Alexaki VI, Fodelianaki G, Neuwirth A, Mund C, Kourgiantaki A, Ieronimaki E, Lyroni K, Troullinaki M, Fujii C, Kanczkowski W, Ziogas A, Peitzsch M, Grossklaus S, Sönnichsen B, Gravanis A, Bornstein SR, Charalampopoulos I, Tsatsanis C, Chavakis T. DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway. Mol Psychiatry. 2018;23(6):1410–20. https://doi.org/10.1038/mp.2017.167.

Article  PubMed  CAS  Google Scholar 

Andropoulos DB, Greene MF. Anesthesia and developing brains - implications of the FDA warning. N Engl J Med. 2017;376(10):905–7. https://doi.org/10.1056/NEJMp1700196.

Article  PubMed  Google Scholar 

Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain. Br J Anaesth. 2018;120(4):768–78. https://doi.org/10.1016/j.bja.2017.12.039.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Aurelian L, Balan I. GABA(A)R α2-activated neuroimmune signal controls binge drinking and impulsivity through regulation of the CCL2/CX3CL1 balance. Psychopharmacology. 2019;236(10):3023–43. https://doi.org/10.1007/s00213-019-05220-4.

Article  PubMed  CAS  Google Scholar 

Bademosi AT, Steeves J, Karunanithi S, Zalucki OH, Gormal RS, Liu S, Lauwers E, Verstreken P, Anggono V, Meunier FA, van Swinderen B. Trapping of syntaxin1a in presynaptic nanoclusters by a clinically relevant general anesthetic. Cell Rep. 2018;22(2):427–40. https://doi.org/10.1016/j.celrep.2017.12.054.

Article  PubMed  CAS  Google Scholar 

Balan I, Beattie MC, O’Buckley TK, Aurelian L, Morrow AL. Endogenous neurosteroid (3α,5α)3-hydroxypregnan-20-one inhibits toll-like-4 receptor activation and pro-inflammatory signaling in macrophages and brain. Sci Rep. 2019;9(1):1220. https://doi.org/10.1038/s41598-018-37409-6.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Balan I, Grusca A, O’Buckley TK, Morrow AL. Neurosteroid [3α,5α]-3-hydroxy-pregnan-20-one enhances IL-10 production via endosomal TRIF-dependent TLR4 signaling pathway. Front Endocrinol (Lausanne). 2023a;14:1299420. https://doi.org/10.3389/fendo.2023.1299420.

Article  PubMed  Google Scholar 

Balan I, Patterson R, Boero G, Krohn H, O’Buckley TK, Meltzer-Brody S, Morrow AL. Brexanolone therapeutics in post-partum depression involves inhibition of systemic inflammatory pathways. EBioMedicine. 2023b;89:104473. https://doi.org/10.1016/j.ebiom.2023.104473.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Banerjee P, Rossi MG, Anghelescu DL, Liu W, Breazeale AM, Reddick WE, Glass JO, Phillips NS, Jacola LM, Sabin ND, Inaba H, Srivastava D, Robison LL, Pui CH, Hudson MM, Krull KR. Association between anesthesia exposure and neurocognitive and neuroimaging outcomes in long-term survivors of childhood acute lymphoblastic leukemia. JAMA Oncol. 2019;5(10):1456–63. https://doi.org/10.1001/jamaoncol.2019.1094.

Article  PubMed  Google Scholar 

Bethlehem RAI, Seidlitz J, White SR, Vogel JW, Anderson KM, Adamson C, Adler S, Alexopoulos GS, Anagnostou E, Areces-Gonzalez A, Astle DE, Auyeung B, Ayub M, Bae J, Ball G, Baron-Cohen S, Beare R, Bedford SA, Benegal V,…, Alexander-Bloch AF. Brain charts for the human lifespan. Nature. 2022;604(7906):525-533. https://doi.org/10.1038/s41586-022-04554-y

Bi C, Cai Q, Shan Y, Yang F, Sun S, Wu X, Liu H. Sevoflurane induces neurotoxicity in the developing rat hippocampus by upregulating connexin 43 via the JNK/c-Jun/AP-1 pathway. Biomed Pharmacother. 2018;108:1469–76. https://doi.org/10.1016/j.biopha.2018.09.111.

Article  PubMed  CAS  Google Scholar 

Boscolo A, Milanovic D, Starr JA, Sanchez V, Oklopcic A, Moy L, Ori CC, Erisir A, Jevtovic-Todorovic V. Early exposure to general anesthesia disturbs mitochondrial fission and fusion in the developing rat brain. Anesthesiology. 2013;118(5):1086–97. https://doi.org/10.1097/ALN.0b013e318289bc9b.

