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Exosomal GDNF from Bone Marrow Mesenchymal Stem Cells Moderates Neuropathic Pain in a Rat Model of Chronic Constriction Injury
Exosomal GDNF from Bone Marrow Mesenchymal Stem Cells Moderates Neuropathic Pain in a Rat Model of Chronic Constriction Injury
Both of exosomes derived from mesenchymal stem cells (MSCs) and glial cell line-derived neurotrophic factor (GDNF) show po...
Neuroprotective Effects of VGLUT1 Inhibition in HT22 Cells Overexpressing VGLUT1 Under Oxygen Glucose Deprivation Conditions
Neuroprotective Effects of VGLUT1 Inhibition in HT22 Cells Overexpressing VGLUT1 Under Oxygen Glucose Deprivation Conditions
Glutamate (Glu) is a major excitatory neurotransmitter in the brain, essential for synaptic plasticity, neuronal activity,...
Dysregulated Purinergic Signalling in Fragile X Syndrome Cortical Astrocytes
Dysregulated Purinergic Signalling in Fragile X Syndrome Cortical Astrocytes
The symptoms of fragile X syndrome (FXS), caused by a single gene mutation to Fmr1, have been increasingly linked to disor...
Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury
Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury
As the primary connection between the eye and brain, the optic nerve plays a pivotal role in visual information transmissi...
The Blood-Cerebrospinal Fluid Barrier Dysfunction in Brain Disorders and Stroke: Why, How, What For?
The Blood-Cerebrospinal Fluid Barrier Dysfunction in Brain Disorders and Stroke: Why, How, What For?
Ischemic stroke (IS) results in the interruption of blood flow to the brain, which can cause significant damage. The patho...
Identification of Disulfidptosis-Related Genes in Ischemic Stroke by Combining Single-Cell Sequencing, Machine Learning Algorithms, and In Vitro Experiments
Identification of Disulfidptosis-Related Genes in Ischemic Stroke by Combining Single-Cell Sequencing, Machine Learning Algorithms, and In Vitro Experiments
Ischemic stroke (IS) is a severe neurological disorder with a pathogenesis that remains incompletely understood. Recently,...
Continuous Theta Burst Stimulation Inhibits Oxidative Stress-Induced Inflammation and Autophagy in Hippocampal Neurons by Activating Glutathione Synthesis Pathway, Improving Cognitive Impairment in Sleep-Deprived Mice
Continuous Theta Burst Stimulation Inhibits Oxidative Stress-Induced Inflammation and Autophagy in Hippocampal Neurons by Activating Glutathione Synthesis Pathway, Improving Cognitive Impairment in Sleep-Deprived Mice
Sleep deprivation (SD) has been reported to have a negative impact on cognitive function. Continuous theta burst stimulati...
Clinical Implication of Time of Ischaemic Stroke Among Post-Stroke Survivors from Eastern India: A Circadian Perspective
Clinical Implication of Time of Ischaemic Stroke Among Post-Stroke Survivors from Eastern India: A Circadian Perspective
The circadian variation in stroke occurrence is a well-documented phenomenon. However, the circadian effect on stroke outc...
Distinct Hippocampal Expression Profiles of lncRNAs in Obese Type 2 Diabetes Mice Exhibiting Cognitive Impairment
Distinct Hippocampal Expression Profiles of lncRNAs in Obese Type 2 Diabetes Mice Exhibiting Cognitive Impairment
Cognitive dysfunction has been accepted as a possible complication of type 2 diabetes (T2D), but few studies revealed the ...
USP15 as a Potential Therapeutic Target in Cerebral Ischemia: Modulation of Ferroptosis and Cognitive Dysfunction via the Nrf2/GPX4 Axis in Mice
USP15 as a Potential Therapeutic Target in Cerebral Ischemia: Modulation of Ferroptosis and Cognitive Dysfunction via the Nrf2/GPX4 Axis in Mice
This study aimed to investigate the role of ubiquitin-specific peptidase 15 (USP15) in ischemic cognitive dysfunction usin...
Unraveling the Nexus: The Role of Collapsin Response Mediator Protein 2 Phosphorylation in Neurodegeneration and Neuroregeneration
Unraveling the Nexus: The Role of Collapsin Response Mediator Protein 2 Phosphorylation in Neurodegeneration and Neuroregeneration
Neurodegenerative disease characterized by the progressive damage of the nervous system, and neuropathies caused by the ne...
STAT3 Inhibitor Increases α-Synuclein in PFF-Treated Astroglia Cells by Dysregulating Autophagy and Potentially Affects Exosome Biogenesis
STAT3 Inhibitor Increases α-Synuclein in PFF-Treated Astroglia Cells by Dysregulating Autophagy and Potentially Affects Exosome Biogenesis
Astrocytes are the most abundant cells in the brain and show neuroprotective function in CNS and reactive astrocytes are c...
Noradrenergic Projections from the Locus Coeruleus to the Medial Prefrontal Cortex Enhances Stress Coping Behavior in Mice Following Long-Term Intermittent Fasting
Noradrenergic Projections from the Locus Coeruleus to the Medial Prefrontal Cortex Enhances Stress Coping Behavior in Mice Following Long-Term Intermittent Fasting
Intermittent fasting has been shown to alleviate stress, anxiety, and depressive symptoms. Although noradrenaline, also kn...
