Abdul Khaliq H et al (2024) 5’AMP-activated protein kinase: an emerging target of phytochemicals to treat chronic inflammatory diseases. Crit Rev Food Sci Nutr 64(14):4763–4788. https://doi.org/10.1080/10408398.2022.2145264
Article CAS PubMed Google Scholar
Alam J, Sharma L (2019) Potential enzymatic targets in Alzheimer’s: a comprehensive review. Curr Drug Targets 20(3):316–339. https://doi.org/10.2174/1389450119666180820104723
Article CAS PubMed Google Scholar
Ali T et al (2020) Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation. J Pineal Res 69(2):e12667. https://doi.org/10.1111/jpi.12667
Article CAS PubMed Google Scholar
Alkon DL et al (2007) PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer’s disease. Trends Pharmacol Sci 28(2):51–60. https://doi.org/10.1016/j.tips.2006.12.002
Article CAS PubMed Google Scholar
Aziz N (2023) Exploring novel therapeutic strategies for the treatment of epilepsy-associated neuroinflammation. Dissertation, Archivio Dei Prodotti Della Ricerca Dell’Università Di Ferrara.
Bahrami F et al (2019) Peroxisome proliferator-activated receptor (PPAR)-γ modifies Aβ neurotoxin-induced electrophysiological alterations in rat primary cultured hippocampal neurons. Iran J Pharm Res 18(3):1403. https://doi.org/10.22037/ijpr.2019.1100783
Article CAS PubMed PubMed Central Google Scholar
Baldi S et al (2025) Advancements in protein kinase inhibitors: from discovery to clinical applications. Research 8:0747. https://doi.org/10.34133/research.0747
Article CAS PubMed PubMed Central Google Scholar
Barrantes FJ (2024) Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders. Front Aging Neurosci 16:1476909. https://doi.org/10.3389/fnagi.2024.1476909
Article CAS PubMed PubMed Central Google Scholar
Beck I et al (2009) Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr Rev 30(7):830–882. https://doi.org/10.1210/er.2009-0013
Article CAS PubMed PubMed Central Google Scholar
Berners-Price SJ, Filipovska A (2011) Gold compounds as therapeutic agents for human diseases. Metallomics 3(9):863–873. https://doi.org/10.1039/c1mt00062d
Article CAS PubMed Google Scholar
Bharati AC et al (2024) Herbs and their bioactive compound’s role in the management of rheumatoid arthritis and related inflammatory conditions. Chem inside Spices Herbs Res Dev 3:46–65. https://doi.org/10.2174/97898151968011240301
Bindoli A, Rigobello MP (2013) Principles in redox signaling: from chemistry to functional significance. Antioxid Redox Signal 18(13):1557–1593. https://doi.org/10.1089/ars.2012.4655
Article CAS PubMed Google Scholar
Callender JA, Newton AC (2017) Conventional protein kinase C in the brain: 40 years later. Neuronal Signal 1(2):NS20160005. https://doi.org/10.1042/NS20160005
Article PubMed PubMed Central Google Scholar
Català-Solsona J (2020) Role of Nr4a2 transcription factor in hippocampal synaptic plasticity. Possible therapeutic target for Alzheimer’s disease. Dissertation, UAB, Universitat Autonoma de Barcelona.
Champion G D (1997) The anti-rheumatic gold complexes: Chemistry, cellular metabolism, pharmacology and therapeutics. UNSW Sydney.
Chen BC, Lin WW (2001) PKC-and ERK-dependent activation of IκB kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation. Br J Pharmacol 134(5):1055–1065. https://doi.org/10.1038/sj.bjp.0704334
Article CAS PubMed PubMed Central Google Scholar
Chen Z, Zhong C (2013) Decoding Alzheimer’s disease from perturbed cerebral glucose 3 metabolism: implications for diagnostic and therapeutic strategies. Prog Neurobiol 108:21–43. https://doi.org/10.1016/j.pneurobio.2013.06.004
Article CAS PubMed Google Scholar
Cherkasova V (2023) The potential molecular mechanisms of various treatment combinations between cisplatin, cannabidiol, cannabis extracts, and intermittent serum starvation on colorectal cancer cell lines. University of Lethbridge (Canada).
