YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through mA-dependent binding

Bao MH, Szeto V, Yang BB, Zhu SZ, Sun HS, Feng ZP. Long non-coding RNAs in ischemic stroke. Cell Death Dis. 2018;9:281. https://doi.org/10.1038/s41419-018-0282-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Broix L, Roy R, Shohayeb B, Oomoto I, Umeshima H, Wang DO. m (6)A RNA methylation-mediated control of global APC expression is required for local translation of beta-actin and axon development. Cell Rep. 2025;44:115727. https://doi.org/10.1016/j.celrep.2025.115727

Bu ZQ, Yu HY, Wang J, He X, Cui YR, Feng JC, Feng J. Emerging Role of Ferroptosis in the Pathogenesis of Ischemic Stroke: A New Therapeutic Target? ASN Neuro. 2021;13:17590914211037504. https://doi.org/10.1177/17590914211037505.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Long T, Chen J, Wei H, Meng J, Kang M, Wang J, Zhang X, Xu Q, Zhang C, Xiong K. WTAP participates in neuronal damage by protein translation of NLRP3 in an m6A-YTHDF1-dependent manner after traumatic brain injury. Int J Surg. 2024. https://doi.org/10.1097/JS9.0000000000001794.

Article  PubMed  PubMed Central  Google Scholar 

Chokkalla AK, Mehta SL, Kim T, Chelluboina B, Kim J, Vemuganti R. Transient Focal Ischemia Significantly Alters the m (6)A Epitranscriptomic Tagging of RNAs in the Brain. Stroke. 2019;50:2912–21. https://doi.org/10.1161/STROKEAHA.119.026433.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chokkalla AK, Arruri V, Mehta SL, Vemuganti R. Loss of Epitranscriptomic Modification N (6)-Methyladenosine (m (6)A) Reader YTHDF1 Exacerbates Ischemic Brain Injury in a Sexually Dimorphic Manner. Transl Stroke Res. 2024. https://doi.org/10.1007/s12975-024-01267-4.

Article  PubMed  Google Scholar 

Collaborators GBDS. Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2021;20:795–820. https://doi.org/10.1016/S1474-4422(21)00252-0.

Article  Google Scholar 

Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, Sorek R, Rechavi G. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012;485:201–6. https://doi.org/10.1038/nature11112.

Article  CAS  PubMed  Google Scholar 

Gao J, Liu J, Li Y, Liu J, Wang H, Chai M, Dong Y, Zhang Z, Su G, Wang M. Targeting p53 for neuroinflammation: New therapeutic strategies in ischemic stroke. J Neurosci Res. 2023;101:1393–408. https://doi.org/10.1002/jnr.25200.

Article  CAS  PubMed  Google Scholar 

Group ISTc, Sandercock P, Wardlaw JM, Lindley RI, Dennis M, Cohen G, Murray G, Innes K, Venables G, Czlonkowska A, Kobayashi A, Ricci S, Murray V, Berge E, Slot KB, Hankey GJ, Correia M, Peeters A, Matz K, Lyrer P, Gubitz G, Phillips SJ, Arauz A. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial. Lancet. 2012;379:2352–63. https://doi.org/10.1016/S0140-6736(12)60768-5.

Article  CAS  Google Scholar 

Guan X, Li X, Yang X, Yan J, Shi P, Ba L, Cao Y, Wang P. The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation. Life Sci. 2019;235:116795. https://doi.org/10.1016/j.lfs.2019.116795.

Article  CAS  PubMed  Google Scholar 

Guo J, Tuo QZ, Lei P. Iron, ferroptosis, and ischemic stroke. J Neurochem. 2023;165:487–520. https://doi.org/10.1111/jnc.15807.

Article  CAS  PubMed  Google Scholar 

Guo W, Xu X, Xiao Y, Zhang J, Shen P, Lu X, Fan X. Salvianolic acid C attenuates cerebral ischemic injury through inhibiting neuroinflammation via the TLR4-TREM1-NF-kappaB pathway. Chin Med. 2024;19:46. https://doi.org/10.1186/s13020-024-00914-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han F. N (6)-methyladenosine modification in ischemic stroke: Functions, regulation, and therapeutic potential. Heliyon. 2024;10:e25192. https://doi.org/10.1016/j.heliyon.2024.e25192.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hou W, Xie Y, Song X, Sun X, Lotze MT, Zeh HJ 3rd, Kang R, Tang D. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy. 2016;12:1425–8. https://doi.org/10.1080/15548627.2016.1187366.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hou L, Li S, Li S, Wang R, Zhao M, Liu X. FTO inhibits oxidative stress by mediating m6A demethylation of Nrf2 to alleviate cerebral ischemia/reperfusion injury. J Physiol Biochem. 2023;79:133–46. https://doi.org/10.1007/s13105-022-00929-x.

