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Repeated 7-day exposure to ketamine induces anxiety-like behaviors and neuronal apoptosis in mice via DRD1-medicated inhibition of Akt/Gsk-3β phosphorylation
Repeated 7-day exposure to ketamine induces anxiety-like behaviors and neuronal apoptosis in mice via DRD1-medicated inhibition of Akt/Gsk-3β phosphorylation
Repeated exposure to ketamine leads to mental behavioral disorders and cognitive deficits in mice. As a neurotransmitter r...
Synovial macrophage rhoa protects against osteoarthritis by suppressing YAP/IL-17C mediated chondrocyte senescence
Synovial macrophage rhoa protects against osteoarthritis by suppressing YAP/IL-17C mediated chondrocyte senescence
The GTPase RhoA is known as a regulator involved in cartilage degeneration and subchondral bone remodeling related to oste...
LncRNA-Gm5532 deficiency alleviates bone resorption by inhibiting mitochondrial respiration through iASPP/NRF2
LncRNA-Gm5532 deficiency alleviates bone resorption by inhibiting mitochondrial respiration through iASPP/NRF2
Osteoporosis, characterized by excessive osteoclast activity and bone resorption, is closely linked to mitochondrial respi...
METTL7B-stabilized lncRNA-MIR22HG to drive p53-mediated neuronal apoptosis via the ubiquitinating JARID2 in cerebral ischemia/reperfusion injury
METTL7B-stabilized lncRNA-MIR22HG to drive p53-mediated neuronal apoptosis via the ubiquitinating JARID2 in cerebral ischemia/reperfusion injury
Ischemic stroke (IS) constitutes a leading driver of mortality and morbidity worldwide, with neuronal apoptosis representi...
NAA20-mediated ACF1 lactylation drives neuroblastoma progression through enhancing GCLM-dependent glutathione synthesis
NAA20-mediated ACF1 lactylation drives neuroblastoma progression through enhancing GCLM-dependent glutathione synthesis
Neuroblastoma (NBL) is a pediatric malignancy with poor prognosis in high-risk cases. This study explores the function of ...
EGR1/miR-4306/MAT2A axis aggravates pyroptosis and extracellular matrix degradation of nucleus pulposus cells in intervertebral disc degeneration
EGR1/miR-4306/MAT2A axis aggravates pyroptosis and extracellular matrix degradation of nucleus pulposus cells in intervertebral disc degeneration
Intervertebral disc degeneration (IVDD) acts as the prerequisite and pathological basis for a series of spinal degenerativ...
Sublethal heat stress synergizes with the tumor microenvironment to drive recurrence of hepatocellular carcinoma after thermal ablation: mechanisms, molecular predictors, and targeted interventions
Sublethal heat stress synergizes with the tumor microenvironment to drive recurrence of hepatocellular carcinoma after thermal ablation: mechanisms, molecular predictors, and targeted interventions
Although thermal ablation has emerged as a minimally invasive and effective local treatment for hepatocellular carcinoma (...
Mycotoxins, gut microbiota alterations and liver disease in animals: A scoping review
Mycotoxins, gut microbiota alterations and liver disease in animals: A scoping review
Mycotoxins are fungal secondary metabolites widely detected in up to eighty percent of frequently consumed foods, strongly...
Lipocalin 2: a double-edged sword in cellular ferroptosis
Lipocalin 2: a double-edged sword in cellular ferroptosis
Ferroptosis is a novel form of programmed cell death that is distinct from apoptosis, necrosis, and autophagy (macroautoph...
Overloaded mitochondrial stress drives reproductive damage in GC-1 mouse spermatogonia cells exposed to nickel nanoparticle
Overloaded mitochondrial stress drives reproductive damage in GC-1 mouse spermatogonia cells exposed to nickel nanoparticle
Nickel nanoparticles (Ni NPs) are widely used in industrial and commercial sectors, raising concerns about their potential...
Inhibition of acalabrutinib metabolism by finerenone and its molecular docking studies
Inhibition of acalabrutinib metabolism by finerenone and its molecular docking studies
Acalabrutinib is a frontline agent for chronic lymphocytic leukemia (CLL). The objective of this experiment was to screen ...
Brain organoids in environmental neurotoxicology: applications, mechanisms, and future perspectives
Brain organoids in environmental neurotoxicology: applications, mechanisms, and future perspectives
The advent of human induced pluripotent stem cell (hiPSC)-derived brain organoids represents a significant advance in envi...
Toxicogenomic Characterization of Perfluorooctanoic Acid–Associated Bladder Carcinogenesis
Toxicogenomic Characterization of Perfluorooctanoic Acid–Associated Bladder Carcinogenesis
This study aims to bridge toxicological target prediction and bladder cancer transcriptomics by systematically identifying...
Lactate Dehydrogenase B delactylation promotes gastric cancer metastasis via enhancing glutathione-mediated resistance to ferroptosis
Lactate Dehydrogenase B delactylation promotes gastric cancer metastasis via enhancing glutathione-mediated resistance to ferroptosis
To elucidate the role of protein lactylation in gastric adenocarcinoma progression, focusing on lactate dehydrogenase B (L...
