Altered Microglial Plasticity in the Periaqueductal Grey of Pre-Symptomatic -Heterozygous Mice Following Early-Life Stress

Abellán-Álvaro, M., Stork, O., Agustín-Pavón, C., & Santos, M. (2021). MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice. Journal of Neurodevelopmental Disorders. https://doi.org/10.1186/s11689-021-09409-7

Article  PubMed  PubMed Central  Google Scholar 

Ährlund-richter, S., Harpe, J., Fernandes, G., Lam, R., & Sur, M. (2025). Persistent Disruptions in Prefrontal Connectivity Despite Behavioral Rescue by Environmental Enrichment in a Mouse Model of Rett Syndrome. 1–32.

Amir, R. E., Van Den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999). Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl- CpG-binding protein 2. Nature Genetics. https://doi.org/10.1038/13810

Article  PubMed  Google Scholar 

Arganda-Carreras, I., Fernández-González, R., Muñoz-Barrutia, A., & Ortiz-De-Solorzano, C. (2010). 3D reconstruction of histological sections: Application to mammary gland tissue. Microscopy Research and Technique. https://doi.org/10.1002/jemt.20829

Article  PubMed  Google Scholar 

Barnes, K. V., Coughlin, F. R., O’Leary, H. M., Bruck, N., Bazin, G. A., Beinecke, E. B., Walco, A. C., Cantwell, N. G., & Kaufmann, W. E. (2015). Anxiety-like behavior in Rett syndrome: Characteristics and assessment by anxiety scales. Journal of Neurodevelopmental Disorders. https://doi.org/10.1186/s11689-015-9127-4

Article  PubMed  PubMed Central  Google Scholar 

Barney, C. C., Feyma, T., Beisang, A., & Symons, F. J. (2015). Pain experience and expression in Rett syndrome: subjective and objective measurement approaches. Journal of Developmental and Physical Disabilities. https://doi.org/10.1007/s10882-015-9427-3

Article  PubMed  PubMed Central  Google Scholar 

Belichenko, N. P., Belichenko, P. V., Hong, H. L., Mobley, W. C., & Francke, U. (2008). Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome. Journal of Comparative Neurology. https://doi.org/10.1002/cne.21673

Article  PubMed  Google Scholar 

Berton, O., Covington, H. E., Ebner, K., Tsankova, N. M., Carle, T. L., Ulery, P., Bhonsle, A., Barrot, M., Krishnan, V., Singewald, G. M., Singewald, N., Birnbaum, S., Neve, R. L., & Nestler, E. J. (2007). Induction of ΔFosB in the periaqueductal gray by stress promotes active coping responses. Neuron. https://doi.org/10.1016/j.neuron.2007.06.033

Article  PubMed  Google Scholar 

Bolton, J. L., Short, A. K., Othy, S., Kooiker, C. L., Shao, M., Gunn, B. G., Beck, J., Bai, X., Law, S. M., Savage, J. C., Lambert, J. J., Belelli, D., Tremblay, M. È., Cahalan, M. D., & Baram, T. Z. (2022). Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses. Cell Reports. https://doi.org/10.1016/j.celrep.2022.110600

Article  PubMed  Google Scholar 

Catale, C., Gironda, S., Iacono, L. . Lo., & Carola, V. (2020). Microglial function in the effects of early-life stress on brain and behavioral development. Journal of Clinical Medicine. https://doi.org/10.3390/jcm9020468

Article  PubMed  PubMed Central  Google Scholar 

Cosentino, L., Witt, S. H., Dukal, H., Zidda, F., Siehl, S., Flor, H., & De Filippis, B. (2023). Methyl-CpG binding protein 2 expression is associated with symptom severity in patients with PTSD in a sex-dependent manner. Translational Psychiatry. https://doi.org/10.1038/s41398-023-02529-9

Article  PubMed  PubMed Central  Google Scholar 

Coulombe, M. A., Erpelding, N., Kucyi, A., & Davis, K. D. (2016). Intrinsic functional connectivity of periaqueductal gray subregions in humans. Human Brain Mapping. https://doi.org/10.1002/hbm.23117

Article  PubMed  PubMed Central  Google Scholar 

Cronk, J. C., Derecki, N. C., Ji, E., Xu, Y., Lampano, A. E., Smirnov, I., Baker, W., Norris, G. T., Marin, I., Coddington, N., Wolf, Y., Turner, S. D., Aderem, A., Klibanov, A. L., Harris, T. H., Jung, S., Litvak, V., & Kipnis, J. (2015). Methyl-CpG binding protein 2 regulates microglia and macrophage gene expression in response to inflammatory stimuli. Immunity. https://doi.org/10.1016/j.immuni.2015.03.013

Article  PubMed  PubMed Central  Google Scholar 

Cuitavi, J., Martínez-Rodríguez, E., Abellán-Álvaro, M., García-Arencibia, M., Santos, M., Hipólito, L., Forte, A., Agustín-Pavón, C., & Torres-Pérez, J. V. (2025). Longitudinal Analysis in Mecp2-het Female Mice Reveals Atypical Nociceptive Behaviours. https://doi.org/10.21203/rs.3.rs-5804567/v1