Article  PubMed  CAS  Google Scholar 

Brambrink AM, Back SA, Riddle A, Gong X, Moravec MD, Dissen GA, Creeley CE, Dikranian KT, Olney JW. Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain. Ann Neurol. 2012;72(4):525–35. https://doi.org/10.1002/ana.23652.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Briz V, Baudry M. Estrogen regulates protein synthesis and actin polymerization in hippocampal neurons through different molecular mechanisms. Front Endocrinol (Lausanne). 2014;5:22. https://doi.org/10.3389/fendo.2014.00022.

Article  PubMed  Google Scholar 

Cabrera OH, Tesic V, Tat QL, Chastain S, Quillinan N, Jevtovic-Todorovic V. Sevoflurane-induced dysregulation of cation-chloride cotransporters NKCC1 and KCC2 in neonatal mouse brain. Mol Neurobiol. 2020;57(1):1–10. https://doi.org/10.1007/s12035-019-01751-1.

Article  PubMed  CAS  Google Scholar 

Calvo-Rodriguez M, Bacskai BJ. Mitochondria and calcium in Alzheimer’s disease: From cell signaling to neuronal cell death. Trends Neurosci. 2021;44(2):136–51. https://doi.org/10.1016/j.tins.2020.10.004.

Article  PubMed  CAS  Google Scholar 

Cattano D, Young C, Straiko MM, Olney JW. Subanesthetic doses of propofol induce neuroapoptosis in the infant mouse brain. Anesth Analg. 2008;106(6):1712–4. https://doi.org/10.1213/ane.0b013e318172ba0a.

Article  PubMed  CAS  Google Scholar 

Chen B, Deng X, Wang B, Liu H. Etanercept, an inhibitor of TNF-a, prevents propofol-induced neurotoxicity in the developing brain. Int J Dev Neurosci. 2016;55:91–100. https://doi.org/10.1016/j.ijdevneu.2016.10.002.

Article  PubMed  CAS  Google Scholar 

Chen J, Zhang DM, Feng X, Wang J, Qin YY, Zhang T, Huang Q, Sheng R, Chen Z, Li M, Qin ZH. TIGAR inhibits ischemia/reperfusion-induced inflammatory response of astrocytes. Neuropharmacology. 2018;131:377–88. https://doi.org/10.1016/j.neuropharm.2018.01.012.

Article  PubMed  CAS  Google Scholar 

Chen ZW, Bracamontes JR, Budelier MM, Germann AL, Shin DJ, Kathiresan K, Qian MX, Manion B, Cheng WWL, Reichert DE, Akk G, Covey DF, Evers AS. Multiple functional neurosteroid binding sites on GABAA receptors. PLoS Biol. 2019;17(3):e3000157. https://doi.org/10.1371/journal.pbio.3000157.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen K, Lu D, Yang X, Zhou R, Lan L, Wu Y, Wang C, Xu X, Jiang MH, Wei M, Feng X. Enhanced hippocampal neurogenesis mediated by PGC-1α-activated OXPHOS after neonatal low-dose Propofol exposure. Front Aging Neurosci. 2022a;14:925728. https://doi.org/10.3389/fnagi.2022.925728.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen Z, Ding Y, Zeng Y, Zhang XP, Chen JY. Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway. BMC Pharmacol Toxicol. 2022b;23(1):18. https://doi.org/10.1186/s40360-022-00555-9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Choi EH, Blasiak A, Lee J, Yang IH. Modulation of neural activity for myelination in the central nervous system. Front Neurosci. 2019;13:952. https://doi.org/10.3389/fnins.2019.00952.

Article  PubMed  PubMed Central  Google Scholar 

Cohen-Cory S, Kidane AH, Shirkey NJ, Marshak S. Brain-derived neurotrophic factor and the development of structural neuronal connectivity. Dev Neurobiol. 2010;70(5):271–88. https://doi.org/10.1002/dneu.20774.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Creeley C, Dikranian K, Dissen G, Martin L, Olney J, Brambrink A. Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain. Br J Anaesth. 2013;110(Suppl 1):i29-38. https://doi.org/10.1093/bja/aet173.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Davidson AJ, Disma N, De Graaff JC, Withington DE, Dorris L, Bell G, Stargatt R, Bellinger DC, Schuster T, Arnup SJ, Hardy P, Hunt RW, Takagi MJ, Giribaldi G, Hartmann PL, Salvo I, Morton NS, von Ungern Sternberg BS, Locatelli BG,…, McCann ME. Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial. Lancet. 2016;387(10015):239-250. https://doi.org/10.1016/s0140-6736(15)00608-x

Deoni S, Dean D 3rd, Joelson S, O’Regan J, Schneider N. Early nutrition influences developmental myelination and cognition in infants and young children. Neuroimage. 2018;178:649–59. https://doi.org/10.1016/j.neuroimage.2017.12.056.

Article  PubMed  Google Scholar 

DiGruccio MR, Joksimovic S, Joksovic PM, Lunardi N, Salajegheh R, Jevtovic-Todorovic V, Beenhakker MP, Goodkin HP, Todorovic SM. Hyper