Exploring the role of antigen-presenting cancer-associated fibroblasts and CD74 on the pancreatic ductal adenocarcinoma tumor microenvironment

Karpińska M, Czauderna M. Pancreas—its functions, disorders, and physiological impact on the mammals’ organism. Front Physiol. 2022;13:807632.

Article  PubMed  PubMed Central  Google Scholar 

Vanek P, Urban O, Zoundjiekpon V, Falt P. Current screening strategies for pancreatic cancer. Biomedicines. 2022;10:2056.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63.

Article  PubMed  Google Scholar 

Ushio J, Kanno A, Ikeda E, Ando K, Nagai H, Miwata T, et al. Pancreatic ductal adenocarcinoma: epidemiology and risk factors. Diagnostics. 2021;11:562.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh G, Kutcher D, Lally R, Rai V. Targeting neoantigens in pancreatic ductal adenocarcinoma. Cancers. 2024;16:2101.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Foley K, Kim V, Jaffee E, Zheng L. Current progress in immunotherapy for pancreatic cancer. Cancer Lett. 2016;381:244–51.

Article  CAS  PubMed  Google Scholar 

Qin Q, Yu R, Eriksson JE, Tsai H, Zhu H. Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma therapy: challenges and opportunities. Cancer Lett. 2024;591:216859.

Article  CAS  PubMed  Google Scholar 

Olaoba OT, Yang M, Adelusi TI, Maidens T, Kimchi ET, Staveley-O’Carroll KF, et al. Targeted therapy for highly desmoplastic and immunosuppressive tumor microenvironment of pancreatic ductal adenocarcinoma. Cancers. 2024;16:1470.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ren B, Cui M, Yang G, Wang H, Feng M, You L, et al. Tumor microenvironment participates in metastasis of pancreatic cancer. Mol Cancer. 2018;17:108.

Article  PubMed  PubMed Central  Google Scholar 

Zainab H, Sultana A, Shaimaa. Stromal desmoplasia as a possible prognostic indicator in different grades of oral squamous cell carcinoma. J Oral Maxillofac Pathol. 2019;23:338–43.

Norton J, Foster D, Chinta M, Titan A, Longaker M. Pancreatic cancer associated fibroblasts (CAF): under-explored target for pancreatic cancer treatment. Cancers. 2020;12:1347.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuen A, Díaz B. The impact of hypoxia in pancreatic cancer invasion and metastasis. Hypoxia. 2014;2:91–106.

PubMed  PubMed Central  Google Scholar 

Ferdek PE, Jakubowska MA. Biology of pancreatic stellate cells—more than just pancreatic cancer. Pflüg Arch Eur J Physiol. 2017;469:1039–50.

Article  CAS  Google Scholar 

Tang D, Wang D, Yuan Z, Xue X, Zhang Y, An Y, et al. Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma. Int J Cancer. 2013;132:993–1003.

Article  CAS  PubMed  Google Scholar 

Mace TA, Ameen Z, Collins A, Wojcik S, Mair M, Young GS, et al. Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner. Cancer Res. 2013;73:3007–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu T, Han C, Wang S, Fang P, Ma Z, Xu L, et al. Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy. J Hematol OncolJ Hematol Oncol. 2019;12:86.

Article  CAS  Google Scholar 

Brichkina A, Polo P, Sharma SD, Visestamkul N, Lauth M. A quick guide to CAF subtypes in pancreatic cancer. Cancers. 2023;15:2614.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Menezes S, Okail MH, Jalil SMA, Kocher HM, Cameron AJM. Cancer-associated fibroblasts in pancreatic cancer: new subtypes, new markers, new targets. J Pathol. 2022;257:526–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Timmer FEF, Geboers B, Nieuwenhuizen S, Dijkstra M, Schouten EAC, Puijk RS, et al. Pancreatic cancer and immunotherapy: a clinical overview. Cancers. 2021;13:4138.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang Q, Jurisica I, Do T, Hedley DW. Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer. Cancer Res. 2011;71:3110–20.

Article  CAS  PubMed  Google Scholar 

Lin S, Chai Y, Zheng X, Xu X. The role of HIF in angiogenesis, lymphangiogenesis, and tumor microenvironment in urological cancers. Mol Biol Rep. 2023;51:14.

Article  PubMed  PubMed Central  Google Scholar 

Gustafsson MV, Zheng X, Pereira T, Gradin K, Jin S, Lundkvist J, et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell. 2005;9:617–28.

Article  CAS  PubMed  Google Scholar 

Ortmann BM. Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity. BMJ Oncol. 2024;3:e000154.

Article  Google Scholar 

Magar AG, Morya VK, Kwak MK, Oh JU, Noh KC. A molecular perspective on HIF-1α and angiogenic stimulator networks and their role in solid tumors: an update. Int J Mol Sci. 2024;25:3313.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liberti MV, Locasale JW. The Warburg effect: how does it benefit cancer cells? Trends Biochem Sci. 2016;41:211–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosa ML, Reinert T, Pauletto MM, Sartori G, Graudenz M, Barrios CH. Implications of tumor-infiltrating lymphocytes in early-stage triple-negative breast cancer: clinical oncologist perspectives. Transl Breast Cancer Res. 2023;5:4.

Article  PubMed  PubMed Central  Google Scholar 

Poh AR, Ernst M. Tumor-associated macrophages in pancreatic ductal adenocarcinoma: therapeutic opportunities and clinical challenges. Cancers. 2021;13:2860.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mirlekar B. Tumor promoting roles of IL-10, TGF-β, IL-4, and IL-35: its implications in cancer immunotherapy. SAGE Open Med. 2022;10:20503121211069012.

Article  PubMed  PubMed Central  Google Scholar 

Guo M, Niu Y, Xie M, Liu X, Li X. Notch signaling, hypoxia, and cancer. Front Oncol. 2023;13:1078768.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feig C, Gopinathan A, Neesse A, Chan DS, Cook N, Tuveson DA. The pancreas cancer microenvironment. Clin Cancer Res. 2012;18:4266–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Avila JL, Kissil JL. Notch signaling in pancreatic cancer: oncogene or tumor suppressor? Trends Mol Med. 2013;19:320–7.

Article  CAS  PubMed  PubMed Central 

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