Karpińska M, Czauderna M. Pancreas—its functions, disorders, and physiological impact on the mammals’ organism. Front Physiol. 2022;13:807632.
Article PubMed PubMed Central Google Scholar
Vanek P, Urban O, Zoundjiekpon V, Falt P. Current screening strategies for pancreatic cancer. Biomedicines. 2022;10:2056.
Article CAS PubMed PubMed Central Google Scholar
Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63.
Ushio J, Kanno A, Ikeda E, Ando K, Nagai H, Miwata T, et al. Pancreatic ductal adenocarcinoma: epidemiology and risk factors. Diagnostics. 2021;11:562.
Article CAS PubMed PubMed Central Google Scholar
Singh G, Kutcher D, Lally R, Rai V. Targeting neoantigens in pancreatic ductal adenocarcinoma. Cancers. 2024;16:2101.
Article CAS PubMed PubMed Central Google Scholar
Foley K, Kim V, Jaffee E, Zheng L. Current progress in immunotherapy for pancreatic cancer. Cancer Lett. 2016;381:244–51.
Article CAS PubMed Google Scholar
Qin Q, Yu R, Eriksson JE, Tsai H, Zhu H. Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma therapy: challenges and opportunities. Cancer Lett. 2024;591:216859.
Article CAS PubMed Google Scholar
Olaoba OT, Yang M, Adelusi TI, Maidens T, Kimchi ET, Staveley-O’Carroll KF, et al. Targeted therapy for highly desmoplastic and immunosuppressive tumor microenvironment of pancreatic ductal adenocarcinoma. Cancers. 2024;16:1470.
Article CAS PubMed PubMed Central Google Scholar
Ren B, Cui M, Yang G, Wang H, Feng M, You L, et al. Tumor microenvironment participates in metastasis of pancreatic cancer. Mol Cancer. 2018;17:108.
Article PubMed PubMed Central Google Scholar
Zainab H, Sultana A, Shaimaa. Stromal desmoplasia as a possible prognostic indicator in different grades of oral squamous cell carcinoma. J Oral Maxillofac Pathol. 2019;23:338–43.
Norton J, Foster D, Chinta M, Titan A, Longaker M. Pancreatic cancer associated fibroblasts (CAF): under-explored target for pancreatic cancer treatment. Cancers. 2020;12:1347.
Article CAS PubMed PubMed Central Google Scholar
Yuen A, Díaz B. The impact of hypoxia in pancreatic cancer invasion and metastasis. Hypoxia. 2014;2:91–106.
PubMed PubMed Central Google Scholar
Ferdek PE, Jakubowska MA. Biology of pancreatic stellate cells—more than just pancreatic cancer. Pflüg Arch Eur J Physiol. 2017;469:1039–50.
Tang D, Wang D, Yuan Z, Xue X, Zhang Y, An Y, et al. Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma. Int J Cancer. 2013;132:993–1003.
Article CAS PubMed Google Scholar
Mace TA, Ameen Z, Collins A, Wojcik S, Mair M, Young GS, et al. Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner. Cancer Res. 2013;73:3007–18.
Article CAS PubMed PubMed Central Google Scholar
Liu T, Han C, Wang S, Fang P, Ma Z, Xu L, et al. Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy. J Hematol OncolJ Hematol Oncol. 2019;12:86.
Brichkina A, Polo P, Sharma SD, Visestamkul N, Lauth M. A quick guide to CAF subtypes in pancreatic cancer. Cancers. 2023;15:2614.
Article CAS PubMed PubMed Central Google Scholar
Menezes S, Okail MH, Jalil SMA, Kocher HM, Cameron AJM. Cancer-associated fibroblasts in pancreatic cancer: new subtypes, new markers, new targets. J Pathol. 2022;257:526–44.
Article CAS PubMed PubMed Central Google Scholar
Timmer FEF, Geboers B, Nieuwenhuizen S, Dijkstra M, Schouten EAC, Puijk RS, et al. Pancreatic cancer and immunotherapy: a clinical overview. Cancers. 2021;13:4138.
Article CAS PubMed PubMed Central Google Scholar
Chang Q, Jurisica I, Do T, Hedley DW. Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer. Cancer Res. 2011;71:3110–20.
Article CAS PubMed Google Scholar
Lin S, Chai Y, Zheng X, Xu X. The role of HIF in angiogenesis, lymphangiogenesis, and tumor microenvironment in urological cancers. Mol Biol Rep. 2023;51:14.
Article PubMed PubMed Central Google Scholar
Gustafsson MV, Zheng X, Pereira T, Gradin K, Jin S, Lundkvist J, et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell. 2005;9:617–28.
Article CAS PubMed Google Scholar
Ortmann BM. Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity. BMJ Oncol. 2024;3:e000154.
Magar AG, Morya VK, Kwak MK, Oh JU, Noh KC. A molecular perspective on HIF-1α and angiogenic stimulator networks and their role in solid tumors: an update. Int J Mol Sci. 2024;25:3313.
Article CAS PubMed PubMed Central Google Scholar
Liberti MV, Locasale JW. The Warburg effect: how does it benefit cancer cells? Trends Biochem Sci. 2016;41:211–8.
Article CAS PubMed PubMed Central Google Scholar
Rosa ML, Reinert T, Pauletto MM, Sartori G, Graudenz M, Barrios CH. Implications of tumor-infiltrating lymphocytes in early-stage triple-negative breast cancer: clinical oncologist perspectives. Transl Breast Cancer Res. 2023;5:4.
Article PubMed PubMed Central Google Scholar
Poh AR, Ernst M. Tumor-associated macrophages in pancreatic ductal adenocarcinoma: therapeutic opportunities and clinical challenges. Cancers. 2021;13:2860.
Article CAS PubMed PubMed Central Google Scholar
Mirlekar B. Tumor promoting roles of IL-10, TGF-β, IL-4, and IL-35: its implications in cancer immunotherapy. SAGE Open Med. 2022;10:20503121211069012.
Article PubMed PubMed Central Google Scholar
Guo M, Niu Y, Xie M, Liu X, Li X. Notch signaling, hypoxia, and cancer. Front Oncol. 2023;13:1078768.
Article CAS PubMed PubMed Central Google Scholar
Feig C, Gopinathan A, Neesse A, Chan DS, Cook N, Tuveson DA. The pancreas cancer microenvironment. Clin Cancer Res. 2012;18:4266–76.
Article CAS PubMed PubMed Central Google Scholar
Avila JL, Kissil JL. Notch signaling in pancreatic cancer: oncogene or tumor suppressor? Trends Mol Med. 2013;19:320–7.
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