Ahmed S, Kwatra M, Panda SR, Murty USN, Naidu VGM (2021) Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease. Brain Behav Immun 91:142–158. https://doi.org/10.1016/j.bbi.2020.09.017

Article  PubMed  Google Scholar 

Ahmed S, Naidu V (2020) Andrograholide protect microglial activation via inhibiting mitochondrial ROS generation and NLRP3 inflammasome activation in in-vitro and in-vivo model of Parkinson’s disease. Mov Disord. https://doi.org/10.1002/mds.28268

Article  Google Scholar 

Ahmed S, Panda SR, Kwatra M, Sahu BD, Naidu V (2022) Perillyl alcohol attenuates NLRP3 inflammasome activation and rescues dopaminergic neurons in experimental in vitro and in vivo models of Parkinson’s disease. ACS Chem Neurosci 13(1):53–68. https://doi.org/10.1021/acschemneuro.1c00550

Article  CAS  PubMed  Google Scholar 

Arioz BI, Tastan B, Tarakcioglu E, Tufekci KU, Olcum M, Ersoy N, Bagriyanik A, Genc K, Genc S (2019) Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1/Nrf2 pathway. Front Immunol. https://doi.org/10.3389/fimmu.2019.01511

Article  PubMed  PubMed Central  Google Scholar 

Ascherio A, Schwarzschild MA (2016) The epidemiology of Parkinson’s disease: Risk factors and prevention. Lancet Neurol 15(12):1257–1272. https://doi.org/10.1016/S1474-4422(16)30230-7

Article  PubMed  Google Scholar 

Ashraf SA, Elkhalifa AEO, Siddiqui AJ, Patel M, Awadelkareem AM, Snoussi M, Ashraf MS, Adnan M, Hadi S (2020) Cordycepin for health and wellbeing: a potent bioactive metabolite of an entomopathogenic cordyceps medicinal fungus and its nutraceutical and therapeutic potential. Molecules (Basel, Switzerland) 25(12):2735. https://doi.org/10.3390/molecules25122735

Article  CAS  PubMed  Google Scholar 

Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E (2009) Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression Abstract. J Immun 183(2):787–791. https://doi.org/10.4049/jimmunol.0901363

Article  PubMed  Google Scholar 

Bell-Temin H, Culver-Cochran AE, Chaput D, Carlson CM, Kuehl M, Burkhardt BR, Bickford PC, Liu B, Stevens SM (2015) Novel molecular insights into classical and alternative activation states of microglia as revealed by stable isotope labeling by amino acids in cell culture (SILAC)-based proteomics. Mol Cellul Proteomics: MCP 14(12):3173–3184. https://doi.org/10.1074/mcp.M115.053926

Article  CAS  Google Scholar 

Braak H, Del Tredici K, Rüb U, de Vos RAI, Jansen Steur ENH, Braak E (2003) Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging 24(2):197–211. https://doi.org/10.1016/s0197-4580(02)00065-9

Article  PubMed  Google Scholar 

Cheng X, Xu S, Zhang C, Qin K, Yan J, Shao X (2020) The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson’s disease models. Biochem Biophys Res Commun 522(3):647–654. https://doi.org/10.1016/j.bbrc.2019.11.141

Article  CAS  PubMed  Google Scholar 

Dobbs RJ, Charlett A, Purkiss AG, Dobbs SM, Weller C, Peterson DW (1999) Association of circulating TNF-alpha and IL-6 with ageing and parkinsonism. Acta Neurol Scand 100(1):34–41. https://doi.org/10.1111/j.1600-0404.1999.tb00721.x

Article  CAS  PubMed  Google Scholar 

Fan Z, Liang Z, Yang H, Pan Y, Zheng Y, Wang X (2017) Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia. J Neuroinflam. https://doi.org/10.1186/s12974-017-1036-x

Article  Google Scholar 

Fernandez F, Lu D, Ha P, Costacurta P, Chavez R, Heller HC, Ruby NF (2014) Dysrhythmia in the suprachiasmatic nucleus inhibits memory processing. Science 346(6211):854–857. https://doi.org/10.1126/science.1259652

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao M-R, Wang M, Jia Y-Y, Tian D-D, Liu A, Wang W-J, Yang L, Chen J-Y, Yang Q, Liu R, Wu Y-M (2020) Echinacoside protects dopaminergic neurons by inhibiting NLRP3/Caspase-1/IL-1β signaling pathway in MPTP-induced Parkinson’s disease model. Brain Res Bull 164:55–64. https://doi.org/10.1016/j.brainresbull.2020.08.015

