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Advancing hepatotoxicity assessment: current advances and future directions
Advancing hepatotoxicity assessment: current advances and future directions
During drug development, it is crucial to ensure that a drug exhibits effective activity in its target cells and organs. H...
Effect of red yeast rice on the growth of male SD rats: a 90-day feeding study
Effect of red yeast rice on the growth of male SD rats: a 90-day feeding study
Red yeast rice (RYR) is commonly used as colouring and flavouring agent in foods throughout East Asia. RYR contains monaco...
Artificial intelligence‑based quantitative analysis of hepatic fibrosis in carbon tetrachloride-induced mouse model of metabolic dysfunction-associated steatohepatitis
Artificial intelligence‑based quantitative analysis of hepatic fibrosis in carbon tetrachloride-induced mouse model of metabolic dysfunction-associated steatohepatitis
Liver fibrosis, a major histopathological indicator of chronic liver injury, is also a key feature of metabolic dysfunctio...
Validation of a B cell acute lymphoblastic leukemia xenograft rat model for integrated efficacy, pharmacokinetics and safety of CD19 CAR-T
Validation of a B cell acute lymphoblastic leukemia xenograft rat model for integrated efficacy, pharmacokinetics and safety of CD19 CAR-T
In preclinical studies of B cell acute lymphoblastic leukemia (B-ALL), mouse models have limitations related to their smal...
Molecular modulation of cholinergic and neuromuscular signaling following long-term acetaminophen administration
Molecular modulation of cholinergic and neuromuscular signaling following long-term acetaminophen administration
Acetaminophen is widely used as an analgesic and antipyretic; however, its long-term neurochemical actions remain incomple...
The oncogenic signalosome: SQSTM1/p62 as a master integrator of signaling, metabolism, and autophagy in cancer
The oncogenic signalosome: SQSTM1/p62 as a master integrator of signaling, metabolism, and autophagy in cancer
Sequestosome 1 (SQSTM1/p62), long established as a selective autophagy receptor and ubiquitin-binding scaffold, is now rec...
Development of in vitro skin corrosion test using KeraSkin™
Development of in vitro skin corrosion test using KeraSkin™
Skin corrosion and irritation are critical local toxicological endpoints associated with chemical exposure. OECD has appro...
Skin absorption and metabolism of [C]-labeled C12-benzalkonium chloride (C12-BKC) in ex vivo porcine ear skin using UPLC-β-RAM analysis
Skin absorption and metabolism of [C]-labeled C12-benzalkonium chloride (C12-BKC) in ex vivo porcine ear skin using UPLC-β-RAM analysis
Benzalkonium chloride is a quaternary ammonium disinfectant widely used in pharmaceutical, cosmetic, and household product...
Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs following 4 weeks of daily dermal administration
Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs following 4 weeks of daily dermal administration
ATB1651 gel is an antifungal drug candidate that enhances antifungal activity through substitution of several aryl rings, ...
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from and
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from and
HemoHIM G is a functional food ingredient composed of a triple herbal combination of Angelica sinensis, Ligusticum chuanxi...
Evaluation of acute, repeated dose 28-day and 13-week oral toxicity and genotoxicity of a standardized fraction (HemoHIM) from
Evaluation of acute, repeated dose 28-day and 13-week oral toxicity and genotoxicity of a standardized fraction (HemoHIM) from
HemoHIM is a functional food ingredient comprising a triple herbal combination of extracts from Angelica gigas Nakai, Cnid...
Toxicity assessment using neural organoids: innovative approaches and challenges
Toxicity assessment using neural organoids: innovative approaches and challenges
Assessment of toxicity and efficacy in the nervous system is essential to ensure the safety of compounds and the efficacy ...
Short-term health effects of tear agents chlorobenzylidenemalononitrile and oleoresin capsicum during the civil riots of Santiago de Chile in 2019–2020
Short-term health effects of tear agents chlorobenzylidenemalononitrile and oleoresin capsicum during the civil riots of Santiago de Chile in 2019–2020
Chlorobenzylidenemalononitrile (CS) and Oleoresin Capsicum (OC) were tear gasses used as anti-riot control agents during s...
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora
HemoHIM G is a functional food ingredient composed of a triple herbal combination of Angelica sinensis, Ligusticum chuanxi...
Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure
Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure
Chronic renal failure (CRF) resulting in vascular calcification, which does damage to blood vessels and endothelium, is an...
Pulmonary toxicity assessment of polypropylene, polystyrene, and polyethylene microplastic fragments in mice
Pulmonary toxicity assessment of polypropylene, polystyrene, and polyethylene microplastic fragments in mice
Polypropylene (PP), polystyrene (PS), and polyethylene (PE) plastics are commonly used in household items such as electron...
Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs (Sus scrofa) following 4 weeks of daily dermal administration
Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs (Sus scrofa) following 4 weeks of daily dermal administration
ATB1651 gel is an antifungal drug candidate that enhances antifungal activity through substitution of several aryl rings, ...
Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption
Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption
Several patients with cutaneous adverse drug reactions exhibit extracutaneous organ damages, and it becomes severe in a fe...
The impact of manganese on vascular endothelium
The impact of manganese on vascular endothelium
Manganese (Mn) is an essential trace element involved in various physiological processes, but excessive exposure may lead ...
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs
Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs
MicroRNAs (miRNAs), molecules comprising 18–22 nucleotides, regulate expression of genes post-transcriptionally at t...
Evaluation of acute, repeated dose 28-day and 13-week oral toxicity and genotoxicity of a standardized fraction (HemoHIM) from Angelica gigas, Cnidium officinale, and Paeonia lactiflora
Evaluation of acute, repeated dose 28-day and 13-week oral toxicity and genotoxicity of a standardized fraction (HemoHIM) from Angelica gigas, Cnidium officinale, and Paeonia lactiflora
HemoHIM is a functional food ingredient comprising a triple herbal combination of extracts from Angelica gigas Nakai, Cnid...
Distribution of molybdenum in soft tissues and blood of rats after intratracheal instillation of molybdenum(IV) sulfide nano- and microparticles
Distribution of molybdenum in soft tissues and blood of rats after intratracheal instillation of molybdenum(IV) sulfide nano- and microparticles
There is still little literature data on the toxicity and safety of the commonly used molybdenum (Mo) disulfide which is p...
Molecular mechanism of empagliflozin cardioprotection in 5-fluorouracil (5-FU)-induced cardiotoxicity via modulation of SGLT2 and TNFα/TLR/NF-κB signaling pathway in rats
Molecular mechanism of empagliflozin cardioprotection in 5-fluorouracil (5-FU)-induced cardiotoxicity via modulation of SGLT2 and TNFα/TLR/NF-κB signaling pathway in rats
One of the commoly used chemotherapeutic agents is 5-Fluorouracil (5-FU). Unfortunately, the clinical administration of 5-...
Assessment of reproductive toxicity of gold nanoparticles and its reversibility in male albino rats
Assessment of reproductive toxicity of gold nanoparticles and its reversibility in male albino rats
Nanotechnology has become a trending area in science all over the world. Although gold nanoparticles (AuNPs) have been uti...
Potential role of inducible nitric oxide synthase (iNOS) activity in testicular dysfunction following co-administration of alcohol and combination antiretroviral therapy (cART) in diabetic rats: an immunohistochemistry study
Potential role of inducible nitric oxide synthase (iNOS) activity in testicular dysfunction following co-administration of alcohol and combination antiretroviral therapy (cART) in diabetic rats: an immunohistochemistry study
Diabetes, alcohol abuse, and combination antiretroviral therapy (cART) use have been reported to cause multi-organ complic...
Re-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora
Re-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora
As veterinary drugs available for fish is very restricted, there is growing trials for repurposing livestock drugs as aqua...
Acute toxicity assessment of nine organic UV filters using a set of biotests
Acute toxicity assessment of nine organic UV filters using a set of biotests
UV filters in environmental compartments are a source of concern related to their ecotoxicological effects. However, littl...
Impacts of PAH accumulation on reproductive hormones, indices of oxidative stress and BPDE-albumin adduct in women with recurrent pregnancy loss
Impacts of PAH accumulation on reproductive hormones, indices of oxidative stress and BPDE-albumin adduct in women with recurrent pregnancy loss
Chronic exposure to Poly aromatic hydrocarbons (PAHs) may be associated with adverse pregnancy outcomes. Disruption of hor...
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model
Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model
The Organization for Economic Co-operation and Development approved a reconstructed human epidermis (RHE) model for in vit...
A comparative study on the implementation of deep learning algorithms for detection of hepatic necrosis in toxicity studies
A comparative study on the implementation of deep learning algorithms for detection of hepatic necrosis in toxicity studies
Deep learning has recently become one of the most popular methods of image analysis. In non-clinical studies, several tiss...
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