Dayananda, K. K., Ahmed, S., Wang, D., Polis, B., Islam, R., & Kaffman, A. (2023). Early life stress impairs synaptic pruning in the developing hippocampus. Brain, Behavior, and Immunity,. https://doi.org/10.1016/j.bbi.2022.09.014

Article  PubMed  Google Scholar 

Deng, J. V., Rodriguiz, R. M., Hutchinson, A. N., Kim, I. H., Wetsel, W. C., & West, A. E. (2010). MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. Nature Neuroscience. https://doi.org/10.1038/nn.2614

Article  PubMed  PubMed Central  Google Scholar 

Derecki, N. C., Cronk, J. C., Lu, Z., Xu, E., Abbott, S. B. G., Guyenet, P. G., & Kipnis, J. (2012). Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature, 484(7392), 105–109. https://doi.org/10.1038/nature10907

Article  CAS  PubMed  PubMed Central  Google Scholar 

Downs, J., Géranton, S. M., Bebbington, A., Jacoby, P., Bahi-Buisson, N., Ravine, D., & Leonard, H. (2010). Linking MECP2 and pain sensitivity: The example of Rett syndrome. American Journal of Medical Genetics, Part A, 152(5), 1197–1205. https://doi.org/10.1002/ajmg.a.33314

Article  Google Scholar 

Doyle, H. H., Eidson, L. N., Sinkiewicz, D. M., & Murphy, A. Z. (2017). Sex differences in microglia activity within the periaqueductal gray of the rat: A potential mechanism driving the dimorphic effects of morphine. Journal of Neuroscience, 37(12), 3202–3214. https://doi.org/10.1523/JNEUROSCI.2906-16.2017

Article  CAS  PubMed  Google Scholar 

Glaze, D. G. (2005). Neurophysiology of Rett syndrome. Journal of Child Neurology. https://doi.org/10.1177/08830738050200090801

Article  PubMed  Google Scholar 

Guy, J., Hendrich, B., Holmes, M., Martin, J. E., & Bird, A. (2001). A mouse Mecp2-null mutation causes neurological symptoms that mimic rett syndrome. Nature Genetics. https://doi.org/10.1038/85899

Article  PubMed  Google Scholar 

Harry, G. J., & Kraft, A. D. (2008). Neuroinflammation and microglia: Considerations and approaches for neurotoxicity assessment. Expert Opinion on Drug Metabolism and Toxicology. https://doi.org/10.1517/17425255.4.10.1265

Article  PubMed  Google Scholar 

Ho, Y. C., Lin, T. Bin., Hsieh, M. C., Lai, C. Y., Chou, D., Chau, Y. P., Chen, G. Den., & Peng, H. Y. (2018). Periaqueductal gray glutamatergic transmission governs chronic stress-induced depression. Neuropsychopharmacology. https://doi.org/10.1038/npp.2017.199

Article  PubMed  Google Scholar 

Imai, Y., Ibata, I., Ito, D., Ohsawa, K., & Kohsaka, S. (1996). A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochemical and Biophysical Research Communications. https://doi.org/10.1006/bbrc.1996.1112

Article  PubMed  Google Scholar 

Imbe, H., & Ihara, H. (2023). Mu opioid receptor expressing neurons in the rostral ventromedial medulla are the source of mechanical hypersensitivity induced by repeated restraint stress. Brain Research. https://doi.org/10.1016/j.brainres.2023.148465

Article  PubMed  Google Scholar 

Irfan, J., Febrianto, M. R., Sharma, A., Rose, T., Mahmudzade, Y., Di Giovanni, S., Nagy, I., & Torres-Perez, J. V. (2022). DNA Methylation and non-coding RNAs during tissue-injury associated pain. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms23020752

Article  PubMed  PubMed Central  Google Scholar 

Ishiyama, M., Tamura, S., Ito, H., Takei, H., Hoshi, M., Asano, M., Itoh, M., & Shirakawa, T. (2019). Early postnatal treatment with valproate induces gad1 promoter remodeling in the brain and reduces apnea episodes in mecp2-null mice. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20205177

Article  PubMed  PubMed Central  Google Scholar 

Ito, D., Imai, Y., Ohsawa, K., Nakajima, K., Fukuuchi, Y., & Kohsaka, S. (1998). Microglia-specific localisation of a novel calcium binding protein, Iba1. Molecular Brain Research. https://doi.org/10.1016/S0169-328X(98)00040-0

Article  PubMed  Google Scholar 

Johnston, M. V., Jeon, O. H., Pevsner, J., Blue, M. E., & Naidu, S. B. (2001). Neurobiology of Rett syndrome: a genetic disorder of synapse development. Brain and Development. https://doi.org/10.1016/S0387-7604(01)00351-5

Article  PubMed  Google Scholar 

La-Vu, M. Q., Sethi, E., Maesta-Pereira, S., Schuette, P. J., Tobias, B. C., Reis, F. M. C. V., Wang, W., Torossian, A., Bishop, A., Leonard, S. J., Lin, L., Cahill, C. M., & Adhikari, A. (2022). Sparse genetically defined neurons refine the canonical role of periaqueductal gray columnar organization. ELife. https://doi.org/10.7554/eLife.77115

Article  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif