Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Przeglad Gastroenterol. 2019;14(1):26.
Hamashima C. Current issues and future perspectives of gastric cancer screening. World J Gastroenterol: WJG. 2014;20(38):13767.
PubMed PubMed Central Google Scholar
Lee YK, et al. Benefit of adjuvant traditional herbal medicine with chemotherapy for resectable gastric cancer. Integr Cancer Ther. 2018;17(3):619–27.
PubMed PubMed Central Google Scholar
Liu Q, et al. Medical application of Spirulina platensis derived C-phycocyanin. Evidence-Based Complement Alternat Med. 2016. https://doi.org/10.1155/2016/7803846.
Grover P, et al. C-Phycocyanin-a novel protein from Spirulina platensis- In vivo toxicity, antioxidant and immunomodulatory studies. Saudi J Biol Sci. 2021;28(3):1853–9.
Jiang L, et al. Phycocyanin: a potential drug for cancer treatment. J Cancer. 2017;8(17):3416.
PubMed PubMed Central Google Scholar
Jiang L, et al. C-Phycocyanin exerts anti-cancer effects via the MAPK signaling pathway in MDA-MB-231 cells. Cancer Cell Int. 2018;18(1):1–14.
Li C, et al. Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway. Sci Rep. 2017;7(1):1–12.
Agrawal M, et al. Phycocyanin alleviates ICV-STZ induced cognitive and molecular deficits via PI3-Kinase dependent pathway. Food Chem Toxicol. 2020;145:111684.
Hao S, et al. Phycocyanin reduces proliferation of melanoma cells through downregulating GRB2/ERK signaling. J Agric Food Chem. 2018;66(41):10921–9.
Liu Q, et al. Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway. J Oceanol Limnol. 2019;37(5):1678–85.
Carballo GB, Honorato JR, de Lopes GPF. A highlight on Sonic hedgehog pathway. Cell Commun Signal. 2018;16(1):1–15.
Mastrangelo E, Milani M. Role and inhibition of GLI1 protein in cancer. Lung Cancer (Auckl). 2018;9:35–43.
Skoda AM, et al. The role of the Hedgehog signaling pathway in cancer: A comprehensive review. Bosn J Basic Med Sci. 2018;18(1):8.
CAS PubMed PubMed Central Google Scholar
Xu M, et al. Sonic hedgehog-glioma associated oncogene homolog 1 signaling enhances drug resistance in CD44+/Musashi-1+ gastric cancer stem cells. Cancer Lett. 2015;369(1):124–33.
Hu Q, et al. Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells. J Exp Clin Cancer Res. 2017;36(1):1–11.
Bigelow RL, et al. Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J Biol Chem. 2004;279(2):1197–205.
Braune S, et al. Phycocyanin from arthrospira platensis as potential anti-cancer drug: Review of in vitro and in vivo studies. Life. 2021;11(2):91.
CAS PubMed PubMed Central Google Scholar
Fattahi S, et al. Application of unique sequence index (USI) barcode to gene expression profiling in gastric adenocarcinoma. J Cell Commun Signal. 2017;11(1):97–104.
PubMed PubMed Central Google Scholar
Fattahi S, et al. Development of a Universal Taqman Probe for mRNA Gene Expression Analysis. Iran J Sci Technol Trans A: Sci. 2018;42(2):363–70.
Vijayakumar S, Menakha M. Pharmaceutical applications of cyanobacteria—A review. JACME. 2015;5(1):15–23.
Razzak KSB, et al. Mechanism of herbal medicine for treatment of cancer. Biotica Res Today. 2020;2(11):1111–2.
Liu Y, et al. Inhibitory effect of phycocyanin from Spirulina platensis on the growth of human leukemia K562 cells. J Appl Phycol. 2000;12(2):125–30.
Kunte M, Desai K. The inhibitory effect of C-phycocyanin containing protein extract (C-PC Extract) on human matrix metalloproteinases (MMP-2 and MMP-9) in hepatocellular cancer cell line (HepG2). Protein J. 2017;36(3):186–95.
Ying J, et al. Transcriptome analysis of phycocyanin inhibitory effects on SKOV-3 cell proliferation. Gene. 2016;585(1):58–64.
Hao S, et al. The in vitro antitumor activity of phycocyanin against non-small cell lung cancer cells. Mar Drugs. 2018;16(6):178.
PubMed PubMed Central Google Scholar
Gantar M, Dhandayuthapani S, Rathinavelu A. Phycocyanin induces apoptosis and enhances the effect of topotecan on prostate cell line LNCaP. J Med Food. 2012;15(12):1091–5.
Ying J, et al. Effects of phycocyanin on apoptosis of human laryngeal cancer HEP-2 cells. Chinese J Pathophysiol. 2015;7:1189–96.
Thayer SP, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 2003;425(6960):851–6.
CAS PubMed PubMed Central Google Scholar
Han M-E, et al. Hedgehog signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2. Int J Mol Sci. 2009;10(7):3033–43.
CAS PubMed PubMed Central Google Scholar
Ma Z, et al. Silibinin induces apoptosis by inhibiting the mTOR-GLI1-BCL2 pathway in renal cell carcinoma. Oncol Rep. 2015;34(5):2461–8.
Ma X, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. 2005;26(10):1698–705.
Hegde GV, et al. Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target. Mol Cancer Res. 2008;6(12):1928–36.
Li B, et al. Study of the synergistic effects of all-transretinoic acid and C-phycocyanin on the growth and apoptosis of A549 cells. Eur J Cancer Prev. 2016;25(2):97–101.
Kaur P, et al. Molecular mechanism of C-phycocyanin induced apoptosis in LNCaP cells. Bioorg Med Chem. 2020;28(3):115272.
Pardhasaradhi BV, et al. Phycocyanin-mediated apoptosis in AK-5 tumor cells involves down-regulation of Bcl-2 and generation of ROS. Mol Cancer Ther. 2003;2(11):1165–70.
Subhashini J, et al. Molecular mechanisms in C-Phycocyanin induced apoptosis in human chronic myeloid leukemia cell line-K562. Biochem Pharmacol. 2004;68(3):453–62.
Gupta M, Dwivedi UN, Khandelwal S. C-Phycocyanin: an effective protective agent against thymic atrophy by tributyltin. Toxicol Lett. 2011;204(1):2–11.
Hashem MA, et al. The antitumor activity of Arthrospira platensis and/or cisplatin in a murine model of Ehrlich ascites carcinoma with hematinic and hepato-renal protective action. J Funct Foods. 2020;66:103831.
Khan M, et al. Protective effect of Spirulina against doxorubicin-induced cardiotoxicity. Phytother Res: An Int J Devoted Pharmacol Toxicol Eval Natural Product Deriv. 2005;19(12):1030–7.
Li X-L, et al. Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways. Int J Biochem Cell Biol. 2009;41(7):1526–35.
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