Exosomes in esophageal cancer: function and therapeutic prospects

Ho ALK, Smyth EC. A global perspective on oesophageal cancer: two diseases in one. Lancet Gastroenterol Hepatol. 2020;5(6):521–2.

Article  PubMed  Google Scholar 

Morgan E, et al. The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality in 2020 and projections to 2040: new estimates from GLOBOCAN 2020. Gastroenterology. 2022;163(3):649-658.e2.

Article  PubMed  Google Scholar 

Thrift AP. Global burden and epidemiology of Barrett oesophagus and oesophageal cancer. Nat Rev Gastroenterol Hepatol. 2021;18(6):432–43.

Article  PubMed  Google Scholar 

He S, Xu J, Liu X, Zhen Y. Advances and challenges in the treatment of esophageal cancer. Acta Pharm Sin B. 2021;11(11):3379–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang X, Wang Y, Meng L. Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma: New opportunities towards molecularly targeted therapy. Acta Pharm Sin B. 2022;12(3):1054–67.

Article  CAS  PubMed  Google Scholar 

Sheikh M, Roshandel G, McCormack V, Malekzadeh R. Current status and future prospects for esophageal cancer. Cancers (Basel). 2023;15(3):765.

Article  PubMed  Google Scholar 

Yang CS, Chen XL. Research on esophageal cancer: With personal perspectives from studies in China and Kenya. Int J Cancer. 2021;149(2):264–76.

Article  CAS  PubMed  Google Scholar 

Cao F, et al. Proteomics comparison of exosomes from serum and plasma between ultracentrifugation and polymer-based precipitation kit methods. Electrophoresis. 2019;40(23–24):3092–8.

Article  CAS  PubMed  Google Scholar 

Hu X, Zhong Y, Kong Y, Chen Y, Feng J, Zheng J. Lineage-specific exosomes promote the odontogenic differentiation of human dental pulp stem cells (DPSCs) through TGFβ1/smads signaling pathway via transfer of microRNAs. Stem Cell Res Ther. 2019;10(1):170.

Article  PubMed  PubMed Central  Google Scholar 

Derkus B, Emregul KC, Emregul E. A new approach in stem cell research-exosomes: their mechanism of action via cellular pathways. Cell Biol Int. 2017;41(5):466–75.

Article  PubMed  Google Scholar 

Tang Z, Li D, Hou S, Zhu X. The cancer exosomes: clinical implications, applications and challenges. Int J Cancer. 2020;146(11):2946–59.

Article  CAS  PubMed  Google Scholar 

Araujo-Abad S, Berna JM, Lloret-Lopez E, López-Cortés A, Saceda M, de Juan Romero C. Exosomes: from basic research to clinical diagnostic and therapeutic applications in cancer. Cell Oncol (Dordr). 2024. https://doi.org/10.1007/s13402-024-00990-2

Article  PubMed  Google Scholar 

Patel G, et al. Exosomes: a potential diagnostic and treatment modality in the quest for counteracting cancer. Cell Oncol (Dordr). 2023;46(5):1159–79.

Article  CAS  PubMed  Google Scholar 

Han L, Zhao Z, He C, Li J, Li X, Lu M. Removing the stumbling block of exosome applications in clinical and translational medicine: expand production and improve accuracy. Stem Cell Res Ther. 2023;14(1):57.

Article  PubMed  PubMed Central  Google Scholar 

Akers JC, Gonda D, Kim R, Carter BS, Chen CC. Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. J Neurooncol. 2013;113(1):1–11.

Article  PubMed  PubMed Central  Google Scholar 

Wang J, Chen D, Ho EA. Challenges in the development and establishment of exosome-based drug delivery systems. J Control Release. 2021;329:894–906.

Article  CAS  PubMed  Google Scholar 

Jia Z, Jia J, Yao L, Li Z. Crosstalk of exosomal non-Coding RNAs in the tumor microenvironment: novel frontiers. Front Immunol. 2022;13: 900155.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou X, et al. Exosomal ncRNAs facilitate interactive ‘dialogue’ between tumor cells and tumor-associated macrophages. Cancer Lett. 2023;552: 215975.

Article  CAS  PubMed  Google Scholar 

Jangholi A, et al. Exosomes at the crossroad between therapeutic targets and therapy resistance in head and neck squamous cell carcinoma. Biochim Biophys Acta Rev Cancer. 2022;1877(5): 188784.

Article  CAS  PubMed  Google Scholar 

Han C, Yang J, Sun J, Qin G. Extracellular vesicles in cardiovascular disease: biological functions and therapeutic implications. Pharmacol Ther. 2022;233: 108025.

Article  CAS  PubMed  Google Scholar 

Lai JJ, et al. Exosome Processing and Characterization Approaches for Research and Technology Development. Adv Sci (Weinh). 2022;9(15): e2103222.

Article  PubMed  Google Scholar 

Tenchov R, Sasso JM, Wang X, Liaw WS, Chen CA, Zhou QA. Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics. ACS Nano. 2022;16(11):17802–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han QF, et al. Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer. Mol Cancer. 2022;21(1):207.

Article  PubMed  PubMed Central  Google Scholar 

Yu D, et al. Exosomes as a new frontier of cancer liquid biopsy. Mol Cancer. 2022;21(1):56.

Article  PubMed  PubMed Central  Google Scholar 

Sun Y, et al. Radiation induces NORAD expression to promote ESCC radiotherapy resistance via EEPD1/ATR/Chk1 signalling and by inhibiting pri-miR-199a1 processing and the exosomal transfer of miR-199a-5p. J Exp Clin Cancer Res. 2021;40(1):306.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Puhr HC, Prager GW, Ilhan-Mutlu A. How we treat esophageal squamous cell carcinoma. ESMO Open. 2023;8(1): 100789.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hagens ERC, van Berge Henegouwen MI, Gisbertz SS. Distribution of lymph node metastases in esophageal carcinoma patients undergoing upfront surgery: a systematic review. Cancers (Basel). 2020;12(6):1592.

Article  PubMed  Google Scholar 

Zhu Y, et al. Cancer-secreted exosomal MiR-620 inhibits ESCC aerobic glycolysis via FOXM1/HER2 pathway and promotes metastasis. Front Oncol. 2022;12: 756109.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang L, et al. Proteomic profiling of plasma exosomes reveals CD82 involvement in the development of esophageal squamous cell carcinoma. J Proteomics. 2022;265: 104662.

Article  CAS  PubMed  Google Scholar 

Erozenci LA, Böttger F, Bijnsdorp IV, Jimenez CR. Urinary exosomal proteins as (pan-)cancer biomarkers: insights from the proteome. FEBS Lett. 2019;593(13):1580–97.

Article  CAS  PubMed  Google Scholar 

Ogawa Y, Taketomi Y, Murakami M, Tsujimoto M, Yanoshita R. Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing. Biol Pharm Bull. 2013;36(1):66–75.

Article  CAS  PubMed  Google Scholar 

Li K, et al. A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study. Mol Cancer. 2022;21(1):21.

Comments (0)

No login
gif