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Towards prospective identification of respiratory sensitizers: effects of piperazine, chloramine-T, and toluene-diisocyanate in an air–liquid interface model comprising human bronchial epithelial cells
Towards prospective identification of respiratory sensitizers: effects of piperazine, chloramine-T, and toluene-diisocyanate in an air–liquid interface model comprising human bronchial epithelial cells
Exposure to respiratory sensitizers (RSs) is the leading cause of occupational asthma. Although the prospective identifica...
Dihydromyricetin restores lysosomal function in Schwann cells to alleviate bortezomib-induced peripheral neuropathy via ERK/TFEB signaling
Dihydromyricetin restores lysosomal function in Schwann cells to alleviate bortezomib-induced peripheral neuropathy via ERK/TFEB signaling
Bortezomib (BTZ) serves as a first-line drug for multiple myeloma (MM) treatment by reversibly inhibiting of the proteasom...
Unraveling the Hsp70-ROS-autophagy axis in pentachlorophenol-challenged lung and liver epithelial cells
Unraveling the Hsp70-ROS-autophagy axis in pentachlorophenol-challenged lung and liver epithelial cells
Pentachlorophenol (PCP) was extensively utilized as an organochlorine pesticide and wood preservative in the United States...
Thalidomide-induced limb malformations: an update and reevaluation
Thalidomide-induced limb malformations: an update and reevaluation
Historically, thalidomide-induced congenital malformations have served as an important example of the enhanced susceptibil...
ITGA1, the alpha 1 subunit of integrin receptor, is a novel marker of drug-resistant senescent melanoma cells in vitro
ITGA1, the alpha 1 subunit of integrin receptor, is a novel marker of drug-resistant senescent melanoma cells in vitro
Chemotherapy-induced senescence may promote drug resistance and treatment failure. Precise detection and elimination of se...
Intracellular hydrogen sulfide induces stress granule formation and translational repression through eIF2α phosphorylation
Intracellular hydrogen sulfide induces stress granule formation and translational repression through eIF2α phosphorylation
Acute exposure to high concentrations of hydrogen sulfide (H2S), a toxic gaseous substance, can cause potentially lethal r...
The role of redox signaling in mitochondria and endoplasmic reticulum regulation in kidney diseases
The role of redox signaling in mitochondria and endoplasmic reticulum regulation in kidney diseases
Kidney diseases are among the fastest worldwide growing pathologies. This growth together with their high mortality rate e...
Alterations in acetylcholinesterase activity and oxidative stress parameters induced by pure cylindrospermopsin in brain of orally exposed rats and determination of potential metabolites
Alterations in acetylcholinesterase activity and oxidative stress parameters induced by pure cylindrospermopsin in brain of orally exposed rats and determination of potential metabolites
Cylindrospermopsin (CYN) is a secondary metabolite produced by cyanobacteria. In view of its toxic effects, CYN is frequen...
Key genes and processes affected by atorvastatin treatment in mouse diaphragm muscle
Key genes and processes affected by atorvastatin treatment in mouse diaphragm muscle
Statins are one of the top prescribed medications and are used for preventing or treating cardiovascular diseases. Myalgia...
Perfluorooctane sulfonic acid: a possible risk factor of endothelial dysfunction based on in silico and in vitro studies
Perfluorooctane sulfonic acid: a possible risk factor of endothelial dysfunction based on in silico and in vitro studies
Perfluorooctane sulfonic acid (PFOS) is a fluorinated chemical utilized in a variety of industrial and household products....
Partial amelioration of a chronic cigarette-smoke-induced phenotype in mice by switching to electronic cigarettes
Partial amelioration of a chronic cigarette-smoke-induced phenotype in mice by switching to electronic cigarettes
Electronic cigarettes (“e-cigarettes”) are often marketed as smoking cessation tools and are used by smokers t...
Biotransformation of ketamine in terminal in vivo experiments under chronic intermittent hypoxia conditions and the role of AhR
Biotransformation of ketamine in terminal in vivo experiments under chronic intermittent hypoxia conditions and the role of AhR
We were pioneers in describing aryl hydrocarbon receptor (AhR) activation by chronic intermittent hypoxia (CIH) in a rat p...
Extension and validation of a physiologically based toxicokinetic model for risk assessment of aluminium exposure in humans
Extension and validation of a physiologically based toxicokinetic model for risk assessment of aluminium exposure in humans
The safety of aluminium (Al) exposure from sources such as food, parenteral nutrition or adjuvanted medicinal products is ...
Unveiling CYP450 inhibition by the pesticide prothioconazole through integrated in vitro studies and PBPK modeling
Unveiling CYP450 inhibition by the pesticide prothioconazole through integrated in vitro studies and PBPK modeling
Prothioconazole (PTC), a widely used triazole fungicide with low human toxicity, was evaluated for its potential to inhibi...
