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Multi-session transcutaneous spinal cord stimulation prevents chloride homeostasis imbalance and the development of hyperreflexia after spinal cord injury in rat
Multi-session transcutaneous spinal cord stimulation prevents chloride homeostasis imbalance and the development of hyperreflexia after spinal cord injury in rat
Spasticity is a complex and multidimensional disorder that impacts nearly 75% of individuals with spinal cord injury (SCI)...
Social isolation initiated post-weaning augments ischemic brain injury by promoting pro-inflammatory responses
Social isolation initiated post-weaning augments ischemic brain injury by promoting pro-inflammatory responses
Social isolation, experienced during early development or in adulthood, has detrimental consequences for physical and ment...
PI3Kδ inhibition alleviates the brain injury during cerebral ischemia reperfusion via suppressing pericyte contraction in a TNF-α dependent manner
PI3Kδ inhibition alleviates the brain injury during cerebral ischemia reperfusion via suppressing pericyte contraction in a TNF-α dependent manner
As the common type of stroke, ischemic stroke is the leading cause of the permanent disability worldwide, and brings about...
To evaluate the effect of endothelin receptor agonist IRL-1620 alone and in combination with donepezil in modulating neurodegeneration elicited by amyloid-β in rats
To evaluate the effect of endothelin receptor agonist IRL-1620 alone and in combination with donepezil in modulating neurodegeneration elicited by amyloid-β in rats
Alzheimer's disease (AD) which is the most prevailing class of dementia, accounting for nearly two-thirds of dementia inst...
Ndfip1 protected dopaminergic neurons via regulating mitochondrial function and ferroptosis in Parkinson's disease
Ndfip1 protected dopaminergic neurons via regulating mitochondrial function and ferroptosis in Parkinson's disease
PD is a common neurodegenerative disease with both motor and non-motor symptoms. The main pathological changes of PD are t...
Investigating neuropathological changes and underlying neurobiological mechanisms in the early stages of primary blast-induced traumatic brain injury: Insights from a rat model
Investigating neuropathological changes and underlying neurobiological mechanisms in the early stages of primary blast-induced traumatic brain injury: Insights from a rat model
The use of explosive weapons and chemical agents has resulted in an increase in blast-induced traumatic brain injury (bTBI...
Effects of dim light at night in C57BL/6 J mice on recovery after spinal cord injury
Effects of dim light at night in C57BL/6 J mice on recovery after spinal cord injury
The Earth has rotated on its axis for billions of years, creating daily environmental rhythms of light and dark. These pre...
Nfe2l3 promotes neuroprotection and long-distance axon regeneration after injury in vivo
Nfe2l3 promotes neuroprotection and long-distance axon regeneration after injury in vivo
Nfe2l3 (also known as Nrf3) belongs to the Cap'n'collar (Cnc) family of proteins, along with Nfe2l1 and Nfe2l2, which regu...
Engineered PDGFA-ligand-modified exosomes delivery T3 for demyelinating disease targeted therapy
Engineered PDGFA-ligand-modified exosomes delivery T3 for demyelinating disease targeted therapy
Demyelination is a proper syndrome in plenty of central nervous system (CNS) diseases, which is the main obstacle to recov...
microRNA-9a-5p disrupts the ELAVL1/VEGF axis to alleviate traumatic brain injury
microRNA-9a-5p disrupts the ELAVL1/VEGF axis to alleviate traumatic brain injury
Traumatic brain injury (TBI) is damage to the brain caused by an external force (Stocchetti et al., 2017). The major cause...
4-PBA exerts brain-protective effects against sepsis-associated encephalopathy in a mouse model of sepsis
4-PBA exerts brain-protective effects against sepsis-associated encephalopathy in a mouse model of sepsis
SAE is a diffuse brain dysfunction characterized by a progressively developing state of sepsis (Spapen et al., 2010). The ...
AAV-mediated VEGFA overexpression promotes angiogenesis and recovery of locomotor function following spinal cord injury via PI3K/Akt signaling
AAV-mediated VEGFA overexpression promotes angiogenesis and recovery of locomotor function following spinal cord injury via PI3K/Akt signaling
Spinal cord injury (SCI) is a disorder of the central nervous system resulting from various factors such as trauma, inflam...
State-dependent alteration of respiration in a rat model of Parkinson's disease
State-dependent alteration of respiration in a rat model of Parkinson's disease
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder. Besides major deficits in motor coordinat...
Cisplatin induces BDNF downregulation in middle-aged female rat model while BDNF enhancement attenuates cisplatin neurotoxicity
Cisplatin induces BDNF downregulation in middle-aged female rat model while BDNF enhancement attenuates cisplatin neurotoxicity
Cancer survivors often experience neuropsychological changes, including cognitive impairment, anxiety, and depression duri...