Article  CAS  PubMed  Google Scholar 

Gao S, Xu T, Guo H, Deng Q, Xun C, Liang W, Sheng W (2019) Ameliorative effects of echinacoside against spinal cord injury via inhibiting NLRP3 inflammasome signaling pathway. Life Sci 237:116978. https://doi.org/10.1016/j.lfs.2019.116978

Article  CAS  PubMed  Google Scholar 

Gilligan PJ (2015) Recent progress in drug discovery for Parkinson’s disease. Curr Top Med Chem 15(10):905–907. https://doi.org/10.2174/156802661510150328222828

Article  CAS  PubMed  Google Scholar 

Gordon R, Albornoz EA, Christie DC, Langley MR, Kumar V, Mantovani S, Robertson AAB, Butler MS, Rowe DB, O’Neill LA, Kanthasamy AG, Schroder K, Cooper MA, Woodruff TM (2018) Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Sci Transl Med. https://doi.org/10.1126/scitranslmed.aah4066

Article  PubMed  PubMed Central  Google Scholar 

Han X, Sun S, Sun Y, Song Q, Zhu J, Song N, Chen M, Sun T, Xia M, Ding J, Lu M, Yao H, Hu G (2019) Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: Implications for Parkinson disease. Autophagy 15(11):1860–1881. https://doi.org/10.1080/15548627.2019.1596481

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han X, Xu T, Fang Q, Zhang H, Yue L, Hu G, Sun L (2021) Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy. Redox Biol 44:102010. https://doi.org/10.1016/j.redox.2021.102010

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harms AS, Ferreira SA, Romero-Ramos M (2021) Periphery and brain, innate and adaptive immunity in Parkinson’s disease. Acta Neuropathol 141(4):527–545. https://doi.org/10.1007/s00401-021-02268-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng T-C, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT (2013) NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice. Nature 493(7434):674–678. https://doi.org/10.1038/nature11729

Article  CAS  PubMed  Google Scholar 

Hooijmans CR, Rovers MM, De Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW (2014a) SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol 14(1):43. https://doi.org/10.1186/1471-2288-14-43

Article  PubMed  PubMed Central  Google Scholar 

Hooijmans CR, Rovers MM, de Vries RBM, Leenaars M, Ritskes-Hoitinga M, Langendam MW (2014b) SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol. https://doi.org/10.1186/1471-2288-14-43

Article  PubMed  PubMed Central  Google Scholar 

Huang S, Chen Z, Fan B, Chen Y, Zhou L, Jiang B, Long H, Zhong W, Li X, Li Y (2021) A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson’s disease. J Neuroimmunol 354:577543. https://doi.org/10.1016/j.jneuroim.2021.577543

Article  CAS  PubMed  Google Scholar 

Huang S, Liu H, Lin Y, Liu M, Li Y, Mao H, Zhang Z, Zhang Y, Ye P, Ding L, Zhu Z, Yang X, Chen C, Zhu X, Huang X, Guo W, Xu P, Lu L (2020) Berberine protects against NLRP3 inflammasome via ameliorating autophagic impairment in MPTP-induced Parkinson’s disease model. Front Pharmacol 11:618787. https://doi.org/10.3389/fphar.2020.618787

Article  CAS  PubMed  Google Scholar 

Jiang X, Tang P-C, Chen Q, Zhang X, Fan Y-Y, Yu B-C, Gu X-X, Sun Y, Ge X-Q, Zhang X-L (2019) Cordycepin exerts neuroprotective effects via an anti-apoptotic mechanism based on the mitochondrial pathway in a rotenone-induced parkinsonism rat model. CNS Neurol Disord Drug Targets 18(8):609–620. https://doi.org/10.2174/1871527318666190905152138

Article  CAS  PubMed  Google Scholar 

Jiang Z, Yin X, Wang M, Wang Y, Li F, Gao Y, Han G, Gao Z, Wang Z (2022) β-Hydroxybutyrate alleviates pyroptosis in MPP+/MPTP-induced Parkinson’s disease models via inhibiting STAT3/NLRP3/GSDMD pathway. Int Immunopharmacol 113(Pt B):109451. https://doi.org/10.1016/j.intimp.2022.109451

Article