Chi AS, Wen PY (2007) Inhibiting kinases in malignant gliomas. Expert Opin Ther Targets 11(4):473–496. https://doi.org/10.1517/14728222.11.4.473
Article CAS PubMed Google Scholar
Chopra H et al (2022) Application of artificial intelligence in drug discovery. Curr Pharm des 28(33):2690–2703. https://doi.org/10.2174/1381612828666220608141049
Article CAS PubMed Google Scholar
Cifuentes J et al (2021) Antioxidant and neuroprotective properties of non-centrifugal cane sugar and other sugarcane derivatives in an in vitro induced Parkinson’s model. Antioxidants 10(7):1040. https://doi.org/10.3390/antiox10071040
Article CAS PubMed PubMed Central Google Scholar
De Marco P et al (2011) Human neural tube defects: genetic causes and prevention. BioFactors 37(4):261–268
Devi KP et al (2009) Emerging role of flavonoids in inhibition of NF-κB-mediated signaling pathway: a review. Int J Biomed Pharm Sci 3(1):31–45
Dolzhenko A, Sagalovsky S (2015) Inhibition of nuclear faktor–kB (NF-kB) signaling as a potential therapeutic strategy for rheumatoid arthritis. Клiнiчнa Тa Eкcпepимeнтaльнa Пaтoлoгiя 14(2):214–224
Du Y et al (2018) Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer’s disease phenotypes. J Exp Med 215(6):1665–1677. https://doi.org/10.1084/jem.20171193
Article CAS PubMed PubMed Central Google Scholar
Engin A (2024) Protein kinases in obesity, and the kinase-targeted therapy. Obes Lipotoxicity 1460:199–229. https://doi.org/10.1007/978-3-031-63657-8_7
Eriksson M (2005) Ap-1 transcription factor in cell differentiation and survival. Helsinki University Biomedical Dissertations No. 66.
Ferrari et al (2014) Wnt/β-catenin signaling in Alzheimer’s. CNS Neurol Disord-Drug Targets-CNS Neurol Disord 13(5):745–754. https://doi.org/10.2174/1871527312666131223113900
Ferrer I et al (2002) Active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates are differentially expressed following systemic administration of kainic acid to the adult rat. Acta Neuropathol 103(4):391–407. https://doi.org/10.1007/s00401-001-0481-9
Article CAS PubMed Google Scholar
Georgiou A et al (2017) Klotho: the protein of faith. EC Neurol 75:189–223
Ghosh A et al (2016) Mitoapocynin treatment protects against neuroinflammation and dopaminergic neurodegeneration in a preclinical animal model of Parkinson’s disease. J Neuroimmune Pharmacol 11(2):259–278. https://doi.org/10.1007/s11481-016-9650-4
Article PubMed PubMed Central Google Scholar
Grados M et al (2024) A selective review of inhibitors of protein kinase C gamma: a neuroplasticity-related common pathway for psychiatric illness. Front Drug Deliv 4:1364037. https://doi.org/10.3389/fddev.2024.1364037
Article PubMed PubMed Central Google Scholar
Hadi F et al (2020) Wnt signalling pathway and tau phosphorylation: a comprehensive study on known connections. Cell Biochem Funct 38(6):686–694. https://doi.org/10.1002/cbf.3530
Article CAS PubMed Google Scholar
Hornbeck-Kirouac L N (2016) The concerted regulation of intracellular signaling by amyloid precursor protein and Aβ peptide. Dissertation, University of South Florida.
Hwangbo H et al (2021) Anti-inflammatory effect of auranofin on palmitic acid and LPS-induced inflammatory response by modulating TLR4 and NOX4-mediated NF-κB signaling pathway in RAW264. 7 macrophages. Int J Mol Sci 22(11):5920. https://doi.org/10.3390/ijms22115920
Article CAS PubMed PubMed Central Google Scholar
Jubaidi FF et al (2022) The role of PKC-MAPK signalling pathways in the development of hyperglycemia-induced cardiovascular complications. Int J Mol Sci 23(15):8582. https://doi.org/1
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