Al Mamun A, Shao C, Geng P, Wang S, Xiao J (2024) The mechanism of pyroptosis and its application prospect in diabetic wound healing. J Inflamm Res 17:1481–1501

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balasubramanian A, Hsu AY, Ghimire L, Tahir M, Devant P, Fontana P, Du G, Liu X, Fabin D, Kambara H, Xie X, Liu F, Hasegawa T, Xu R, Yu H, Chen M, Kolakowski S, Trauger S, Larsen MR, Wei W, Wu H, Kagan JC, Lieberman J, Luo HR (2024) The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis. Sci Immunol 9(94):eadn1452

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balkwill F (1997) Cytokine amplification and inhibition of immune and inflammatory responses. J Viral Hepat 4:6–15

Article  PubMed  Google Scholar 

Bandharam N, Lockey RF, Kolliputi N (2023) Pyroptosis inhibition in disease treatment: opportunities and challenges. Cell Biochem Biophys 81(4):615–619

Article  CAS  PubMed  Google Scholar 

Barré-Sinoussi F, Montagutelli X (2015) Animal models are essential to biological research: issues and perspectives. Future Sci OA 1(4):Fso63

Article  PubMed  PubMed Central  Google Scholar 

Bhat TA, Panzica L, Kalathil SG, Thanavala Y (2015) Immune dysfunction in patients with chronic obstructive pulmonary disease. Ann Am Thorac Soc 12(Suppl 2):S169-175

Article  PubMed  PubMed Central  Google Scholar 

Bhat AA, Afzal M, Goyal A, Gupta G, Thapa R, Kazmi I, Alzarea SI, Shahwan M, Paudel KR, Ali H (2024) The impact of formaldehyde exposure on lung inflammatory disorders: insights into asthma, bronchitis, and pulmonary fibrosis. Chem-Biol Interact. https://doi.org/10.1016/j.cbi.2024.111002

Article  PubMed  Google Scholar 

Bhattarai K, Bhattarai K, Kabir ME, Bastola R, Baral B (2021) Fungal natural products galaxy: biochemistry and molecular genetics toward blockbuster drugs discovery. Adv Genet 107:193–284

Article  CAS  PubMed  Google Scholar 

Boucher D, Monteleone M, Coll RC, Chen KW, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS, Schroder K (2018) Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. J Exp Med 215(3):827–840

Article  CAS  PubMed  PubMed Central  Google Scholar 

Broz P (2025) Pyroptosis: molecular mechanisms and roles in disease. Cell Res 35(5):334–344

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buldukoglu OC, Ocal S, Akca S, Atar GE, Kaya B, Isik MD, Koca O, Harmandar FA, Cekin Y, Cekin AH (2025) A novel inflammatory biomarker in assessing disease activity in ulcerative colitis: gasdermin D. BMC Gastroenterol 25(1):418

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burgoyne RA, Fisher AJ, Borthwick LA (2021) The role of epithelial damage in the pulmonary immune response. Cells 10(10):2763

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cañeque T, Baron L, Müller S, Carmona A, Colombeau L, Versini A, Solier S, Gaillet C, Sindikubwabo F, Sampaio J, Sabatier M, Mishima E, Picard-Bernes A, Syx L, Servant N, Lombard B, Loew D, Zheng J, Proneth B, Rodriguez R (2025) Activation of lysosomal iron triggers ferroptosis in cancer. Nature 642:492–500

Article  PubMed  PubMed Central  Google Scholar 

Chang MX (2023) Emerging mechanisms and functions of inflammasome complexes in teleost fish. Front Immunol 14:1065181

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen KW, Monteleone M, Boucher D, Sollberger G, Ramnath D, Condon ND, von Pein JB, Broz P, Sweet MJ, Schroder K (2018) Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps. Sci Immunol 3(26):eaar6676

