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Targeting protein kinase C signaling cascades in alzheimer’s disease: emerging neuroprotective roles of aurothioglucose
Targeting protein kinase C signaling cascades in alzheimer’s disease: emerging neuroprotective roles of aurothioglucose
Protein Kinase C (PKC), a zinc-dependent signaling enzyme pivotal for neuronal survival and synaptic plasticity, has emerg...
Inhibitor of hyaluronic acid synthesis 4-methylumbelliferone (4-MU) as a potential anti-inflammatory substance in acute neuroinflammation model in vivo
Inhibitor of hyaluronic acid synthesis 4-methylumbelliferone (4-MU) as a potential anti-inflammatory substance in acute neuroinflammation model in vivo
Cytokine and oxylipin profiles in rat brain homogenates were characterized as an inflammatory response 6 h after ...
Anti-arthritic appraisal of L. extracts in complete Freund’s adjuvant‑induced arthritic Wistar rats regulating inflammatory cytokines and OPG/RANKL pathway
Anti-arthritic appraisal of L. extracts in complete Freund’s adjuvant‑induced arthritic Wistar rats regulating inflammatory cytokines and OPG/RANKL pathway
Acorus calamus L. is a traditional remedy for inflammatory, neurological, and gastrointestinal disorders. Herein, we explo...
Dual anti-inflammatory and immunomodulatory effects of clove essential oil and eugenol: targeting neutrophil functions and experimental arthritis
Dual anti-inflammatory and immunomodulatory effects of clove essential oil and eugenol: targeting neutrophil functions and experimental arthritis
Polymorphonuclear neutrophils (PMNs) contribute to the pathogenesis of arthritis by releasing excessive reactive oxygen sp...
Unveiling phytoconstituents and the anti-inflammatory potential of L. in ulcerative colitis: A focus on the PPARγ/SIRT1 axis
Unveiling phytoconstituents and the anti-inflammatory potential of L. in ulcerative colitis: A focus on the PPARγ/SIRT1 axis
Crassula species are traditionally used and possess anti-inflammatory properties, but Crassula tetragona L. remains largel...
Neuroprotective effects of SRS11-92 against oxidative stress–induced senescence via Nrf2/HO-1/NF-κB in Alzheimer’s disease models
Neuroprotective effects of SRS11-92 against oxidative stress–induced senescence via Nrf2/HO-1/NF-κB in Alzheimer’s disease models
Oxidative stress, neuroinflammation, and cellular senescence interact to drive Alzheimer’s disease (AD) progression....
Stigmasterol attenuates nociplastic pain and fatigue-like symptoms in a reserpine-induced fibromyalgia model in mice
Stigmasterol attenuates nociplastic pain and fatigue-like symptoms in a reserpine-induced fibromyalgia model in mice
Fibromyalgia is a widespread painful condition prevalent in women. The main manifestations include spontaneous pain, mecha...
Molecular mechanisms and risk factors in rheumatoid arthritis: a comprehensive review
Molecular mechanisms and risk factors in rheumatoid arthritis: a comprehensive review
Rheumatoid arthritis is a chronic systemic inflammatory disease that predominantly affects synovial joints, resulting in p...
Phytochemicals and nanoformulation strategies for rheumatoid arthritis: mechanistic insights, therapeutic advances, and translational challenges
Phytochemicals and nanoformulation strategies for rheumatoid arthritis: mechanistic insights, therapeutic advances, and translational challenges
Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease characterized by persistent joint inflammation, car...
Pulmonary fibrosis in post-COVID-19: epithelial-mesenchymal transition as a key mechanism and target for therapy
Pulmonary fibrosis in post-COVID-19: epithelial-mesenchymal transition as a key mechanism and target for therapy
Pulmonary fibrosis is a serious threat to global health, especially in after math of covid-19 infection, eventually result...
Neuroprotective mechanism of syringic acid targeting oxidative damage and neuroinflammation in an experimental model of traumatic brain injury
Neuroprotective mechanism of syringic acid targeting oxidative damage and neuroinflammation in an experimental model of traumatic brain injury
Traumatic brain injury (TBI) is a complex neurological condition, with accumulating evidence highlighting the critical rol...
Targeting gasdermin D–mediated pyroptosis: a precision anti-inflammatory strategy for acute and chronic lung diseases
Targeting gasdermin D–mediated pyroptosis: a precision anti-inflammatory strategy for acute and chronic lung diseases
Gasdermin D (GSDMD) is currently considered the major effector of pyroptosis, a lytic proinflammatory programmed cell deat...
Heightened anti-inflammatory and antioxidant effects of bone marrow stem cell-conditioned media with mono and doped TiO nanoparticles in Carrageenan-induced inflammation
Heightened anti-inflammatory and antioxidant effects of bone marrow stem cell-conditioned media with mono and doped TiO nanoparticles in Carrageenan-induced inflammation
Inflammation and oxidative stress are key mediators of tissue damage in numerous pathological conditions. This study inves...
Fluvoxamine attenuates inflammation in experimental sepsis via novel non-canonical pathways
Fluvoxamine attenuates inflammation in experimental sepsis via novel non-canonical pathways
Sepsis is characterized by a dysregulated systemic inflammatory response to infection and remains a major global health ch...
