Abraham E, Wunderink R, Silverman H et al (1995) Efficacy and safety of monoclonal antibody to human tumor necrosis factor α in patients with sepsis syndrome: a randomized, controlled, double-blind, multicenter clinical trial. JAMA J Am Med Assoc 273(12):934–941. https://doi.org/10.1001/jama.1995.03520360048038
Annane D (2011) Corticosteroids for severe sepsis: an evidence-based guide for physicians. Ann Intensive Care 1:7. https://doi.org/10.1186/2110-5820-1-7
Article CAS PubMed PubMed Central Google Scholar
Bolo NR, Hodé Y, Nédélec JF et al (2000) Brain pharmacokinetics and tissue distribution in vivo of fluvoxamine and fluoxetine by fluorine magnetic resonance spectroscopy. Neuropsychopharmacology 23:428–438. https://doi.org/10.1016/S0893-133X(00)00116-0
Article CAS PubMed Google Scholar
Bravo-Caparrós I, Ruiz-Cantero MC, Perazzoli G et al (2020) Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury. FASEB J 34:5951–5966. https://doi.org/10.1096/fj.201901921R
Article CAS PubMed Google Scholar
Cain DW, Cidlowski JA (2017) Nat Rev Immunol 17:233–247. https://doi.org/10.1038/nri.2017.1
Article CAS PubMed PubMed Central Google Scholar
Center for Drug Evaluation and Research (2005) Guidance for industry: estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. US Department of Health and Human Services
Costa LHA, Santos BM, Branco LGS (2020) Can selective serotonin reuptake inhibitors have a neuroprotective effect during COVID-19? Eur J Pharmacol 889:173629. https://doi.org/10.1016/j.ejphar.2020.173629
Costa RA, Amatnecks JA, de Oliveira Guaita G et al (2024) Sexual dimorphism of hypothalamic serotonin release during systemic inflammation: role of endothelin-1. J Neuroimmunol 394:578427. https://doi.org/10.1016/j.jneuroim.2024.578427
Article CAS PubMed Google Scholar
Denaro S, Pasquinucci L, Turnaturi R et al (2024) Sigma-1 receptor inhibition reduces mechanical allodynia and modulate neuroinflammation in chronic neuropathic pain. Mol Neurobiol 61:2672–2685. https://doi.org/10.1007/s12035-023-03717-w
Article CAS PubMed Google Scholar
Fisher CJ, Dhainaut JA, Opal SM (1994) Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. JAMA 271:1836–1843. https://doi.org/10.1001/jama.271.23.1836
Fleischmann-Struzek C, Mikolajetz A, Schwarzkopf D et al (2018) Challenges in assessing the burden of sepsis and understanding the inequalities of sepsis outcomes between National Health Systems: secular trends in sepsis and infection incidence and mortality in Germany. Intensive Care Med 44:1826–1835. https://doi.org/10.1007/s00134-018-5377-4
Article CAS PubMed PubMed Central Google Scholar
Gallagher J, Fisher C, Sherman B et al (2001) A multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNF-α antibody afelimomab in patients with sepsis syndrome. Intensive Care Med 27:1169–1178. https://doi.org/10.1007/s001340100973
Article CAS PubMed Google Scholar
Gallant RM, Sanchez KK, Joulia E et al (2025) Fluoxetine promotes IL-10–dependent metabolic defenses to protect from sepsis-induced lethality. Sci Adv 11:eadu4034. https://doi.org/10.1126/sciadv.adu4034
Hajhashemi V, Sadeghi H, Minaiyan M et al (2010) The role of central mechanisms in the anti-inflammatory effect of amitriptyline on carrageenan-induced paw edema in rats. Clinics 65:1183–1187. https://doi.org/10.1590/S1807-59322010001100022
Article PubMed PubMed Central Google Scholar
Herr N, Bode C, Duerschmied D (2017) The effects of serotonin in immune cells. Front Cardiovasc Med. https://doi.org/10.3389/fcvm.2017.00048
Article PubMed PubMed Central Google Scholar