Article  PubMed  Google Scholar 

Chen P, Wang Y, Tang H, Liu Z, Wang J, Wang T, Xu Y, Ji SL (2024) Gastrodenol suppresses NLRP3/GSDMD mediated pyroptosis and ameliorates inflammatory diseases. Cell Immunol 405–406:104888

Article  PubMed  Google Scholar 

Chen R, Tang X, Wang Y, Wang B, Mao F (2025) Protein palmitoylation: an emerging regulator of inflammatory signaling and diseases. Front Immunol 16:1652741

Article  PubMed  PubMed Central  Google Scholar 

Cheng CK, Yi M, Wang L, Huang Y (2024) Role of gasdermin D in inflammatory diseases: from mechanism to therapeutics. Front Immunol 15:1456244

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colarusso C, Terlizzi M, Molino A, Pinto A, Sorrentino R (2017) Role of the inflammasome in chronic obstructive pulmonary disease (COPD). Oncotarget 8(47):81813–81824

Article  PubMed  PubMed Central  Google Scholar 

Corry J, Kettenburg G, Upadhyay AA, Wallace M, Marti MM, Wonderlich ER, Bissel SJ, Goss K, Sturgeon TJ, Watkins SC, Reed DS, Bosinger SE, Barratt-Boyes SM (2022) Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primates. PLoS Pathog 18(3):e1010395

Article  CAS  PubMed  PubMed Central  Google Scholar 

D’Agnillo F, Walters KA, Xiao Y, Sheng ZM, Scherler K, Park J, Gygli S, Rosas LA, Sadtler K, Kalish H, Blatti CA 3rd, Zhu R, Gatzke L, Bushell C, Memoli MJ, O’Day SJ, Fischer TD, Hammond TC, Lee RC, Cash JC, Powers ME, O’Keefe GE, Butnor KJ, Rapkiewicz AV, Travis WD, Layne SP, Kash JC, Taubenberger JK (2021) Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19. Sci Transl Med 13(620):eabj7790

Article  PubMed  PubMed Central  Google Scholar 

Dai Z, Liu WC, Chen XY, Wang X, Li JL, Zhang X (2023) Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors. Front Immunol 14:1178662

Article  CAS  PubMed  PubMed Central  Google Scholar 

Daniel C, Leppkes M, Muñoz LE, Schley G, Schett G, Herrmann M (2019) Extracellular DNA traps in inflammation, injury and healing. Nat Rev Nephrol 15(9):559–575

Article  CAS  PubMed  Google Scholar 

Das S, Miller M, Beppu AK, Mueller J, McGeough MD, Vuong C, Karta MR, Rosenthal P, Chouiali F, Doherty TA, Kurten RC, Hamid Q, Hoffman HM, Broide DH (2016) GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation. Proc Natl Acad Sci U S A 113(46):13132–13137

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dawson RE, Jenkins BJ (2024) The role of inflammasome-associated innate immune receptors in cancer. Immune Netw 24(5):e38

Article  PubMed  PubMed Central  Google Scholar 

Devant P, Kagan J (2023a) Molecular mechanisms of gasdermin D pore-forming activity. Nat Immunol 24(7):1064–1075

Article  CAS  PubMed  PubMed Central  Google Scholar 

Devant P, Kagan JC (2023b) Molecular mechanisms of gasdermin D pore-forming activity. Nat Immunol 24(7):1064–1075

Article  CAS  PubMed  PubMed Central  Google Scholar 

Devant P, Boršić E, Ngwa EM, Xiao H, Chouchani ET, Thiagarajah JR, Hafner-Bratkovič I, Evavold CL, Kagan JC (2023) Gasdermin D pore-forming activity is redox-sensitive. Cell Rep 42(1):112008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding P, Yang R, Li C, Fu HL, Ren GL, Wang P, Zheng DY, Chen W, Yang LY, Mao YF, Yuan HB, Li YH (2023) Fibroblast growth factor 21 attenuates ventilator-induced lung injury by inhibiting the NLRP3/caspa