role of lncRNA in androgen metabolism and follicle growth arrest in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and follicular growth arrest. This study investigate...
ADT increases prostate cancer cell invasion via altering AR/SALL4/SOX2-OCT4 stem cell signaling
ADT increases prostate cancer cell invasion via altering AR/SALL4/SOX2-OCT4 stem cell signaling
Early studies indicated that the androgen-deprivation-therapy with antiandrogen Enzalutamide (Enz) could increase prostate...
Therapeutic targeting of PRSS3 to alleviate kidney damage in DKD
Therapeutic targeting of PRSS3 to alleviate kidney damage in DKD
As a primary contributor to end-stage renal disease, diabetic kidney disease (DKD) is characterized by metabolic and infla...
KMT2D/ZNF460-induced COL9A1-mediated extracellular matrix stiffness maintains the cancer stem cell pool to promote colorectal cancer progression
KMT2D/ZNF460-induced COL9A1-mediated extracellular matrix stiffness maintains the cancer stem cell pool to promote colorectal cancer progression
Collagen is a central component of the extracellular matrix (ECM) in tissues, and ECM can promote tumor cell immune evasio...
YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through mA-dependent binding
YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through mA-dependent binding
The rapid escalation of oxidative and nitrosative stress during ischemia/reperfusion (I/R) triggers neuronal damage, leadi...
TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension
TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension
Based on bioinformatics insights, this study investigates the functions of lysophosphatidic acid receptor 3 (LPAR3) and TE...
NGR-modified curcumin nanovesicles reverse immunotherapy resistance in triple-negative breast cancer via TLR9 and mTOR pathway modulation
NGR-modified curcumin nanovesicles reverse immunotherapy resistance in triple-negative breast cancer via TLR9 and mTOR pathway modulation
Curcumin (Cur), a natural bioactive compound extracted from Curcuma longa, has garnered extensive interest due to its modu...
cGAS-STING targeting offers novel therapeutic regimen in sepsis-associated organ dysfunction
cGAS-STING targeting offers novel therapeutic regimen in sepsis-associated organ dysfunction
Sepsis is clinically defined as a life-threatening syndrome characterized by dysregulated host responses to infection, cul...
Single-nucleus rna sequencing identifies universal camk1d upregulation and dysregulated c-ltmr subtypes as key drivers of paclitaxel-induced neuropathy
Single-nucleus rna sequencing identifies universal camk1d upregulation and dysregulated c-ltmr subtypes as key drivers of paclitaxel-induced neuropathy
Neuropathic pain triggered by chemotherapy poses a significant clinical challenge. Investigating cell type-specific altera...
Advances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers
Advances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers
Hybrid hydrogels have emerged as multifunctional biomaterials for targeted drug delivery and tissue engineering in gynecol...
ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling
ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling
Acetaminophen (APAP) stands as the predominant contributor to drug-induced liver injury (DILI), and limited options are av...
Deficiency of copper responsive gene stmn4 induces retinal developmental defects
Deficiency of copper responsive gene stmn4 induces retinal developmental defects
As part of the central nervous system (CNS), the retina senses light and also conducts and processes visual impulses. The ...
POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer
POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer
This study investigated the effect and mechanism of POU6F1 and lncRNA-CASC2 on ferroptosis of gastric cancer (GC) cells. G...
m6A modification mediates SLC3A2/SLC7A5 translation in 3-methylcholanthrene-induced uroepithelial transformation
m6A modification mediates SLC3A2/SLC7A5 translation in 3-methylcholanthrene-induced uroepithelial transformation
3-Methylcholanthracene (3-MC) is one of the most carcinogenic polycyclic aromatic hydrocarbons (PAHs). Long-term exposure ...
LOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer
LOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer
Colorectal cancer (CRC) is a leading cause of cancer mortality globally. Lymph node metastasis and immunosuppression are m...
TFEB and TFE3 cooperate in regulating inorganic arsenic-induced autophagy-lysosome impairment and immuno-dysfunction in primary dendritic cells
TFEB and TFE3 cooperate in regulating inorganic arsenic-induced autophagy-lysosome impairment and immuno-dysfunction in primary dendritic cells
Arsenic (As) is a prevalent and hazardous environmental toxicant associated with cancer and various health problems, which...
circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis
circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis
Air pollution has greatly increased the risk of idiopathic pulmonary fibrosis (IPF). Circular RNAs (circRNAs) have been fo...
METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke
METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke
Stroke is a major medical problem, and novel therapeutic targets are urgently needed. This study investigates the protecti...
Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1
Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1
Circular RNAs (circRNAs) have been documented to play crucial roles in the biology of various cancers. However, their inve...
CD36 inhibition reduces non-small-cell lung cancer development through AKT-mTOR pathway
CD36 inhibition reduces non-small-cell lung cancer development through AKT-mTOR pathway
Lung cancer is the most common cause of cancer-related deaths worldwide and is caused by multiple factors, including high-...
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