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HDAC3 Epigenetic Suppression by Electroacupuncture Restores AMPA Receptor Function and Synaptic Plasticity in Alzheimer’s Disease Models
HDAC3 Epigenetic Suppression by Electroacupuncture Restores AMPA Receptor Function and Synaptic Plasticity in Alzheimer’s Disease Models
Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by continuous cognitive deterioration, ...
Glutamic Acid at Position 168 Is a Constitutive Activator of Tank Binding Kinase 1 Catalytic Function
Glutamic Acid at Position 168 Is a Constitutive Activator of Tank Binding Kinase 1 Catalytic Function
TANK binding kinase 1 (TBK1) is serine/threonine protein kinase member of the inhibitor of nuclear factor-kB kinase family...
Longikaurin A - Mediated Regulation of ROS/JNK Signaling Counteracts Epithelial-Mesenchymal Transition in Glioblastoma
Longikaurin A - Mediated Regulation of ROS/JNK Signaling Counteracts Epithelial-Mesenchymal Transition in Glioblastoma
Glioblastoma (GBM) is a highly aggressive brain tumor characterized by rapid proliferation, therapy resistance, and extens...
Comparative Hippocampal Transcriptomics Reveals Model-Specific Pathways and Convergent Inflammation in Sepsis-Associated Encephalopathy
Comparative Hippocampal Transcriptomics Reveals Model-Specific Pathways and Convergent Inflammation in Sepsis-Associated Encephalopathy
Sepsis-associated encephalopathy (SAE) is a serious sepsis complication with high mortality. Animal models, including ceca...
Targeting Microglial Activation to Modulate Neuroinflammation in Alzheimer’s Disease
Targeting Microglial Activation to Modulate Neuroinflammation in Alzheimer’s Disease
Alzheimer’s disease is a multifaceted neurodegenerative condition marked by the build-up of amyloid plaques and neur...
Genetic Evidence Linking Lactylation-Related Gene Expression To Dementia Risk
Genetic Evidence Linking Lactylation-Related Gene Expression To Dementia Risk
Lactylation has been identified as a novel epigenetic modification involved in neuroinflammation, mitochondrial dysfunctio...
SAT1 Knockdown Decreases Glutamate-Induced Oxidative Stress, Ferroptosis, and Apoptosis in HT22 Cells via Activating the Nrf2/ARE Pathway
SAT1 Knockdown Decreases Glutamate-Induced Oxidative Stress, Ferroptosis, and Apoptosis in HT22 Cells via Activating the Nrf2/ARE Pathway
Glutamate toxicity is involved in the pathogenesis of neurological disorders, including epilepsy. Here we aimed to investi...
Anti-Inflammatory Potential of Stearidonic Acid Ethanolamide in a Model of Mild Traumatic Brain Injury in Mice
Anti-Inflammatory Potential of Stearidonic Acid Ethanolamide in a Model of Mild Traumatic Brain Injury in Mice
Chronic neuroinflammation is recognized as a pivotal mechanism responsible for secondary damage following mild traumatic b...
In Silico Phosphoproteomic Analysis Reveals Divergent Regulation of Presenilin 1 and Presenilin 2
In Silico Phosphoproteomic Analysis Reveals Divergent Regulation of Presenilin 1 and Presenilin 2
The Presenilins are multi-pass transmembrane proteins that form part of the multi-protein gamma secretase complex. The hyd...
Spinal Cord Involvement in Patients with Adult-Onset Multiple Acyl-CoA Dehydrogenase Deficiency
Spinal Cord Involvement in Patients with Adult-Onset Multiple Acyl-CoA Dehydrogenase Deficiency
Riboflavin responsive multiple acyl-CoA dehydrogenase deficiency (RR-MADD) is an inherited metabolic disorder which is goo...
Myelin Lipid Reserves as a Conditional Metabolic Buffer: Implications for Alzheimer’s Disease and Ischemic Stroke
Myelin Lipid Reserves as a Conditional Metabolic Buffer: Implications for Alzheimer’s Disease and Ischemic Stroke
Brain energetics rely on a distributed partnership among cell types and fuel sources. Beyond astrocytic glycogen, the brai...
Neuronal Subtype-Specific Expression of γ-Enolase: Its Role in Neuronal Differentiation
Neuronal Subtype-Specific Expression of γ-Enolase: Its Role in Neuronal Differentiation
Neuronal differentiation into specific subtypes is crucial for nervous system development and function, guided by neurotro...
Phloretin as a Multitarget Neuroprotective Agent: Mechanistic Insights into the Modulation of Oxidative Stress, Inflammation, and Apoptosis
Phloretin as a Multitarget Neuroprotective Agent: Mechanistic Insights into the Modulation of Oxidative Stress, Inflammation, and Apoptosis
Neurodegenerative diseases impose a substantial and growing global burden, affecting millions worldwide and leading to hig...
Simvastatin Ameliorates Lipid Metabolism-Mediated Endothelial Inflammation and Tight Junction Impairment in Chronic Cerebral Hypoperfusion
Simvastatin Ameliorates Lipid Metabolism-Mediated Endothelial Inflammation and Tight Junction Impairment in Chronic Cerebral Hypoperfusion
Chronic cerebral hypoperfusion (CCH) is a key pathological hallmark observable in multiple subtypes of cerebral small vess...
Searching for New Possible Peripheral Biomarkers of Cognitive Decline in Down Syndrome: The Role of IL-18 Pathway and its Interaction with TGF-β1 and TNF-α
Searching for New Possible Peripheral Biomarkers of Cognitive Decline in Down Syndrome: The Role of IL-18 Pathway and its Interaction with TGF-β1 and TNF-α
Down syndrome (DS) represents one of the most common genetic disorders attributable to a partial or complete trisomy of ch...
