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The neuroprotective potential of in a neuronal demyelination rat model through the modulation of interleukins, cyclooxygenase and tumor necrosis factor-α
The neuroprotective potential of in a neuronal demyelination rat model through the modulation of interleukins, cyclooxygenase and tumor necrosis factor-α
Multiple sclerosis is characterized by the demyelination of neurons, which is a chronic inflammatory disease of the centra...
From bench to bedside: exploring curcumin-driven signaling pathways in immune cells for cancer management
From bench to bedside: exploring curcumin-driven signaling pathways in immune cells for cancer management
The use of natural compounds as effective therapeutic agents is an expanding area of health and disease research. Curcumin...
Gut microbiota and Parkinson’s Disease: a new frontier in understanding neurological health
Gut microbiota and Parkinson’s Disease: a new frontier in understanding neurological health
Increasingly recognized as a neurodegenerative disease with motor manifestations and progressive cognitive decline, PD has...
The presumable combined effects of hydroxychloroquine and its metabolites on the blood lipids and glucose in the treatment of rheumatoid arthritis
The presumable combined effects of hydroxychloroquine and its metabolites on the blood lipids and glucose in the treatment of rheumatoid arthritis
To explore the potential combined effects of hydroxycholoroquine (HCQ) and its metabolites on blood lipids and glucose in ...
Can pyridoxine function as an anti-pyroptosis agent? A narrative review
Can pyridoxine function as an anti-pyroptosis agent? A narrative review
Pyroptosis, a highly inflammatory form of programmed cell death, plays a key role in diseases such as sepsis, rheumatoid a...
Phytochemical analysis of leaf extract of and investigation of its biological activities
Phytochemical analysis of leaf extract of and investigation of its biological activities
This study investigates the phytoconstituents of the less explored leaf of Piper nigrum, a common ethnomedicinal plant as ...
The role of Ergothioneine in cognition and age-related neurodegenerative disease: a systematic review
The role of Ergothioneine in cognition and age-related neurodegenerative disease: a systematic review
Ergothioneine (ET) is an under recognised diet-derived compound which has the potential to be a “longevity vitamin&#...
Deciphering the role of cell signaling pathways in gout pathogenesis and the therapeutic potential of phytoconstituents in their modulation
Deciphering the role of cell signaling pathways in gout pathogenesis and the therapeutic potential of phytoconstituents in their modulation
Gout, a type of inflammatory arthritis, arises from the accumulation of monosodium urate crystals in joints, leading to se...
Impact of corticoid receptors on Alzheimer’s disease: a neuroendocrine perspective
Impact of corticoid receptors on Alzheimer’s disease: a neuroendocrine perspective
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that has been strongly associated with changes in...
Exploring the therapeutic potential of NLRP3 inhibitors in Parkinson's Disease: a systematic review of in-vivo studies
Exploring the therapeutic potential of NLRP3 inhibitors in Parkinson's Disease: a systematic review of in-vivo studies
Parkinson's disease is a progressive neurodegenerative disorder characterized by motor symptoms such as tremors, rigid...
Ocimene mitigates pyroptosis through TLR4/NLRP3-mediated mechanisms in CFA-induced inflammation
Ocimene mitigates pyroptosis through TLR4/NLRP3-mediated mechanisms in CFA-induced inflammation
The monocyclic monoterpenoid ocimene (OC) has undergone pharmacological testing as a possible inhibitor of pyroptosis trig...
Voclosporin promotes neurological function recovery by inhibiting inflammation and maintaining blood–brain barrier integrity following rtPA reperfusion after MCAO in mice
Voclosporin promotes neurological function recovery by inhibiting inflammation and maintaining blood–brain barrier integrity following rtPA reperfusion after MCAO in mice
Hemorrhagic transformation (HT) is the most serious complication after rtPA thrombolytic therapy in patients with acute is...
Tetrylpyamethrazine alleviates hepatic fibrosis induced by experimental mansonic schistosomiasis
Tetrylpyamethrazine alleviates hepatic fibrosis induced by experimental mansonic schistosomiasis
Hepatic fibrosis resulting from human mansonic schistosomiasis significantly impairs liver function and contributes substa...
NSAID-encapsulated nanoparticles as a targeted therapeutic platform for modulating chronic inflammation and inhibiting cancer progression: a review
NSAID-encapsulated nanoparticles as a targeted therapeutic platform for modulating chronic inflammation and inhibiting cancer progression: a review
Recent advancements in nanotechnology have significantly advanced nanocarrier-mediated drug delivery systems, promoting th...
Role of TRPV1 and TRPA1 nociceptive neurons in delayed-onset muscle soreness: inhibition by hesperidin methyl chalcone
Role of TRPV1 and TRPA1 nociceptive neurons in delayed-onset muscle soreness: inhibition by hesperidin methyl chalcone
Delayed-onset muscle soreness (DOMS) is a type of pain caused by muscle injury provoked by eccentric, high intensity, or l...
fruit pulp extracts mitigate collagen-induced arthritis via regulation of oxidative stress and inflammation
fruit pulp extracts mitigate collagen-induced arthritis via regulation of oxidative stress and inflammation
Rheumatoid arthritis (RA) is an autoimmune inflammation disorder affecting the joints, it has a complex pathophysiology in...
