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Unlocking Alzheimer’s Disease: The Role of BDNF Signaling in Neuropathology and Treatment
Unlocking Alzheimer’s Disease: The Role of BDNF Signaling in Neuropathology and Treatment
Alzheimer’s disease (AD) remains one of the most debilitating neurodegenerative disorders, with its pathological hal...
Hydro-Alcoholic Extract of Ameliorates Malathion-Induced Neurocognitive Behavior and Neurotoxicity
Hydro-Alcoholic Extract of Ameliorates Malathion-Induced Neurocognitive Behavior and Neurotoxicity
Organophosphate insecticides like malathion, though less toxic than other compounds in the same class, remain a significan...
Exploring Proteomic Alterations in Intellectual Disability: Insights from Hyperlipidemia and Hyperphosphatasia Subgroups
Exploring Proteomic Alterations in Intellectual Disability: Insights from Hyperlipidemia and Hyperphosphatasia Subgroups
A significant increase of neurodevelopment disorders (NDDs) among children presents growing healthcare challenge worldwide...
Improvement of Parkinson’s Disease Symptoms by Butylphthalide Through Modulation of Microglial Activation
Improvement of Parkinson’s Disease Symptoms by Butylphthalide Through Modulation of Microglial Activation
Microglia-mediated neuroinflammation plays an important role in the pathogenesis of Parkinson’s disease (PD). Studie...
Molecular Determinants of A9 Dopaminergic Neurons
Molecular Determinants of A9 Dopaminergic Neurons
In the human brain, the nigrostriatal pathway regulates motor functions, and its selective deterioration leads to the onse...
Protective Effect of the LRRK2 Kinase Inhibition in Human Fibroblasts Bearing the Genetic Variant GBA1 K198E: Implications for Parkinson’s Disease
Protective Effect of the LRRK2 Kinase Inhibition in Human Fibroblasts Bearing the Genetic Variant GBA1 K198E: Implications for Parkinson’s Disease
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder for which there are currently no cura...
Deregulation of Neuroinflammatory and Neurotrophic Factors as Biological Events Triggered by D-Galactose Chronic Administration in Wistar Rats
Deregulation of Neuroinflammatory and Neurotrophic Factors as Biological Events Triggered by D-Galactose Chronic Administration in Wistar Rats
The chronic administration of D-galactose (D-gal) is widely used to model brain senescence in rodents. However, the effect...
Tau from SPAM Transgenic Mice Exhibit Potent Strain-Specific Prion-Like Seeding Properties Characteristic of Human Neurodegenerative Diseases
Tau from SPAM Transgenic Mice Exhibit Potent Strain-Specific Prion-Like Seeding Properties Characteristic of Human Neurodegenerative Diseases
Tauopathies, including Alzheimer’s disease and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FT...
Memory-Enhancing Effects of Dauricine in Mice: Possible Molecular Interventions Through In Vivo and In Silico Studies
Memory-Enhancing Effects of Dauricine in Mice: Possible Molecular Interventions Through In Vivo and In Silico Studies
The bisbenzylisoquinoline alkaloid dauricine (DAU) is known for its neuroprotective effects in animals. This study investi...
Altered Microglial Plasticity in the Periaqueductal Grey of Pre-Symptomatic -Heterozygous Mice Following Early-Life Stress
Altered Microglial Plasticity in the Periaqueductal Grey of Pre-Symptomatic -Heterozygous Mice Following Early-Life Stress
Rett syndrome (RTT), a severe neurodevelopmental disorder primarily affecting girls, is commonly caused by MECP2 loss-of-f...
Xanthoxylin Regulating the Inflammatory Microenvironment After Spinal Cord Injury Through Inhibition of the NF-κB Signaling Pathway
Xanthoxylin Regulating the Inflammatory Microenvironment After Spinal Cord Injury Through Inhibition of the NF-κB Signaling Pathway
Spinal Cord Injury (SCI) is a severe disorder of the central nervous system, typically caused by trauma or disease, which ...
Knockdown of RUNX2 Attenuated A1 Astrocyte Overactivation, Brain Injury, and Cerebral Edema During Ischemic Stroke
Knockdown of RUNX2 Attenuated A1 Astrocyte Overactivation, Brain Injury, and Cerebral Edema During Ischemic Stroke
Although researchers began to unravel the potential significance of Runt-related transcription factor 2 (RUNX2) in some of...
Scopoletin Attenuates Reserpine-Induced Pain-Depression Dyad in Mice via Modulation of Inflammation, Oxidative Stress, and Monoaminergic Pathways
Scopoletin Attenuates Reserpine-Induced Pain-Depression Dyad in Mice via Modulation of Inflammation, Oxidative Stress, and Monoaminergic Pathways
Pain and depression frequently are comorbid and have common mechanisms such as monoamine depletion, inflammation, an...
Dysbiosis and Neurodegeneration in ALS: Unraveling the Gut–Brain Axis
Dysbiosis and Neurodegeneration in ALS: Unraveling the Gut–Brain Axis
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a neurodegenerative disorder marked by t...
Equol as a Multitarget Agent Against Neurodegeneration: Mechanistic Insights into Its Molecular Modulation
Equol as a Multitarget Agent Against Neurodegeneration: Mechanistic Insights into Its Molecular Modulation
Neurodegenerative diseases consist of a group of progressive disorders characterized by the gradual decline in the structu...
Ca-Affinitive and Non-Ca-Affinitive Synaptotagmins in Human Pan-cancer
Ca-Affinitive and Non-Ca-Affinitive Synaptotagmins in Human Pan-cancer
Synaptotagmins (Syts) are a family of crucial Ca2+ sensors for cellular secretions, while half of the Syt isoforms are evo...