Microparticles Mediate Lipopolysaccharide-induced Inflammation and Chronic Pain in Mouse Model
Microparticles Mediate Lipopolysaccharide-induced Inflammation and Chronic Pain in Mouse Model
Recent evidence highlights microparticles (MPs) as crucial players in intercellular communication among immune cells, yet ...
Transcriptomic Profiling Reveals Sex-Specific Epigenetic Dynamics Involving kdm6b and H3K27 Methylation in Cerebral Ischemia-Induced Neurogenesis and Recovery
Transcriptomic Profiling Reveals Sex-Specific Epigenetic Dynamics Involving kdm6b and H3K27 Methylation in Cerebral Ischemia-Induced Neurogenesis and Recovery
Cerebral ischemic stroke ranks among the leading causes of death and disability worldwide. A significant challenge, beyond...
Schizophrenia Biomarkers: Blood Transcriptome Suggests Two Molecular Subtypes
Schizophrenia Biomarkers: Blood Transcriptome Suggests Two Molecular Subtypes
Schizophrenia is a chronic illness that imposes a significant burden on patients, their families, and the health care syst...
Current Status of Research on Nanomaterials Combined with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke
Current Status of Research on Nanomaterials Combined with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke
Ischemic stroke (IS) is a disease with high mortality and disability rates worldwide and is a serious threat to patient he...
Recent Advances in the miRNA-Mediated Regulation of Neuronal Differentiation and Death
Recent Advances in the miRNA-Mediated Regulation of Neuronal Differentiation and Death
The review aims to focus on the role of miRNA in gene regulation, related to differentiation and apoptosis of neurons, foc...
Increased IL-6 Levels and the Upregulation of Iron Regulatory Biomarkers Contribute to the Progression of Japanese Encephalitis Virus Infection’s Pathogenesis
Increased IL-6 Levels and the Upregulation of Iron Regulatory Biomarkers Contribute to the Progression of Japanese Encephalitis Virus Infection’s Pathogenesis
Integrated analysis of iron regulatory biomarkers and inflammatory response could be an important strategy for Japanese en...
MicroRNAs as a Tool for Differential Diagnosis of Neuromuscular Disorders
MicroRNAs as a Tool for Differential Diagnosis of Neuromuscular Disorders
Neuromuscular disorders (NMD) are a class of progressive disorders that are characterized by wasting of the muscles. Some ...
Author Correction: Potential of Quercetin to Protect Cadmium Induced Cognitive Deficits in Rats by Modulating NMDA‑R Mediated Downstream Signaling and PI3K/AKT—Nrf2/ARE Signaling Pathways in Hippocampus
Author Correction: Potential of Quercetin to Protect Cadmium Induced Cognitive Deficits in Rats by Modulating NMDA‑R Mediated Downstream Signaling and PI3K/AKT—Nrf2/ARE Signaling Pathways in Hippocampus
In the original version of this article, the affiliation “Academy of Scientific and Innovative Research (AcSIR), Ghaziabad...
Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice
Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice
Orexin and its receptors are closely related to the pathogenesis of Alzheimer’s disease (AD). Although the expressio...
CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy
CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy
Anxiety manifestations and cognitive dysfunction are common sequelae in patients with sepsis-associated encephalopathy (SA...
Genetic Variations and Altered Blood mRNA Level of Circadian Genes and BDNF as Risk Factors of Post-Stroke Cognitive Impairment Among Eastern Indians
Genetic Variations and Altered Blood mRNA Level of Circadian Genes and BDNF as Risk Factors of Post-Stroke Cognitive Impairment Among Eastern Indians
Post-stroke cognitive impairment (PSCI) is a clinical outcome in around 30% of post-stroke survivors. BDNF is a major gene...
Fibroblast Growth Factor Receptor 2 (FGFR2), a New Gene Involved in the Genesis of Autism Spectrum Disorder
Fibroblast Growth Factor Receptor 2 (FGFR2), a New Gene Involved in the Genesis of Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a long-known complex neurodevelopmental disorder, and over the past decades, with the en...
Author Correction: Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
Author Correction: Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
Expression levels of activated inflammasome components, pro-inflammatory cytokine maturation and markers of cell death in ...
Neuroprotective Effects of Sinomenine on Experimental Autoimmune Encephalomyelitis via Anti-Inflammatory and Nrf2-Dependent Anti-Oxidative Stress Activity
Neuroprotective Effects of Sinomenine on Experimental Autoimmune Encephalomyelitis via Anti-Inflammatory and Nrf2-Dependent Anti-Oxidative Stress Activity
Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS). Sinomenine (SIN), a bio...
Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR
Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR
Medulloblastoma (MB) is a heterogeneous group of malignant pediatric brain tumors, divided into molecular groups with dist...
CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis
CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis
Activated microglia play dual roles in ischemic stroke (IS) according to its polarization states. Herein, we investigated ...
Optogenetic Inhibition of Glutamatergic Neurons in the Dysgranular Posterior Insular Cortex Modulates Trigeminal Neuropathic Pain in CCI-ION Rat
Optogenetic Inhibition of Glutamatergic Neurons in the Dysgranular Posterior Insular Cortex Modulates Trigeminal Neuropathic Pain in CCI-ION Rat
In individuals with chronic neuropathic pain, the posterior insular cortex (PIC) has been found to exhibit increased gluta...
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