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Neurodegeneration in Parkinson’s disease: are we looking at the right spot?
Neurodegeneration in Parkinson’s disease: are we looking at the right spot?
Parkinson’s disease (PD) is recognized as the fastest-growing neurodegenerative disorder, impacting millions of indi...
Peripheral substance P induces deficits in hippocampal synaptic plasticity and memory
Peripheral substance P induces deficits in hippocampal synaptic plasticity and memory
Substance P (SP) is a neuropeptide that functions in both the central and peripheral nervous systems. Although the periphe...
Generation of a new Slc20a2 knockout mouse line as in vivo model for primary brain calcification
Generation of a new Slc20a2 knockout mouse line as in vivo model for primary brain calcification
Primary brain calcification (PBC) is a neurodegenerative disease that causes bilateral ectopic calcification in the brain....
Comprehensive behavioral phenotyping of male Septin 3-deficient mice reveals task-specific abnormalities
Comprehensive behavioral phenotyping of male Septin 3-deficient mice reveals task-specific abnormalities
The septin cytoskeleton is recognized as the fourth component of the cytoskeleton. Septin 3 (SEPT3)/G-septin is a neuron-s...
Knockout of AMPA receptor binding protein Neuron-specific gene 2 (NSG2) enhances associative learning and cognitive flexibility
Knockout of AMPA receptor binding protein Neuron-specific gene 2 (NSG2) enhances associative learning and cognitive flexibility
The vast majority of gene mutations and/or gene knockouts result in either no observable changes, or significant deficits ...
Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry
Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry
Rapid adaptation to novel environments is crucial for survival, and this ability is impaired in many neuropsychiatric diso...
Serotonin enhances neurogenesis biomarkers, hippocampal volumes, and cognitive functions in Alzheimer’s disease
Serotonin enhances neurogenesis biomarkers, hippocampal volumes, and cognitive functions in Alzheimer’s disease
Research on serotonin reveals a lack of consensus regarding its role in brain volume, especially concerning biomarkers lin...
Dynamic changes in the hippocampal neuronal circuits activity following acute stress revealed by miniature fluorescence microscopy imaging
Dynamic changes in the hippocampal neuronal circuits activity following acute stress revealed by miniature fluorescence microscopy imaging
Coordinated activity of neuronal ensembles is a basis for information processing in the brain. Recent development of minis...
Nek6 regulates autophagy through the mTOR signaling pathway to alleviate cerebral ischemia–reperfusion injury
Nek6 regulates autophagy through the mTOR signaling pathway to alleviate cerebral ischemia–reperfusion injury
Cerebral ischemia–reperfusion injury (CIRI) is a major obstacle to neurological recovery after clinical treatment of...
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment
Cognitive dysfunction increases as menopause progresses. We previously found that estrogen receptors (ERs) contribute to d...
Effects of MAP4K inhibition on neurite outgrowth
Effects of MAP4K inhibition on neurite outgrowth
Protein kinases are responsible for protein phosphorylation and are involved in important intracellular signal transductio...
MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
Necroptosis is known to play an important role in the pathophysiology of cerebral ischemia; however, its role in the occur...
Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1
Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1
Familial hemiplegic migraine type-1 (FHM-1) is a form of migraine with aura caused by mutations in the P/Q-type (Cav2.1) v...
Limitations of the human iPSC-derived neuron model for early-onset Alzheimer’s disease
Limitations of the human iPSC-derived neuron model for early-onset Alzheimer’s disease
Non-familial Alzheimer’s disease (AD) occurring before 65 years of age is commonly referred to as early-ons...
Impact of volume and expression time in an AAV-delivered channelrhodopsin
Impact of volume and expression time in an AAV-delivered channelrhodopsin
Optogenetics has revolutionised neuroscience research, but at the same time has brought a plethora of new variables to con...
Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning
Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning
A critical feature of episodic memory formation is to associate temporally segregated events as an episode, called tempora...
AAV-compatible optogenetic tools for activating endogenous calcium channels in vivo
AAV-compatible optogenetic tools for activating endogenous calcium channels in vivo
Calcium ions (Ca2+) play pivotal roles in regulating diverse brain functions, including cognition, emotion, locomotion, an...
Anterior cingulate cortex regulates pain catastrophizing-like behaviors in rats
Anterior cingulate cortex regulates pain catastrophizing-like behaviors in rats
Negative pain expectation including pain catastrophizing is a well-known clinical phenomenon whereby patients amplify the ...
Rab11a in the spinal cord: an essential contributor to complete Freund’s adjuvant-induced inflammatory pain in mice
Rab11a in the spinal cord: an essential contributor to complete Freund’s adjuvant-induced inflammatory pain in mice
Inflammatory pain is a commonly observed clinical symptom in a range of acute and chronic diseases. However, the mechanism...
Electrophysiological characterization of a Cav3.2 calcium channel missense variant associated with epilepsy and hearing loss
Electrophysiological characterization of a Cav3.2 calcium channel missense variant associated with epilepsy and hearing loss
T-type calcium channelopathies encompass a group of human disorders either caused or exacerbated by mutations in the genes...
Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study
Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study
Novelty-induced memory consolidation is a well-established phenomenon that depends on the activation of a locus coeruleus-...
Comparison of Huntington’s disease phenotype progression in male and female heterozygous FDNQ175 mice
Comparison of Huntington’s disease phenotype progression in male and female heterozygous FDNQ175 mice
Huntington’s Disease (HD) is an inherited autosomal dominant neurodegenerative disorder that leads to progressive mo...
Inhibitory insula-ACC projections modulate affective but not sensory aspects of neuropathic pain
Inhibitory insula-ACC projections modulate affective but not sensory aspects of neuropathic pain
The insula and anterior cingulate cortex (ACC) are brain regions that undergo structural and functional reorganization in ...
Profiling tyrosine kinase inhibitors as AD therapeutics in a mouse model of AD
Profiling tyrosine kinase inhibitors as AD therapeutics in a mouse model of AD
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by Aβ deposition, tauopathy, neuroinflamm...
Specific vulnerability of iPSC-derived motor neurons with TDP-43 gene mutation to oxidative stress
Specific vulnerability of iPSC-derived motor neurons with TDP-43 gene mutation to oxidative stress
Amyotrophic lateral sclerosis (ALS) is a disease that affects motor neurons and has a poor prognosis. We focused on TAR DN...
C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity
C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity
Changes in neural activity induced by learning and novel environments have been reported to lead to the formation of new s...
Antihyperalgesic effect of joint mobilization requires Cav3.2 calcium channels
Antihyperalgesic effect of joint mobilization requires Cav3.2 calcium channels
The present study was undertaken to explore the relative contributions of Cav3.2 T-type channels to mediating the...
The lateral habenula nucleus regulates pruritic sensation and emotion
The lateral habenula nucleus regulates pruritic sensation and emotion
Itch is a complex aversive sensory and emotional experience. As a most upsetting symptom in many dermatological and system...
BCAT1 controls embryonic neural stem cells proliferation and differentiation in the upper layer neurons
BCAT1 controls embryonic neural stem cells proliferation and differentiation in the upper layer neurons
The regulation of neural stem cell (NSC) proliferation and differentiation during brain development is a precisely control...
Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice
Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice
Angiotensin (Ang)-converting-enzyme (ACE) 2 converts Ang II into Ang (1–7), which in turn acts on MAS recep...
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