Concentration–time profiles of the nerve agent VX and the pesticide parathion in five different cell culture plates
Concentration–time profiles of the nerve agent VX and the pesticide parathion in five different cell culture plates
Cell cultivation tools are usually not considered the primary factors influencing research results. In this study, we sele...
Towards a good environmental status: a 4-year monitoring study on the contamination of the Bay of Luebeck with energetic compounds prior to munitions remediation
Towards a good environmental status: a 4-year monitoring study on the contamination of the Bay of Luebeck with energetic compounds prior to munitions remediation
In the Bay of Luebeck, two out of several munition dumping areas in the German Baltic Sea are located, where approximately...
LINE-1 DNA methylation mediates smoking-related risk in site-specific urothelial carcinoma: a Taiwan case–control study
LINE-1 DNA methylation mediates smoking-related risk in site-specific urothelial carcinoma: a Taiwan case–control study
While environmental and lifestyle factors contribute to urothelial carcinoma (UC) development, their differential effects ...
Absolute oral bioavailability, quantitative toxicokinetics and metabolite profiling of alternariol and alternariol monomethyl ether in pigs
Absolute oral bioavailability, quantitative toxicokinetics and metabolite profiling of alternariol and alternariol monomethyl ether in pigs
The mycotoxins alternariol (AOH) and alternariol monomethyl ether (AME), produced by Alternaria spp., are common contamina...
Correction: Species-differences in the in vitro biotransformation of trifluoroethene (HFO-1123)
Correction: Species-differences in the in vitro biotransformation of trifluoroethene (HFO-1123)
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Interleukin 1β and interleukin 6 production in human immune cells is stimulated by the antibacterial compound Triclosan
Interleukin 1β and interleukin 6 production in human immune cells is stimulated by the antibacterial compound Triclosan
Triclosan (TCS) is an antimicrobial compound widely used in personal hygiene products such as mouthwash and toothpaste; an...
Kinetically-derived maximal dose (KMD) indicates lack of human carcinogenicity of ethylbenzene
Kinetically-derived maximal dose (KMD) indicates lack of human carcinogenicity of ethylbenzene
The kinetically-derived maximal dose (KMD) is defined as the maximal external dose at which kinetics are unchanged relativ...
Cyanobacterial harmful bloom lipopolysaccharides: pro-inflammatory effects on epithelial and immune cells in vitro
Cyanobacterial harmful bloom lipopolysaccharides: pro-inflammatory effects on epithelial and immune cells in vitro
Cyanobacterial harmful blooms (CyanoHABs) pose a global ecological problem, and their lipopolysaccharides (LPS) are among ...
The prediction of acute toxicity (LD50) for organophosphorus-based chemical warfare agents (V-series) using toxicology in silico methods
The prediction of acute toxicity (LD50) for organophosphorus-based chemical warfare agents (V-series) using toxicology in silico methods
Nerve agents are organophosphate chemical warfare agents that exert their toxic effects by irreversibly inhibiting acetylc...
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Idiosyncratic drug-induced liver injury (DILI) associated with drug reactions with eosinophilia and systemic symptoms (DRE...
Grouping of esters of 4-hydroxybenzoic acid for hazard assessment
Grouping of esters of 4-hydroxybenzoic acid for hazard assessment
Hazardous properties of a large number of esters of 4-hydroxybenzoic acid (parabens) have been proposed by ECHA to be asse...
Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Monsé et al.
Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Monsé et al.
Brand P, Beilmann V, Thomas K et al (2019) The effects of exposure time on systemic inflammation in subjects with exposure...
Quantification of 108 illicit drugs and metabolites in bile matrix by LC–MS/MS for the toxicological testing of sudden death cases
Quantification of 108 illicit drugs and metabolites in bile matrix by LC–MS/MS for the toxicological testing of sudden death cases
Sudden death could occur after assumption of illicit drugs for recreational purposes in adults or after intoxication in ch...
Involvement of mitochondrial dynamics and mitophagy in diabetic endothelial dysfunction and cardiac microvascular injury
Involvement of mitochondrial dynamics and mitophagy in diabetic endothelial dysfunction and cardiac microvascular injury
Endothelial cells (ECs), found in the innermost layer of blood vessels, are crucial for maintaining the structure and func...
Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS
Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS
Aflatoxin B1 (AFB1) is a highly hepatotoxic and carcinogenic mycotoxin produced by Aspergillus species. The compo...
Hypermethylation of the ADIRF promoter regulates its expression level and is involved in NNK-induced malignant transformation of lung bronchial epithelial cells
Hypermethylation of the ADIRF promoter regulates its expression level and is involved in NNK-induced malignant transformation of lung bronchial epithelial cells
The carcinogenic mechanism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a well-known tobacco carcinogen, has n...
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