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The effect of methylation and hydroxymethylation of cytosine on activity and fidelity of Pol λ and Pol β
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Targeting dePARylation in cancer therapy
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Role of NEIL1 in genome maintenance
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The hidden elephant: Modified abasic sites and their consequences
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Repair pathway coordination from gap filling by polβ and subsequent nick sealing by LIG1 or LIG3α governs BER efficiency at the downstream steps
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Obituary: Francis Fabre (1940–2024): Yeast geneticist that contributed to our understanding of the control of homologous recombination
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Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome
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Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae
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Transport of DNA repair proteins to the cell nucleus by the classical nuclear importin pathway – a structural overview
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The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis
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Stained DNA Dot Detection (SD3): An automated tool for quantifying fluorescent features along single stretched DNA molecules
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Temporal and spatial dynamics of DNA double-strand break repair centers
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Identification of a novel pathogenic XPC:c.2420 + 1 G>C variant in a patient with xeroderma pigmentosum
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The replication stress response: Mechanisms and functions
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Werner helicase as a therapeutic target in mismatch repair deficient colorectal cancer
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Building an integrated view of R-loops, transcription, and chromatin
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Role of HSP40 proteins in genome maintenance, insulin signaling and cancer therapy
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Modulation of OGG1 enzymatic activities by small molecules, promising tools and current challenges
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PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy
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Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]
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FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe
FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe
WEE1 kinase phosphorylates CDK1 and CDK2 to regulate origin firing and mitotic entry. Inhibition of WEE1 has become an att...
Targeted nuclear irradiation with a proton microbeam induces oxidative DNA base damage and triggers the recruitment of DNA glycosylases OGG1 and NTH1
Targeted nuclear irradiation with a proton microbeam induces oxidative DNA base damage and triggers the recruitment of DNA glycosylases OGG1 and NTH1
DNA is considered a major target for ionizing radiation (IR)-based therapies [1], [2], [3]. Exposure of cells to IR has lo...
Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair
Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair
The major innate immune responder to the DNA of pathogens is the cyclic GMP-AMP (cGAMP) synthase (cGAS) - stimulator of in...
Somatic Mutation Patterns at Ig and Non-Ig Loci
Somatic Mutation Patterns at Ig and Non-Ig Loci
AbbreviationsAadenosine (in RNA) and deoxyadenosine (in DNA)A>>Tmutations in DNA at A exceed mutations at TA-to-Iade...
Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses
Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses
SWI/SNF complexes are a conserved eukaryotic family of chromatin remodelling activities. In mammalian cells, this family c...
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1
Mitoxantrone, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione (Fig. 1 A), is an approved...
A non-canonical nucleotide from viral genomes interferes with the oxidative DNA damage repair system
A non-canonical nucleotide from viral genomes interferes with the oxidative DNA damage repair system
Anna V. Yudkina: Methodology, Formal analysis, Investigation, Resources, Data Curation, Writing - Original Draft, Visualiz...
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites
Genomic integrity is critical to maintain the normal function of organisms. Pathological DNA double strand breaks (DSBs) h...
NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation
NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation
Renal cell carcinoma (RCC) is a malignancy in the urinary system originating from the renal tubular epithelium with a high...
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2
ADP-ribosyl transferase Diptheria toxin-like 1 (ARTD1), also known as Poly(ADP-ribose) polymerase 1 (PARP1), is a 116 kDa,...
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