Hoffmann JP, Liu JA, Seddu K, Klein SL (2023) Sex hormone signaling and regulation of immune function. Immunity 56:2472–2491. https://doi.org/10.1016/j.immuni.2023.10.008
Article CAS PubMed Google Scholar
Kasten KR, Muenzer JT, Caldwell CC (2010) Neutrophils are significant producers of IL-10 during sepsis. Biochem Biophys Res Commun 393:28–31. https://doi.org/10.1016/j.bbrc.2010.01.066
Article CAS PubMed PubMed Central Google Scholar
Kim JM, Jeong SW, Yang J et al (2015) Spinal 5-HT1A, not the 5-HT1B or 5-HT3 receptors, mediates descending serotonergic inhibition for late-phase mechanical allodynia of carrageenan-induced peripheral inflammation. Neurosci Lett 600:91–97. https://doi.org/10.1016/j.neulet.2015.05.058
Article CAS PubMed Google Scholar
Kirenga BJ, Mugenyi L, Sánchez-Rico M et al (2023) Association of fluvoxamine with mortality and symptom resolution among inpatients with COVID-19 in Uganda: a prospective interventional open-label cohort study. Mol Psychiatry 28:5411–5418. https://doi.org/10.1038/s41380-023-02004-3
Article CAS PubMed PubMed Central Google Scholar
Kostadinov I, Delev D, Petrova M et al (2015) Study on anti-inflammatory and immunomodulatory effects of fluoxetine in rat models of inflammation. Eur J Inflamm 13:173–182. https://doi.org/10.1177/1721727X15618671
Kourrich S, Su TP, Fujimoto M, Bonci A (2012) The sigma-1 receptor: roles in neuronal plasticity and disease. Trends Neurosci 35:762–771. https://doi.org/10.1016/j.tins.2012.09.007
Article CAS PubMed PubMed Central Google Scholar
Lenze EJ, Mattar C, Zorumski CF et al (2020) Fluvoxamine vs placebo and clinical deterioration in outpatients with symptomatic COVID-19: a randomized clinical trial. JAMA 324:2292–2300. https://doi.org/10.1001/jama.2020.22760
Article CAS PubMed PubMed Central Google Scholar
López A, Lorente JA, Steingrub J et al (2004) Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 32:21–30. https://doi.org/10.1097/01.CCM.0000105581.01815.C6
Article CAS PubMed Google Scholar
Mostel Z, Perl A, Marck M et al (2019) Post-sepsis syndrome- a n evolving entity that afflicts survivors of sepsis. Mol Med 26:6. https://doi.org/10.1186/s10020-019-0132-z
Article CAS PubMed PubMed Central Google Scholar
Mota CMD, Borges GS, Amorim MR et al (2019) Central serotonin prevents hypotension and hypothermia and reduces plasma and spleen cytokine levels during systemic inflammation. Brain Behav Immun 80:255–265. https://doi.org/10.1016/j.bbi.2019.03.017
Article CAS PubMed Google Scholar
Narita N, Hashimoto K, Tomitaka SI, Minabe Y (1996) Interactions of selective serotonin reuptake inhibitors with subtypes of σ receptors in rat brain. Eur J Pharmacol 307:117–119. https://doi.org/10.1016/0014-2999(96)00254-3
Article CAS PubMed Google Scholar
Nykamp MJ, Zorumski CF, Reiersen AM et al (2022) Opportunities for drug repurposing of serotonin reuptake inhibitors: potential uses in inflammation, infection, cancer, neuroprotection, and Alzheimer’s disease prevention. Pharmacopsychiatry 55:24–29. https://doi.org/10.1055/a-1686-9620
Article CAS PubMed Google Scholar
Opal SM, Fisher CJ, Dhainaut JFA et al (1997) Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: A phase III, randomized, double-blind, placebo-controlled, multicenter trial. Crit Care Med 25:1115–1124. https://doi.org/10.1097/00003246-199707000-00010
Article CAS PubMed Google Scholar
Passaglia P, Kanashiro A, Batista Silva H et al (2024) Diminazene aceturate attenuates systemic inflammation via microbiota gut-5-HT brain-spleen sympathetic axis in male mice. Brain Behav Immun 119:105–119. https://doi.org/10.1016/j.bbi.2024.03.037
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