Lipopolysaccharide-induced intestinal inflammation on AIM2-mediated pyroptosis in the brain of rats with cerebral small vessel disease
Lipopolysaccharide-induced intestinal inflammation on AIM2-mediated pyroptosis in the brain of rats with cerebral small vessel disease
Cerebral small vessel disease (CSVD) is a cerebral vascular disease with insidious onset and poor clinical treatment effec...
Pharmacological and stem cell therapy of stroke in animal models: Do they accurately reflect the response of humans?
Pharmacological and stem cell therapy of stroke in animal models: Do they accurately reflect the response of humans?
Volume 376, June 2024, 114753Author links open overlay panel, , , , , , , AbstractCerebrovascular diseases are the second ...
BMSC-Exosomes attenuate ALP dysfunction by restoring lysosomal function via the mTOR/TFEB Axis to reduce cerebral ischemia-reperfusion injury
BMSC-Exosomes attenuate ALP dysfunction by restoring lysosomal function via the mTOR/TFEB Axis to reduce cerebral ischemia-reperfusion injury
BackgroundThe complex pathophysiological changes following cerebral ischemia-reperfusion injury (CIRI) include the accumul...
Floralozone regulates MiR-7a-5p expression through AMPKα2 activation to improve cognitive dysfunction in vascular dementia
Floralozone regulates MiR-7a-5p expression through AMPKα2 activation to improve cognitive dysfunction in vascular dementia
Vascular dementia (VD) is a serious sequela of cerebrovascular diseases that can significantly affect memory, emotion, and...
Characterization of the intrahippocampal kainic acid model in female mice with a special focus on seizure suppression by antiseizure medications
Characterization of the intrahippocampal kainic acid model in female mice with a special focus on seizure suppression by antiseizure medications
Despite special challenges in the medical treatment of women with epilepsy, in particular preclinical animal studies were ...
The role of dorsolateral striatum in the effects of deep cerebellar stimulation-mediated motor recovery following ischemic stroke in rodents
The role of dorsolateral striatum in the effects of deep cerebellar stimulation-mediated motor recovery following ischemic stroke in rodents
KeywordsDeep brain stimulationIschemiaMotor recoveryLateral cerebellar nucleusCorticostriatalCerebellumAbbreviationsDTCden...
Screening of potent RIPK3 inhibitors to attenuate necroptosis and inflammation in mouse traumatic brain injury models
Screening of potent RIPK3 inhibitors to attenuate necroptosis and inflammation in mouse traumatic brain injury models
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in relatively healthy individuals worldwide, an...
Model matters: Differential outcomes in traumatic optic neuropathy pathophysiology between blunt and blast-wave mediated head injuries
Model matters: Differential outcomes in traumatic optic neuropathy pathophysiology between blunt and blast-wave mediated head injuries
Traumatic brain injury (TBI) comprises 1/3rd of all injury related deaths in the United States (Prevention, 2022). While m...
Mechanisms of ferroptosis in hypoxic-ischemic brain damage in neonatal rats
Mechanisms of ferroptosis in hypoxic-ischemic brain damage in neonatal rats
Neonatal hypoxic-ischemic brain damage (HIBD) is a serious neurological disease that can result in cerebral palsy, epileps...
The interplay between neuroinflammatory pathways and Parkinson's disease
The interplay between neuroinflammatory pathways and Parkinson's disease
Parkinson's disease (PD), initially coined as “Shaking Palsy” by James Parkinson in 1817, stands as the second most common...
Human stem cells hold the key to the study of human neural infectious disorders
Human stem cells hold the key to the study of human neural infectious disorders
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The role of ferroptosis and its mechanism in ischemic stroke
The role of ferroptosis and its mechanism in ischemic stroke
In recent years, the morbidity, mortality and disability of stroke have been increasing in most countries, with ischemic s...
Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review
Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review
Stroke is a devastating cerebrovascular pathology with high morbidity and mortality. Inflammation plays a central role in ...
Bone marrow mesenchymal stem cells therapy regulates sphingolipid and glycerophospholipid metabolism to promote neurological recovery in stroke rats: A metabolomics analysis
Bone marrow mesenchymal stem cells therapy regulates sphingolipid and glycerophospholipid metabolism to promote neurological recovery in stroke rats: A metabolomics analysis
Acute ischemic stroke (AIS) is a prevalent disease with high morbidity, disability, and recurrence rate (Feigin et al., 20...
Spinal interleukin-24 contributes to neuropathic pain after peripheral nerve injury through interleukin-20 receptor2 in mice
Spinal interleukin-24 contributes to neuropathic pain after peripheral nerve injury through interleukin-20 receptor2 in mice
Neuropathic pain (NP) caused by somatosensory nervous system injury or disease is a common condition, with a global incide...
Fragmentation of functional resting state brain networks in a transgenic mouse model of tau pathology: A metabolic connectivity study using [18F]FDG-PET
Fragmentation of functional resting state brain networks in a transgenic mouse model of tau pathology: A metabolic connectivity study using [18F]FDG-PET
In a previous study, regional reductions in cerebral glucose metabolism have been demonstrated in the tauopathy mouse mode...
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