Inflammatory Markers and their Relationship with Cognitive Function in Alzheimer’s Disease and Mild Cognitive Impairment. Systematic Review and Meta-Analysis
Inflammatory Markers and their Relationship with Cognitive Function in Alzheimer’s Disease and Mild Cognitive Impairment. Systematic Review and Meta-Analysis
This study estimates the association between blood levels of inflammatory markers and cognitive function in adults with Al...
Exploring Core Genes Involved in Ischemic Stroke and the Therapeutic Potential of Hyperbaric Oxygen: Insights from Transcriptomic Analysis
Exploring Core Genes Involved in Ischemic Stroke and the Therapeutic Potential of Hyperbaric Oxygen: Insights from Transcriptomic Analysis
Ischemic stroke (IS) is a complex neurological disorder caused by reduced cerebral blood flow, typically resulting in tiss...
Platycodin D Attenuates Behavioral Deficits, Amyloid-β Accumulation and Mitochondrial Impairment in AD Models by Inhibiting the cGAS-STING Pathway
Platycodin D Attenuates Behavioral Deficits, Amyloid-β Accumulation and Mitochondrial Impairment in AD Models by Inhibiting the cGAS-STING Pathway
The characteristics of Alzheimer’s disease (AD) include behavioral deficits, amyloid-β (Aβ) accumulation, ...
Phosphocreatine Mitigates Doxorubicin-Induced Neurotoxicity in Rats by Regulating Mitochondrial Function and Apoptosis via the NF-κB/PGC-1α Pathway
Phosphocreatine Mitigates Doxorubicin-Induced Neurotoxicity in Rats by Regulating Mitochondrial Function and Apoptosis via the NF-κB/PGC-1α Pathway
Doxorubicin (DOX) is an effective chemotherapeutic agent, but its clinical utility is limited by its neurotoxic side effec...
Exosomal GDNF from Bone Marrow Mesenchymal Stem Cells Moderates Neuropathic Pain in a Rat Model of Chronic Constriction Injury
Exosomal GDNF from Bone Marrow Mesenchymal Stem Cells Moderates Neuropathic Pain in a Rat Model of Chronic Constriction Injury
Both of exosomes derived from mesenchymal stem cells (MSCs) and glial cell line-derived neurotrophic factor (GDNF) show po...
Neuroprotective Effects of VGLUT1 Inhibition in HT22 Cells Overexpressing VGLUT1 Under Oxygen Glucose Deprivation Conditions
Neuroprotective Effects of VGLUT1 Inhibition in HT22 Cells Overexpressing VGLUT1 Under Oxygen Glucose Deprivation Conditions
Glutamate (Glu) is a major excitatory neurotransmitter in the brain, essential for synaptic plasticity, neuronal activity,...
Dysregulated Purinergic Signalling in Fragile X Syndrome Cortical Astrocytes
Dysregulated Purinergic Signalling in Fragile X Syndrome Cortical Astrocytes
The symptoms of fragile X syndrome (FXS), caused by a single gene mutation to Fmr1, have been increasingly linked to disor...
Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury
Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury
As the primary connection between the eye and brain, the optic nerve plays a pivotal role in visual information transmissi...
The Blood-Cerebrospinal Fluid Barrier Dysfunction in Brain Disorders and Stroke: Why, How, What For?
The Blood-Cerebrospinal Fluid Barrier Dysfunction in Brain Disorders and Stroke: Why, How, What For?
Ischemic stroke (IS) results in the interruption of blood flow to the brain, which can cause significant damage. The patho...
Identification of Disulfidptosis-Related Genes in Ischemic Stroke by Combining Single-Cell Sequencing, Machine Learning Algorithms, and In Vitro Experiments
Identification of Disulfidptosis-Related Genes in Ischemic Stroke by Combining Single-Cell Sequencing, Machine Learning Algorithms, and In Vitro Experiments
Ischemic stroke (IS) is a severe neurological disorder with a pathogenesis that remains incompletely understood. Recently,...
Continuous Theta Burst Stimulation Inhibits Oxidative Stress-Induced Inflammation and Autophagy in Hippocampal Neurons by Activating Glutathione Synthesis Pathway, Improving Cognitive Impairment in Sleep-Deprived Mice
Continuous Theta Burst Stimulation Inhibits Oxidative Stress-Induced Inflammation and Autophagy in Hippocampal Neurons by Activating Glutathione Synthesis Pathway, Improving Cognitive Impairment in Sleep-Deprived Mice
Sleep deprivation (SD) has been reported to have a negative impact on cognitive function. Continuous theta burst stimulati...
Clinical Implication of Time of Ischaemic Stroke Among Post-Stroke Survivors from Eastern India: A Circadian Perspective
Clinical Implication of Time of Ischaemic Stroke Among Post-Stroke Survivors from Eastern India: A Circadian Perspective
The circadian variation in stroke occurrence is a well-documented phenomenon. However, the circadian effect on stroke outc...
Distinct Hippocampal Expression Profiles of lncRNAs in Obese Type 2 Diabetes Mice Exhibiting Cognitive Impairment
Distinct Hippocampal Expression Profiles of lncRNAs in Obese Type 2 Diabetes Mice Exhibiting Cognitive Impairment
Cognitive dysfunction has been accepted as a possible complication of type 2 diabetes (T2D), but few studies revealed the ...
USP15 as a Potential Therapeutic Target in Cerebral Ischemia: Modulation of Ferroptosis and Cognitive Dysfunction via the Nrf2/GPX4 Axis in Mice
USP15 as a Potential Therapeutic Target in Cerebral Ischemia: Modulation of Ferroptosis and Cognitive Dysfunction via the Nrf2/GPX4 Axis in Mice
This study aimed to investigate the role of ubiquitin-specific peptidase 15 (USP15) in ischemic cognitive dysfunction usin...
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