Aggarwal BB, Shishodia S (2006) Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71:1397–1421. https://doi.org/10.1016/j.bcp.2006.02.009

Article  CAS  PubMed  Google Scholar 

Ahmad N, Fazal H, Abbasi B, Farooq S, Ali M, Khan M (2012) Biological role of Piper nigrum L. (black pepper): a review. Asian Pac J Trop Biomed 2(3):S1945–S1953. https://doi.org/10.1016/S2221-1691(12)60524-3

Article  Google Scholar 

Arun A, Ansari M, Popli P, Jaiswal S, Mishra A, Dwivedi A, Hajela K, Konwar R (2018) New piperidine derivative DTPEP acts as dual-acting anti-breast cancer agent by targeting ER α and downregulating PI 3K/Akt-PKC α leading to caspase-dependent apoptosis. Cell Prolif 51:e12501. https://doi.org/10.1111/cpr.12501

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ashokkumar K, Murugan M, Dhanya M, Pandian A, Warkentin TD (2021) Phytochemistry and therapeutic potential of black pepper [Piper nigrum (L.)] essential oil and piperine: a review. Clin Phytosci 7:52. https://doi.org/10.1186/s40816-021-00292-2

Article  CAS  Google Scholar 

Bahia RK, Hao X, Hassam R, Cseh O, Bozek DA, Luchman HA, Weiss S (2023) Epigenetic and molecular coordination between HDAC2 and SMAD3-SKI regulates essential brain tumour stem cell characteristics. Nat Commun 14:5051. https://doi.org/10.1038/s41467-023-40776-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhuyan B, Baishya K (2013) Ethno medicinal value of various plants used in the preparation of traditional rice beer by different tribes of Assam, India. Drug Invention Today 5:335–341. https://doi.org/10.1016/j.dit.2013.09.002

Article  CAS  Google Scholar 

Biswas P, Anand U, Saha SC, Kant N, Mishra T, Masih H, Bar A, Pandey DK, Jha NK, Majumder M, Das N, Gadekar VS, Shekhawat MS, Kumar M, Radha Proćków J, Lastra JMP, Dey A (2022) Betelvine (Piper betle L.): a comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes. J Cell Mol Med 26:3083–3119. https://doi.org/10.1111/jcmm.17323

Article  PubMed  PubMed Central  Google Scholar 

Bonetti F, Brombo G, Zuliani G (2017) Nootropics, functional foods, and dietary patterns for prevention of cognitive decline. In Nutrition and functional foods for healthy aging. Academic Press: 211–232

Chowdhury R, Leung IK, Tian YM, Abboud MI, Ge W, Domene C, Cantrelle FX, Landrieu I, Hardy AP, Pugh CW (2016) Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun 7:12673. https://doi.org/10.1038/ncomms12673

Article  CAS  PubMed  PubMed Central  Google Scholar 

da Silva ARP, Fungaro MHP, Silva JJ, Martins LM, Taniwaki MH, Iamanaka BT (2021) Ochratoxin A and related fungi in Brazilian black pepper (Piper nigrum L.). Food Res Int 142:110207. https://doi.org/10.1016/j.foodres.2021.110207

Article  CAS  PubMed  Google Scholar 

da Silva Jr IF, de Oliveira RG, Soares IM, da Costa AT, Ascêncio SD, de Oliveira Martins DT (2014) Evaluation of acute toxicity, antibacterial activity, and mode of action of the hydroethanolic extract of Piper umbellatum L. J Ethnopharmacol 151:137–143. https://doi.org/10.1016/j.jep.2013.10.011

Article  CAS  PubMed  Google Scholar 

Dalibalta S, Majdalawieh AF, Manjikian H (2020) Health benefits of sesamin on cardiovascular disease and its associated risk factors. Saudi Pharmaceut J 28(10):1276–1289. https://doi.org/10.1016/j.jsps.2020.08.018

Article  CAS  Google Scholar 

Damanhouri ZA, Ahmad A (2014) A review on therapeutic potential of Piper nigrum L. Medicinal & Aromatic Plants 3:161. https://doi.org/10.4172/2167-0412.1000161

Article  CAS  Google Scholar 

DeLano WL (2002) Pymol: an open-source molecular graphics tool. Protein Crystallography 40:82–92

Google Scholar 

Deng Y, Sriwiriyajan S, Tedasen A, Hiransai P, Graidist P (2016) Anti-cancer effects of Piper nigrum via inducing multiple molecular signaling in vivo and in vitro. J Ethnopharmacol 188:87–95. https://doi.org/10.1016/j.jep.2016.04.047

Article  CAS  PubMed  Google Scholar 

Druce H (2013) Aroma characterization of various ‘true’ and ‘false’ peppers from around the globe. MDc Thesis: University of Sydney, Australia