Annexin A1-FPR1 Interaction in dendritic cells promotes immune microenvironment modulation in Thyroid Cancer
Annexin A1-FPR1 Interaction in dendritic cells promotes immune microenvironment modulation in Thyroid Cancer
Thyroid cancer (THCA) is profoundly influenced by its immune microenvironment, with dendritic cells (DCs) serving as key m...
Loss of YTHDF1 suppresses the progression of malignant rhabdoid tumor of the kidney by regulating Glutathione S-transferase Mu 2 (GSTM2)
Loss of YTHDF1 suppresses the progression of malignant rhabdoid tumor of the kidney by regulating Glutathione S-transferase Mu 2 (GSTM2)
Malignant rhabdoid tumor of the kidney (MRTK) is a rare renal tumor with poor prognosis. While germline mutations of SMARC...
Dissecting the METTL3/STC2 axis in colorectal cancer: implications for drug resistance and metastasis
Dissecting the METTL3/STC2 axis in colorectal cancer: implications for drug resistance and metastasis
In recent years, the role of epigenetic modifications, especially N6-methyladenosine (m6A) modifications, in the occurrenc...
Correction to: Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue
Correction to: Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
SENP3 alleviates osteoporosis via promoting SIRT3 transcription through the increase of DLX2 stability via SUMO2/3
SENP3 alleviates osteoporosis via promoting SIRT3 transcription through the increase of DLX2 stability via SUMO2/3
Recent studies have indicated a close relationship between SENP3 and osteoporosis. However, the detailed molecular mechani...
Oral squamous cell carcinoma: Insights into cellular heterogeneity, drug resistance, and evolutionary trajectories
Oral squamous cell carcinoma: Insights into cellular heterogeneity, drug resistance, and evolutionary trajectories
Oral squamous cell carcinoma (OSCC) can lead to metastasis and high mortality rates known for its aggressive and invasive ...
NFATC2/SERPINE1/JAK3/STAT3 signaling feedback loop in gastric cancer: immune evasion and anti-PD-1 resistance
NFATC2/SERPINE1/JAK3/STAT3 signaling feedback loop in gastric cancer: immune evasion and anti-PD-1 resistance
This research investigates how the SERPINE1-associated tumor microenvironment influences anti-PD-1 treatment response in g...
GelMA hydrogel-loaded extracellular vesicles derived from keratinocytes promote skin microvasculature regeneration and wound healing in diabetic mice through activation of the PDGF-induced PI3K/AKT pathway
GelMA hydrogel-loaded extracellular vesicles derived from keratinocytes promote skin microvasculature regeneration and wound healing in diabetic mice through activation of the PDGF-induced PI3K/AKT pathway
This study explores how extracellular vesicles (EVs) derived from keratinocytes cultured in Gelatin Methacryloyl (GelMA) h...
From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics
From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics
The brain growth spurt (BGS) represents a pivotal window in neurodevelopment, defined by rapid neurogenesis, heightened sy...
Single-cell spatial proteomics of non-relapse small cell lung cancer identifies tumor microenvironment determinants of survival
Single-cell spatial proteomics of non-relapse small cell lung cancer identifies tumor microenvironment determinants of survival
Small cell lung cancer (SCLC) is characterized by high malignancy and early propensity for metastasis, and modest response...
The role of lncRNA in androgen metabolism and follicle growth arrest in polycystic ovary syndrome
The role of lncRNA in androgen metabolism and follicle growth arrest in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and follicular growth arrest. This study investigate...
ADT increases prostate cancer cell invasion via altering AR/SALL4/SOX2-OCT4 stem cell signaling
ADT increases prostate cancer cell invasion via altering AR/SALL4/SOX2-OCT4 stem cell signaling
Early studies indicated that the androgen-deprivation-therapy with antiandrogen Enzalutamide (Enz) could increase prostate...
Therapeutic targeting of PRSS3 to alleviate kidney damage in DKD
Therapeutic targeting of PRSS3 to alleviate kidney damage in DKD
As a primary contributor to end-stage renal disease, diabetic kidney disease (DKD) is characterized by metabolic and infla...
KMT2D/ZNF460-induced COL9A1-mediated extracellular matrix stiffness maintains the cancer stem cell pool to promote colorectal cancer progression
KMT2D/ZNF460-induced COL9A1-mediated extracellular matrix stiffness maintains the cancer stem cell pool to promote colorectal cancer progression
Collagen is a central component of the extracellular matrix (ECM) in tissues, and ECM can promote tumor cell immune evasio...
YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through mA-dependent binding
YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through mA-dependent binding
The rapid escalation of oxidative and nitrosative stress during ischemia/reperfusion (I/R) triggers neuronal damage, leadi...
TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension
TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension
Based on bioinformatics insights, this study investigates the functions of lysophosphatidic acid receptor 3 (LPAR3) and TE...
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