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3,3'-Dichlorobiphenyl (PCB 11) alters the hepatic expression of cytochrome P450 enzymes in the liver of mouse dams exposed orally during pregnancy and lactation
3,3'-Dichlorobiphenyl (PCB 11) alters the hepatic expression of cytochrome P450 enzymes in the liver of mouse dams exposed orally during pregnancy and lactation
Healthy maternal metabolism is critical during pregnancy and lactation to support fetal development and protect against en...
In-vivo toxicokinetics of chromium in human blood and urine after intravenous injection of chromate
In-vivo toxicokinetics of chromium in human blood and urine after intravenous injection of chromate
Although intoxication with hexavalent chromium [Cr(VI)] compounds can be fatal to humans, reliable data on chromium toxico...
Projection-based molecular feature maps for CNN-driven nephrotoxicity prediction
Projection-based molecular feature maps for CNN-driven nephrotoxicity prediction
The development of reliable predictive models for nephrotoxic agents remains a critical challenge in drug development, giv...
Exploring the potential of liver microphysiological systems of varied configurations to model cholestatic chemical effects
Exploring the potential of liver microphysiological systems of varied configurations to model cholestatic chemical effects
Human in vitro liver tissue models have evolved to maintain hallmarks of hepatocellular function for extended periods with...
Predicting xenobiotic metabolism: a computational approach mining LC–MS/MS data with SIRIUS and BioTransformer
Predicting xenobiotic metabolism: a computational approach mining LC–MS/MS data with SIRIUS and BioTransformer
Drug biotransformation and bioactivation play a pivotal role in drug discovery, driving the development of analytical meth...
Biodistribution and pulmonary toxicity of branched polyethyleneimine in rats following intratracheal and intravenous exposure
Biodistribution and pulmonary toxicity of branched polyethyleneimine in rats following intratracheal and intravenous exposure
Branched polyethyleneimine (BPEI) is a cationic polymer widely utilized in household products (e.g., fragrances, antimicro...
Correction: Effect of ‑acetyltransferase 2 genetic polymorphism on 4,4′‑methylenebis(2‑chloroaniline)‑induced genotoxicity and oxidative stress
Correction: Effect of ‑acetyltransferase 2 genetic polymorphism on 4,4′‑methylenebis(2‑chloroaniline)‑induced genotoxicity and oxidative stress
Cite this articleHabil, M.R., Salazar‑González, R.A., Doll, M.A. et al. Correction: Effect of N‑acetyltransferase 2 geneti...
Mechanism of liver fibrosis induced by life-long triclosan exposure in offspring rats: an adverse outcome pathway framework validated by in vivo and in vitro experiments
Mechanism of liver fibrosis induced by life-long triclosan exposure in offspring rats: an adverse outcome pathway framework validated by in vivo and in vitro experiments
Triclosan (TCS), a broad-spectrum lipophilic antiseptic, is frequently found in household and healthcare supplies. Its inc...
Insights into the human metabolism and in silico receptor activity of gidazepam and desalkylgidazepam
Insights into the human metabolism and in silico receptor activity of gidazepam and desalkylgidazepam
Desalkylgidazepam, an active gidazepam metabolite, first appeared on the illicit drug market in 2022 and has been detected...
Scorpion venom as a molecular treasure: emerging bioactive compounds and translational therapeutic insights
Scorpion venom as a molecular treasure: emerging bioactive compounds and translational therapeutic insights
Scorpion venom contains a diverse array of bioactive compounds, including peptides, proteins, enzymes, and alkaloids, whic...
Cross-ancestry meta-analysis identifies a variant in the polycyclic aromatic hydrocarbons metabolism-related pathway contributing to colorectal cancer susceptibility
Cross-ancestry meta-analysis identifies a variant in the polycyclic aromatic hydrocarbons metabolism-related pathway contributing to colorectal cancer susceptibility
Unhealthy diets (e.g., higher red meat consumption) and tobacco exposure are major risk factors for colorectal cancer (CRC...
Developmental vulnerability to fluoride toxicity: enamel and clearance differences in adolescent versus mature mice
Developmental vulnerability to fluoride toxicity: enamel and clearance differences in adolescent versus mature mice
Fluoride plays a dual role in dental health—preventing caries at optimal levels but causing fluorosis when excessive...
SARS-CoV-2 mRNA vaccines: unresolved mechanisms of myocardial damage
SARS-CoV-2 mRNA vaccines: unresolved mechanisms of myocardial damage
Myopericarditis requiring emergency care or hospitalization after COVID-19 mRNA vaccination occurs most frequently in adol...
Qualitative and quantitative in silico toxicity profiling of “angel dust”: phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE)
Qualitative and quantitative in silico toxicity profiling of “angel dust”: phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE)
Phencyclidine (PCP), historically known as “angel dust,” and its analogues (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-...
Toxicological profiling of venoms from ten major Chinese snakes: a mass spectrometry-based proteomic and multiroute assessment
Toxicological profiling of venoms from ten major Chinese snakes: a mass spectrometry-based proteomic and multiroute assessment
Snake envenomation, a neglected tropical disease, presents complex and species-dependent systemic pathophysiology. Here, w...
