SCI Abstract

search
+
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling
This study investigated the effects of physical exercise (PE) on the modulation of purinergic signaling and inflammatory p...
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function
Hyperactivation of cutaneous macrophages promotes the development of chronic pain. Stimulation of nociceptive regions prom...
P2 receptors signaling in the esophagus: from inflammation to cancer
P2 receptors signaling in the esophagus: from inflammation to cancer
The signaling mechanisms of nucleotides and nucleosides have been extensively studied over the past decades in various con...
Role of macrophage ATP metabolism disorder in SiO‑induced pulmonary fibrosis: a review
Role of macrophage ATP metabolism disorder in SiO‑induced pulmonary fibrosis: a review
Silicosis, a chronic lung disease, results from prolonged inhalation of silica dust (SiO2) in occupational environments, a...
Depletion of P2X4 receptor alleviates prostate cancer bone metastasis through reduced cancer cell invasiveness and enhanced cell adhesion activities
Depletion of P2X4 receptor alleviates prostate cancer bone metastasis through reduced cancer cell invasiveness and enhanced cell adhesion activities
Prostate cancer (PCa) preferentially metastasizes to bone, which remains incurable and contributes significantly to mortal...
Acute effects of guanosine or inosine in a porcine model of hemorrhagic shock
Acute effects of guanosine or inosine in a porcine model of hemorrhagic shock
Hemorrhagic shock (HS) leads to systemic hypoperfusion, impaired tissue oxygenation, and multi-organ dysfunction, includin...
State of the art indicators for imaging purinergic dynamics in vitro and in vivo
State of the art indicators for imaging purinergic dynamics in vitro and in vivo
Purinergic neurotransmission, a dynamic signaling system using adenosine triphosphate (ATP), adenosine diphosphate (ADP), ...
Electroacupuncture alleviates capsaicin-induced rectal visceral pain in rats via inhibiting TRPV1 expression by blocking the P2X4R-activated p38 pathway
Electroacupuncture alleviates capsaicin-induced rectal visceral pain in rats via inhibiting TRPV1 expression by blocking the P2X4R-activated p38 pathway
Electroacupuncture (EA), as a combination of traditional acupuncture and modern electrotherapy, and has analgesic effects ...
The CALHM1 blocker CGP37157 increases seizure severity during status epilepticus in adult mice
The CALHM1 blocker CGP37157 increases seizure severity during status epilepticus in adult mice
Epilepsy is one of the most common chronic brain diseases affecting up to 70 million people worldwide. Major challenges of...
The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia
The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia
Endometriosis is a chronic gynecological condition characterized by endometrial tissue outside the uterine cavity. Recent ...
Therapeutic potential of P2X7 receptor in retinal diseases
Therapeutic potential of P2X7 receptor in retinal diseases
Retinal diseases affect the health of millions of people worldwide and activated P2X7 receptors (P2X7Rs) are associated wi...
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia
Correction to: Purinergic SignallingUnfortunately, the original published version of ...
Adenosine receptors and acute kidney injury: perspectives for future therapy
Adenosine receptors and acute kidney injury: perspectives for future therapy
Adenosine is a key modulator in the pathophysiology of acute kidney injury (AKI), particularly through its influence on in...
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats
An increasing number of traditional Chinese medicine(TCM) have been confirmed to possess analgesic bioactivity. 701 Dieda ...
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex
Increasing evidence indicated that purinergic signalling involved in electroacupuncture (EA)-induced analgesia. Whether pu...
Mechanosensitive release of ATP in the urinary bladder mucosa
Mechanosensitive release of ATP in the urinary bladder mucosa
The urinary bladder mucosa (urothelium and suburothelium/lamina propria) functions as a barrier between the content of the...
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats
Our previous work had identified that at the acupuncture point (acupoint), acupuncture-induced ATP release was a pivotal e...
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells
The P2X7 receptor, an ATP-gated ion channel which belongs to the P2X receptor family, plays critical roles in recognizing ...
The role of the P2X7 receptor in inactivated SARS-CoV-2-induced lung injury
The role of the P2X7 receptor in inactivated SARS-CoV-2-induced lung injury
Purinergic signaling plays a role in the pathophysiology of different viral infections. Recently, we showed that COVID-19 ...
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk
Purines are important mediators of intercellular communication in the enteric nervous system (ENS) that participate in phy...
Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist
Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist
P2X4 receptors are ATP-gated cation channels that were proposed as novel drug targets due to their role in inflammation an...
Machine learning-aided search for ligands of P2Y6 and other P2Y receptors
Machine learning-aided search for ligands of P2Y6 and other P2Y receptors
The P2Y6 receptor, activated by uridine diphosphate (UDP), is a target for antagonists in inflammatory, neurodegenerative,...
Purinergic regulation of pulmonary vascular tone
Purinergic regulation of pulmonary vascular tone
Purinergic signaling is a crucial determinant in the regulation of pulmonary vascular physiology and presents a promising ...
Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools
Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools
There is growing interest in the P2X4 receptor as a therapeutic target for several cardiovascular, inflammatory and neurol...
Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes
Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes
Intestinal low-grade inflammation induced by a high-fat diet has been found to detonate chronic systemic inflammation, whi...
Cutaneous melanoma and purinergic modulation by phenolic compounds
Cutaneous melanoma and purinergic modulation by phenolic compounds
Cutaneous melanoma is a complex pathology that still has only treatments that lack efficiency and offer many adverse effec...
Metastasis and angiogenesis in cervical cancer: key aspects of purinergic signaling in platelets and possible therapeutic targets
Metastasis and angiogenesis in cervical cancer: key aspects of purinergic signaling in platelets and possible therapeutic targets
Cervical cancer ranks as the fourth most common and fatal cancer among women worldwide. Studies have demonstrated a strong...
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR
One of the leading causes of cancer-related deaths worldwide is colorectal cancer (CRC). Extracellular ATP (e-ATP) and pur...
Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors
Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors
P2X7 receptors (P2X7Rs) are membrane-bound ATP-gated ion channels that are composed of three subunits. Different subunit s...
Purinergic signaling in the battlefield of viral infections
Purinergic signaling in the battlefield of viral infections
Purinergic signaling has been associated with immune defenses against pathogens such as bacteria, protozoa, fungi, and vir...
Load More
format_indent_increase