Article  CAS  PubMed  Google Scholar 

Huang J, Jiang B, Li GW, Zheng D, Li M, Xie X, Pan Y, Wei M, Liu X, Jiang X, Zhang X, Yang L, Bao L, Wang B. m (6)A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation. Cell Rep. 2022;41:111693. https://doi.org/10.1016/j.celrep.2022.111693.

Article  CAS  PubMed  Google Scholar 

Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, Baer R, Gu W. Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015;520:57–62. https://doi.org/10.1038/nature14344.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuribayashi K, El-Deiry WS. Regulation of programmed cell death by the p53 pathway. Adv Exp Med Biol. 2008;615:201–21. https://doi.org/10.1007/978-1-4020-6554-5_10.

Article  CAS  PubMed  Google Scholar 

Lai K, Pritisanac I, Liu ZQ, Liu HW, Gong LN, Li MX, Lu JF, Qi X, Xu TL, Forman-Kay J, Shi HB, Wang LY, Yin SK. Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury. Nature. 2024;631:826–34. https://doi.org/10.1038/s41586-024-07684-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, An P, Han F, Yu M, Yu Z, Li Y. Silencing of YTHDF1 attenuates cerebral stroke by inducing PTEN degradation and activating the PTEN/AKT/mTOR pathway. Mol Biotechnol. 2022. https://doi.org/10.1007/s12033-022-00575-0.

Article  PubMed  PubMed Central  Google Scholar 

Lin L, Wang X, Yu Z. Ischemia-reperfusion injury in the brain: mechanisms and potential therapeutic strategies. Biochem Pharmacol (Los Angel). 2016;5. https://doi.org/10.4172/2167-0501.1000213

Liu L, Li H, Hu D, Wang Y, Shao W, Zhong J, Yang S, Liu J, Zhang J. Insights into N6-methyladenosine and programmed cell death in cancer. Mol Cancer. 2022;21:32. https://doi.org/10.1186/s12943-022-01508-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu C, Chen H, Tao X, Li C, Li A, Wu W. ALKBH5 protects against stroke by reducing endoplasmic reticulum stress-dependent inflammation injury via the STAT5/PERK/EIF2alpha/CHOP signaling pathway in an m (6)A-YTHDF1-dependent manner. Exp Neurol. 2024;372:114629. https://doi.org/10.1016/j.expneurol.2023.114629.

Article  CAS  PubMed  Google Scholar 

Livneh I, Moshitch-Moshkovitz S, Amariglio N, Rechavi G, Dominissini D. The m (6)A epitranscriptome: transcriptome plasticity in brain development and function. Nat Rev Neurosci. 2020;21:36–51. https://doi.org/10.1038/s41583-019-0244-z.

Article  CAS  PubMed  Google Scholar 

Lu X, Li D, Lin Z, Gao T, Gong Z, Zhang Y, Wang H, Xia X, Lu F, Song J, Xu G, Jiang J, Ma X, Zou F. HIF-1alpha-induced expression of the m6A reader YTHDF1 inhibits the ferroptosis of nucleus pulposus cells by promoting SLC7A11 translation. Aging Cell. 2024;e14210. https://doi.org/10.1111/acel.14210

Lyden PD, Diniz MA, Bosetti F, Lamb J, Nagarkatti KA, Rogatko A, Kim S, Cabeen RP, Koenig JI, Akhter K, Arbab AS, Avery BD, Beatty HE, Bibic A, Cao S, Simoes Braga Boisserand L, Chamorro A, Chauhan A, Diaz-Perez S, Dhandapani K, Dhanesha N, Goh A, Herman AL, Hyder F, Imai T, Johnson CW, Khan MB, Kamat P, Karuppagounder SS, Kumskova M, Mihailovic JM, Mandeville JB, Morais A, Patel RB, Sanganahalli BG, Smith C, Shi Y, Sutariya B, Thedens D, Qin T, Velazquez SE, Aronowski J, Ayata C, Chauhan AK, Leira EC, Hess DC, Koehler RC, McCullough LD, Sansing LH. A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke. Sci Transl Med. 2023;15:eadg8656. https://doi.org/10.1126/scitranslmed.adg8656

Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi SY, Hirano T, Martin KC, Pellegrini M, Wang DO. Synaptic N (6)-methyladenosine (m (6)A) epitranscriptome reveals functional partitioning of localized transcripts. Nat Neurosci. 2018;21:1004–14. https://doi.org/10.1038/s41593-018-0173-6.

Article  CAS  PubMed  Google Scholar 

Mirzaei H, Momeni F, Saadatpour L, Sahebkar A, Goodarzi M, Masoudifar A, Kouhpayeh S, Salehi H, Mirzaei HR, Jaafari MR. MicroRNA: Relevance to stroke diagnosis, prognosis, and therapy. J Cell Physiol. 2018;233:856–65. https://doi.org/10.1002/jcp.25787.

Article  CAS  PubMed 

Comments (0)

No login
gif