Cigarette smoking combines with genetic variants to regulate FOXN3 and associate with bladder cancer risk
Cigarette smoking combines with genetic variants to regulate FOXN3 and associate with bladder cancer risk
FOXN family genes (FOXNs) have a significant role in the progression of various malignancies; nevertheless, the relationsh...
Mechanism-based new approach methodologies for in vitro detection of chemical-induced liver steatosis
Mechanism-based new approach methodologies for in vitro detection of chemical-induced liver steatosis
Liver steatosis resulting from chemical exposure is a growing clinical concern, pointing to the need for early detection i...
Health impacts of micro- and nanoplastics: key influencing factors, limitations, and future perspectives
Health impacts of micro- and nanoplastics: key influencing factors, limitations, and future perspectives
Micro- and nanoplastics (MNPs) are emerging environmental threats, with increasing evidence of their profound ecotoxicolog...
Towards prospective identification of respiratory sensitizers: effects of piperazine, chloramine-T, and toluene-diisocyanate in an air–liquid interface model comprising human bronchial epithelial cells
Towards prospective identification of respiratory sensitizers: effects of piperazine, chloramine-T, and toluene-diisocyanate in an air–liquid interface model comprising human bronchial epithelial cells
Exposure to respiratory sensitizers (RSs) is the leading cause of occupational asthma. Although the prospective identifica...
Dihydromyricetin restores lysosomal function in Schwann cells to alleviate bortezomib-induced peripheral neuropathy via ERK/TFEB signaling
Dihydromyricetin restores lysosomal function in Schwann cells to alleviate bortezomib-induced peripheral neuropathy via ERK/TFEB signaling
Bortezomib (BTZ) serves as a first-line drug for multiple myeloma (MM) treatment by reversibly inhibiting of the proteasom...
Unraveling the Hsp70-ROS-autophagy axis in pentachlorophenol-challenged lung and liver epithelial cells
Unraveling the Hsp70-ROS-autophagy axis in pentachlorophenol-challenged lung and liver epithelial cells
Pentachlorophenol (PCP) was extensively utilized as an organochlorine pesticide and wood preservative in the United States...
Thalidomide-induced limb malformations: an update and reevaluation
Thalidomide-induced limb malformations: an update and reevaluation
Historically, thalidomide-induced congenital malformations have served as an important example of the enhanced susceptibil...
ITGA1, the alpha 1 subunit of integrin receptor, is a novel marker of drug-resistant senescent melanoma cells in vitro
ITGA1, the alpha 1 subunit of integrin receptor, is a novel marker of drug-resistant senescent melanoma cells in vitro
Chemotherapy-induced senescence may promote drug resistance and treatment failure. Precise detection and elimination of se...
Intracellular hydrogen sulfide induces stress granule formation and translational repression through eIF2α phosphorylation
Intracellular hydrogen sulfide induces stress granule formation and translational repression through eIF2α phosphorylation
Acute exposure to high concentrations of hydrogen sulfide (H2S), a toxic gaseous substance, can cause potentially lethal r...
The role of redox signaling in mitochondria and endoplasmic reticulum regulation in kidney diseases
The role of redox signaling in mitochondria and endoplasmic reticulum regulation in kidney diseases
Kidney diseases are among the fastest worldwide growing pathologies. This growth together with their high mortality rate e...
Alterations in acetylcholinesterase activity and oxidative stress parameters induced by pure cylindrospermopsin in brain of orally exposed rats and determination of potential metabolites
Alterations in acetylcholinesterase activity and oxidative stress parameters induced by pure cylindrospermopsin in brain of orally exposed rats and determination of potential metabolites
Cylindrospermopsin (CYN) is a secondary metabolite produced by cyanobacteria. In view of its toxic effects, CYN is frequen...
Key genes and processes affected by atorvastatin treatment in mouse diaphragm muscle
Key genes and processes affected by atorvastatin treatment in mouse diaphragm muscle
Statins are one of the top prescribed medications and are used for preventing or treating cardiovascular diseases. Myalgia...
Perfluorooctane sulfonic acid: a possible risk factor of endothelial dysfunction based on in silico and in vitro studies
Perfluorooctane sulfonic acid: a possible risk factor of endothelial dysfunction based on in silico and in vitro studies
Perfluorooctane sulfonic acid (PFOS) is a fluorinated chemical utilized in a variety of industrial and household products....
Partial amelioration of a chronic cigarette-smoke-induced phenotype in mice by switching to electronic cigarettes
Partial amelioration of a chronic cigarette-smoke-induced phenotype in mice by switching to electronic cigarettes
Electronic cigarettes (“e-cigarettes”) are often marketed as smoking cessation tools and are used by smokers t...
Biotransformation of ketamine in terminal in vivo experiments under chronic intermittent hypoxia conditions and the role of AhR
Biotransformation of ketamine in terminal in vivo experiments under chronic intermittent hypoxia conditions and the role of AhR
We were pioneers in describing aryl hydrocarbon receptor (AhR) activation by chronic intermittent hypoxia (CIH) in a rat p...
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