Abdelhafiz D, Baker T, Glascow DA, Abdelhafiz A (2023) Biomarkers for the diagnosis and treatment of rheumatoid arthritis—a systematic review. Postgrad Med 135(3):214–223. https://doi.org/10.1080/00325481.2022.2052626
Article CAS PubMed Google Scholar
Ahmad T, Kadam P, Bhiyani G, Ali H, Akbar M, Siddique MU, Shahid M (2024) Artemisia pallens W. attenuates inflammation and oxidative stress in freund’s complete adjuvant-induced rheumatoid arthritis in Wistar rats. Diseases 12(10):e230. https://doi.org/10.3390/diseases12100230
Akpinar D, Mercan T, Demir H, Ozdemir S, Demir C, Kavak S (2023) Protective effects of thymoquinone on doxorubicin-induced lipid peroxidation and antioxidant enzyme levels in rat peripheral tissues. Pak Vet J 43(4):651–658. https://doi.org/10.29261/pakvetj/2023.070
Aleem A, Aslam B, Alim MB, Hussain A, Faisal MN, Sindhu ZD (2023) Phytochemical analysis and gastroprotective effect of Stellaria media (L.) Vill. Methanolic extract on piroxicam-induced gastric ulcer in Wistar rats. Pak J Pharm Sci 36(5):1425–1434. https://doi.org/10.36721/PJPS.2023.36.5.REG.1425-1434.1
Article CAS PubMed Google Scholar
Ali A, Saadullah M, Fakhar-e-Alam M, Siddique R, Atif M (2024) Appraisal of the anti-arthritic potential of Strelitzia reginae in Wistar rats via modulating molecular inflammatory cascades IL-6, IL-17a, IL-1β, TNF-α, IFN-γ, RANKL, OPG, and IL-4 and attenuating oxidative stress biomarkers. J King Saud Uni Sci 36(8):e103315. https://doi.org/10.1016/j.jksus.2024.103315
Ananthia S, Gayathri V, Malarvizhi R, Bhardwaj M, Vasanthi HR (2017) Anti-arthritic potential of marine macroalgae Turbinaria ornata in complete freund’s adjuvant induced rats. Exp Toxicol Pathol 69(8):672–680. https://doi.org/10.1016/j.etp.2017.06.006
Ansari P, Reberio AD, Ansari NJ, Kumar S, Khan JT, Chowdhury S, Abd El-Mordy FM, Hannan JM, Flatt PR, Abdel-Wahab YH, Seidel V (2025) Therapeutic potential of medicinal plants and their phytoconstituents in diabetes, cancer, infections, cardiovascular diseases, inflammation and Gastrointestinal disorders. Biomedicines 13(2):e454. https://doi.org/10.3390/biomedicines13020454
Arya P, Singh K, Sharma D, Dhobi M, Gupta KK, Singh IK, Nissapatorn V, Kayesth J, Kayesth S (2023) Herbal and traditional medicines pharmacovigilance for holistic treatment. Indian J Nat Prod Resour 14(1):13–21. https://doi.org/10.56042/ijnpr.v14i1.1137
Aslam B, Hussain A, Faisal MN, Sindhu ZU, Khan RU, Alhidary IA, Naz S, Tufarelli V (2023) Curcumin co-encapsulation potentiates anti-arthritic efficacy of meloxicam biodegradable nanoparticles in adjuvant-induced arthritis animal model. Biomedicines 11(10):e2662. https://doi.org/10.3390/biomedicines11102662
Atzeni F, Rodríguez-Carrio J, Popa CD, Nurmohamed MT, Szűcs G, Szekanecz Z (2021) Cardiovascular effects of approved drugs for rheumatoid arthritis. Nat Rev Rheumatol 17(5):270–290. https://doi.org/10.1038/s41584-021-00593-3
Banik B, Das MK, Bhowmik M, Dey S (2024) Design and development of an herbal anti-arthritic gel incorporating Alstonia scholaris latex. J Biol Act Prod Nat 14(1):112–133. https://doi.org/10.1080/22311866.2024.2304599
Bari MU, Aslam B, Faisal MN, Hussain A, Majeed W, Alhidary IA, Abdelrahman SH, Taricone S (2024) The protective effects of Acorus calamus L. rhizome extracts against rheumatoid arthritis-associated dyslipidemia, oxidative stress, and liver injury in rats. J Appl Anim Res 52(1):e2402045. https://doi.org/10.1080/09712119.2024.2402045
Bari MU, Aslam B, Majeed W, Faisal MN (2025) Phytochemical analysis and investigation of anti-inflammatory, anti-nociceptive, and anti-pyretic activities of Acorus calamus Linn. rhizome extracts in animal models. Pak J Zool 57(6):2543–2554. https://doi.org/10.17582/journal.pjz/20240506024014
Behl T, Mehta K, Sehgal A, Singh S, Sharma N, Ahmadi A, Arora S, Bungau S (2022) Exploring the role of polyphenols in rheumatoid arthritis. Crit Rev Food Sci Nutr 62(19):5372–5393. https://doi.org/10.1080/10408398.2021.1924613
Article CAS PubMed Google Scholar
Bhol NK, Bhanjadeo MM, Singh AK, Dash UC, Ojha RR, Majhi S, Duttaroy AK, Jena AB (2024) The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds. Biomed Pharmacother 178:e117177. https://doi.org/10.1016/j.biopha.2024.117177