Ďuračková Z (2010) Some current insights into oxidative stress. Physiol Res https://doi.org/10.33549/physiolres.931844

Dutta P, Dey T, Manna P, Kalita J (2016) Antioxidant potential of Vespa affinis L., a traditional edible insect species of North East India. PLoS ONE 11:e0156107. https://doi.org/10.1371/journal.pone.0156107

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elisia I, Pae HB, Lam V, Cederberg R, Hofs E, Krystal G (2018) Comparison of RAW264. 7, human whole blood and PBMC assays to screen for immunomodulators. J Immunol Methods 452:26–31. https://doi.org/10.1016/j.jim.2017.10.004

Article  CAS  PubMed  Google Scholar 

Enyang D, Sonibare MA, Tchamgoue AD, Tchokouaha LR, Yadang FS, Nfor GN, Kom CW, Betote PD, Tchinda CF, Tiogo SS (2024) Protective and Ameliorative Effects of Hydroethanolic Extract of Piper nigrum (L.) Stem against Antiretroviral Therapy-Induced Hepatotoxicity and Dyslipidemia in Wistar Rats. J Toxicol 2024:5811080. https://doi.org/10.1155/2024/5811080

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan Y, Mao R, Yang J (2013) NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein Cell 4:176–185. https://doi.org/10.1007/s13238-013-2084-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu LC, Liu WT, Shirakawa H, Chen YH, Xiao Q, Yang SC (2024) Effects of sesamin on sleep quality and the antioxidative status in patients with low arousal threshold obstructive sleep apnea syndrome and those at risk of obstructive sleep apnea syndrome. J Funct Foods 123:106564. https://doi.org/10.1016/j.jff.2024.106564

Article  CAS  Google Scholar 

Ge SX, Jung D, Yao R (2020) ShinyGO: a graphical gene-set enrichment tool for animals and plants. Bioinformatics 36:2628–2629. https://doi.org/10.1093/bioinformatics/btz931

Article  CAS  PubMed  Google Scholar 

Gogoi M, Boruah JLH, Bora PK, Das DJ, Famhawite V, Biswas A, Puro N, Kalita J, Haldar S, Baishya R (2021) Citrus macroptera induces apoptosis via death receptor and mitochondrial mediated pathway as prooxidant in human non-small cell lung cancer cells. Food Biosci 43:101293. https://doi.org/10.1016/j.fbio.2021.101293

Article  CAS  Google Scholar 

Greenshields AL, Doucette CD, Sutton KM, Madera L, Annan H, Yaffe PB, Knickle AF, Dong Z, Hoskin DW (2015) Piperine inhibits the growth and motility of triple-negative breast cancer cells. Cancer Lett 357:129–140. https://doi.org/10.1016/j.canlet.2014.11.017

Article  CAS  PubMed  Google Scholar 

Guan G, Zhang Y, Lu Y, Liu L, Shi D, Wen Y, Yang L, Ma Q, Liu T, Zhu X (2015) The HIF-1α/CXCR4 pathway supports hypoxia-induced metastasis of human osteosarcoma cells. Cancer Lett 357:254–264. https://doi.org/10.1016/j.canlet.2014.11.034

Article  CAS  PubMed  Google Scholar 

Gupta A, Gupta M, Gupta SJIJoP, Research P (2013) Isolation of piperine and few sesquiterpenes from the cold petroleum ether extract of Piper nigrum (black pepper) and its antibacterial activity. International Journal of Pharmacognosy and Phytochemical Research 5: 3–7.ISSN: 0975–4873

Hirata N, Tokunaga M, Naruto S, Iinuma M, Matsuda H (2007) Testosterone 5α-reductase inhibitory active constituents of Piper nigrum leaf. Biol Pharm Bull 30(12):2402–2405. https://doi.org/10.1248/bpb.30.2402

Article  CAS  PubMed  Google Scholar 

Hoesel B, Schmid JA (2013) The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer 12:1–15. https://doi.org/10.1186/1476-4598-12-86

Article  CAS  Google Scholar 

Hortová-Kohoutková M, Tidu F, De Zuani M, Šrámek V, Helán M, Fric J (2020) Phagocytosis–inflammation crosstalk in sepsis: new avenues for therapeutic intervention. Shock 54:606–614. https://doi.org/10.1097/SHK.0000000000001541

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huxford T, Huang DB, Malek S, Ghosh G (1998) The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation. Cell 95:759–770. https://doi.org/10.1016/S0092-8674(00)81699-2

Article  CAS  PubMed  Google Scholar 

Janiszewska M, Primi MC, Izard TJ (2020) Cell adhesion in cancer: Beyond the migration of single cells. J Biol Chem 295:2495–2505