Pterostilbene Orchestrates Synaptic Remodeling and Mitochondrial Functional Reconstitution to Attenuate Ischemic Vascular Dementia
Pterostilbene Orchestrates Synaptic Remodeling and Mitochondrial Functional Reconstitution to Attenuate Ischemic Vascular Dementia
Vascular dementia (VaD), a major contributor to cognitive decline, arises primarily from impaired regulation of cerebral c...
Montelukast Modulates MPTP-induced Ferroptosis and Neuroinflammation Linked To the GPX4/ACSL4/5-LOX Pathway
Montelukast Modulates MPTP-induced Ferroptosis and Neuroinflammation Linked To the GPX4/ACSL4/5-LOX Pathway
Ferroptosis, an iron-dependent form of regulated cell death, has been increasingly linked to neurodegeneration in Parkinso...
Early-Age Cuprizone Exposure Induces Region-Specific Demyelination and Neuroinflammation in Mice
Early-Age Cuprizone Exposure Induces Region-Specific Demyelination and Neuroinflammation in Mice
Myelin, essential for rapid nerve conduction and axonal integrity in the central and peripheral nervous systems, is compro...
Miro1 in Parkinson’s Disease: A Key Regulator of Mitochondrial Homeostasis and Neurodegeneration
Miro1 in Parkinson’s Disease: A Key Regulator of Mitochondrial Homeostasis and Neurodegeneration
Parkinson’s disease (PD), is slowly advancing disease condition of the nervous system, which leads to interruption o...
Unlocking Alzheimer’s Disease: The Role of BDNF Signaling in Neuropathology and Treatment
Unlocking Alzheimer’s Disease: The Role of BDNF Signaling in Neuropathology and Treatment
Alzheimer’s disease (AD) remains one of the most debilitating neurodegenerative disorders, with its pathological hal...
Hydro-Alcoholic Extract of Ameliorates Malathion-Induced Neurocognitive Behavior and Neurotoxicity
Hydro-Alcoholic Extract of Ameliorates Malathion-Induced Neurocognitive Behavior and Neurotoxicity
Organophosphate insecticides like malathion, though less toxic than other compounds in the same class, remain a significan...
Exploring Proteomic Alterations in Intellectual Disability: Insights from Hyperlipidemia and Hyperphosphatasia Subgroups
Exploring Proteomic Alterations in Intellectual Disability: Insights from Hyperlipidemia and Hyperphosphatasia Subgroups
A significant increase of neurodevelopment disorders (NDDs) among children presents growing healthcare challenge worldwide...
Improvement of Parkinson’s Disease Symptoms by Butylphthalide Through Modulation of Microglial Activation
Improvement of Parkinson’s Disease Symptoms by Butylphthalide Through Modulation of Microglial Activation
Microglia-mediated neuroinflammation plays an important role in the pathogenesis of Parkinson’s disease (PD). Studie...
Molecular Determinants of A9 Dopaminergic Neurons
Molecular Determinants of A9 Dopaminergic Neurons
In the human brain, the nigrostriatal pathway regulates motor functions, and its selective deterioration leads to the onse...
Protective Effect of the LRRK2 Kinase Inhibition in Human Fibroblasts Bearing the Genetic Variant GBA1 K198E: Implications for Parkinson’s Disease
Protective Effect of the LRRK2 Kinase Inhibition in Human Fibroblasts Bearing the Genetic Variant GBA1 K198E: Implications for Parkinson’s Disease
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder for which there are currently no cura...
Deregulation of Neuroinflammatory and Neurotrophic Factors as Biological Events Triggered by D-Galactose Chronic Administration in Wistar Rats
Deregulation of Neuroinflammatory and Neurotrophic Factors as Biological Events Triggered by D-Galactose Chronic Administration in Wistar Rats
The chronic administration of D-galactose (D-gal) is widely used to model brain senescence in rodents. However, the effect...
Tau from SPAM Transgenic Mice Exhibit Potent Strain-Specific Prion-Like Seeding Properties Characteristic of Human Neurodegenerative Diseases
Tau from SPAM Transgenic Mice Exhibit Potent Strain-Specific Prion-Like Seeding Properties Characteristic of Human Neurodegenerative Diseases
Tauopathies, including Alzheimer’s disease and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FT...
Memory-Enhancing Effects of Dauricine in Mice: Possible Molecular Interventions Through In Vivo and In Silico Studies
Memory-Enhancing Effects of Dauricine in Mice: Possible Molecular Interventions Through In Vivo and In Silico Studies
The bisbenzylisoquinoline alkaloid dauricine (DAU) is known for its neuroprotective effects in animals. This study investi...
Altered Microglial Plasticity in the Periaqueductal Grey of Pre-Symptomatic -Heterozygous Mice Following Early-Life Stress
Altered Microglial Plasticity in the Periaqueductal Grey of Pre-Symptomatic -Heterozygous Mice Following Early-Life Stress
Rett syndrome (RTT), a severe neurodevelopmental disorder primarily affecting girls, is commonly caused by MECP2 loss-of-f...
Xanthoxylin Regulating the Inflammatory Microenvironment After Spinal Cord Injury Through Inhibition of the NF-κB Signaling Pathway
Xanthoxylin Regulating the Inflammatory Microenvironment After Spinal Cord Injury Through Inhibition of the NF-κB Signaling Pathway
Spinal Cord Injury (SCI) is a severe disorder of the central nervous system, typically caused by trauma or disease, which ...
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