Effect of Quercetin on inflammatory markers in diabetes mellitus: a systematic review and meta-analysis of animal studies
Effect of Quercetin on inflammatory markers in diabetes mellitus: a systematic review and meta-analysis of animal studies
Diabetes mellitus (DM) is associated with severe complications driven by chronic inflammation, which releases cytokines, c...
Ivarmacitinib provides rapid and continuous improvement in patients with moderate-to-severe atopic dermatitis: a focus on different anatomical regions
Ivarmacitinib provides rapid and continuous improvement in patients with moderate-to-severe atopic dermatitis: a focus on different anatomical regions
Ivarmacitinib (SHR0302) has demonstrated promising efficacy and safety profiles in patients with moderate-to-severe atopic...
A systematic review of therapeutic and paradoxical roles of tumor necrosis factor α inhibitors in autoimmune blistering diseases
A systematic review of therapeutic and paradoxical roles of tumor necrosis factor α inhibitors in autoimmune blistering diseases
Autoimmune blistering diseases (AIBDs), including pemphigus diseases, pemphigoid diseases, linear immunoglobulin A (IgA) b...
The neuroprotective potential of in a neuronal demyelination rat model through the modulation of interleukins, cyclooxygenase and tumor necrosis factor-α
The neuroprotective potential of in a neuronal demyelination rat model through the modulation of interleukins, cyclooxygenase and tumor necrosis factor-α
Multiple sclerosis is characterized by the demyelination of neurons, which is a chronic inflammatory disease of the centra...
From bench to bedside: exploring curcumin-driven signaling pathways in immune cells for cancer management
From bench to bedside: exploring curcumin-driven signaling pathways in immune cells for cancer management
The use of natural compounds as effective therapeutic agents is an expanding area of health and disease research. Curcumin...
Gut microbiota and Parkinson’s Disease: a new frontier in understanding neurological health
Gut microbiota and Parkinson’s Disease: a new frontier in understanding neurological health
Increasingly recognized as a neurodegenerative disease with motor manifestations and progressive cognitive decline, PD has...
The presumable combined effects of hydroxychloroquine and its metabolites on the blood lipids and glucose in the treatment of rheumatoid arthritis
The presumable combined effects of hydroxychloroquine and its metabolites on the blood lipids and glucose in the treatment of rheumatoid arthritis
To explore the potential combined effects of hydroxycholoroquine (HCQ) and its metabolites on blood lipids and glucose in ...
Can pyridoxine function as an anti-pyroptosis agent? A narrative review
Can pyridoxine function as an anti-pyroptosis agent? A narrative review
Pyroptosis, a highly inflammatory form of programmed cell death, plays a key role in diseases such as sepsis, rheumatoid a...
Phytochemical analysis of leaf extract of and investigation of its biological activities
Phytochemical analysis of leaf extract of and investigation of its biological activities
This study investigates the phytoconstituents of the less explored leaf of Piper nigrum, a common ethnomedicinal plant as ...
The role of Ergothioneine in cognition and age-related neurodegenerative disease: a systematic review
The role of Ergothioneine in cognition and age-related neurodegenerative disease: a systematic review
Ergothioneine (ET) is an under recognised diet-derived compound which has the potential to be a “longevity vitamin&#...
Deciphering the role of cell signaling pathways in gout pathogenesis and the therapeutic potential of phytoconstituents in their modulation
Deciphering the role of cell signaling pathways in gout pathogenesis and the therapeutic potential of phytoconstituents in their modulation
Gout, a type of inflammatory arthritis, arises from the accumulation of monosodium urate crystals in joints, leading to se...
Impact of corticoid receptors on Alzheimer’s disease: a neuroendocrine perspective
Impact of corticoid receptors on Alzheimer’s disease: a neuroendocrine perspective
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that has been strongly associated with changes in...
Exploring the therapeutic potential of NLRP3 inhibitors in Parkinson's Disease: a systematic review of in-vivo studies
Exploring the therapeutic potential of NLRP3 inhibitors in Parkinson's Disease: a systematic review of in-vivo studies
Parkinson's disease is a progressive neurodegenerative disorder characterized by motor symptoms such as tremors, rigid...
Ocimene mitigates pyroptosis through TLR4/NLRP3-mediated mechanisms in CFA-induced inflammation
Ocimene mitigates pyroptosis through TLR4/NLRP3-mediated mechanisms in CFA-induced inflammation
The monocyclic monoterpenoid ocimene (OC) has undergone pharmacological testing as a possible inhibitor of pyroptosis trig...
Voclosporin promotes neurological function recovery by inhibiting inflammation and maintaining blood–brain barrier integrity following rtPA reperfusion after MCAO in mice
Voclosporin promotes neurological function recovery by inhibiting inflammation and maintaining blood–brain barrier integrity following rtPA reperfusion after MCAO in mice
Hemorrhagic transformation (HT) is the most serious complication after rtPA thrombolytic therapy in patients with acute is...
Tetrylpyamethrazine alleviates hepatic fibrosis induced by experimental mansonic schistosomiasis
Tetrylpyamethrazine alleviates hepatic fibrosis induced by experimental mansonic schistosomiasis
Hepatic fibrosis resulting from human mansonic schistosomiasis significantly impairs liver function and contributes substa...
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