Chen D, Liu H, Wang Y, Chen S, Liu J, Li W, Dou H, Hou W, Meng M (2019a) Study of the adoptive immunotherapy on rheumatoid arthritis with thymus-derived invariant natural killer T cells. Int Immunopharmacol 67(1):427–440. https://doi.org/10.1016/j.intimp.2018.12.040
Article CAS PubMed Google Scholar
Chen Z, Bozec A, Ramming A, Schett G (2019b) Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis. Nat Rev Rheumatol 15(1):9–17. https://doi.org/10.1038/s41584-018-0109-2
Article CAS PubMed Google Scholar
Choudhary N, Bhatt LK, Prabhavalkar KS (2018) Experimental animal models for rheumatoid arthritis. Immunopharmacol Immunotoxicol 40(3):193–200. https://doi.org/10.1080/08923973.2018.1434793
Article CAS PubMed Google Scholar
de Lima EP, Laurindo LF, Catharin VC, Direito R, Tanaka M, Jasmin Santos German I, Lamas CB, Guiguer EL, Araújo AC, Fiorini AM, Barbalho SM (2025) Polyphenols, alkaloids, and terpenoids against neurodegeneration: evaluating the neuroprotective effects of phytocompounds through a comprehensive review of the current evidence. Metabolites 15(2):e124. https://doi.org/10.3390/metabo15020124
Dekkers JS, Schoones JW, Huizinga TW, Toes RE, Van Helm-Van Mil D AH (2017) Possibilities for preventive treatment in rheumatoid arthritis? Lessons from experimental animal models of arthritis: A systematic literature review and meta-analysis. Ann Rheum Dis 76(2):458–467. https://doi.org/10.1136/annrheumdis-2016-209830
Article CAS PubMed Google Scholar
Dogra A, Kour D, Bhardwaj M, Dhiman S, Kumar A, Vij B, Kumar A, Nandi U (2022) Glabridin plays dual action to augment the efficacy and attenuate the hepatotoxicity of methotrexate in arthritic rats. ACS Omega 7(38):34341–34351. https://doi.org/10.1021/acsomega.2c03948
Article CAS PubMed Central PubMed Google Scholar
Efthymiou E, Grammatikopoulou MG, Gkiouras K, Efthymiou G, Zafiriou E, Goulis DG, Sakkas LI, Bogdanos DP (2022) Time to deal with rheumatoid cachexia: prevalence, diagnostic criteria, treatment effects and evidence for management. Mediterr J Rheumatol 33(3):271–290. https://doi.org/10.31138/mjr.33.3.271
Article PubMed Central PubMed Google Scholar
Ehsan N, Ali S, Hamza A, Batool M, Al-Ghanim KA, Atique U, Ijaz MU (2023) Attenuative effects of Ginkgetin against polystyrene microplastics-induced renal toxicity in rats. Pak Vet J 43(4):819–823. https://doi.org/10.29261/pakvetj/2023.104
Esmaealzadeh N, Iranpanah A, Sarris J, Rahimi R (2022) A literature review of the studies concerning selected plant-derived adaptogens and their general function in body with a focus on animal studies. Phytomedicine 105(1):e154354. https://doi.org/10.1016/j.phymed.2022.154354
Fadda S, Hamdy A, Abulkhair E, Elsify HM, Mostafa A (2015) Serum levels of osteoprotegerin and RANKL in patients with rheumatoid arthritis and their relation to bone mineral density and disease activity. Egypt Rheumatol 37(1):1–6. https://doi.org/10.1016/j.ejr.2014.06.001
Faheem MA, Akhtar T, Naseem N, Aftab U, Zafar MS, Hussain S, Shahzad M, Gobe GC (2023) Chrysin is immunomodulatory and anti-inflammatory against complete freund’s adjuvant-induced arthritis in a pre-clinical rodent model. Pharmaceutics 15(4):e1225. https://doi.org/10.3390/pharmaceutics15041225
Ganna S (2014) The prevalence of anemia in rheumatoid arthritis. Rev Bras Rheumatol 54(4):257–259. https://doi.org/10.1016/j.rbr.2014.03.023
Gao C, Song XD, Chen FH, Wei GL, Guo CY (2024) The protective effect of natural medicines in rheumatoid arthritis via inhibit angiogenesis. Front Pharmacol 15:e1380098. https://doi.org/10.3389/fphar.2024.1380098
Gasmi A, Shanaida M, Oleshchuk O, Semenova Y, Mujawdiya PK, Ivankiv Y, Pokryshko O, Noor S, Piscopo S, Adamiv S, Bjørklund G (2023) Natural ingredients to improve immunity. Pharmaceuticals 16(4):e528. https://doi.org/10.3390/ph16040528
Hafeez H, Israr B, Butt MS, Faisal MN (2024) Therapeutic intervention of Opuntia ficus indica (L.) fruit and seed powder against CCl 4-induced acute liver injury in Wistar rats. Pak Vet J 44(2):369–376. https://doi.org/10.29261/pakvetj/20
Comments (0)