Molecular mechanisms and treatment strategies for estrogen deficiency-related and glucocorticoid-induced osteoporosis: a comprehensive review
Molecular mechanisms and treatment strategies for estrogen deficiency-related and glucocorticoid-induced osteoporosis: a comprehensive review
Osteoporosis, a debilitating condition characterized by reduced bone mass and increased fracture risk, is notably influenc...
Natural agents as wound-healing promoters
Natural agents as wound-healing promoters
The management of acute and chronic wounds resulting from diverse injuries poses a significant challenge to clinical pract...
Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-α and COX-2
Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-α and COX-2
Medicinal plants play a pivotal role in the prevention of chronic non-communicable diseases including arthritis. Despite t...
Using aspirin to prevent and treat cancer
Using aspirin to prevent and treat cancer
This review will discuss evidence that aspirin possesses anticancer activity. Long-term observational retrospective studie...
Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane
Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane
Natural products are recognized as potential analgesics since many of them are part of modern medicine to relieve pain wit...
Resveratrol protects against Schistosoma mansoni-induced liver fibrosis by targeting the Sirt-1/NF-κB axis
Resveratrol protects against Schistosoma mansoni-induced liver fibrosis by targeting the Sirt-1/NF-κB axis
Hepatic schistosomiasis is a prevalent form of chronic liver disease that drastically affects human health. Nevertheless, ...
Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19
Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19
Recently, a global outbreak of COVID-19 has rapidly spread to various national regions. As the number of COVID-19 patients...
Linking NLRP3 inflammasome and pulmonary fibrosis: mechanistic insights and promising therapeutic avenues
Linking NLRP3 inflammasome and pulmonary fibrosis: mechanistic insights and promising therapeutic avenues
Pulmonary fibrosis is a devastating disorder distinguished by redundant inflammation and matrix accumulation in the lung i...
Liensinine reduces acute lung injury brought on by lipopolysaccharide by inhibiting the activation of the NF-κB signaling pathway through modification of the Src/TRAF6/TAK1 axis
Liensinine reduces acute lung injury brought on by lipopolysaccharide by inhibiting the activation of the NF-κB signaling pathway through modification of the Src/TRAF6/TAK1 axis
ALI is characterized by macrophage-driven inflammation, causing severe lung damage. Currently, there are limited therapeut...
L-Carnitine augments probenecid anti-inflammatory effect in monoiodoacetate-induced knee osteoarthritis in rats: involvement of miRNA-373/P2X7/NLRP3/NF-κB milieu
L-Carnitine augments probenecid anti-inflammatory effect in monoiodoacetate-induced knee osteoarthritis in rats: involvement of miRNA-373/P2X7/NLRP3/NF-κB milieu
Osteoarthritis (OA) is a degenerative joint disease, whereas the underlying molecular trails involved in its pathogenesis ...
Synthesis of novel nonsteroidal anti-inflammatory galloyl β-sitosterol-loaded lignin-capped Ag-based drug
Synthesis of novel nonsteroidal anti-inflammatory galloyl β-sitosterol-loaded lignin-capped Ag-based drug
Biocompatible anti-inflammatory lignin-capped Ag (LCAg) nanoparticles (NPs) were synthesized for the delivery of galloyl &...
Ibuprofen inhibits anaplastic thyroid cells in vivo and in vitro by triggering NLRP3-ASC-GSDMD-dependent pyroptosis
Ibuprofen inhibits anaplastic thyroid cells in vivo and in vitro by triggering NLRP3-ASC-GSDMD-dependent pyroptosis
Pyroptosis is a novel type of proinflammatory programmed cell death that is associated with inflammation, immunity, and ca...
Synthesis, molecular docking, analgesic, anti-inflammatory, and ulcerogenic evaluation of thiophene-pyrazole candidates as COX, 5-LOX, and TNF-α inhibitors
Synthesis, molecular docking, analgesic, anti-inflammatory, and ulcerogenic evaluation of thiophene-pyrazole candidates as COX, 5-LOX, and TNF-α inhibitors
The thiophene bearing pyrazole derivatives (7a-j) were synthesized and examined for their in vitro cyclooxygenase, 5-lipox...
Innovative preconditioning strategies for improving the therapeutic efficacy of extracellular vesicles derived from mesenchymal stem cells in gastrointestinal diseases
Innovative preconditioning strategies for improving the therapeutic efficacy of extracellular vesicles derived from mesenchymal stem cells in gastrointestinal diseases
Gastrointestinal (GI) diseases have become a global health issue and an economic burden due to their wide distribution, la...
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