ITGA1, the alpha 1 subunit of integrin receptor, is a novel marker of drug-resistant senescent melanoma cells in vitro

Abdelmohsen K, Mazan-Mamczarz K, Munk R et al (2024) Identification of senescent cell subpopulations by CITE -seq analysis. Aging Cell. https://doi.org/10.1111/acel.14297

Article  PubMed  PubMed Central  Google Scholar 

Althubiti M, Lezina L, Carrera S et al (2014) Characterization of novel markers of senescence and their prognostic potential in cancer. Cell Death Dis. https://doi.org/10.1038/cddis.2014.489

Article  PubMed  PubMed Central  Google Scholar 

Amor C, Feucht J, Leibold J et al (2020) Senolytic CAR T cells reverse senescence-associated pathologies. Nature 583:127–132. https://doi.org/10.1038/s41586-020-2403-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ascierto PA, Schadendorf D, Berking C et al (2013) MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. Lancet Oncol 14:249–256. https://doi.org/10.1016/S1470-2045(13)70024-X

Article  CAS  PubMed  Google Scholar 

Bloniarz D, Adamczyk-Grochala J, Lewinska A, Wnuk M (2021) The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence. Aging. https://doi.org/10.18632/aging.203203

Article  PubMed  PubMed Central  Google Scholar 

Bu D, Luo H, Huo P et al (2021) KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis. Nucleic Acids Res 49:W317–W325. https://doi.org/10.1093/nar/gkab447

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chapman PB, Hauschild A, Robert C et al (2011) Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation. N Engl J Med 364:2507–2516. https://doi.org/10.1056/NEJMoa1103782

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conway JR, Lex A, Gehlenborg N (2017) UpSetR: an R package for the visualization of intersecting sets and their properties. Bioinformatics 33:2938–2940. https://doi.org/10.1093/bioinformatics/btx364

Article  CAS  PubMed  PubMed Central  Google Scholar 

Das Thakur M, Salangsang F, Landman AS et al (2013) Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance. Nature 494:251–255. https://doi.org/10.1038/nature11814

Article  CAS  PubMed  Google Scholar 

Deinhardt-Emmer S, Deshpande S, Kitazawa K et al (2023) Role of the senescence-associated factor dipeptidyl peptidase 4 in the pathogenesis of SARS-CoV-2 infection. Aging Dis. https://doi.org/10.14336/AD.2023.0812

Article  PubMed  PubMed Central  Google Scholar 

Deng Y, Liu T, Scifo E et al (2024) Analysis of the senescence-associated cell surfaceome reveals potential senotherapeutic targets. Aging Cell. https://doi.org/10.1111/acel.14312

Article  PubMed  PubMed Central  Google Scholar 

Di Micco R, Krizhanovsky V, Baker D, d’Adda di Fagagna F (2021) Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat Rev Mol Cell Biol 22:75–95. https://doi.org/10.1038/s41580-020-00314-w

Article  CAS  PubMed  Google Scholar 

Ekpenyong-Akiba AE, Poblocka M, Macip S (2020) Targeted senolytic strategies based on the senescent surfaceome. In: Muñoz-Espin D, Demaria M (eds) Senolytics in Disease, Ageing and Longevity. Springer International Publishing, Cham, pp 103–130

Chapter  Google Scholar 

Franovic A, Elliott KC, Seguin L et al (2015) Glioblastomas require integrin αvβ3/pak4 signaling to escape senescence. Cancer Res 75:4466–4473. https://doi.org/10.1158/0008-5472.CAN-15-0988

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Q, Li N, Pan Y et al (2024) Hepatocyte growth factor promotes melanoma metastasis through ubiquitin-specific peptidase 22-mediated integrins upregulation. Cancer Lett 604:217196. https://doi.org/10.1016/j.canlet.2024.217196

Article  CAS  PubMed  Google Scholar 

Guillon J, Petit C, Toutain B et al (2019) Chemotherapy-induced senescence, an adaptive mechanism driving resistance and tumor heterogeneity. Cell Cycle 18:2385–2397. https://doi.org/10.1080/15384101.2019.1652047

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haferkamp S, Borst A, Adam C et al (2013) Vemurafenib induces senescence features in melanoma cells. J Invest Dermatol 133:1601–1609. https://doi.org/10.1038/jid.2013.6

Article  CAS  PubMed  Google Scholar 

Herman AB, Tsitsipatis D, Anerillas C et al (2023) DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice. J Clin Invest. https://doi.org/10.1172/JCI165933

Article  PubMed  PubMed Central  Google Scholar 

Hernandez-Segura A, Nehme J, Demaria M (2018) Hallmarks of cellular senescence. Trends Cell Biol 28:436–453. https://doi.org/10.1016/j.tcb.2018.02.001

Article  CAS  PubMed  Google Scholar 

Jost T, Heinzerling L, Fietkau R et al (2021) Palbociclib induces senescence in melanoma and breast cancer cells and leads to additive growth arrest in combination with irradiation. Front Oncol. https://doi.org/10.3389/fonc.2021.740002

Article  PubMed  PubMed Central  Google Scholar 

Jung SH, Lee M, Park HA et al (2019) Integrin α6β4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues. Cell Death Differ 26:245–259. https://doi.org/10.1038/s41418-018-0114-7

Article  CAS  PubMed  Google Scholar 

Kim KM, Noh JH, Bodogai M et al (2017) Identification of senescent cell surface targetable protein DPP4. Genes Dev 31:1529–1534. https://doi.org/10.1101/gad.302570.117

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim KM, Noh JH, Gorospe M (2020) Senolysis and Senostasis Through the Plasma Membrane. In: Muñoz-Espin D, Demaria M (eds) Senolytics in disease, ageing and longevity. Springer International Publishing, Cham, pp 131–143

Chapter  Google Scholar 

Kozlova NI, Morozevich GE, Berman AE (2021) Implication of integrin α2β1 in senescence of SK-Mel-147 human melanoma cells. Aging. https://doi.org/10.18632/aging.203309

Article  PubMed  PubMed Central  Google Scholar 

Kuphal S, Bauer R, Bosserhoff A-K (2005) Integrin signaling in malignant melanoma. Cancer Metastasis Rev 24:195–222. https://doi.org/10.1007/s10555-005-1572-1

Article  CAS  PubMed  Google Scholar 

Lacaria L, Lange JR, Goldmann WH et al (2020) αvβ3 integrin expression increases elasticity in human melanoma cells. Biochem Biophys Res Commun 525:836–840. https://doi.org/10.1016/j.bbrc.2020.02.156

Article  CAS  PubMed  Google Scholar 

Lenci RE, Rachakonda PS, Kubarenko AV et al (2012) Integrin genes and susceptibility to human melanoma. Mutagenesis 27:367–373. https://doi.org/10.1093/mutage/ger090

Article  CAS  PubMed  Google Scholar 

Lewinska A, Adamczyk-Grochala J, Bloniarz D et al (2020) AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts. Redox Biol. https://doi.org/10.1016/j.redox.2019.101337

Article  PubMed  Google Scholar 

Liu X, Yin D, Zhang Y et al (2007) Vascular endothelial cell senescence mediated by integrin β4 in vitro. FEBS Lett 581:5337–5342. https://doi.org/10.1016/j.febslet.2007.10.027

Article 

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